DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1T and Scn10a

DIOPT Version :9

Sequence 1:NP_001259267.1 Gene:Ca-alpha1T / 31550 FlyBaseID:FBgn0264386 Length:3218 Species:Drosophila melanogaster
Sequence 2:NP_058943.2 Gene:Scn10a / 29571 RGDID:3629 Length:1956 Species:Rattus norvegicus


Alignment Length:2762 Identity:551/2762 - (19%)
Similarity:927/2762 - (33%) Gaps:1096/2762 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly   282 RALTQYTRPRNWCLMLIT--------------NPWFERVSILVILLNCITLGMYQPCVDDACVTN 332
            |.:::::  ..|.|.|.:              :.||.....:.||:||:            |:|.
  Rat    99 RTISRFS--ATWALWLFSPFNLIRRTAIKVSVHSWFSIFITITILVNCV------------CMTR 149

  Fly   333 RC---KILQIFDDIIFAFFALEMTIKMVAMGIC-GKNTYLADSWNRLDFFIVLAGLLEYV-MHVE 392
            ..   |:..:| .:|:.|.||   ||::|.|.| .:.|||.|.||.|||.::   .|.|| ..::
  Rat   150 TDLPEKVEYVF-TVIYTFEAL---IKILARGFCLNEFTYLRDPWNWLDFSVI---TLAYVGAAID 207

  Fly   393 NLNLTAIRTIRVLRPLRAINRIPSMRILVMLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWEGIL 457
            ...::.:||.||||.|:.::.||.::::|..|:.::..|.:|.:|..|...:|.::|:||::|.|
  Rat   208 LRGISGLRTFRVLRALKTVSVIPGLKVIVGALIHSVRKLADVTILTVFCLSVFALVGLQLFKGNL 272

  Fly   458 RQRCSLMRTEGMVYPLTVPEVYRVRVRVNSLSQYYEFSKDQDYICSTPNDSGMHLCGN------F 516
            :.:|....|:        |.      :.::||     |:..:||...|..:...||||      .
  Rat   273 KNKCIRNGTD--------PH------KADNLS-----SEMAEYIFIKPGTTDPLLCGNGSDAGHC 318

  Fly   517 PPYRIGSLVCNEEAKLFDFNEPTNTSCVNWNQYYTTCKQSGENPFQGTISFDNIGMAWVAIFLVI 581
            |    |..||.:.....|||             ||              |||:...|::::|.::
  Rat   319 P----GGYVCLKTPDNPDFN-------------YT--------------SFDSFAWAFLSLFRLM 352

  Fly   582 SLEGWTDIMYYVQDAHSFWDWIYFVLLIVIGSFFMINLCLVVIATQFSETKKREMERMRQERARY 646
            :.:.|..:......|......::|||:|.:|||:::||.|.|:...:.|                
  Rat   353 TQDSWERLYQQTLRASGKMYMVFFVLVIFLGSFYLVNLILAVVTMAYEE---------------- 401

  Fly   647 TSTSTLASSTNNSEPATCYAEIVKYIAHLWRRFKRRMLKKYR--LYKYQRQQRKEGLLPNADNLT 709
            .|.:|:|......                         ||::  |...|::|.            
  Rat   402 QSQATIAEIEAKE-------------------------KKFQEALEVLQKEQE------------ 429

  Fly   710 FSPSRIKCHHPKCPKYSNRKPSSIQDQMITVMVPLNSASNNINNNNNNNSNSSNHNGSGNHTAAG 774
                                          |:..|...:.::.:::.:...|.|.|         
  Rat   430 ------------------------------VLAALGIDTTSLQSHSGSPLASKNAN--------- 455

  Fly   775 GGNNNNNNNNNNAASCTTVALVNGINGSAASVTMSSAHHQQHQLLQHQQQQHQNQQQQQQQQQHS 839
                                                                   :::.:.:...
  Rat   456 -------------------------------------------------------ERRPRVKSRV 465

  Fly   840 SSDNTEQSLAPDGLPRSSSLKKSTAHHQLKPEGSAAEQKTILLKFPQQMIDSEQLILQLGNLGKS 904
            |..:|:.:.:|          :|..::|.:            :.|         |.|..|....|
  Rat   466 SEGSTDDNRSP----------QSDPYNQRR------------MSF---------LGLSSGRRRAS 499

  Fly   905 HPCTSGFLSPPTSASRRPSVMFNEYVLLHTPPALNADPATAGTTTTVAPTVATVAGTAAAAAAAA 969
            |.....|.:|....|              .|..:..|                            
  Rat   500 HGSVFHFRAPSQDIS--------------FPDGITDD---------------------------- 522

