DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ca-alpha1T and Cacna1g

DIOPT Version :9

Sequence 1:	NP_001259267.1	Gene:	Ca-alpha1T / 31550	FlyBaseID:	FBgn0264386	Length:	3218	Species:	Drosophila melanogaster
Sequence 2:	XP_008766207.2	Gene:	Cacna1g / 29717	RGDID:	68942	Length:	2388	Species:	Rattus norvegicus

Alignment Length:	3238	Identity:	1133/3238 - (34%)
Similarity:	1460/3238 - (45%)	Gaps:	1088/3238 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   213 DAAAATAAGRSR--------SRGGGRTGGAVSSSTGSSCNGSCSSDDGDSSHTSSSSSSSSSGEP 269
            |.|.|..:|:.|        |..|||.|           .||...|.|       |:.|.:.|
  Rat     6 DGAGAEESGQPRSFTQLNDLSGAGGRQG-----------PGSTEKDPG-------SADSEAEG-- 50

  Fly   270 NLPYPGFPEISIRALTQYTRPRNWCLMLITNPWFERVSILVILLNCITLGMYQPCVDDACVTNRC 334
             ||||....:....|:|.:|||:|||..:.||||||||:|||||||:||||::||.|.||.:.||
  Rat    51 -LPYPALAPVVFFYLSQDSRPRSWCLRTVCNPWFERVSMLVILLNCVTLGMFRPCEDIACDSQRC 114

  Fly   335 KILQIFDDIIFAFFALEMTIKMVAMGICGKNTYLADSWNRLDFFIVLAGLLEYVMHVENLNLTAI 399
            :|||.|||.||||||:||.:||||:||.||..||.|:|||||||||:||:|||.:.::|::.:|:
  Rat   115 RILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAV 179

  Fly   400 RTIRVLRPLRAINRIPSMRILVMLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWEGILRQRCSLM 464
            ||:|||||||||||:|||||||.|||||||||||||||||||||||||:|||||.|:||.||.|
  Rat   180 RTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFL- 243

  Fly   465 RTEGMVYPLTVPEVYRVRVRVNSLSQYYEFSKDQD--YICSTPNDSGMHLCGNFPPYR---IGSL 524
             .|....||:|           .|..||:...:.:  :|||.|.::||..|.:.|..|   .|..
  Rat   244 -PENFSLPLSV-----------DLEPYYQTENEDESPFICSQPRENGMRSCRSVPTLRGEGGGGP 296

  Fly   525 VCNEEAKLFDFNEPTNTSCVNWNQYYTTCKQSGENPFQGTISFDNIGMAWVAIFLVISLEGWTDI 589
            .|:.:.:  .:|..:||:|||||||||.|.....|||:|.|:|||||.||:|||.||:||||.||
  Rat   297 PCSLDYE--TYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDI 359

  Fly   590 MYYVQDAHSFWDWIYFVLLIVIGSFFMINLCLVVIATQFSETKKREMERMRQERARYTS-TSTLA 653
            ||:|.|||||:::|||:|||::|||||||||||||||||||||:||.:.||::|.|:.| .||||
  Rat   360 MYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNASTLA 424

  Fly   654 SSTNNSEPATCYAEIVKYIAHLWRRFKRRMLKKYRLYKYQRQQRKEGLLPNADNLTFSPSRIKCH 718
            |.   |||.:||.|::||:.::.|:..||:.:..|....     :.|||
  Rat   425 SF---SEPGSCYEELLKYLVYILRKAARRLAQVSRAIGV-----RAGLL---------------- 465

  Fly   719 HPKCPKYSNRKPSSIQDQMITVMVPLNSASNNINNNNNNNSNSSNHNGSGNHTAAGGGNNNNNNN 783
                                                      ||....||......|
  Rat   466 ------------------------------------------SSPVARSGQEPQPSG-------- 480

  Fly   784 NNNAASCTTVALVNGINGSAASVTMSSAHHQQHQLLQHQQQQHQNQQQQQQQQQHSSSDNTEQSL 848
                 |||            .|....|.||    |:.|....|.:        .|..:....
  Rat   481 -----SCT------------RSHRRLSVHH----LVHHHHHHHHH--------YHLGNGTLR--- 513

