DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ca-alpha1T and Scn11a

DIOPT Version :9

Sequence 1:NP_001259267.1 Gene:Ca-alpha1T / 31550 FlyBaseID:FBgn0264386 Length:3218 Species:Drosophila melanogaster
Sequence 2:NP_062138.1 Gene:Scn11a / 29701 RGDID:3630 Length:1765 Species:Rattus norvegicus


Alignment Length:2572 Identity:500/2572 - (19%)
Similarity:845/2572 - (32%) Gaps:1074/2572 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly   291 RNWCLMLITNPWFERVSILVILLNCITLGMYQPCVDDACVTNRCKILQIFDD-----IIFAFFAL 350
            |:..:.:..:..|....|..:::||:.:..              .:.:.||:     :....:.|
  Rat   119 RSLMIRISVHSVFSMFIICTVIINCMFMAN--------------SMERSFDNDIPEYVFIGIYIL 169

  Fly   351 EMTIKMVAMG-ICGKNTYLADSWNRLDFFIVLAGLLEYVMHVENLNLTAIRTIRVLRPLRAINRI 414
            |..||::|.| |..:.::|.|.||.|| |||:...:........:||:|:||.||.|.|:||:.|
  Rat   170 EAVIKILARGFIVDEFSFLRDPWNWLD-FIVIGTAIATCFPGSQVNLSALRTFRVFRALKAISVI 233

  Fly   415 PSMRILVMLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWEGILRQRCSLMRTEGMVYPLTVPEVY 479
            ..::::|..||.::..|.:|::|..|...||.::|.||:.|||.|:|                  
  Rat   234 SGLKVIVGALLRSVKKLVDVMVLTLFCLSIFALVGQQLFMGILNQKC------------------ 280

  Fly   480 RVRVRVN------SLSQYYEFSKD-QDYICSTPNDSGMHLCGNFPPYRIGSLVCNEEAKLFDFNE 537
               ::.|      |....:|..|| :|:|          :||.:    :||..|           
  Rat   281 ---IKHNCGPNPASNKDCFEKEKDSEDFI----------MCGTW----LGSRPC----------- 317

  Fly   538 PTNTSCVNWNQYYTTCKQSGENPFQGTISFDNIGMAWVAIFLVISLEGWTDIMYYVQDAHSFWDW 602
            |..          :||.::..||......|||.|.:::|:|.|::.:.|..:...:......:..
  Rat   318 PNG----------STCDKTTLNPDNNYTKFDNFGWSFLAMFRVMTQDSWERLYRQILRTSGIYFV 372

  Fly   603 IYFVLLIVIGSFFMINLCLVVIATQFSETKKREMERMRQERARYTSTSTLASSTNNSEPATCYAE 667
            .:||::|.:|||:::||.|.|:...:.|                                     
  Rat   373 FFFVVVIFLGSFYLLNLTLAVVTMAYEE------------------------------------- 400

  Fly   668 IVKYIAHLWRRFKRRMLKKYRLYKYQRQQRKEGLLPNADNLTFSPSRIKCHHPKCPKYSNRKPSS 732
                                                                             
  Rat   401 ----------------------------------------------------------------- 400

  Fly   733 IQDQMITVMVPLNSASNNINNNNNNNSNSSNHNGSGNHTAAGGGNNNNNNNNNNAASCTTVALVN 797
                                                              .|.|.|:.|      
  Rat   401 --------------------------------------------------QNRNVAAET------ 409

  Fly   798 GINGSAASVTMSSAHHQQHQLLQHQQQQHQNQQQQQQQQQHSSSDNTEQSLAPDGLPRSSSLKKS 862
                                  :.:::..|..||..:::        :::|...|:.|||     
  Rat   410 ----------------------EAKEKMFQEAQQLLREE--------KEALVAMGIDRSS----- 439

  Fly   863 TAHHQLKPEGSAAEQKTILLKFPQQMIDSEQLILQLGNLGKSHPCTSGFLSPPTSASRRPSVMFN 927
                                               |.:|..|            |.|.:....| 
  Rat   440 -----------------------------------LNSLQAS------------SFSPKKRKFF- 456

  Fly   928 EYVLLHTPPALNADPATAGTTTTVAPTVATVAGTAAAAAAAAATGSGSGNNNHQNGGASGGAGTG 992
                                                                            |
  Rat   457 ----------------------------------------------------------------G 457

