DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ca-alpha1T and Cacna1b

DIOPT Version :9

Sequence 1:	NP_001259267.1	Gene:	Ca-alpha1T / 31550	FlyBaseID:	FBgn0264386	Length:	3218	Species:	Drosophila melanogaster
Sequence 2:	XP_006233631.1	Gene:	Cacna1b / 257648	RGDID:	628852	Length:	2359	Species:	Rattus norvegicus

Alignment Length:	3146	Identity:	662/3146 - (21%)
Similarity:	1051/3146 - (33%)	Gaps:	1176/3146 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   228 GGRTGGAVSSSTGSSCNGSCSSDDGDSSHTSSSSSSSSSGEPNLPYPGFPEISIRALTQYTRPRN 292
            |||.||     ||.          |:.:....:..:...|:..|| ||...:..:::.|..|
  Rat     9 GGRYGG-----TGG----------GERARGGGAGGAGGPGQGGLP-PGQRVLYKQSIAQRAR--- 54

  Fly   293 WCLMLITNP--------------------------------W--FERVSILVILLNCITLGMYQ- 322
              .|.:.||                                |  ||.:.:..|:.|||.|.:.|
  Rat    55 --TMALYNPIPVKQNCFTVNRSLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQH 117

  Fly   323 -PCVDDACVTNRCKILQIFDDIIFAFFALEMTIKMVAMG-ICGKNTYLADSWNRLDFFIVLAGLL 385
             |..|...::.|   |...:......|..|..||::|:| :..|.:||.:.||.:||.:||.|:|
  Rat   118 LPDGDKTPMSER---LDDTEPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGIL 179

  Fly   386 EYVMHVENLNLTAIRTIRVLRPLRAINRIPSMRILVMLLLDTLPMLGNVLLLCFFVFFIFGIIGV 450
              .....:.:|..:|.:||||||:.::.|||:::::..::..:..|..:.||.||...:|.|||:
  Rat   180 --ATAGTDFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGL 242

  Fly   451 QLWEGILRQRCSLMRTEGMVYPLTVPEVYRVRVRVNSLSQYYEFSKDQDYICSTPNDSGMHLCGN 515
            :.:.|...:.|                                          .||.:.....|:
  Rat   243 EFYMGKFHKAC------------------------------------------FPNSTDAEPVGD 265

  Fly   516 FPPYRIGSLVCNEE--AKLFDFNEPTNTSCVNWNQYYTTCKQSGENPFQGTISFDNIGMAWVAIF 578
            ||        |.:|  |:|.|.:              |.|::....|..|..:||||..|.:.:|
  Rat   266 FP--------CGKEAPARLCDSD--------------TECREYWPGPNFGITNFDNILFAILTVF 308

  Fly   579 LVISLEGWTDIMYYVQD-AHSFWDWIYFVLLIVIGSFFMINLCLVVIATQFSETKKREMERMRQE 642
            ..|::||||||:|...| |.:.|:|:||:.||:||||||:||.|.|::.:|:    :|.||:...
  Rat   309 QCITMEGWTDILYNTNDAAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFA----KERERVENR 369

  Fly   643 RARYTSTSTLASSTNNSEPATCYAEIVKYIAHLWRRFKRRMLKKYRLYKYQRQQRKEGLLPNADN 707
            ||                                            ..|.:|||:.|..|.....
  Rat   370 RA--------------------------------------------FLKLRRQQQIERELNGYLE 390

  Fly   708 LTFSPSRIKCHHPKCPKYSNRKPSSIQDQMITVMVPLNSASNNINNNNNNNSNSSNHNGSGNHTA 772
            ..|....:
  Rat   391 WIFKAEEV--------------------------------------------------------- 398

  Fly   773 AGGGNNNNNNNNNNAASCTTVALVNGINGSAASVTMSSAHHQQHQLLQHQQQQHQNQQQQQQQQQ 837

  Rat   399 ----------------------------------------------------------------- 398

  Fly   838 HSSSDNTEQSLAPDGLPRSSSLKKSTAHHQLKPEGSAAEQKTILLKFPQQMIDSEQLILQLGNLG 902
                                         .|..|...||:|
  Rat   399 -----------------------------MLAEEDKNAEEK------------------------ 410