  Fly   970 ATGSGSGNNNHQNGGASGGAGTGGTTEKSNIFSTEKMTQAGDGSIWQVNLPQTIGTIANP---YA 1031
              |...|:...:.|....|.|.|.|                 |.:.:..|||:    .||   :.
  Rat   523 --GVFHGDQESRRGSILLGRGAGQT-----------------GPLPRSPLPQS----PNPGRRHG 564

  Fly  1032 DCSELGIHDAMTCQELLAFSVAFSAALPTGQSTLESFYTSLARCDPHTAEALRAHHKPRSVPTGQ 1096
            :..:||:                    |||:.|                         ...|.|.
  Rat   565 EEGQLGV--------------------PTGELT-------------------------AGAPEGP 584

  Fly  1097 NQTTPGAEGATVMVASTAGDTGQTLQPSTVSAVVGGTIDSHAANHRRKEHHQQSHHHHNNNNTTS 1161
            ...|.|                   |.|.:||                                 
  Rat   585 ALDTTG-------------------QKSFLSA--------------------------------- 597

  Fly  1162 HSRNYRSRQGQGNSRMREPRAPTGNYMEDYACCYDLYQNALSPLDERPRQRSPTTRCLIS----- 1221
                     |..|...|..||.:         ...:..:.:..|:|...:..|   ||||     
  Rat   598 ---------GYLNEPFRAQRAMS---------VVSIMTSVIEELEESKLKCPP---CLISFAQKY 641

  Fly  1222 -VYRCMSRVCSWIRRY---IRRLVEHKYFQQGILLAILINTLSMGIEYHNQPPELTAIVETSNVV 1282
             ::.|    |...|::   :..||...:.:..|.|.|::||:.|.:|::.......|:::..|:|
  Rat   642 LIWEC----CPKWRKFKMALFELVTDPFAELTITLCIVVNTVFMAMEHYPMTDAFDAMLQAGNIV 702

  Fly  1283 FSGIFAVEMLLKVVAEGPFRYIANGFNVFDGIIVILSAIEICQTFMGNGTGGGGSGLSVLRTFRL 1347
            |:..|.:||..|::|..|:.|....:|:||.:||.:|.:|:..:..|:        |||||||||
  Rat   703 FTVFFTMEMAFKIIAFDPYYYFQKKWNIFDCVIVTVSLLELSASKKGS--------LSVLRTFRL 759

  Fly  1348 LRILKLVRFMPNLRRQLFVMLRTMDNVAVFFSLLVLFIFIFSILGMYLFGGKFCKFLDESGLERE 1412
            ||:.||.:..|.|...:.::..::..:.....:|.:.:|||:::|                    
  Rat   760 LRVFKLAKSWPTLNTLIKIIGNSVGALGNLTFILAIIVFIFALVG-------------------- 804

  Fly  1413 CTCPEIISRHPQCECD----------RKHFNNILWATVTVFQILTQEDWNVVLFNGMEKTSHWAA 1467
               .:::|....|..|          |.|..:...:.:.||:||..| |...::..||.:.....
  Rat   805 ---KQLLSEDYGCRKDGVSVWNGEKLRWHMCDFFHSFLVVFRILCGE-WIENMWVCMEVSQKSIC 865

  Fly  1468 L-YFVALMTFGNYVLFNLLVAILVEGFSSERNERREREQRELVKKLREETLAENYSDGMYDESRS 1531
            | .|:.:|..||.|:.||.:|:|:..||::                                   
  Rat   866 LILFLTVMVLGNLVVLNLFIALLLNSFSAD----------------------------------- 895

  Fly  1532 EADSSTTNDSYYEVRNRWRSAEDVRKLQDSVELIIEAKSNMHRQRLLQPTHDYQINELPASSAAP 1596
                                                        .|..|..|.::|.|..:.|..
  Rat   896 --------------------------------------------NLTAPEDDGEVNNLQLALARI 916

  Fly  1597 SASGTSGASAPGDRERDRDRDRDRERDRDRDRERDREAGGGGKEEGAQHAKPRGGLKKTYSIKER 1661
            ...|...:.|..                                              :|.....
  Rat   917 QVLGHRASRAIA----------------------------------------------SYISSHC 935

  Fly  1662 RSEAPRLSKIRLARDPPIITTTA----ATPQDSPSTTLEPGMSFRQWGDMEPPSPPSP-----SL 1717
            |...|:: :.:|...||:.::.|    ||  |:.|..:         |::..|:..||     ..
  Rat   936 RFRWPKV-ETQLGMKPPLTSSEAKNHIAT--DAVSAAV---------GNLTKPALSSPKENHGDF 988

