DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1T and Nalcn

DIOPT Version :9

Sequence 1:NP_001259267.1 Gene:Ca-alpha1T / 31550 FlyBaseID:FBgn0264386 Length:3218 Species:Drosophila melanogaster
Sequence 2:XP_036014574.1 Gene:Nalcn / 338370 MGIID:2444306 Length:1787 Species:Mus musculus


Alignment Length:2075 Identity:389/2075 - (18%)
Similarity:723/2075 - (34%) Gaps:677/2075 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly  1228 RVCSWIRRYIRRLVEHKYFQQGILLAILINTLSMGIEYHNQPPELTAIVETSNVVFSGIFAVEML 1292
            |:|:.|.                ::::.:|| .|..|::   |.|..:..|.:.:...::..||:
Mouse    59 RICAIIS----------------VISVCMNT-PMTFEHY---PPLQYVTFTLDTLLMFLYTAEMI 103

  Fly  1293 LKV----VAEGPFRYIANGFNVFDGIIV-------ILSAIEICQTFMGNGTGGGGSGLSVLRTFR 1346
            .|:    :.:|...|:.:.:.||||.:|       :|...||..........|   .|.:.|...
Mouse   104 AKMHIRGIVKGDSSYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWG---MLRIPRPLI 165

  Fly  1347 LLRILKL-VRFMPNLRRQLFVMLRTMDNVAVFFSLLVLFIFIFSILGMYLFG------------- 1397
            ::|..:: .||.....|...::.|:.:.:......|:.|:.::.|||:.:||             
Mouse   166 MIRAFRIYFRFELPRTRITNILKRSGEQIWSVSIFLLFFLLLYGILGVQMFGTFTYHCVVNDTKP 230

  Fly  1398 ---------------------------GKFCKFLDESGLERECTCPEIISRHPQCECDRKHFNNI 1435
                                       |..|..|::.||.|:             |.....||.|
Mouse   231 GNVTWNSLAIPDTHCSPELEEGYQCPPGFKCMDLEDLGLSRQ-------------ELGYSGFNEI 282

  Fly  1436 LWATVTVFQILTQEDWNVVLFNGMEKTSHWAA-LYFVALMTFGNYVLFNLLVAILVEGFSSERNE 1499
            ..:..||::..:||.|..:::..::....|.: .||:.|:.|..:::.|:.:|:::|.|:..|.:
Mouse   283 GTSIFTVYEASSQEGWVFLMYRAIDSFPRWRSYFYFITLIFFLAWLVKNVFIAVIIETFAEIRVQ 347

  Fly  1500 RREREQRELVKKLREETLAENYSDGMYDESRSEADSSTTNDSYYEVRNRWR-SAEDVRKLQD--- 1560
            .::                      |:....|...::||...:.:....|: .|.||.|.|.   
Mouse   348 FQQ----------------------MWGTRSSTTSTATTQMFHEDAAGGWQLVAVDVNKPQGRAP 390

  Fly  1561 --------------------SVELIIEAKSNMHRQRLLQPTHDYQINELPASSAAPSASGTSGAS 1605
                                :|::|:.|.:....:...:...::.:.|:..:...          
Mouse   391 ACLQKMMRSSVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEFYLAEVAFTVLF---------- 445

  Fly  1606 APGDRERDRDRDRDRERDRDRDRERDREAGGGGKEEGAQHAKPRGGLKKTYSIKERRSEAPRLSK 1670
                                     |.||                 |.|.:.:......:..|.|
Mouse   446 -------------------------DLEA-----------------LLKIWCLGFTGYISSSLHK 468

  Fly  1671 IRLARDPPIITTTAATPQDSPSTTLEPGMSFRQWGDMEPPSPPSPSLLRPPNIFTGGQRSLDEGI 1735
            ..|..   :|.||                                 |...|::: ..|.:..:.:
Mouse   469 FELLL---VIGTT---------------------------------LHVYPDLY-HSQFTYFQVL 496

  Fly  1736 PSIDLIPPSPVLSHKPLNILNASQLGVGMGGGVPSTAGSSSSMHSV------IIDDISKSSSSTA 1794
            ..:.||..||.|......|...   |..:|..|..||.....|.::      .::::.:.::...
Mouse   497 RVVRLIKISPALEDFVYKIFGP---GKKLGSLVVFTASLLIVMSAISLQMFCFVEELDRFTTFPR 558

  Fly  1795 AATPIY-VPTISSTADAQSQSHSLNDVSVGSSPGGEIP-------AT------------------ 1833
            |...:: :.|.....|...|  :||.|....:|...|.       ||                  
Mouse   559 AFMSMFQILTQEGWVDVMDQ--TLNAVGHMWAPLVAIYFILYHLFATLILLSLFVAVILDNLELD 621

