DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ca-alpha1T and Nalcn

DIOPT Version :9

Sequence 1:	NP_001259267.1	Gene:	Ca-alpha1T / 31550	FlyBaseID:	FBgn0264386	Length:	3218	Species:	Drosophila melanogaster
Sequence 2:	NP_001380622.1	Gene:	Nalcn / 266760	RGDID:	628710	Length:	1770	Species:	Rattus norvegicus

Alignment Length:	2080	Identity:	391/2080 - (18%)
Similarity:	715/2080 - (34%)	Gaps:	688/2080 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly  1228 RVCSWIRRYIRRLVEHKYFQQGILLAILINTLSMGIEYHNQPPELTAIVETSNVVFSGIFAVEML 1292
            |:|:.|.                ::::.:|| .|..|::   |.|..:..|.:.:...::..||:
  Rat    43 RICAIIS----------------VISVCMNT-PMTFEHY---PPLQYVTFTLDTLLMFLYTAEMI 87

  Fly  1293 LKV----VAEGPFRYIANGFNVFDGIIV-------ILSAIEICQTFMGNGTGGGGSGLSVLRTFR 1346
            .|:    :.:|...|:.:.:.||||.:|       :|...||..........|   .|.:.|...
  Rat    88 AKMHIRGIVKGDSSYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWG---MLRIPRPLI 149

  Fly  1347 LLRILKL-VRFMPNLRRQLFVMLRTMDNVAVFFSLLVLFIFIFSILGMYLFG------------- 1397
            ::|..:: .||.....|...::.|:.:.:......|:.|:.::.|||:.:||
  Rat   150 MIRAFRIYFRFELPRTRITNILKRSGEQIWSVSIFLLFFLLLYGILGVQMFGTFTYHCVVNDTKP 214

  Fly  1398 ---------------------------GKFCKFLDESGLERECTCPEIISRHPQCECDRKHFNNI 1435
                                       |..|..|::.||.|:             |.....||.|
  Rat   215 GNVTWNSLAIPDTHCSPELEEGYQCPPGFKCMDLEDLGLSRQ-------------ELGYSGFNEI 266

  Fly  1436 LWATVTVFQILTQEDWNVVLFNGMEKTSHWAA-LYFVALMTFGNYVLFNLLVAILVEGFSSERNE 1499
            ..:..||::..:||.|..:::..::....|.: .||:.|:.|..:::.|:.:|:::|.|:..|.:
  Rat   267 GTSIFTVYEASSQEGWVFLMYRAIDSFPRWRSYFYFITLIFFLAWLVKNVFIAVIIETFAEIRVQ 331

  Fly  1500 RREREQRELVKKLREETLAENYSDGMYDESRSEADSSTTNDSYYEVRNRWR-SAEDVRKLQD--- 1560
            .::                      |:....|...::||...:.:....|: .|.||.|.|.
  Rat   332 FQQ----------------------MWGTRSSTTSTATTQMFHEDAAGGWQLVAVDVNKPQGRAP 374

  Fly  1561 --------------------SVELIIEAKSNMHRQRLLQPTHDYQINELPASSAAPSASGTSGAS 1605
                                :|::|:.|.:....:...:...::.:.|:..:...
  Rat   375 ACLQKMMRSSVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEFYLAEVAFTVLF---------- 429

  Fly  1606 APGDRERDRDRDRDRERDRDRDRERDREAGGGGKEEGAQHAKPRGGLKKTYSIKERRSEAPRLSK 1670
                                     |.||                 |.|.:.:......:..|.|
  Rat   430 -------------------------DLEA-----------------LLKIWCLGFTGYISSSLHK 452

  Fly  1671 IRLARDPPIITTTAATPQDSPSTTLEPGMSFRQWGDMEPPSPPSPSLLRPPNIFTGGQRSLDEGI 1735
            ..|..   :|.||                                 |...|::: ..|.:..:.:
  Rat   453 FELLL---VIGTT---------------------------------LHVYPDLY-HSQFTYFQVL 480

  Fly  1736 PSIDLIPPSPVLSHKPLNILNASQLGVGMGGGVPSTAGSSSSMHSV------IIDDISKSSSSTA 1794
            ..:.||..||.|......|...   |..:|..|..||.....|.::      .::::.:.::...
  Rat   481 RVVRLIKISPALEDFVYKIFGP---GKKLGSLVVFTASLLIVMSAISLQMFCFVEELDRFTTFPR 542

  Fly  1795 AATPIY-VPTISSTADAQSQSHSLNDVSVGSSPGGEIP-------AT------------------ 1833
            |...:: :.|.....|...|  :||.|....:|...|.       ||
  Rat   543 AFMSMFQILTQEGWVDVMDQ--TLNAVGHMWAPLVAIYFILYHLFATLILLSLFVAVILDNLELD 605

