Protein Alignment Ca-alpha1T and Cacna1d

DIOPT Version :10

• Sequence 1: NP_001259267.1
• Gene: Ca-alpha1T / 31550
• FlyBaseID: FBgn0264386
• Length: 3218
• Species: Drosophila melanogaster
• Sequence 2: XP_017455544.1
• Gene: Cacna1d / 29716
• RGDID: 70973
• Length: 2207
• Species: Rattus norvegicus
• Alignment Length: 2743
• Identity: 524/2743 - (19%)
• Similarity: 816/2743 - (29%)
• Gaps: 1374/2743 - (50%)

  Fly   184 RHERRDRRDEQQAARRRTGRR-------------HSGASSLSDAAAATAAGRSRSRGGGRTGGAV 235
            :|:|:.:.|....|....|.|             .|..:.||..||..||.::::       ...
  Rat    11 QHQRQQQEDHANEANYARGTRLPISGEGPTSQPNSSKQTVLSWQAAIDAARQAKA-------AQT 68

  Fly   236 SSSTGSSCNGSCSSDDGDSSHTSSSSSSSSSGEPNLPYPGFPEISIRALTQYTRPRNWCLMLITN 300
            .|::.....||.|.........|....:||:..|           .|||        :||.| .|
  Rat    69 MSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRP-----------ARAL--------FCLSL-NN 113

  Fly   301 P----------W--FERVSILVILLNCITLGMYQPC-VDDACVTNRCKILQIFDDIIFAF---FA 349
            |          |  |:...:|.|..||:.|.:|.|. .||:..||     ...:.:.:||   |.
  Rat   114 PIRRACISIVDWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTN-----HNLEKVEYAFLIIFT 173

  Fly   350 LEMTIKMVAMG-ICGKNTYLADSWNRLDFFIVLAGLLEYVMHVENL-----------------NL 396
            :|..:|::|.| :...|.|:.:.||.|||.||:.||...::  |.|                 ::
  Rat   174 VETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVIL--EQLTKETEGGNHSSGKSGGFDV 236

  Fly   397 TAIRTIRVLRPLRAINRIPSMRILVMLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWEGILRQRC 461
            .|:|..|||||||.::.:||:::::..::..:..|.::.||..||..|:.|||::|:.|.:.:.|
  Rat   237 KALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTC 301

  Fly   462 SLMRTEGMVYPLTVPEVYRVRVRVNSLSQYYEFSKDQDYICSTPNDSGMHLCGNFPPYRIGSLVC 526
                                            |..|.|                        :|.
  Rat   302 --------------------------------FFADSD------------------------IVA 310

  Fly   527 NEEAKLFDFNEPTNTSCVNWNQYYTTCKQSGENPFQGTISFDNIGMAWVAIFLVISLEGWTDIMY 591
            .|:.....|:........|.    |.|:.....|..|..:|||...|.:.:|..|::|||||::|
  Rat   311 EEDPAPCAFSGNGRQCAANG----TECRSGWVGPNGGITNFDNFAFAMLTVFQCITMEGWTDVLY 371

  Fly   592 YVQDAHSF-WDWIYFVLLIVIGSFFMINLCLVVIATQFSETKKREMERMRQERARYTSTSTLASS 655
            :|.||..: |.|:|||.||::||||::||.|.|::.:||  |:||..:.|.:
  Rat   372 WVNDAIGWEWPWVYFVSLIILGSFFVLNLVLGVLSGEFS--KEREKAKARGD------------- 421

  Fly   656 TNNSEPATCYAEIVKYIAHLWRRFKRRMLKKYRLYKYQRQQRKEGLLPNADNLTFSPSRIKCHHP 720
                                        .:|.|    ::||.:|.|
  Rat   422 ----------------------------FQKLR----EKQQLEEDL------------------- 435

