DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ca-alpha1T and NALCN

DIOPT Version :9

Sequence 1:	NP_001259267.1	Gene:	Ca-alpha1T / 31550	FlyBaseID:	FBgn0264386	Length:	3218	Species:	Drosophila melanogaster
Sequence 2:	XP_024305104.1	Gene:	NALCN / 259232	HGNCID:	19082	Length:	1786	Species:	Homo sapiens

Alignment Length:	1996	Identity:	377/1996 - (18%)
Similarity:	705/1996 - (35%)	Gaps:	633/1996 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly  1228 RVCSWIRRYIRRLVEHKYFQQGILLAILINTLSMGIEYHNQPPELTAIVETSNVVFSGIFAVEML 1292
            |:|:.|.                ::::.:|| .|..|::   |.|..:..|.:.:...::..||:
Human    62 RICAIIS----------------VISVCMNT-PMTFEHY---PPLQYVTFTLDTLLMFLYTAEMI 106

  Fly  1293 LKV----VAEGPFRYIANGFNVFDGIIV-------ILSAIEICQTFMGNGTGGGGSGLSVLRTFR 1346
            .|:    :.:|...|:.:.:.||||.:|       :|...||..........|   .|.:.|...
Human   107 AKMHIRGIVKGDSSYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWG---MLRIPRPLI 168

  Fly  1347 LLRILKL-VRFMPNLRRQLFVMLRTMDNVAVFFSLLVLFIFIFSILGMYLFG------------- 1397
            ::|..:: .||.....|...::.|:.:.:......|:.|:.::.|||:.:||
Human   169 MIRAFRIYFRFELPRTRITNILKRSGEQIWSVSIFLLFFLLLYGILGVQMFGTFTYHCVVNDTKP 233

  Fly  1398 ---------------------------GKFCKFLDESGLERECTCPEIISRHPQCECDRKHFNNI 1435
                                       |..|..|::.||.|:             |.....||.|
Human   234 GNVTWNSLAIPDTHCSPELEEGYQCPPGFKCMDLEDLGLSRQ-------------ELGYSGFNEI 285

  Fly  1436 LWATVTVFQILTQEDWNVVLFNGMEKTSHWAA-LYFVALMTFGNYVLFNLLVAILVEGFSSERNE 1499
            ..:..||::..:||.|..:::..::....|.: .||:.|:.|..:::.|:.:|:::|.|:..|.:
Human   286 GTSIFTVYEAASQEGWVFLMYRAIDSFPRWRSYFYFITLIFFLAWLVKNVFIAVIIETFAEIRVQ 350

  Fly  1500 RREREQRELVKKLREETLAENYSDGMYDESRSEADSSTTNDSYYE-VRNRWR-SAEDVRKLQD-- 1560
            .::                      |:. |||...|:.|...::| ....|: .|.||.|.|.
Human   351 FQQ----------------------MWG-SRSSTTSTATTQMFHEDAAGGWQLVAVDVNKPQGRA 392

  Fly  1561 ---------------------SVELIIEAKSNMHRQRLLQPTHDYQINELPASSAAPSASGTSGA 1604
                                 :|::|:.|.:....:...:...::.:.|:..:...
Human   393 PACLQKMMRSSVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEFYLAEVAFTVLF--------- 448

  Fly  1605 SAPGDRERDRDRDRDRERDRDRDRERDREAGGGGKEEGAQHAKPRGGLKKTYSIKERRSEAPRLS 1669
                                      |.||                 |.|.:.:......:..|.
Human   449 --------------------------DLEA-----------------LLKIWCLGFTGYISSSLH 470

  Fly  1670 KIRLARDPPIITTTAATPQDSPSTTLEPGMSFRQWGDMEPPSPPSPSLLRPPNIFTGGQRSLDEG 1734
            |..|..   :|.||                                 |...|::: ..|.:..:.
Human   471 KFELLL---VIGTT---------------------------------LHVYPDLY-HSQFTYFQV 498

  Fly  1735 IPSIDLIPPSPVLSHKPLNILNASQLGVGMGGGVPSTAGSSSSMHSV------IIDDISKSSSST 1793
            :..:.||..||.|......|...   |..:|..|..||.....|.::      .::::.:.::..
Human   499 LRVVRLIKISPALEDFVYKIFGP---GKKLGSLVVFTASLLIVMSAISLQMFCFVEELDRFTTFP 560