  Fly  1834 -GMSRNANTGASTSGSSSSERLPLAPPPQQGSFKQRLRRGSSKKRRASALALA--TDDNPARRTL 1895
             .:.:......|.:.:.:.|:|||           |||.......|...:.::  ..|....:..
  Rat   606 EDLKKLKQLKQSEANADTKEKLPL-----------RLRIFEKFPNRPQMVKISKLPSDFTVPKIR 659

  Fly  1896 DNQARRTQDEEEEQQQLNNGGDNSCLLRNSNAVVSGSSSGTK----ETNRLSPQN------SIRR 1950
            ::..::..|.:::        |..||.|...:..|.|....|    |.|:...|.      || |
  Rat   660 ESFMKQFIDRQQQ--------DTCCLFRILPSTSSSSCDNPKRPTVEDNKYIDQKLRKSVFSI-R 715

  Fly  1951 LSNTLSIGSGPVGSRRASACIFNSQVYQNL------NQPPKLRPGSGQRRMSSIELAFSKTSHLN 2009
            ..|.|.       ...|...|..:...|.:      .||.|      :|.:.|::
  Rat   716 ARNLLE-------KETAVTKILRACTRQRMLSGSFEGQPAK------ERSILSVQ---------- 757

  Fly  2010 LHNLEANRKSLSYTNSKMDLDKWNKSYGNLNEPDNMLQQYMEARDKRKNSISHYNLKKRLEEKEL 2074
             |::...|:||.:.::...:.: .||...|.:..:...:|..|
  Rat   758 -HHIRQERRSLRHGSNSQRISR-GKSLETLTQDHSNTVRYRNA---------------------- 798

  Fly  2075 QQLQQLHQQQLLQQRQDSFSSTTQQQQQQLQQHRLSKDQQQLAMQPHSMVPGGGERYSKLKMLIE 2139
                         ||:||.....|::::|.:..|                          |:..|
  Rat   799 -------------QREDSEIKMIQEKKEQAEMKR--------------------------KVQEE 824

  Fly  2140 QLTPKH--FTTEREDYSLYIFPEDNRFRQICTWFVNQK--------------------------- 2175
            :|...|  |     |..|:|...::|||..|...|..:
  Rat   825 ELRENHPYF-----DKPLFIVGREHRFRNFCRVVVRARFNASKTDPVTGAVKNTKYHQLYDLLGL 884

  Fly  2176 --WFDNVVLLFIALNCITLAMERP--NIPPSSTERLFLATANYVFTVVFTVEMFIKVVATGMFYG 2236
              :.|.|::.....:||::..|.|  .:..:.|    |..|.|||.:..::|:.:|::|.|:|:.
  Rat   885 VTYLDWVMITVTICSCISMMFESPFRRVMHAPT----LQIAEYVFVIFMSIELNLKIMADGLFFT 945

  Fly  2237 HDAYFTSGWNIMDGSLVTISIIDLLMSLISESSPRIFGILRVFRLLRSLRPLRVINRAPGLKLVV 2301
            ..|.......:||..:..:|:|  .:..:.::.|...| .::..:||.|||||:....|.::.||
  Rat   946 PTAVIRDFGGVMDIFIYLVSLI--FLCWMPQNVPAESG-AQLLMVLRCLRPLRIFKLVPQMRKVV 1007

  Fly  2302 QTLLSSLRPIGNIVLICCTFFIIFGILGVQLFKGTFYYCEGENIKGVRNADECRRI--------- 2357
            :.|.|..:.|..:.::..|..::|...|||||.|....|...||  :|..| |..|
  Rat  1008 RELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAKCNDPNI--IRRED-CNGIFRINVSVSK 1069

  Fly  2358 ------------PG----NVWTN-RKYNFDDLGKALMSLFVLSSRDGWVNIMYTGLDAVGVDQQP 2405
                        ||    .||.| |.:|||::|.|:::||.:.|..|||.:....:..||    |
  Rat  1070 NLNLKLRPGEKKPGFWVPRVWANPRNFNFDNVGNAMLALFEVLSLKGWVEVRDVIIHRVG----P 1130

  Fly  2406 IVNYNEWRLLYFIAFILLVGFFVLNMFVGVVVENFHRCR------EEQEKEEKIRRAAKRALQME 2464
            |..      :|...|:.|.....|.:|||||:.||:..:      .:|.:.|.::...|.|
  Rat  1131 IHG------IYIHVFVFLGCMIGLTLFVGVVIANFNENKGTALLTVDQRRWEDLKSRLKIA---- 1185