  Fly   721 KCPKYSNRKPSSIQDQMITVMVPLNSASNNINNNNNNNSNSSNHNGSGNHTAAGGGNNNNNNNNN 785
                                                                             
  Rat   436 ----------------------------------------------------------------- 435

  Fly   786 NAASCTTVALVNGINGSAASVTMSSAHHQQHQLLQHQQQQHQNQQQQQQQQQHSSSDNTEQSLAP 850
                                                                             
  Rat   436 ----------------------------------------------------------------- 435

  Fly   851 DGLPRSSSLKKSTAHHQLKPEGSAAEQKTILLKFPQQMIDSEQLILQLGNLGKSHPCTSGFLSPP 915
                                                                      .|:|...
  Rat   436 ----------------------------------------------------------KGYLDWI 442

  Fly   916 TSASRRPSVMFNEYVLLHTPPALNADPATAGTTTTVAPTVATVAGTAAAAAAAAATGSGSGNNNH 980
            |.|.                   :.||                                   .|.
  Rat   443 TQAE-------------------DIDP-----------------------------------ENE 453

  Fly   981 QNGGASGGAGTGGTTEKSNIFSTEKMTQAGD-----GSIWQVNLPQTIGTIANPYADC--SELGI 1038
            :.||..|...|...|.::...:||.::..|:     ||:|                 |  ...|
  Rat   454 EEGGEEGKRNTSMPTSETESVNTENVSGEGETQGCCGSLW-----------------CWWKRRG- 500

  Fly  1039 HDAMTCQELLAFSVAFSAALPTGQSTLESFYTSLARCDPHTAEALRAHHKPRSVPTGQNQTTPGA 1103
                              |..||                               |:|..:
  Rat   501 ------------------AAKTG-------------------------------PSGCRR----- 511

  Fly  1104 EGATVMVASTAGDTGQTLQPSTVSAVVGGTIDSHAANHRRKEHHQQSHHHHNNNNTTSHSRNYRS 1168
                         .||.:..|.:                                    ||.:|
  Rat   512 -------------WGQAISKSKL------------------------------------SRRWR- 526

  Fly  1169 RQGQGNSRMREPRAPTGNYMEDYACCYDLYQNALSPLDERPRQRSPTTRCLISVYRCMSRVCS-- 1231
            |..:.|.|                                               ||.:.|.|
  Rat   527 RWNRFNRR-----------------------------------------------RCRAAVKSVT 544

  Fly  1232 --WIRRYIRRLVEHKYFQQGILLAILINTLSMGIEYHNQPPELTAIVETSNVVFSGIFAVEMLLK 1294
              |:                :::.:.:|||::..|::|||..||.|.:.:|.|...:|..|||:|
  Rat   545 FYWL----------------VIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVK 593

  Fly  1295 VVAEGPFRYIANGFNVFDGIIV-------ILSAIEICQTFMGNGTGGGGSGLSVLRTFRLLRILK 1352
            :.:.|...|..:.||.||..:|       ||..:|:....          |:||.|..|||||.|
  Rat   594 MYSLGLQAYFVSLFNRFDCFVVCGGITETILVELELMSPL----------GVSVFRCVRLLRIFK 648

  Fly  1353 LVRFMPNLRRQLFVMLRTMDNVAVFFSLLVLFIFIFSILGMYLFGGKFCKFLDESGLERECTCPE 1417
            :.|...:|...:..:|.:|.::|....||.|||.|||:|||.||||||  ..||:
  Rat   649 VTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKF--NFDET---------- 701

  Fly  1418 IISRHPQCECDRKHFNNILWATVTVFQILTQEDWNVVLFNGM------EKTSHWAALYFVALMTF 1476
                    :..|..|:|...|.:|||||||.||||.|:::|:      ..:.....:||:.|...
  Rat   702 --------QTKRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFIC 758

  Fly  1477 GNYVLFNLLVAILVEGFSSERN----ERREREQRELVKKLREETLAENYSDGMYDESR-SEADSS 1536
            |||:|.|:.:||.|:..:...:    ::.|.|::|..|..|:|:| ||..:...:.:: :.:|:.
  Rat   759 GNYILLNVFLAIAVDNLADAESLNTAQKEEAEEKERKKIARKESL-ENKKNNKPEVNQIANSDNK 822