  Fly  1834 -GMSRNANTGASTSGSSSSERLPLAPPPQQGSFKQRLRRGSSKKRRASALALA--TDDNPARRTL 1895
             .:.:......|.:.:.:.|:|||           |||.......|...:.::  ..|....:..
Mouse   622 EDLKKLKQLKQSEANADTKEKLPL-----------RLRIFEKFPNRPQMVKISKLPSDFTVPKIR 675

  Fly  1896 DNQARRTQDEEEEQQQLNNGGDNSCLLR----NSNAVVSGSSSGTKETNRLSPQN------SIRR 1950
            ::..::..|.:::        |..||.|    .|::........|.|.|:...|.      || |
Mouse   676 ESFMKQFIDRQQQ--------DTCCLFRILPSTSSSSCDNPKKPTAEDNKYIDQKLRKSVFSI-R 731

  Fly  1951 LSNTLSIGSGPVGSRRASACIFNSQVYQNL------NQPPKLRPGSGQRRMSSIELAFSKTSHLN 2009
            ..|.|.       ...|...|..:...|.:      .||.|      :|.:.|::          
Mouse   732 ARNLLE-------KETAVTKILRACTRQRMLSGSFEGQPAK------ERSILSVQ---------- 773

  Fly  2010 LHNLEANRKSLSYTNSKMDLDKWNKSYGNLNEPDNMLQQYMEARDKRKNSISHYNLKKRLEEKEL 2074
             |::...|:||.:.::...:.: .||...|.:..:...:|..|                      
Mouse   774 -HHIRQERRSLRHGSNSQRISR-GKSLETLTQDHSNTVRYRNA---------------------- 814

  Fly  2075 QQLQQLHQQQLLQQRQDSFSSTTQQQQQQLQQHRLSKDQQQLAMQPHSMVPGGGERYSKLKMLIE 2139
                         ||:||.....|::::|.:..|                          |:..|
Mouse   815 -------------QREDSEIKMIQEKKEQAEMKR--------------------------KVQEE 840

  Fly  2140 QLTPKH--FTTEREDYSLYIFPEDNRFRQICTWFVNQK--------------------------- 2175
            :|...|  |     |..|:|...::|||..|...|..:                           
Mouse   841 ELRENHPYF-----DKPLFIVGREHRFRNFCRVVVRARFNASKTDPVTGAVKNTKYHQLYDLLGL 900

  Fly  2176 --WFDNVVLLFIALNCITLAMERP--NIPPSSTERLFLATANYVFTVVFTVEMFIKVVATGMFYG 2236
              :.|.|::.....:||::..|.|  .:..:.|    |..|.|||.:..::|:.:|::|.|:|:.
Mouse   901 VTYLDWVMITVTICSCISMMFESPFRRVMHAPT----LQIAEYVFVIFMSIELNLKIMADGLFFT 961

  Fly  2237 HDAYFTSGWNIMDGSLVTISIIDLLMSLISESSPRIFGILRVFRLLRSLRPLRVINRAPGLKLVV 2301
            ..|.......:||..:..:|:|  .:..:.::.|...| .::..:||.|||||:....|.::.||
Mouse   962 PTAVIRDFGGVMDIFIYLVSLI--FLCWMPQNVPAESG-AQLLMVLRCLRPLRIFKLVPQMRKVV 1023

  Fly  2302 QTLLSSLRPIGNIVLICCTFFIIFGILGVQLFKGTFYYCEGENIKGVRNADECRRI--------- 2357
            :.|.|..:.|..:.::..|..::|...|||||.|....|...||  :|..| |..|         
Mouse  1024 RELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAKCNDPNI--IRRED-CNGIFRINVSVSK 1085

  Fly  2358 ------------PG----NVWTN-RKYNFDDLGKALMSLFVLSSRDGWVNIMYTGLDAVGVDQQP 2405
                        ||    .||.| |.:|||::|.|:::||.:.|..|||.:....:..||    |
Mouse  1086 NLNLKLRPGEKKPGFWVPRVWANPRNFNFDNVGNAMLALFEVLSLKGWVEVRDVIIHRVG----P 1146

  Fly  2406 IVNYNEWRLLYFIAFILLVGFFVLNMFVGVVVENFHRCR------EEQEKEEKIRRAAKRALQME 2464
            |..      :|...|:.|.....|.:|||||:.||:..:      .:|.:.|.::...|.|    
Mouse  1147 IHG------IYIHVFVFLGCMIGLTLFVGVVIANFNENKGTALLTVDQRRWEDLKSRLKIA---- 1201