  Fly   903 KSHPCTSGFLSPPTSASRRPSVMFNEYVLLHTPPALNADPATAGTTTTVAPTVATVAGTAAAAAA 967
                      ||..:..:|.:...:...|:|
  Rat   411 ----------SPLDAVLKRAATKKSRNDLIH---------------------------------- 431

  Fly   968 AAATGSGSGNNNHQNGGASGGAGTGGTTEKSNIFSTEKMTQAGDGSIWQVNLPQTIGTIANPYAD 1032
                 :..|.:...:..|:|                                        :|:|
  Rat   432 -----AEEGEDRFVDLCAAG----------------------------------------SPFA- 450

  Fly  1033 CSELGIHDAMTCQELLAFSVAFSAALPTGQSTLESFYTSLARCDPHTAEALRAHHKPRSVPTGQN 1097
                                  .|:|.:|::...|::
  Rat   451 ----------------------RASLKSGKTESSSYF---------------------------- 465

  Fly  1098 QTTPGAEGATVMVASTAGDTGQTLQPSTVSAVVGGTIDSHAANHRRKEHHQQSHHHHNNNNTTSH 1162
                                                        ||||
  Rat   466 --------------------------------------------RRKE----------------- 469

  Fly  1163 SRNYRSRQGQGNSRMREPRAPTGNYMEDYACCYDLYQNALSPLDERPRQRSPTTRCLISVYRCMS 1227

  Rat   470 ----------------------------------------------------------------- 469

  Fly  1228 RVCSWIRRYIRRLVEHKYFQQGILLAILINTLSMGIEYHNQPPELTAIVETSNVVFSGIFAVEML 1292
               ...|..|||:|:.:.|...:|..:.:|||.:.:.::|||..||..:..:..||.|:|..||.
  Rat   470 ---KMFRFLIRRMVKAQSFYWVVLCVVALNTLCVAMVHYNQPQRLTTALYFAEFVFLGLFLTEMS 531

  Fly  1293 LKVVAEGPFRYIANGFNVFDGIIVILSAIEICQTFMGNGTGGGGSGLSVLRTFRLLRILKLVRFM 1357
            ||:...||..|..:.||.||..:::.|..|:....:..||   ..|:||||..|||||.|:.::.
  Rat   532 LKMYGLGPRSYFRSSFNCFDFGVIVGSIFEVVWAAIKPGT---SFGISVLRALRLLRIFKVTKYW 593

  Fly  1358 PNLRRQLFVMLRTMDNVAVFFSLLVLFIFIFSILGMYLFGGKFCKFLDESGLERECTCPEIISRH 1422
            .:||..:..:|.:|.::.....||.|||.:|::|||.||||:| .|.||:
  Rat   594 NSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQF-NFQDET--------------- 642

  Fly  1423 PQCECDRKHFNNILWATVTVFQILTQEDWNVVLFNGME-----KTSHWAALYFVALMTFGNYVLF 1482
                 ...:|:....|.:|||||||.||||.|:::|:|     ....:::.||:.|..||||.|.
  Rat   643 -----PTTNFDTFPAAILTVFQILTGEDWNAVMYHGIESQGGVSKGMFSSFYFIVLTLFGNYTLL 702

  Fly  1483 NLLVAILVEGFSSERNERREREQRE-------LVKKLRE-----ETLAENYSDGMYDE------S 1529
            |:.:||.|:..::.:...::.|:.|       .::|.:|     ...|.|.|...:.:      |
  Rat   703 NVFLAIAVDNLANAQELTKDEEEMEEAANQKLALQKAKEVAEVSPMSAANISIAAFVKQTRGTVS 767