  Fly   993 GTTEKSNIFSTEKMTQAGDGSIWQVNLPQTIGTIANPYADCSELGIHDAMTCQELLAFSVAFSAA 1057
            ..|.||......|..||.                    |..||   .||....:||..:...|..
  Rat   458 SKTRKSFFMRGSKTAQAS--------------------ASDSE---DDASKNPQLLEQTKRLSQN 499

  Fly  1058 LPTGQSTLESFYTSLARCDPHTAEALRAHHKPRSVPTGQNQTTPGAEGATVMVASTAGDTGQTLQ 1122
            ||     ::.|       |.|....    |:.|::                              
  Rat   500 LP-----VDLF-------DEHVDPL----HRQRAL------------------------------ 518

  Fly  1123 PSTVSAVVGGTIDSHAANHRRKEHHQQSHHHHNNNNTTSHSRNYRSRQGQGNSRMREPRAPTGNY 1187
             |.||.:   ||..                                   |...:.:||..|.|..
  Rat   519 -SAVSIL---TITM-----------------------------------QEQEKFQEPCFPCGKN 544

  Fly  1188 MEDYACCYDLYQNALSPLDERPRQRSPTTRCLISVYRCMSRVCSWIRRYIRRLVEHKYFQQGILL 1252
            :......:|.               ||...|              |::.:|.::...:.:..|.:
  Rat   545 LASKYLVWDC---------------SPQWLC--------------IKKVLRTIMTDPFTELAITI 580

  Fly  1253 AILINTLSMGIEYHNQPPELTAIVETSNVVFSGIFAVEMLLKVVAEGPFRYIANGFNVFDGIIVI 1317
            .|:|||:.:.:|:||....|..|::..|.||:|||..||.||::|..|:.|..:|:||||.|:.:
  Rat   581 CIIINTVFLAVEHHNMDDNLKTILKIGNWVFTGIFIAEMCLKIIALDPYHYFRHGWNVFDSIVAL 645

  Fly  1318 LSAIEICQTFMGNGTGGGGSGLSVLRTFRLLRILKLVRFMPNLRRQLFVMLRTMDNVAVFFSLLV 1382
            ||..::....:.:      :..|.|.:.|:||:.||.:..|.|...:.::..::..:.....:|.
  Rat   646 LSLADVLYNTLSD------NNRSFLASLRVLRVFKLAKSWPTLNTLIKIIGHSVGALGNLTVVLT 704

  Fly  1383 LFIFIFSILGMYLFGGKFCK--FLDESGLERECTCPEIISRHPQCECDRKHFNNILWATVTVFQI 1445
            :.:||||::||.|||.||.|  :..:....|                 |.|.:|...:.:.||:|
  Rat   705 IVVFIFSVVGMRLFGTKFNKTAYATQERPRR-----------------RWHMDNFYHSFLVVFRI 752

  Fly  1446 LTQEDWNVVLFNGMEKT--SHWAALYFVALMTFGNYVLFNLLVAILVEGFSSERNERREREQREL 1508
            |..| |...::..|:..  |....:.||.:|..|..|:.||.:|:|:..||:|            
  Rat   753 LCGE-WIENMWGCMQDMDGSPLCIIVFVLIMVIGKLVVLNLFIALLLNSFSNE------------ 804

  Fly  1509 VKKLREETLAENYSDGMYDESRSEADSSTTNDSYYEVRNRWRSAEDVRKLQDSVELIIEAKSNMH 1573
                                   |.|.|...::              ||.:  |:|.::.     
  Rat   805 -----------------------EKDGSLEGET--------------RKTK--VQLALDR----- 825

  Fly  1574 RQRLLQPTHDYQINELPASSAAPSASGTSGASAPGDRERDRDRDRDRERDRDRDRERDREAGGGG 1638
                .:....:.::.|.:...                      .:.|.::..:.:|......|..
  Rat   826 ----FRRAFSFMLHALQSFCC----------------------KKCRRKNSPKPKETTESFAGEN 864