  Fly  2465 KKRRRMHEPPYYTNYSPTRMFVHNVVTSKYFDLAIAAVIGLNVVTMAMEYYKMPSGLKYALKIFN 2529
               :.:|.||...| ...|..::::....:|...||.::....|.:::: :.:...:...|...:
Mouse  1202 ---QPLHLPPRPDN-DGFRAKMYDITQHPFFKRTIALLVLAQSVLLSVK-WDVDDPVTVPLATMS 1261

  Fly  2530 YFFTAVFILEANMKLVALGWKLYLKDRWNQLDVGIVLLSIVGIVLEELETNTHQIIPINPTIIRV 2594
            ..||.:|:||..||::|:....:.:.|.|:.|:.:..|.:|.:||.....|.:..: :...:| |
Mouse  1262 VVFTFIFVLEVTMKIIAMSPAGFWQSRRNRYDLLVTSLGVVWVVLHFALLNAYTYM-MGACVI-V 1324

  Fly  2595 MRVLRIARVLKLLKMANGIRALLDTVMQALPQVGNLGLLFFLLFFIFAALGVELFGRLECSDEIP 2659
            .|...|......|||      ||.||:.::.:...:.:..|||...:|..||.|||.::..:.| 
Mouse  1325 FRFFSICGKHVTLKM------LLLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLFGTVKYGENI- 1382

  Fly  2660 CQGLGEHAHFANFGMAFLTLFRVATGDNWNGIMKDTLRDN--C--DD----AADCVRNCCVSSVI 2716
                ..||:|::.|.|...|||:.||::||.||.|.:...  |  |:    |.|     |.:...
Mouse  1383 ----NRHANFSSAGKAITVLFRIVTGEDWNKIMHDCMVQPPFCTPDEFTYWATD-----CGNYAG 1438

  Fly  2717 APIFFVIFVLMAQFVLVNVVVAVLMKHLEESHKQMEDEL-------------------------- 2755
            |.::|..|.::..::::|::||:::::....:...||:|                          
Mouse  1439 ALMYFCSFYVIIAYIMLNLLVAIIVENFSLFYSTEEDQLLSYNDLRHFQIIWNMVDDKREGVIPT 1503

  Fly  2756 ------------------------------DME---------------------------VELER 2763
                                          :||                           ::||.
Mouse  1504 FRVKFLLRLLRGRLEVDLDKDKLLFKHMCYEMERLHNGGDVTFHDVLSMLSYRSVDIRKSLQLEE 1568

  Fly  2764 ELVREQ-EFAQEQKLCQQLAEAQSKAAAPPRPLAKVKSLPK---NFIYSTPSLDKKFPAVSGVNN 2824
            .|.||| |:..|:::.:|......|     :.|.::::..:   :.|:|.....::..:...:|.
Mouse  1569 LLAREQLEYTIEEEVAKQTIRMWLK-----KCLKRIRAKQQQSCSIIHSLRESQEQERSRLFLNP 1628

  Fly  2825 PSLTSSAATNLNQVATAGSGGAAPGAVPAGSGAGPRRQTVQYFQQPPQSMLGGLSLAEMGGTLTP 2889
            ||:.::..:.                   .|.|..:..::|......|.:|.. :|::.||:   
Mouse  1629 PSIETTQPSE-------------------DSNANSQDHSMQPETSSQQQLLSP-TLSDRGGS--- 1670

  Fly  2890 QALGARLGEPFGGGGGNKSGPRRQSYWQI---------NPIRKRGVLSKERSLDEQAIRRRNLEA 2945
            :...|..|:|          .|:...|::         .|:.|....|::...:|:.:.:..|..
Mouse  1671 RQDAADTGKP----------QRKIGQWRLPSAAIAEKTAPVNKMSGYSQDPEREEEEVSKGFLAP 1725

  Fly  2946 K----RTSCDSLPWGG---------------DALDC---------RRGTIFESLESDGGG 2977
            |    ..|..:|.:||               |...|         |:.|:    |||..|
Mouse  1726 KPISHSVSSVNLRFGGRTTMKTVVCKMNPMPDTASCGSEVKKWWTRQLTV----ESDESG 1781

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1TNP_001259267.1 Ion_trans 332..636 CDD:278921
Ion_trans 1261..1495 CDD:278921 57/286 (20%)
Ion_trans 2192..2448 CDD:278921 80/289 (28%)
Ion_trans 2510..2728 CDD:278921 61/225 (27%)
NalcnXP_036014574.1 Ion_trans 52..347 CDD:395416 63/323 (20%)
Ion_trans 399..619 CDD:395416 41/313 (13%)
Ion_trans 903..1177 CDD:395416 84/293 (29%)
Ion_trans 1225..1474 CDD:395416 68/267 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.820

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