  Fly  1530 RSEADSSTTN---DSYYEVRNRWRSAEDVRKLQD---SVELII-------------------EAK 1569
            ||.:.||..:   .:..:.|:.|.......:||:   |.|.:.                   :.|
  Rat   768 RSSSVSSVNSPRQQNSAKARSVWEQRASQLRLQNLRASCEALYSEMDPEERLRYASTRHVRPDMK 832

  Fly  1570 SNMHRQRLLQPTHDYQINELPASSAAPSASGTSGASAPGDRERDRDRDRDR-------ERDRDRD 1627
            ::|.|..:::|..|.........|.......|.||..|....|.||||:..       |:|| .|
  Rat   833 THMDRPLVVEPGRDGLRGPAGNKSKPEGTEATEGADPPRRHHRHRDRDKTSASTPAGGEQDR-TD 896

  Fly  1628 RERDREAGGGGKEEGAQHAKPRGGLKKTYSIKERRSEAPRL-SKIRLARDPPIITTTAATPQDSP 1691
            ..:......|.:||   .|:||         :....|||.. :::|..|
  Rat   897 CPKAESTETGAREE---RARPR---------RSHSKEAPGADTQVRCER---------------- 933

  Fly  1692 STTLEPGMSFRQWGDMEPPSPPSPSLLRPPNIFTGGQRSLDEGIPSIDLIPPSPVLSHKPLNILN 1756
                  .....:.|..|..:...|...|                            :|:
  Rat   934 ------SRRHHRRGSPEEATEREPRRHR----------------------------AHR------ 958

  Fly  1757 ASQLGVGMGGGVPSTAGSSSSMHSVIIDDISKSSSSTAAATPIYVPTISSTADAQSQSHSLNDVS 1821
                                  |:   .|.||......|  |:.||.....|..:.
  Rat   959 ----------------------HA---QDSSKEGKEGTA--PVLVPKGERRARHRG--------- 987

  Fly  1822 VGSSPGGEIPATGMSRNANTGASTSGSSSSERLP--LAPPPQQGSFKQRLRRGSSKKRRASALAL 1884
                     |.||.....|:...|....:..::|  |.||.::.:.|:
  Rat   988 ---------PRTGPRETENSEEPTRRHRAKHKVPPTLEPPEREVAEKE----------------- 1026

  Fly  1885 ATDDNPARRTLDNQARRTQDEEEEQQQLNNGGDNSCLLRNSNAVVSGSSSGTKETNRLSPQNSIR 1949
                                                    ||.|     .|.|||....|:....
  Rat  1027 ----------------------------------------SNVV-----EGDKETRNHQPKEPRC 1046

  Fly  1950 RLSNTLSIGSGPVGSRR--ASACIFNSQVYQNLNQPPKLRPGSGQR---RMSSIELAFSKTSHLN 2009
            .|.   :|....|||..  .|.|:      |.:::.|:  ....||   ||.|.....|.|.|:.
  Rat  1047 DLE---AIAVTGVGSLHMLPSTCL------QKVDEQPE--DADNQRNVTRMGSQPSDPSTTVHVP 1100

  Fly  2010 LHNLEANRKSLSYTNSKMDLDKWNKSYGNLNEPDNMLQQYMEARDKRKNSISHYNLKKRLEEKEL 2074
            :.......::....::..||:  .::.|                            ||..|..::
  Rat  1101 VTLTGPPGEATVVPSANTDLE--GQAEG----------------------------KKEAEADDV 1135

  Fly  2075 QQLQQLHQQQLLQQRQDSFSSTTQQQQQQLQQHRLSKDQQQLAMQPHSMVPGGGERYSKLKMLIE 2139
                                                     |...|..:||     ||
  Rat  1136 -----------------------------------------LRRGPRPIVP-----YS------- 1147

  Fly  2140 QLTPKHFTTEREDYSLYIFPEDNRFRQICTWFVNQKWFDNVVLLFIALNCITLAMERPNIPPSST 2204
                          |::.....|..|:.|.:.|..::|:.|:|:.|||:.|.||.|.| :...|.
  Rat  1148 --------------SMFCLSPTNLLRRFCHYIVTMRYFEMVILVVIALSSIALAAEDP-VRTDSF 1197