  Fly  1537 TTNDSYYEVRNRWRSAEDVRKLQDSVELIIEAKSNMHRQRLLQPTHDYQINELPASSAAPSASGT 1601
            .|.|.|.|      .|||
  Rat   823 VTIDDYQE------EAED----------------------------------------------- 834

  Fly  1602 SGASAPGDRERDRDRDRDRERDRDRDRERDREAGGGGKEEGAQHAKPRGGLKKTYSIKERRSEAP 1666
                                                                             
  Rat   835 ----------------------------------------------------------------- 834

  Fly  1667 RLSKIRLARDPPIITTTAATPQDSPSTTLEPGMSFRQWGDMEPPSPPSPSLLRPPNIFTGGQRSL 1731
                                                     :.|.||.
  Rat   835 -----------------------------------------KDPYPPC----------------- 841

  Fly  1732 DEGIPSIDLIPPSPVLSHKPLNILNASQLGVGMGGGVPSTAGSSSSMHSVIIDDISKSSSSTAAA 1796
                                                                             
  Rat   842 ----------------------------------------------------------------- 841

  Fly  1797 TPIYVPTISSTADAQSQSHSLNDVSVGSSPGGEIPATGMSRNANTGASTSGSSSSERLPLAPPPQ 1861
                                  ||.||.
  Rat   842 ----------------------DVPVGE------------------------------------- 847

  Fly  1862 QGSFKQRLRRGSSKKRRASALALATDDNPARRTLDNQARRTQDEEEEQQQLNNGGDNSCLLRNSN 1926
                                                     ::||||:.:
  Rat   848 -----------------------------------------EEEEEEEDE--------------- 856

  Fly  1927 AVVSGSSSGTKETNRLSPQNSIRRLSNTLSIGSGPVGSRRASACIFNSQVYQNLNQPPKLRPGSG 1991
                                                                     |::..|..
  Rat   857 ---------------------------------------------------------PEVPAGPR 864

  Fly  1992 QRRMSSIELAFSKTSHLNLHNLEANRKSLSYTNSKMDLDKWNKSYGNLNEPDNMLQQYMEARDKR 2056
            .||
  Rat   865 PRR-------------------------------------------------------------- 867

  Fly  2057 KNSISHYNLKKRLEEKELQQLQQLHQQQLLQQRQDSFSSTTQQQQQQLQQHRLSKDQQQLAMQPH 2121
               ||..|:|:::
  Rat   868 ---ISELNMKEKI---------------------------------------------------- 877

  Fly  2122 SMVPGGGERYSKLKMLIEQLTPKHFTTEREDYSLYIFPEDNRFRQICTWFVNQKWFDNVVLLFIA 2186
            :.:|.|.                         :.:|..:.|..|..|...:|...|.|::|:||.
  Rat   878 APIPEGS-------------------------AFFILSKTNPIRVGCHKLINHHIFTNLILVFIM 917

  Fly  2187 LNCITLAMERPNIPPSSTERLFLATANYVFTVVFTVEMFIKVVATGMFYGHDAYFTSGWNIMDGS 2251
            |:...||.|.| |...|.....|...:|.||.:||||:.:|:...|.|....|:..:.:|::|..
  Rat   918 LSSAALAAEDP-IRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDML 981

  Fly  2252 LVTISIID--LLMSLISESSPRIFGILRVFRLLRSLRPLRVINRAPGLKLVVQTLLSSLRPIGNI 2314
            :|.:|::.  :..|.||        ::::.|:||.|||||.||||.|||.|||.:..::|.||||
  Rat   982 VVGVSLVSFGIQSSAIS--------VVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI 1038

