DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ca-alpha1T and CATSPER4

DIOPT Version :9

Sequence 1:	NP_001259267.1	Gene:	Ca-alpha1T / 31550	FlyBaseID:	FBgn0264386	Length:	3218	Species:	Drosophila melanogaster
Sequence 2:	NP_937770.1	Gene:	CATSPER4 / 378807	HGNCID:	23220	Length:	472	Species:	Homo sapiens

Alignment Length:	332	Identity:	79/332 - (23%)
Similarity:	139/332 - (41%)	Gaps:	49/332 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly  2482 TRMFVHNVVTSKYFDLAIAAVIGLNVVTMAMEYYKMPSGLKYALKIFNYFFTAV--FILEANMKL 2544
            |.|::..::....|.|.:|.::.:|.:|:|:..........|.|      |:.:  .:|...:..
Human    81 THMYIKQLLRHPAFQLLLALLLVINAITIALRTNSYLDQKHYEL------FSTIDDIVLTILLCE 139

  Fly  2545 VALGWK----LYLKDRWNQLDVGIVLLSIVGIVLEELETNTHQIIPINPTIIRVMRVLRIARVLK 2605
            |.|||.    ::.||.||.|:..||.:.::...:.|:..         |:|...:|.||:..|..
Human   140 VLLGWLNGFWIFWKDGWNILNFIIVFILLLRFFINEINI---------PSINYTLRALRLVHVCM 195

  Fly  2606 LLK-MANGIRALLDTVMQALPQVGNLGLLFFLLFFIFAALGVELFGRLECSDEIPCQGLGEHAHF 2669
            .:: :|..||.:|    |::|.:.|:.:|......:|:..||.|||..     :|       .||
Human   196 AVEPLARIIRVIL----QSVPDMANIMVLILFFMLVFSVFGVTLFGAF-----VP-------KHF 244

  Fly  2670 ANFGMAFLTLFRVATGDNWNGIMKDTLRDNCDDAADCVRNCCVSSVIAPIFFVIFVLMAQFVLVN 2734
            .|..:|..|||...|.|.|..|..|...:..:.|.:         :...|:|.||:.:..|:.:|
Human   245 QNIQVALYTLFICITQDGWVDIYSDFQTEKREYAME---------IGGAIYFTIFITIGAFIGIN 300

  Fly  2735 VVVAVLMKHLEESHKQMEDELDMEVELERELVREQEFAQEQKLCQQLAEAQSKAAAPPRPLA--K 2797
            :.|.|:..:||:..|..|......:........|:|...:..|...:.....|:.....|||  .
Human   301 LFVIVVTTNLEQMMKAGEQGQQQRITFSETGAEEEEENDQLPLVHCVVARSEKSGLLQEPLAGGP 365

  Fly  2798 VKSLPKN 2804
            :.:|.:|
Human   366 LSNLSEN 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ca-alpha1T	NP_001259267.1	Ion_trans	332..636	CDD:278921
		Ion_trans	1261..1495	CDD:278921
		Ion_trans	2192..2448	CDD:278921
		Ion_trans	2510..2728	CDD:278921	55/224 (25%)
CATSPER4	NP_937770.1	Ion_trans	91..313	CDD:306908	66/261 (25%)
CATSPER4	NP_937770.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	416..438
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810