  Fly  1718 LRPPNIFTG-----GQRSLDEGIPSIDLIPPSPVLSHKPLNILNASQLGVGMGGGVPSTAGSSSS 1777
            :..||::..     |:..|||                                            
  Rat   989 ITDPNVWVSVPIAEGESDLDE-------------------------------------------- 1009

  Fly  1778 MHSVIIDDISKSSSSTAAATPIYVPTISSTADAQSQSHSLNDVSVGSSPGGEIPATGMSRNANTG 1842
                :.:|:.::|.|:           ....|.:.|..             ::|......|....
  Rat  1010 ----LEEDMEQASQSS-----------WQEEDPKGQQE-------------QLPQVQKCENHQAA 1046

  Fly  1843 ASTSGSSSSERLPLAPPPQQGSFKQRLRRGSSKKRRASALALATDDNPARRTLDNQARRTQDEEE 1907
            .|.:...|||  .|||           ..|.|.||:         |:|                 
  Rat  1047 RSPASMMSSE--DLAP-----------YLGESWKRK---------DSP----------------- 1072

  Fly  1908 EQQQLNNGGDNSCLLRNSNAVVSGSSSGTKETNRLSPQNSIRRLSNTLSIGSGPVGSRRASACIF 1972
              |....|.|::            |||.....:...|:..:|::.                    
  Rat  1073 --QVPAEGVDDT------------SSSEGSTVDCPDPEEILRKIP-------------------- 1103

  Fly  1973 NSQVYQNLNQPPKLRPGSGQRRMSSIELAFSKTSHLNLHNLEANRKSLSYTNSKMDLDKWNKSYG 2037
                                      |||                                   .
  Rat  1104 --------------------------ELA-----------------------------------D 1107

  Fly  2038 NLNEPDNMLQQYMEARDKRKNSISHYNLKKRLEEKELQQLQQLHQQQLLQQRQDSFSSTTQQQQQ 2102
            :|:|||:...:..    .|:....:.|..|                        |..:|..|   
  Rat  1108 DLDEPDDCFTEGC----TRRCPCCNVNTSK------------------------SPWATGWQ--- 1141

  Fly  2103 QLQQHRLSKDQQQLAMQPHSMVPGGGERYSKLKMLIEQLTPKHFTTEREDYSLYIFPEDNRFRQI 2167
                                                                         .|:.
  Rat  1142 -------------------------------------------------------------VRKT 1145

  Fly  2168 CTWFVNQKWFDNVVLLFIALNCITLAMERPNIPPSSTERLFLATANYVFTVVFTVEMFIKVVATG 2232
            |...|...||::.::..|.|:...||.|...:......:..|...:.|||.:|..||.:|.||  
  Rat  1146 CYRIVEHSWFESFIIFMILLSSGALAFEDNYLEEKPRVKSVLEYTDRVFTFIFVFEMLLKWVA-- 1208

  Fly  2233 MFYGHDAYFTSGWNIMDGSLVTISIIDLLMSLISESSPRIFGILRVFRLLRSLRPLRVINRAPGL 2297
              ||...|||:.|..:|..:|.||:..|:..::..|.   ...::..|.||:|||||.::|..|:
  Rat  1209 --YGFKKYFTNAWCWLDFLIVNISLTSLIAKILEYSD---VASIKALRTLRALRPLRALSRFEGM 1268

  Fly  2298 KLVVQTLLSSLRPIGNIVLICCTFFIIFGILGVQLFKGTFYYC--------EGENIKGVRNADEC 2354
            ::||..|:.::..|.|::|:|..|::||.|:||.||.|.|..|        ...|...|.|..||
  Rat  1269 RVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFSKCVDTRNNPFSNVNSTMVNNKSEC 1333

  Fly  2355 --RRIPGN-VWTNRKYNFDDLGKALMSLFVLSSRDGWVNIMYTGLDAVGVDQQPIVNYNEWRLLY 2416
              :...|: .|.|.|.|||::....::|..:::..||::|||..:|:..::.||....|.:..||
  Rat  1334 HNQNSTGHFFWVNVKVNFDNVAMGYLALLQVATFKGWMDIMYAAVDSGEINSQPNWENNLYMYLY 1398

  Fly  2417 FIAFILLVGFFVLNMFVGVVVENFHRCREE--------QEKEEKIRRAAKRALQMEKKRRRMHEP 2473
            |:.||:..|||.||:||||:::||::.:::        .|:::|...|.|: |..:|.::.:..|
  Rat  1399 FVVFIIFGGFFTLNLFVGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKK-LGSKKPQKPIPRP 1462

