DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1T and Scn5a

DIOPT Version :9

Sequence 1:NP_001259267.1 Gene:Ca-alpha1T / 31550 FlyBaseID:FBgn0264386 Length:3218 Species:Drosophila melanogaster
Sequence 2:XP_038936827.1 Gene:Scn5a / 25665 RGDID:3637 Length:2020 Species:Rattus norvegicus


Alignment Length:2607 Identity:553/2607 - (21%)
Similarity:942/2607 - (36%) Gaps:934/2607 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   280 SIRALTQYTRPRNWCLMLITNPWFERVSILVILLNCITLGMYQPCVDDACVTNRCKILQIFDDII 344
            ::..|:.:...|...:.::.:..|..:.:..||.||:.:..:.|       ....|.::.....|
  Rat   111 ALYVLSPFHPVRRAAVKILVHSLFSMLIMCTILTNCVFMAQHDP-------PPWTKYVEYTFTAI 168

  Fly   345 FAFFALEMTIKMVAMGIC-GKNTYLADSWNRLDF-FIVLAGLLEYVMHVENLNLTAIRTIRVLRP 407
            :.|   |..:|::|.|.| ...|:|.|.||.||| .||:|...|:   |:..|::|:||.||||.
  Rat   169 YTF---ESLVKILARGFCLHAFTFLRDPWNWLDFSVIVMAYTTEF---VDLGNVSALRTFRVLRA 227

  Fly   408 LRAINRIPSMRILVMLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWEGILRQRC----------- 461
            |:.|:.|..::.:|..|:.::..|.:|::|..|...:|.:||:||:.|.||.:|           
  Rat   228 LKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTELNGTN 292

  Fly   462 SLMRTEGMVYPLTVPEVYRVRVRVNSLSQYYEFSKDQDYICSTPNDSGMHLCGNFPPYRIGSLVC 526
            ..:..:|:|:              |||..|  .:...:|:... ..:.:.||||    ...:..|
  Rat   293 GSVEADGLVW--------------NSLDVY--LNDPANYLLKN-GTTDVLLCGN----SSDAGTC 336

  Fly   527 NEEAKLFDFNEPTNTSCVNWNQYYTTCKQSGENPFQGTISFDNIGMAWVAIFLVISLEGWTDIMY 591
            .|..:                     |.::||||..|..|||:...|::|:|.:::.:.|..:  
  Rat   337 PEGYR---------------------CLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERL-- 378

  Fly   592 YVQDAHSFWD--WIYFVLLIVIGSFFMINLCLVVIATQFSETKKREMERMRQERARYTSTSTLAS 654
            |.|...|...  .|:|:|:|.:|||:::||.|.|:|..:.|..:                :|:| 
  Rat   379 YQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQ----------------ATIA- 426

  Fly   655 STNNSEPATCYAEIVKYIAHLWRRFKR--RMLKKYRLYKYQRQQRKEGL-LPNADNLTFSPSRIK 716
            .|...|                :||:.  .||||          ..|.| :...|.::.      
  Rat   427 ETEEKE----------------KRFQEAMEMLKK----------EHEALTIRGVDTVSH------ 459

  Fly   717 CHHPKCPKYSNRKPSSIQDQMITVMVPLNSASNNINNNNNNNSNSSNHNGSGNHTAAGGGNN-NN 780
                          ||::      |.||...:|:...:......||.       |..||.:. ..
  Rat   460 --------------SSLE------MSPLAPVTNHERKSKRRKRLSSG-------TEDGGDDRLPK 497

  Fly   781 NNNNNNAASCTTVALVNGINGSAASVTMSSAHHQQHQLLQHQQQQHQNQQQQQQQQQHSSSDNTE 845
            :::.:...:...::|.:|:  |..|:...|:........:..|                   .:|
  Rat   498 SDSEDGPRALNQLSLTHGL--SRTSMRPRSSRGSIFTFRRRDQ-------------------GSE 541

  Fly   846 QSLAPDGLPRSSSLKKSTAHHQLKPEGSAAEQKTILLKFPQQMIDSEQLILQLGNLGKSHPCTSG 910
            ...|.|        :.|||..      |.:.:.::|:.:|.:                 ||...|
  Rat   542 ADFADD--------ENSTAGE------SESHRTSLLVPWPLR-----------------HPSAQG 575

  Fly   911 FLSPPTSASRRPSVMFNEYVLLHTPPALNADPATAGTTTTVAPTVATVAGTAAAAAAAAATGSGS 975
            ...|..||   |.     |||                                           :
  Rat   576 QPGPGASA---PG-----YVL-------------------------------------------N 589

  Fly   976 GNNNHQNGGASGGAGTGGTTEKSNIFSTEKMTQAGDGSIWQVNLPQTIGTIANPYADCSELGIHD 1040
            |..|             .|.:.:.:.|   :..|||                             
  Rat   590 GKRN-------------STVDCNGVVS---LLGAGD----------------------------- 609

  Fly  1041 AMTCQELLAFSVAFSAALPTGQSTLESFYTSLARCDPHTAEALRAHHKPRSVPTGQNQTTPGAEG 1105
                                                   |||                |:||:..
  Rat   610 ---------------------------------------AEA----------------TSPGSYL 619

