DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ca-alpha1T and CATSPER3

DIOPT Version :9

Sequence 1:	NP_001259267.1	Gene:	Ca-alpha1T / 31550	FlyBaseID:	FBgn0264386	Length:	3218	Species:	Drosophila melanogaster
Sequence 2:	NP_821138.1	Gene:	CATSPER3 / 347732	HGNCID:	20819	Length:	398	Species:	Homo sapiens

Alignment Length:	368	Identity:	103/368 - (27%)
Similarity:	171/368 - (46%)	Gaps:	60/368 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly  2465 KKRRRMHEPPYYTNYSPTRMFVHNVVTSKYFDLAIAAVIGLNVVTMAM-EYYKMPSGLKYALKIF 2528
            ||.:|        |....|.||..|:.|::|.:.:.:.:..|...||: ..|.:...|...|:..
Human    30 KKFKR--------NDDECRAFVKRVIMSRFFKIIMISTVTSNAFFMALWTSYDIRYRLFRLLEFS 86

  Fly  2529 NYFFTAVFILEANMKLVALGWKLYLKDRWNQLDVGIVLLSIVGIVLEELETNTHQIIPINPTIIR 2593
            ..||.::...|.:|| |.:....|.|:.:|.|||.|:::..:...|.:|.....       |.:.
Human    87 EIFFVSICTSELSMK-VYVDPINYWKNGYNLLDVIIIIVMFLPYALRQLMGKQF-------TYLY 143

  Fly  2594 VMRVLRIARVLKLLKMANGIRALLDTVMQALPQVGNLGLLFFLLFFIFAALGVELFGRLECSDEI 2658
            :...::..|:|||:..:.|||.|:..|.|.:..|.::.||.|||.:|||.||..|||..:
Human   144 IADGMQSLRILKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLFGSPD----- 203

  Fly  2659 PCQGLGEHAHFANFGMAFLTLFRVATGDNWNGIMKDTLRDNCDDAADCVRNCCVSSVIAPIFFVI 2723
                .|:|.::.|...||.|||.:||.|.|..:.|..  ||.:.|            ::..|.:|
Human   204 ----NGDHDNWGNLAAAFFTLFSLATVDGWTDLQKQL--DNREFA------------LSRAFTII 250

  Fly  2724 FVLMAQFVLVNVVVAVLMKHLEESHKQMEDELDMEVEL----ERELV--REQE------FAQEQK 2776
            |:|:|.|:.:|:.|.|::.|.|:|.::.|.||.:|.:.    |::::  |:||      ..|:..
Human   251 FILLASFIFLNMFVGVMIMHTEDSIRKFERELMLEQQEMLMGEKQVILQRQQEEISRLMHIQKNA 315

  Fly  2777 LC---QQLAEAQSKAAAPPRPLAKVKSLPKNFIYSTPSLDKKF 2816
            .|   .:|.|...|..:...|:     :..:|..|.|.:|..|
Human   316 DCTSFSELVENFKKTLSHTDPM-----VLDDFGTSLPFIDIYF 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ca-alpha1T	NP_001259267.1	Ion_trans	332..636	CDD:278921
		Ion_trans	1261..1495	CDD:278921
		Ion_trans	2192..2448	CDD:278921
		Ion_trans	2510..2728	CDD:278921	65/218 (30%)
CATSPER3	NP_821138.1	Ion_trans	72..269	CDD:278921	68/227 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810