  Fly  2465 KKRRRMHEPPYYTNYSPTRMFVHNVVTSKYFDLAIAAVIGLNVVTMAMEYYKMPSGLKYALKIFN 2529
               :.:|.||...| ...|..::::....:|...||.::....|.:::: :.:...:...|...:
  Rat  1186 ---QPLHLPPRPDN-DGFRAKMYDITQHPFFKRTIALLVLAQSVLLSVK-WDVEDPVTVPLATMS 1245

  Fly  2530 YFFTAVFILEANMKLVALGWKLYLKDRWNQLDVGIVLLSIVGIVLEELETNTHQIIPINPTIIRV 2594
            ..||.:|:||..||::|:....:.:.|.|:.|:.:..|.:|.:||.....|.:..: :...:| |
  Rat  1246 VVFTFIFVLEVTMKIIAMSPAGFWQSRRNRYDLLVTSLGVVWVVLHFALLNAYTYM-MGACVI-V 1308

  Fly  2595 MRVLRIARVLKLLKMANGIRALLDTVMQALPQVGNLGLLFFLLFFIFAALGVELFGRLECSDEIP 2659
            .|...|......|||      ||.||:.::.:...:.:..|||...:|..||.|||.::..:.|
  Rat  1309 FRFFSICGKHVTLKM------LLLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLFGTVKYGENI- 1366

  Fly  2660 CQGLGEHAHFANFGMAFLTLFRVATGDNWNGIMKDTLRDN--C--DD----AADCVRNCCVSSVI 2716
                ..||:|::.|.|...|||:.||::||.||.|.:...  |  |:    |.|     |.:...
  Rat  1367 ----NRHANFSSAGKAITVLFRIVTGEDWNKIMHDCMVQPPFCTPDEFTYWATD-----CGNYAG 1422

  Fly  2717 APIFFVIFVLMAQFVLVNVVVAVLMKHLEESHKQMEDEL-------------------------- 2755
            |.::|..|.::..::::|::||:::::....:...||:|
  Rat  1423 ALMYFCSFYVIIAYIMLNLLVAIIVENFSLFYSTEEDQLLSYNDLRHFQIIWNMVDDKREGVIPT 1487

  Fly  2756 ------------------------------DME---------------------------VELER 2763
                                          :||                           ::||.
  Rat  1488 FRVKFLLRLLRGRLEVDLDKDKLLFKHMCYEMERLHNGGDVTFHDVLSMLSYRSVDIRKSLQLEE 1552

  Fly  2764 ELVREQ-EFAQEQKLCQQ------------LAEAQSKAAAPPRPLAKVKSLPKNFIYSTPSLDKK 2815
            .|.||| |:..|:::.:|            :...|.::.:....|.:.:....:...:.||::..
  Rat  1553 LLAREQLEYTIEEEVAKQTIRMWLKKCLKRIRAKQQQSCSIIHSLRESQQQELSRFLNPPSIETT 1617

  Fly  2816 FP-----AVSGVNNPSLTSSAATNLNQVATAGSGGAAPGAVPAGSGAGPRRQTVQYFQQPPQSML 2875
            .|     |.|..:|....||:...|.....:..||:...|...|.   |:|:..|:       .|
  Rat  1618 QPSEDTNANSQDHNTQPESSSQQQLLSPTLSDRGGSRQDAADTGK---PQRKIGQW-------RL 1672

  Fly  2876 GGLSLAEMGGTLTPQALGARLGEPFGGGGGNKSGPRRQSYWQINPIRKRGVLSKERSLDEQAIRR 2940
            ...::||                                  :..|:.|....|::...:|:.:.:
  Rat  1673 PSAAIAE----------------------------------KTAPVNKMSSYSQDPEREEEEVSK 1703

  Fly  2941 RNLEAK----RTSCDSLPWGG---------------DALDC---------RRGTIFESLESDGGG 2977
            ..|..|    ..|..:|.:||               |...|         |:.|:    |||..|
  Rat  1704 GFLAPKPISHSVSSVNLRFGGRTTMKSVVCKMNPMPDTASCGSEVKKWWTRQLTV----ESDESG 1764

Fly 2978 2977
Rat 1765 1764

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ca-alpha1T	NP_001259267.1	Ion_trans	332..636	CDD:278921
		Ion_trans	1261..1495	CDD:278921	57/286 (20%)
		Ion_trans	2192..2448	CDD:278921	80/289 (28%)
		Ion_trans	2510..2728	CDD:278921	61/225 (27%)
Nalcn	NP_001380622.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	762..789		6/27 (22%)
Nalcn	NP_001380622.1	PLN03223	<1336..1451	CDD:215637	36/124 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D172471at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920