  Fly   849 APDGLPRSSSLKKSTAHHQLKPE---GSAAEQKTILLKFPQQMIDSEQLILQLGNLGKSHPCTSG 910
                :||:|            ||   ..|...:.::|..|                  |.|..||
  Rat   514 ----VPRAS------------PEIQDRDANGSRRLMLPPP------------------STPTPSG 544

  Fly   911 FLSPPTSASRRPSVMFNEYVLLHTPPA-LNADPATAGTTTTVAPTVATVAGTAAAAAAAAATGSG 974
              .||..|.   ||....:...|..|. ..|.|..       .|:.|:
  Rat   545 --GPPRGAE---SVHSFYHADCHLEPVRCQAPPPR-------CPSEAS----------------- 580

  Fly   975 SGNNNHQNGGASGGAGTGGTTEKSNIFSTEKMTQAGDGSIWQVNLPQTIGTIANPYADCSELGIH 1039
                              |.|             .|.|.::     .|:.|...|
  Rat   581 ------------------GRT-------------VGSGKVY-----PTVHTSPPP---------- 599

  Fly  1040 DAMTCQELLAFSVAFSAALPTGQSTLESFYTSLARCDPHTAEALRAHHKPRSVPTG--------- 1095
                  |:|........|...|..||.||                      ::|.|
  Rat   600 ------EILKDKALVEVAPSPGPPTLTSF----------------------NIPPGPFSSMHKLL 636

  Fly  1096 QNQTTPGAEGATVMVAS--TAGDTGQTLQPSTVSAVVGGTIDSHAANHRRKEHHQQSHHHHNNNN 1158
            :.|:| ||..::..::|  :..|:|.....|.......|..:..:|:|...:...::
  Rat   637 ETQST-GACHSSCKISSPCSKADSGACGPDSCPYCARTGAGEPESADHVMPDSDSEA-------- 692

  Fly  1159 TTSHSRNYRSRQGQGNSRMREPRAPTGNYMEDYACCYDLYQNALSPLDERPRQRS------PTTR 1217
                  .|...|...:|.:|:|.:                         |.||||      |::
  Rat   693 ------VYEFTQDAQHSDLRDPHS-------------------------RRRQRSLGPDAEPSS- 725

  Fly  1218 CLISVYRCMSRVCSWIRRYIRRLVEHKYFQQGILLAILINTLSMGIEYHNQPPELTAIVETSNVV 1282
             :::.:|.   :|.    ..|::|:.|||.:||::|||:||||||||||.||.|||..:|.||:|
  Rat   726 -VLAFWRL---ICD----TFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIV 782

  Fly  1283 FSGIFAVEMLLKVVAEGPFRYIANGFNVFDGIIVILSAIEICQTFMGNGTGGGGSGLSVLRTFRL 1347
            |:.:||:|||||::..|||.||.|.:|:|||:||::|..||        .|..|.||||||||||
  Rat   783 FTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEI--------VGQQGGGLSVLRTFRL 839

  Fly  1348 LRILKLVRFMPNLRRQLFVMLRTMDNVAVFFSLLVLFIFIFSILGMYLFGGKFCKFLDESGLERE 1412
            :|:||||||:|.|:|||.|:::||||||.|..||:|||||||||||:|||   |||..|...:
  Rat   840 MRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFG---CKFASERDGD-- 899

  Fly  1413 CTCPEIISRHPQCECDRKHFNNILWATVTVFQILTQEDWNVVLFNGMEKTSHWAALYFVALMTFG 1477
             |.|           |||:|:::|||.|||||||||||||.||:|||..||.||||||:||||||
  Rat   900 -TLP-----------DRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFG 952

  Fly  1478 NYVLFNLLVAILVEGFSSERNERREREQREL--VKKLREETLAENYSDGMYDESRSEADSSTTND 1540
            ||||||||||||||||.:|...:||....:|  ::      |..|...|...:|.||.|
  Rat   953 NYVLFNLLVAILVEGFQAEEIGKREDASGQLSCIQ------LPVNSQGGDATKSESEPD------ 1005