  Fly  2315 VLICCTFFIIFGILGVQLFKGTFYYCEGENIKGVRNADECRRI-----PGNV---------WTNR 2365
            :::......:|..:|||||||.||.|..|   ...|.:|||.:     .|:|         |.|.
  Rat  1039 MIVTTLLQFMFACIGVQLFKGKFYRCTDE---AKSNPEECRGLFILYKDGDVDSPVVRERIWQNS 1100

  Fly  2366 KYNFDDLGKALMSLFVLSSRDGWVNIMYTGLDAVGVDQQPIVNYNEWRLLYFIAFILLVGFFVLN 2430
            .:|||::..|:|:||.:|:.:||..::|..:|:.|.:..|:.||.....::||.:|::|.||::|
  Rat  1101 DFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENVGPVYNYRVEISIFFIIYIIIVAFFMMN 1165

  Fly  2431 MFVGVVVENFHRCREEQEKEEK-------IRRAAKRALQMEKKRRRMHEPPYYTNYSPTRMFVHN 2488
            :|||.|:..|   :|:.|||.|       .|:..:.||:....||.:.:.||...:       ..
  Rat  1166 IFVGFVIVTF---QEQGEKEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKF-------WY 1220

  Fly  2489 VVTSKYFDLAIAAVIGLNVVTMAMEYYKMPSGLKYALKIFNYFFTAVFILEANMKLVALGWKLYL 2553
            ||.|..|:..:..:|.||.:.:||::|:.......|:.|.|..||.||.:|..:|::|...|.|.
  Rat  1221 VVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYF 1285

  Fly  2554 KDRWNQLDVGIVLLSIVGIVLEELE------TNTHQ------------IIPINPT---------- 2590
            .|.||..|..||:.||:.:.|.|.:      .||..            |..:||:
  Rat  1286 SDAWNTFDSLIVIGSIIDVALSEADHYFTDAWNTFDALIVVGSVVDIAITEVNPSDSENIPLPTA 1350

  Fly  2591 -----------IIRVMRVLRIARVLKLLKMANGIRALLDTVM---QALPQVGNLGLLFFLLFFIF 2641
                       .|...|:.|:.|::|||....|||.||.|.:   ||||.|   .||..:||||:
  Rat  1351 TPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYV---ALLIAMLFFIY 1412

  Fly  2642 AALGVELFGRLECSDEIPCQGLGEHAHFANFGMAFLTLFRVATGDNWNGIMKDTLRDN-CDDAAD 2705
            |.:|:::||::...|.   ..:..:.:|..|..|.|.|||.|||:.|..||...|... ||..:|
  Rat  1413 AVIGMQMFGKVAMRDN---NQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPDSD 1474

  Fly  2706 --------CVRNCCVSSVIAPIFFVIFVLMAQFVLVNVVVAVLM---------------KHLEES 2747
                    |..|      .|.::|:.|.::..|:::|:.|||:|               .||:|
  Rat  1475 YNPGEEYTCGSN------FAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDE- 1532

  Fly  2748 HKQMEDELDMEVE 2760
            .|::..|.|.|.:
  Rat  1533 FKRIWSEYDPEAK 1545

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ca-alpha1T	NP_001259267.1	Ion_trans	300..636	CDD:459842	103/370 (28%)
		Ion_trans	1243..1495	CDD:459842	89/264 (34%)
		Ion_trans	2175..2448	CDD:459842	103/288 (36%)
		Ion_trans	2492..2728	CDD:459842	86/286 (30%)
Cacna1d	XP_017455544.1	Ion_trans	125..417	CDD:459842	102/360 (28%)
		Ion_trans	545..780	CDD:459842	90/280 (32%)
		Ion_trans	905..1182	CDD:459842	104/291 (36%)
		Ion_trans	1224..1523	CDD:459842	92/310 (30%)
		GPHH	1532..1585	CDD:465306	5/15 (33%)
		Ca_chan_IQ	1595..1669	CDD:462591
		CAC1F_C	1690..2206	CDD:465298