  Fly  1639 KEEGAQHAKPRGGLKKTYSIKERRSEAPRLSKIRLARDPPIITTTAATPQDSPSTTLEPGMSFRQ 1703
            |:.....|:|    .|.|.                 .|..:.|..|..|. :|...:|..:.:  
  Rat   865 KDSILPDARP----WKEYD-----------------TDMALYTGQAGAPL-APLAEVEDDVEY-- 905

  Fly  1704 WGDMEPPSPPSPSLLRPPNIFTGGQRSLDEGIPSIDLIPPSPVLSHKPLNILNASQLGVGMGGGV 1768
                                                                      .|.||.:
  Rat   906 ----------------------------------------------------------CGEGGAL 912

  Fly  1769 PSTAGSSSSMHSVIIDDISKSSSSTAAATPIYVPTISSTADAQSQSHSLNDVSVGSSPGGEIPAT 1833
            |      :|.||                           |..|:               |::|  
  Rat   913 P------TSQHS---------------------------AGVQA---------------GDLP-- 927

  Fly  1834 GMSRNANTGASTSGSSSSERLPLAPPPQQGSFKQRLRRGSSKKRRASALALATDDNPARRTLDNQ 1898
                             .|...|..|                                    |:|
  Rat   928 -----------------PETKQLTSP------------------------------------DDQ 939

  Fly  1899 ARRTQDEEEEQQQLNNGGDNSCLLRNSNAVVSGSSSGTKETNRLSPQNSIRRLSNTLSIGSGPVG 1963
            ....:...||...|:.....    :.|:||...|...|.:.|.:     .|.|..|:|       
  Rat   940 GVEMEVFSEEDLHLSIQSPR----KKSDAVSMLSECSTIDLNDI-----FRNLQKTVS------- 988

  Fly  1964 SRRASACIFNSQVYQNLNQPPKLRPGSGQRRMSSIELAFSK--TSHLNLHNLEANRKSLSYTNSK 2026
                                ||.:|          :..|.|  :.|...|.              
  Rat   989 --------------------PKKQP----------DRCFPKGLSCHFLCHK-------------- 1009

  Fly  2027 MDLDKWNKSYGNLNEPDNMLQQYMEARDKRKNS-ISHYNLKKRLEEKELQQLQQLHQQQLLQQRQ 2090
                                      .||||:. :..:|::|                       
  Rat  1010 --------------------------TDKRKSPWVLWWNIRK----------------------- 1025

  Fly  2091 DSFSSTTQQQQQQLQQHRLSKDQQQLAMQPHSMVPGGGERYSKLKMLIEQLTPKHFTTEREDYSL 2155
                                                                             
  Rat  1026 ----------------------------------------------------------------- 1025

  Fly  2156 YIFPEDNRFRQICTWFVNQKWFDNVVLLFIALNCITLAMERPNIPP-SSTERLFLATANYVFTVV 2219
                       .|...|...||::.::..|.|:...|..|..|:|. ...|:|...|.| :||.:
  Rat  1026 -----------TCYQIVKHSWFESFIIFVILLSSGALIFEDVNLPSRPQVEKLLRCTDN-IFTFI 1078

  Fly  2220 FTVEMFIKVVATGMFYGHDAYFTSGWNIMDGSLVTISIIDLLMSLISESSPRIFGILRVFRLLRS 2284
            |.:||.:|.||    :|...||||.|..:|..:|.:|::. ||:|.|         |:.||.||:
  Rat  1079 FLLEMILKWVA----FGFRRYFTSAWCWLDFLIVVVSVLS-LMNLPS---------LKSFRTLRA 1129

  Fly  2285 LRPLRVINRAPGLKLVVQTLLSSLRPIGNIVLICCTFFIIFGILGVQLFKGTFYYC-EGENIK-- 2346
            |||||.:::..|:|:||..|:|::..|.|::|:|..|:::|.||||.||.|.|..| .|.:|.  
  Rat  1130 LRPLRALSQFEGMKVVVYALISAIPAILNVLLVCLIFWLVFCILGVNLFSGKFGRCINGTDINMY 1194

  Fly  2347 ----GVRNADECRRIPGNVWTNRKYNFDDLGKALMSLFVLSSRDGWVNIMYTGLDAVGVDQQPIV 2407
                .|.|..:| .|....|...:.|||::|.|.::|..:::..||:.||...:|:...|:||..
  Rat  1195 LDFTEVPNRSQC-NISNYSWKVPQVNFDNVGNAYLALLQVATYKGWLEIMNAAVDSREKDEQPDF 1258