  Fly  2205 ERLFLATANYVFTVVFTVEMFIKVVATGMFYGHDAYFTSGWNIMD-----GSLVTISIIDLLMSL 2264
            ....|...:|:||.|||.||.||::..|:.....|||...|||:|     |:||..:    ..|.
  Rat  1198 RNNALKYMDYIFTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFA----FSSF 1258

  Fly  2265 ISESSPRIFGILRVFRLLRSLRPLRVINRAPGLKLVVQTLLSSLRPIGNIVLICCTFFIIFGILG 2329
            :..|..:....::..|:||.||||:.|.|.|.||.|...:::||:.:.||:::...|..||.::.
  Rat  1259 MGGSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIA 1323

  Fly  2330 VQLFKGTFYYCEGENIKGVRNADECR-----------RIPGNVWTNRKYNFDDLGKALMSLFVLS 2383
            ||||||.|:||..|:.:..|   :||           ......|....:::|::..||::||.:|
  Rat  1324 VQLFKGKFFYCTDESKELER---DCRGQYLDYEKEEVEAQPRQWKKYDFHYDNVLWALLTLFTVS 1385

  Fly  2384 SRDGWVNIMYTGLDAVGVDQQPIVNYNEWRLLYFIAFILLVGFFVLNMFVGVVVENFHRCREEQE 2448
            :.:||..::...:||...:|.|...:.....::::.:.::..||.:|:||.:::..|      ||
  Rat  1386 TGEGWPMVLKHSVDATYEEQGPSPGFRMELSIFYVVYFVVFPFFFVNIFVALIIITF------QE 1444

  Fly  2449 KEEKIRRAAKRALQMEKKRR-----RMHEPPYYTNYSP--TRMFVHNV---VTSKYFDLAIAAVI 2503
            :.:|:....    .:||..|     .:...| .|.|.|  .:.|.:..   |.|..|:..|.|:|
  Rat  1445 QGDKVMSEC----SLEKNERACIDFAISAKP-LTRYMPQNKQSFQYKTWTFVVSPPFEYFIMAMI 1504

  Fly  2504 GLNVVTMAMEYYKMPSGLKYALKIFNYFFTAVFILEANMKLVALGWKLYLKDRWNQLDVGIVLLS 2568
            .||.|.:.|::|..|...:..||..|..||::|.||..:|::|.|...|.:|.||..|...||.|
  Rat  1505 ALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSLECILKIIAFGVLNYFRDAWNVFDFVTVLGS 1569

  Fly  2569 IVGIVLEEL-ETNTHQIIPINPTIIRVMRVLRIARVLKLLKMANGIRALLDTVMQALPQVGNLGL 2632
            |..|::.|: |||..    ||   :..:|:.|.||::|||:....||.||.|.:|:...:..:.|
  Rat  1570 ITDILVTEIAETNNF----IN---LSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCL 1627

  Fly  2633 LFFLLFFIFAALGVELFGRLECSDEIPCQGLGEHAHFANFGMAFLTLFRVATGDNWNGIMKDTLR 2697
            |..:||||:|.:|:::||.:...|.   ..:..|.:|..|..|.:.|||.|||:.|:.||...|.
  Rat  1628 LIAMLFFIYAIIGMQVFGNIALDDG---TSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLG 1689

  Fly  2698 DN-CD---DAADCVRNCCVSSVIAPIFFVIFVLMAQFVLVNVVVAVLMKHLE----ESHKQMEDE 2754
            :. ||   :|::|      .|..|..:||.|:.:..|:::|:.|||:|.:.|    :|.......
  Rat  1690 NRACDPHANASEC------GSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHH 1748