  Fly  2474 PYYTNYSPTRMFVHNVVTSKYFDLAIAAVIGLNVVTMAMEYYKMPSGLKYALKIFNYFFTAVFIL 2538
                 .:..:.||.::||.:.||:.|..:|.||::||.:|..:........|...|.||.|||..
  Rat  1463 -----LNKYQGFVFDIVTRQAFDIIIMVLICLNMITMMVETDEQGEEKTKVLGRINQFFVAVFTG 1522

  Fly  2539 EANMKLVALGWKLYLKDRWNQLDVGIVLLSIVGI----VLEELETNTHQIIPINPTIIRVMRVLR 2599
            |..||:.||. :.|..:.||..|..:|:|||..:    :|:.||..      .:||:.||:|:.|
  Rat  1523 ECVMKMFALR-QYYFTNGWNVFDFIVVILSIGSLLFSAILKSLENY------FSPTLFRVIRLAR 1580

  Fly  2600 IARVLKLLKMANGIRALLDTVMQALPQVGNLGLLFFLLFFIFAALGVELFGRLECSDEIPCQGLG 2664
            |.|:|:|::.|.|||.||..:|.:||.:.|:|||.||:.||::..|:..|..:  .||   .|:.
  Rat  1581 IGRILRLIRAAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMASFANV--VDE---AGID 1640

  Fly  2665 EHAHFANFGMAFLTLFRVATGDNWNGIMKDTLRDN---CD---DAADCVRNCCVSSVIAPIFFVI 2723
            :..:|..||.:.|.||::.|...|:|::...|...   ||   ..::..|..|.|..:..|||..
  Rat  1641 DMFNFKTFGNSMLCLFQITTSAGWDGLLSPILNTGPPYCDPNLPNSNGSRGNCGSPAVGIIFFTT 1705

  Fly  2724 FVLMAQFVLVNVVVAVLMKHL----EESHKQM-EDELDMEVELERELVRE-QEFAQEQKLCQQLA 2782
            :::::..::||:.:||::::.    |||.:.: ||:.||..|...:...| .:|.....| ...|
  Rat  1706 YIIISFLIVVNMYIAVILENFNVATEESTEPLSEDDFDMFYETWEKFDPEATQFIAFSAL-SDFA 1769

  Fly  2783 EAQSKAAAPPRPLAKV---KSLP-----------------KNFIYSTPSLD-------KKFPAV- 2819
            :..|.....|:|...:   ..||                 ||.:..:..||       :||.|. 
  Rat  1770 DTLSGPLRIPKPNQNILIQMDLPLVPGDKIHCLDILFAFTKNVLGESGELDSLKTNMEEKFMATN 1834

  Fly  2820 ------------------------------SGVNNPSLTSSAATNLNQVATAGSGGAA-PG---- 2849
                                          |.:.:.|||.|   |...|..|...|.: ||    
  Rat  1835 LSKASYEPIATTLRWKQEDLSATVIQKAYRSYMLHRSLTLS---NTLHVPRAEEDGVSLPGEGYV 1896

  Fly  2850 AVPAGSGAGPRRQTVQYFQQPP--QSMLGGLS 2879
            ...|.||...:.:|......||  .|:..|||
  Rat  1897 TFMANSGLPDKSETASATSFPPSYDSVTRGLS 1928

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1TNP_001259267.1 Ion_trans 332..636 CDD:278921 85/314 (27%)
Ion_trans 1261..1495 CDD:278921 65/244 (27%)
Ion_trans 2192..2448 CDD:278921 91/274 (33%)
Ion_trans 2510..2728 CDD:278921 75/227 (33%)
Scn10aNP_058943.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 31..54
I. /evidence=ECO:0000305 116..404 93/372 (25%)
Ion_trans 129..406 CDD:395416 94/361 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 441..484 7/116 (6%)
Na_trans_cytopl <482..614 CDD:403218 44/332 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 537..581 16/109 (15%)
II. /evidence=ECO:0000305 646..910 80/378 (21%)
Ion_trans 663..893 CDD:395416 69/261 (26%)
Na_trans_assoc 903..1148 CDD:399489 70/600 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1008..1094 28/210 (13%)
III. /evidence=ECO:0000305 1141..1450 103/380 (27%)
Ion_trans 1152..1428 CDD:395416 95/282 (34%)
Na_channel_gate 1420..1472 CDD:240441 11/57 (19%)
IV. /evidence=ECO:0000305 1459..1758 100/315 (32%)
Ion_trans 1476..1733 CDD:395416 87/268 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1906..1956 7/23 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.820

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