  Fly  2408 NYNEWRLLYFIAFILLVGFFVLNMFVGVVVENFHRCREE--------QEKEEKIRRAAKRALQME 2464
            ..|.:..|||:.||:...||.||:|:||:::||::.:::        .|:::|...|.|: |..:
  Rat  1259 EANLYAYLYFVVFIIFGSFFTLNLFIGVIIDNFNQQQKKLGGQDIFMTEEQKKYYNAMKK-LGTK 1322

  Fly  2465 KKRRRMHEPPYYTNYSPTRMFVHNVVTSKYFDLAIAAVIGLNVVTMAMEYYKMPSGLKYALKIFN 2529
            |.::.:..|     .:..:.||.::|||:.||:.|..:|.||::.|..|....|..:|....|.|
  Rat  1323 KPQKPIPRP-----LNKCQAFVFDLVTSQVFDVIILGLIVLNMIIMMAESADQPKDVKKTFDILN 1382

  Fly  2530 YFFTAVFILEANMKLVALGWKLYLKDRWNQLDVGIVLLSIVGIVLEELETNTHQIIPINPTIIRV 2594
            ..|..:|.:|..:|:.||. :.|..:.||..|..:|:|||:..::..||.:.   |...||:.||
  Rat  1383 IAFVVIFTIECLIKVFALR-QHYFTNGWNLFDCVVVVLSIISTLVSRLEDSD---ISFPPTLFRV 1443

  Fly  2595 MRVLRIARVLKLLKMANGIRALLDTVMQALPQVGNLGLLFFLLFFIFAALGVELFGRLECSDEIP 2659
            :|:.||.|:|:|::.|.|||.||..:|.:||.:.|:|||.||:.||:|..|:..|.:::..    
  Rat  1444 VRLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLVMFIYAIFGMSWFSKVKKG---- 1504

  Fly  2660 CQGLGEHAHFANFGMAFLTLFRVATGDNWNGIMKDTL--RDNCDDAADCVRNCCVSSVIAPIFFV 2722
             .|:.:..:|..|..:.|.||::.|...|:.::...|  :::|:.::   ::.|....||.::||
  Rat  1505 -SGIDDIFNFETFTGSMLCLFQITTSAGWDTLLNPMLEAKEHCNSSS---QDSCQQPQIAVVYFV 1565

  Fly  2723 IFVLMAQFVLVNVVVAVLMKHLEESHKQMEDEL---DMEVELERELVREQEFAQEQKLCQQLAEA 2784
            .:::::..::||:.:||::::...:.::.||.|   |.|:..|   |.| :|..|.....|.:..
  Rat  1566 SYIIISFLIVVNMYIAVILENFNTATEESEDPLGEDDFEIFYE---VWE-KFDPEASQFIQYSAL 1626

  Fly  2785 QSKAAAPPRPLAKVKSLPKNFIYSTPSLDKKFPAVSG 2821
            ...|.|.|.||...|  |..|.:....|    |.|.|
  Rat  1627 SDFADALPEPLRVAK--PNKFQFLVMDL----PMVMG 1657

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1TNP_001259267.1 Ion_trans 332..636 CDD:278921 83/316 (26%)
Ion_trans 1261..1495 CDD:278921 70/237 (30%)
Ion_trans 2192..2448 CDD:278921 96/271 (35%)
Ion_trans 2510..2728 CDD:278921 68/219 (31%)
Scn11aNP_062138.1 I. /evidence=ECO:0000305 115..403 88/506 (17%)
Ion_trans 160..404 CDD:278921 82/452 (18%)
II. /evidence=ECO:0000305 554..820 87/369 (24%)
Ion_trans 589..807 CDD:278921 73/276 (26%)
Na_trans_assoc 812..1029 CDD:284034 62/633 (10%)
III. /evidence=ECO:0000305 1022..1319 108/412 (26%)
Ion_trans 1051..1297 CDD:278921 96/261 (37%)
Na_channel_gate 1289..1341 CDD:240441 11/57 (19%)
IV. /evidence=ECO:0000305 1328..1619 94/311 (30%)
Ion_trans 1363..1595 CDD:278921 72/243 (30%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.820

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