  Fly  2755 LDMEVELERELVR---EQEFAQEQKLCQQLAEAQSKAAAPPRPLAKVKSLPKNFIYSTPSLDKKF 2816
            ||       |.:|   |.:.|...::.........|..:||..|.  |..|....|      |:.
  Rat  1749 LD-------EFIRVWAEYDPAACGRISYNDMFEMLKHMSPPLGLG--KKCPARVAY------KRL 1798

  Fly  2817 PAVS-GVNNPSLT-SSAATNLNQVATAGSGGAAP-GAVPAGSGAGPRRQTVQYFQQPPQSMLGGL 2878
            ..:: .::|..:| ...:|.:..:.||.....|| |.......|..|::....:...||..|..|
  Rat  1799 VRMNMPISNEDMTVHFTSTLMALIRTALEIKLAPAGTKQHQCDAELRKEISSVWANLPQKTLDLL 1863

  Fly  2879 SLAEMGGTLTPQALGARLGEPFGGGGGNKSGPRRQSYWQINPIRKRGVLSKERSLD---EQ---- 2936
            ........:|...:.|.| ..|.....||: .|.|::.....:.:.|.:|....|.   ||
  Rat  1864 VPPHKPDEMTVGKVYAAL-MIFDFYKQNKT-TRDQTHQAPGGLSQMGPVSLFHPLKATLEQTQPA 1926

  Fly  2937 AIRRRNLEAKRTSCDSLPWGGDALDCRRGTIFESLESDGGGVGGGGSGGGGGGLGGGVSYDLRSV 3001
            .:|...:..::.|..||..|| |:..:...|.|||             ..|......|.|:.|:
  Rat  1927 VLRGARVFLRQKSATSLSNGG-AIQTQESGIKESL-------------SWGTQRTQDVLYEARA- 1976

  Fly  3002 RSADVGHS-EMD-GDVSLSVVSALVPSVTTPLP-----PPL-------SLPIVTPTSTPTPLQLP 3052
             ..:.||| |:. |......|...:.::|...|     |.|       |:|.:...:.|.|...|
  Rat  1977 -PLERGHSAEIPVGQPGALAVDVQMQNMTLRGPDGEPQPGLESQGRAASMPRLAAETQPAPNASP 2040

  Fly  3053 MPMPMPMAHPPPRRPFGWSQSVDQGCLRSNLLLSVPRSMPP------------RSRSGSTKQLFK 3105
            |...:....|   ||.|     .|.|   |.:|..|   ||            |.|....:.|.|
  Rat  2041 MKRSISTLAP---RPHG-----TQLC---NTVLDRP---PPSQVSHHHHHRCHRRRDKKQRSLEK 2091

  Fly  3106 QQALDEDADMDENSLLLPTAAGGG--SGPGSVAVIASSSLDLPDQSGSSKQILPDIALGVSKSDS 3168
            ..:|..|.:...:     ||||.|  .|.||    .....:...:.|.|::         .:..|
  Rat  2092 GPSLSVDTEGAPS-----TAAGSGLPHGEGS----TGCRRERKQERGRSQE---------RRQPS 2138

  Fly  3169 SDILRIISERRRM---DQREQREPEQ 3191
            |.    .||::|.   |:...|||.|
  Rat  2139 SS----SSEKQRFYSCDRFGSREPPQ 2160

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ca-alpha1T	NP_001259267.1	Ion_trans	332..636	CDD:278921	88/307 (29%)
		Ion_trans	1261..1495	CDD:278921	84/238 (35%)
		Ion_trans	2192..2448	CDD:278921	81/271 (30%)
		Ion_trans	2510..2728	CDD:278921	77/222 (35%)
Cacna1b	XP_006233631.1	Ion_trans	112..367	CDD:278921	95/327 (29%)
		Ion_trans	500..721	CDD:278921	84/244 (34%)
		Ion_trans	1186..1448	CDD:278921	83/275 (30%)
		Ion_trans	1511..1742	CDD:278921	84/246 (34%)
		GPHH	1750..1814	CDD:293510	15/78 (19%)
		Ca_chan_IQ	1816..1890	CDD:285917	16/74 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D172471at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820