DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ca-alpha1T and Catsper4

DIOPT Version :9

Sequence 1:	NP_001259267.1	Gene:	Ca-alpha1T / 31550	FlyBaseID:	FBgn0264386	Length:	3218	Species:	Drosophila melanogaster
Sequence 2:	NP_808534.1	Gene:	Catsper4 / 329954	MGIID:	3043288	Length:	442	Species:	Mus musculus

Alignment Length:	326	Identity:	73/326 - (22%)
Similarity:	142/326 - (43%)	Gaps:	58/326 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly  2482 TRMFVHNVVTSKYFDLAIAAVIGLNVVTMAM--------EYYKMPSGLKYALKIFNYFFTAVFIL 2538
            |:|::..::....|.|.:|.::..|.:|:|:        ::|::.|.:       :.....:.|.
Mouse    57 TQMYIKQLLRHPAFQLLLAFLLLSNAITIALRTNSYLGQKHYELFSTI-------DDIVLTILIC 114

  Fly  2539 EANMKLVALGWK----LYLKDRWNQLDVGIVLLSIVGIVLEELETNTHQIIPINPTIIRVMRVLR 2599
            |     |.|||.    ::.||.||.|:..||.:..:|..:::|:            ::.:...||
Mouse   115 E-----VLLGWLNGFWIFWKDGWNILNFAIVFILFMGFFIKQLD------------MVAITYPLR 162

  Fly  2600 IARVLKLLKMANGIRALLDTVMQALPQVGNLGLLFFLLFFIFAALGVELFGRLECSDEIPCQGLG 2664
            :.|::.:......:..::..::|::|.:.|:..|......:|:..||.|||..     :|
Mouse   163 VLRLVHVCMAVEPLARIIKVILQSMPDLANVMALILFFMLVFSVFGVTLFGAF-----VP----- 217

  Fly  2665 EHAHFANFGMAFLTLFRVATGDNWNGIMKDTLRDNCDDAADCVRNCCVSSVIAPIFFVIFVLMAQ 2729
              .||.|.|:|..|||...|.|.|..|..|...|..:.|.:         |...|:|.:|:.:..
Mouse   218 --KHFQNMGVALYTLFICITQDGWLDIYTDFQMDEREYAME---------VGGAIYFAVFITLGA 271

  Fly  2730 FVLVNVVVAVLMKHLEESHKQMEDELDMEVELERELVREQEFAQEQKLCQQLAEAQSKAAAPPRP 2794
            |:.:|:.|.|:..:||:..|..|:|..:.::. .|...::::..|..|.......:..:..|..|
Mouse   272 FIGLNLFVVVVTTNLEQMMKTGEEEGHLNIKF-TETEEDEDWTDELPLVHCTEARKDTSTVPKEP 335

  Fly  2795 L 2795
            |
Mouse   336 L 336

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ca-alpha1T	NP_001259267.1	Ion_trans	332..636	CDD:278921
		Ion_trans	1261..1495	CDD:278921
		Ion_trans	2192..2448	CDD:278921
		Ion_trans	2510..2728	CDD:278921	51/229 (22%)
Catsper4	NP_808534.1	Ion_trans	91..289	CDD:278921	56/242 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810