  Fly  1541 SYYEVRNRWRSAEDVRKLQDSVELIIEAKSNMHRQRLLQPTHDYQINELPASSAAPSASGTSGAS 1605
             ::                                                   :||..|
  Rat  1006 -FF---------------------------------------------------SPSVDG----- 1013

  Fly  1606 APGDRERDRDRDRDRERDRDRDRERDREAGGGGKEEGAQHAKPRGGLKKTYSIKERRSEAPRLSK 1670
                             |.||.:.....|.|       :||:.|..|.
  Rat  1014 -----------------DGDRKKRLALVALG-------EHAELRKSLL----------------- 1037

  Fly  1671 IRLARDPPIITTTAATPQDSPSTTLEPGMSFRQWGDMEPPSPPSPSLLRPPNIFTGGQRSLDEGI 1735
                  ||:|..|||||...|
  Rat  1038 ------PPLIIHTAATPMSLP-------------------------------------------- 1052

  Fly  1736 PSIDLIPPSPVLSHKPLNILNASQLGVG--MGGGVPSTAGSSSSMHSVIIDDISKSSSSTAAATP 1798
                                .:|..|||  :|.|                   |:.:||:.:|.|
  Rat  1053 --------------------KSSSTGVGEALGSG-------------------SRRTSSSGSAEP 1078

  Fly  1799 -IYVPTISSTADAQSQSHSLNDVSVGSSPGGEIPATGMSRNANTGASTSGSSSSERLPLAPPPQQ 1862
             .....:.|...|:|..||              |.:..|      :.||..||...|..||
  Rat  1079 GAAHHEMKSPPSARSSPHS--------------PWSAAS------SWTSRRSSRNSLGRAP---- 1119

  Fly  1863 GSFKQRLRRGSSKKRRASALALATDDNPARRTLDNQARRTQDEEEEQQQLNNGGDNSCLLRNSNA 1927
             |.|   ||..|.:||:              .|..:.:.:|||||
  Rat  1120 -SLK---RRSPSGERRS--------------LLSGEGQESQDEEE-------------------- 1146

  Fly  1928 VVSGSSSGTKETNRLSPQNSIRRLSNTLSIGSGPVGSRRASACIFNSQVYQNLNQPPKLR-PGSG 1991
                    :.|.:|.||..|..|...:|        .|.|.:         :.:.|..|: ||
  Rat  1147 --------SSEEDRASPAGSDHRHRGSL--------EREAKS---------SFDLPDTLQVPG-- 1184

  Fly  1992 QRRMSSIELAFSKTSHLNLHNLEANRKSLSYTNSKMDLDKWNKSYGNLNEPDNMLQQYMEARDKR 2056
                              ||...:.|.|.|                             |.:|..
  Rat  1185 ------------------LHRTASGRSSAS-----------------------------EHQDCN 1202

  Fly  2057 KNSISHYNLKKRLEEKELQQLQQLHQQQLLQQRQDSFSSTTQQQQQQLQQHRLSKDQQQLAMQPH 2121
            ..|.|. .|.:.|...:.|          |....|:            .:..|||
  Rat  1203 GKSASG-RLARTLRTDDPQ----------LDGDDDN------------DEGNLSK---------- 1234

  Fly  2122 SMVPGGGERYSKLKMLIEQLTPKHFTTEREDYSLYIFPEDNRFRQICTWFVNQKWFDNVVLLFIA 2186
                  |||   ::..:....|. ...||:.:|.||||..:|||.:|...:..|.||:|||:.|.
  Rat  1235 ------GER---IQAWVRSRLPA-CCRERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVLVIIF 1289

  Fly  2187 LNCITLAMERPNIPPSSTERLFLATANYVFTVVFTVEMFIKVVATGMFYGHDAYFTSGWNIMDGS 2251
            |||||:|||||.|.|.|.||:||..:||:||.||..||.:||||.|..:|..||..|.||::||.
  Rat  1290 LNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGL 1354