  Fly  1794 AAATPIY-VPTISSTADAQSQSHSLNDVSVGSSPGGEIP-------AT----------------- 1833
            .|...:: :.|.....|...|  :||.|....:|...|.       ||
Human   561 RAFMSMFQILTQEGWVDVMDQ--TLNAVGHMWAPVVAIYFILYHLFATLILLSLFVAVILDNLEL 623

  Fly  1834 --GMSRNANTGASTSGSSSSERLPLAPPPQQGSFKQRLRRGSSKKRRASALALA--TDDNPARRT 1894
              .:.:......|.:.:.:.|:|||           |||.......|...:.::  ..|....:.
Human   624 DEDLKKLKQLKQSEANADTKEKLPL-----------RLRIFEKFPNRPQMVKISKLPSDFTVPKI 677

  Fly  1895 LDNQARRTQDEEEEQQQLNNGGDNSCLLRNSNAVVSGSSSGTKET-------------------- 1939
            .::..::..|.:::        |..||||:.....|.|...:|.:
Human   678 RESFMKQFIDRQQQ--------DTCCLLRSLPTTSSSSCDHSKRSAIEDNKYIDQKLRKSVFSIR 734

  Fly  1940 --NRLSPQNSIRRL--------SNTLSI------GSGPVGSRRASACIFNSQVYQNL-NQPPKLR 1987
              |.|..:.::.::        |:.:||      |.....|....||.....:..:. .||.|
Human   735 ARNLLEKETAVTKILSKRPLPTSSPISIRCCLYLGRSHCHSSGVRACTRQRMLSGSFEGQPAK-- 797

  Fly  1988 PGSGQRRMSSIELAFSKTSHLNLHNLEANRKSLSYTNSKMDLDKWNKSYGNLNEPDNMLQQYMEA 2052
                :|.:.|::           |::...|:||.:.::...:.: .||...|.:..:...:|..|
Human   798 ----ERSILSVQ-----------HHIRQERRSLRHGSNSQRISR-GKSLETLTQDHSNTVRYRNA 846

  Fly  2053 RDKRKNSISHYNLKKRLEEKELQQLQQLHQQQLLQQRQDSFSSTTQQQQQQLQQHRLSKDQQQLA 2117
                                               ||:||.....|::::|.:..|
Human   847 -----------------------------------QREDSEIKMIQEKKEQAEMKR--------- 867

  Fly  2118 MQPHSMVPGGGERYSKLKMLIEQLTPKH--FTTEREDYSLYIFPEDNRFRQICTWFVNQK----- 2175
                             |:..|:|...|  |     |..|:|...::|||..|...|..:
Human   868 -----------------KVQEEELRENHPYF-----DKPLFIVGREHRFRNFCRVVVRARFNASK 910

  Fly  2176 ------------------------WFDNVVLLFIALNCITLAMERP--NIPPSSTERLFLATANY 2214
                                    :.|.|:::....:||::..|.|  .:..:.|    |..|.|
Human   911 TDPVTGAVKNTKYHQLYDLLGLVTYLDWVMIIVTICSCISMMFESPFRRVMHAPT----LQIAEY 971

  Fly  2215 VFTVVFTVEMFIKVVATGMFYGHDAYFTSGWNIMDGSLVTISIIDLLMSLISESSPRIFGILRVF 2279
            ||.:..::|:.:|::|.|:|:...|.......:||..:..:|:|  .:..:.::.|...| .::.
Human   972 VFVIFMSIELNLKIMADGLFFTPTAVIRDFGGVMDIFIYLVSLI--FLCWMPQNVPAESG-AQLL 1033

  Fly  2280 RLLRSLRPLRVINRAPGLKLVVQTLLSSLRPIGNIVLICCTFFIIFGILGVQLFKGTFYYCEGEN 2344
            .:||.|||||:....|.::.||:.|.|..:.|..:.::..|..::|...|||||.|....|...|
Human  1034 MVLRCLRPLRIFKLVPQMRKVVRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAKCNDPN 1098

  Fly  2345 IKGVRNADECRRI---------------------PG----NVWTN-RKYNFDDLGKALMSLFVLS 2383
            |  :|..| |..|                     ||    .||.| |.:|||::|.|:::||.:.
Human  1099 I--IRRED-CNGIFRINVSVSKNLNLKLRPGEKKPGFWVPRVWANPRNFNFDNVGNAMLALFEVL 1160

  Fly  2384 SRDGWVNIMYTGLDAVGVDQQPIVNYNEWRLLYFIAFILLVGFFVLNMFVGVVVENFHRCR---- 2444
            |..|||.:....:..||    ||..      :|...|:.|.....|.:|||||:.||:..:
Human  1161 SLKGWVEVRDVIIHRVG----PIHG------IYIHVFVFLGCMIGLTLFVGVVIANFNENKGTAL 1215