  Fly  2252 LVTISIIDLLMSLISESSPRIFGILRVFRLLRSLRPLRVINRAPGLKLVVQTLLSSLRPIGNIVL 2316
            ||.||:||:|:|::|:|..:|.|:|||.||||:|||||||:||.||||||:||:|||:||||||:
  Rat  1355 LVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVV 1419

  Fly  2317 ICCTFFIIFGILGVQLFKGTFYYCEGENIKGVRNADECRRIPGNVWTNRKYNFDDLGKALMSLFV 2381
            |||.|||||||||||||||.|:.|:||:.:.:.|..:|...... |...|||||:||:|||||||
  Rat  1420 ICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYR-WVRHKYNFDNLGQALMSLFV 1483

  Fly  2382 LSSRDGWVNIMYTGLDAVGVDQQPIVNYNEWRLLYFIAFILLVGFFVLNMFVGVVVENFHRCREE 2446
            |:|:||||:|||.||||||||||||:|:|.|.|||||:|:|:|.||||||||||||||||:||:.
  Rat  1484 LASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQH 1548

  Fly  2447 QEKEEKIRRAAKRALQMEKKRRRMHE-------------------------PPYYTNYSPTRMFV 2486
            ||:||..||..||..::|||||...:                         .|||::||..|:.|
  Rat  1549 QEEEEARRREEKRLRRLEKKRRSKEKQMADLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLV 1613

  Fly  2487 HNVVTSKYFDLAIAAVIGLNVVTMAMEYYKMPSGLKYALKIFNYFFTAVFILEANMKLVALGWKL 2551
            |::.||.|.||.|..||||||||||||:|:.|..|..||||.||.||.:|:.|:..||||.|::.
  Rat  1614 HHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVFESVFKLVAFGFRR 1678

  Fly  2552 YLKDRWNQLDVGIVLLSIVGIVLEELETNTHQIIPINPTIIRVMRVLRIARVLKLLKMANGIRAL 2616
            :.:|||||||:.||||||:||.|||:|.|..  :||||||||:||||||||||||||||.|:|||
  Rat  1679 FFQDRWNQLDLAIVLLSIMGITLEEIEVNAS--LPINPTIIRIMRVLRIARVLKLLKMAVGMRAL 1741

  Fly  2617 LDTVMQALPQVGNLGLLFFLLFFIFAALGVELFGRLECSDEIPCQGLGEHAHFANFGMAFLTLFR 2681
            ||||||||||||||||||.|||||||||||||||.|||.:..||:|||.||.|.|||||||||||
  Rat  1742 LDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFR 1806

  Fly  2682 VATGDNWNGIMKDTLRDNCDDAADCVRNCCVSSVIAPIFFVIFVLMAQFVLVNVVVAVLMKHLEE 2746
            |:||||||||||||||| ||.     .:.|.::||:||:||.|||.|||||||||:|||||||||
  Rat  1807 VSTGDNWNGIMKDTLRD-CDQ-----ESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEE 1865

  Fly  2747 SHKQMEDELDMEVELERELVREQEFAQEQKLCQQLAEAQSKAAAPPRPLAKVKSLPKNFIYSTPS 2811
            |:|:.::|.::|.|||.|:                   ::.:..|..||            .:|.
  Rat  1866 SNKEAKEEAELEAELELEM-------------------KTLSPQPHSPL------------GSPF 1899

  Fly  2812 LDKKFPAVSGVNNPSLTSSAATNLNQVATAGSG-------------------------------- 2844
            |   :|.|.|||:|......|.:......|.||
  Rat  1900 L---WPGVEGVNSPDSPKPGAPHTTAHIGAASGFSLEHPTDRQLFDTISLLIQGSLEGELKLMDE 1961

  Fly  2845 ----GAAPGAVPAGSGAG------PRRQ------TVQYFQQPPQSM-LGGLSLAEMGGTLTPQAL 2892
                |..|.|.|:....|      |..:      |.:...:|..|: |...||.:...||...||
  Rat  1962 LAGPGGQPSAFPSAPSLGDSDPQIPLAEMEALSLTSEIVSEPSCSLALTDDSLPDDTHTLLLSAL 2026

  Fly  2893 GARLGEPFGGGGGNKSGPRRQSYWQINPIRKRGVLSKERSLDEQAIRRRNLEAKRTSCDSLPWGG 2957
            .:.: .|.........||      .:..:||.||                   .||  .|||  .
  Rat  2027 ESNM-VPHPEEVPVPLGP------DLLTVRKSGV-------------------SRT--HSLP--N 2061

  Fly  2958 DALDCRRGTIFE-SLESDGGGVGGGGSGGGGGGLGGGVSYDLRSVRSADVGHSEMDGDVSLSVVS 3021
            |:..||.|:..| ||...|.|:....||               |:.|.   ||:
  Rat  2062 DSYMCRNGSTAERSLGHRGWGLPKAQSG---------------SILSV---HSQ----------- 2097

  Fly  3022 ALVPSVTTPLPPPLSLP-----IVTPTSTPT----PLQLPMPMPMPMAHPPPRRPFG-------- 3069
               |:.|:.:   |.||     ::.|...||    | :||.|...|:|..|.||...
  Rat  2098 ---PADTSCI---LQLPKDVHYLLQPHGAPTWGAIP-KLPPPGRSPLAQRPLRRQAAIRTDSLDV 2155

  Fly  3070 --------------------------WSQSVDQGCLRSNLLLSVPRSM----------------P 3092
                                      |..|..|...||.:...|.:.:                |
  Rat  2156 QGLGSREDLLSEVSGPSCPLTRSSSFWGGSSIQVQQRSGIQSKVSKHIRLPAPCPGLEPSWAKDP 2220

  Fly  3093 PRSRSG-----------------------STKQLFKQQA-------------LDE---------- 3111
            |.:||.                       |.:.|.|..:             |||
  Rat  2221 PETRSSLELDTELSWISGDLLPSSQEEPLSPRDLKKCYSVETQSCRRRPGSWLDEQRRHSIAVSC 2285

  Fly  3112 -DADMDENSLLLPTAAGG------GSGPGSVAVIASSSLDLPDQSGSSKQILPDIALGVSKSDSS 3169
             |:.........|::.||      ||.|.......|.|:|.|:..||.....|.:.|
  Rat  2286 LDSGSQPRLCPSPSSLGGQPLGGPGSRPKKKLSPPSISIDPPESQGSRPPCSPGVCL-------- 2342

  Fly  3170 DILRIISERRRMDQREQREPE----QDQDNEAEDRDSDYKELLLVKSPQSSMD 3218
                    |||....:.::|.    .|....:.....|...|..:.|..:.||
  Rat  2343 --------RRRAPASDSKDPSVSSPLDSTAASPSPKKDTLSLSGLSSDPTDMD 2387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ca-alpha1T	NP_001259267.1	Ion_trans	332..636	CDD:278921	189/308 (61%)
		Ion_trans	1261..1495	CDD:278921	147/233 (63%)
		Ion_trans	2192..2448	CDD:278921	167/255 (65%)
		Ion_trans	2510..2728	CDD:278921	153/217 (71%)
Cacna1g	XP_008766207.2	Ion_trans	80..406	CDD:395416	213/340 (63%)
		Ion_trans	743..969	CDD:395416	158/250 (63%)
		Ion_trans	1277..1549	CDD:395416	179/272 (66%)
		Ion_trans	1619..1860	CDD:395416	177/248 (71%)
		PHA03307	2119..>2370	CDD:223039	47/267 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	438	1.000	Domainoid score	I538
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1649	1.000	Inparanoid score	I73
OMA	1	1.010	-	-		QHG59758
OrthoDB	1	1.010	-	-		D172471at2759
OrthoFinder	1	1.000	-	-		FOG0001656
OrthoInspector	1	1.000	-	-		otm46010
orthoMCL	1	0.900	-	-		OOG6_102692
Panther	1	1.100	-	-	O	PTHR10037
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1056
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.980