  Fly  2445 --EEQEKEEKIRRAAKRALQMEKKRRRMHEPPYYTNYSPTRMFVHNVVTSKYFDLAIAAVIGLNV 2507
              .:|.:.|.::...|.|       :.:|.||...| ...|..::::....:|...||.::....
Human  1216 LTVDQRRWEDLKSRLKIA-------QPLHLPPRPDN-DGFRAKMYDITQHPFFKRTIALLVLAQS 1272

  Fly  2508 VTMAMEYYKMPSGLKYALKIFNYFFTAVFILEANMKLVALGWKLYLKDRWNQLDVGIVLLSIVGI 2572
            |.:::: :.:...:...|...:..||.:|:||..||::|:....:.:.|.|:.|:.:..|.:|.:
Human  1273 VLLSVK-WDVEDPVTVPLATMSVVFTFIFVLEVTMKIIAMSPAGFWQSRRNRYDLLVTSLGVVWV 1336

  Fly  2573 VLEELETNTHQIIPINPTIIRVMRVLRIARVLKLLKMANGIRALLDTVMQALPQVGNLGLLFFLL 2637
            ||.....|.:..: :...:| |.|...|......|||      ||.||:.::.:...:.:..|||
Human  1337 VLHFALLNAYTYM-MGACVI-VFRFFSICGKHVTLKM------LLLTVVVSMYKSFFIIVGMFLL 1393

  Fly  2638 FFIFAALGVELFGRLECSDEIPCQGLGEHAHFANFGMAFLTLFRVATGDNWNGIMKDTLRDN--C 2700
            ...:|..||.|||.::..:.|     ..||:|::.|.|...|||:.||::||.||.|.:...  |
Human  1394 LLCYAFAGVVLFGTVKYGENI-----NRHANFSSAGKAITVLFRIVTGEDWNKIMHDCMVQPPFC 1453

  Fly  2701 --DD----AADCVRNCCVSSVIAPIFFVIFVLMAQFVLVNVVVAVLMKHLEESHKQMEDEL---- 2755
              |:    |.|     |.:...|.::|..|.::..::::|::||:::::....:...||:|
Human  1454 TPDEFTYWATD-----CGNYAGALMYFCSFYVIIAYIMLNLLVAIIVENFSLFYSTEEDQLLSYN 1513

  Fly  2756 ----------------------------------------------------DME---------- 2758
                                                                :||
Human  1514 DLRHFQIIWNMVDDKREGVIPTFRVKFLLRLLRGRLEVDLDKDKLLFKHMCYEMERLHNGGDVTF 1578

  Fly  2759 -----------------VELERELVREQ-EFAQEQKLCQQ------------LAEAQSKAAAPPR 2793
                             ::||..|.||| |:..|:::.:|            :...|.::.:...
Human  1579 HDVLSMLSYRSVDIRKSLQLEELLAREQLEYTIEEEVAKQTIRMWLKKCLKRIRAKQQQSCSIIH 1643

  Fly  2794 PLAKVKSLPKNFIYSTPSLDKKFP-----AVSGVNNPSLTSSAATNLNQVATAGSGGAAPGAVPA 2853
            .|.:.:....:...:.||::...|     |.|..|:....:|:...|.....:..||:...|..|
Human  1644 SLRESQQQELSRFLNPPSIETTQPSEDTNANSQDNSMQPETSSQQQLLSPTLSDRGGSRQDAADA 1708

  Fly  2854 GSGAGPRRQTVQY-FQQPPQSMLGGLSLAEM--GGTLTPQALGARL 2896
            |.   |:|:..|: ....|:.:...:|...:  ||..|.:::..::
Human  1709 GK---PQRKFGQWRLPSAPKPISHSVSSVNLRFGGRTTMKSVVCKM 1751

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ca-alpha1T	NP_001259267.1	Ion_trans	332..636	CDD:278921
		Ion_trans	1261..1495	CDD:278921	57/286 (20%)
		Ion_trans	2192..2448	CDD:278921	80/289 (28%)
		Ion_trans	2510..2728	CDD:278921	61/225 (27%)
NALCN	XP_024305104.1	Ion_trans	55..350	CDD:306908	63/323 (20%)
		Ion_trans	402..622	CDD:306908	41/313 (13%)
		Ion_trans	935..1209	CDD:306908	84/293 (29%)
		Ion_trans	1257..1506	CDD:306908	68/267 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D172471at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820