  Fly  1106 ATVMVASTAGDTGQTLQPSTVSAVVGGTIDSHAANHRRKEHHQQSHHHHNNNNTTSHSRNYRSRQ 1170
            ...||.....||      :|.|...||                                      
  Rat   620 LRPMVLDRPPDT------TTPSEEPGG-------------------------------------- 640

  Fly  1171 GQGNSRMREPRAPTGNYMEDYAC------CYDLYQNALSPLDERPRQRSPTTRCLISVYRCMSRV 1229
                .:|..|:||..:..|:...      ...:..:||..|:|..|:..|........|......
  Rat   641 ----PQMLTPQAPCADGFEEPGARQRALSAVSVLTSALEELEESHRKCPPCWNRFAQHYLIWECC 701

  Fly  1230 CSW--IRRYIRRLVEHKYFQQGILLAILINTLSMGIEYHNQPPELTAIVETSNVVFSGIFAVEML 1292
            ..|  |::.::.:|...:....|.:.|::|||.|.:|::|...|...:::..|:||:|||..||.
  Rat   702 PLWMSIKQKVKFVVMDPFADLTITMCIVLNTLFMALEHYNMTAEFEEMLQVGNLVFTGIFTAEMT 766

  Fly  1293 LKVVAEGPFRYIANGFNVFDGIIVILSAIEICQTFMGNGTGGGGSGLSVLRTFRLLRILKLVRFM 1357
            .|::|..|:.|...|:|:||.||||||.:|:..:.|||        |||||:|||||:.||.:..
  Rat   767 FKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMGN--------LSVLRSFRLLRVFKLAKSW 823

  Fly  1358 PNLRRQLFVMLRTMDNVAVFFSLLVLFIFIFSILGMYLFGGKFCKF---LDESGLERECTCPEII 1419
            |.|...:.::..::..:.....:|.:.:|||:::||.|||..:.:.   :.:|||          
  Rat   824 PTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRHRISDSGL---------- 878

  Fly  1420 SRHPQCECDRKHFNNILWATVTVFQILTQEDWNVVLFNGMEKTSH-WAALYFVALMTFGNYVLFN 1483
                   ..|.|..:...|.:.:|:||..| |...:::.||.:.. ...|.|:.:|..||.|:.|
  Rat   879 -------LPRWHMMDFFHAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLN 935

  Fly  1484 LLVAILVEGFSSERNERREREQRELVKKLREETLAENYSDGMYDESRSEADSSTTNDSYYEVRNR 1548
            |.:|:|:..||::                                                    
  Rat   936 LFLALLLSSFSAD---------------------------------------------------- 948

  Fly  1549 WRSAEDVRKLQDSVELIIEAKSNMHRQRLLQPTHDYQINELPASSAAPSASGTSGASAPGDRERD 1613
                                       .|..|..|.::|.|..:.|.                  
  Rat   949 ---------------------------NLTAPDEDGEMNNLQLALAR------------------ 968

  Fly  1614 RDRDRDRERDRDRDRERDREAGGGGKEEGAQHAKPRGGLKKTY----SIKERRSEAPRLSKIRLA 1674
                                     .:.|.:..|     :.|:    .|..||.:.|        
  Rat   969 -------------------------IQRGLRFVK-----RTTWDFCCGILRRRPKKP-------- 995

  Fly  1675 RDPPIITTTAATPQDSPSTTLEPGMSFRQWGDMEPPSPPSPSLLRPPNIFTGGQRSLDEGIPSID 1739
                   ...||....||..               .:|.||    ||              |.::
  Rat   996 -------AALATHSQLPSCI---------------TAPRSP----PP--------------PEVE 1020

  Fly  1740 LIPPSPVLSHKPLNILNASQLGVGMGGGVPSTAGSSSSMHSVIIDDISKSSSSTAAATPIYVPTI 1804
            .:||                                                             
  Rat  1021 KVPP------------------------------------------------------------- 1024

  Fly  1805 SSTADAQSQSHSLNDVSVGSSPGGEIPATGMSRNANTGASTSGSSSSERLPLAPPPQQGSFKQRL 1869
                 |:.:                   |....:...|..|.|.|.    |:..|          
  Rat  1025 -----ARKE-------------------TRFEEDKRPGQGTPGDSE----PVCVP---------- 1051

  Fly  1870 RRGSSKKRRASALALATDDNPARRTLDNQARRTQDEEEEQQQLNNGGDNSCLLRNSNAVVSGSSS 1934
                        :|:|..|             |:|:||:::. :.|.:.....:..:.||||...
  Rat  1052 ------------IAVAESD-------------TEDQEEDEEN-SLGTEEESSKQQESQVVSGGHE 1090

  Fly  1935 GTKETNRLSPQNSIRRLSNTLSIGSGPVGSRRASACIFNSQVYQNLNQPPKLRPGSGQRRMSSIE 1999
            ..:|....|      ::|.|.|..:|...|:..         :|...:.....||.|:    :.|
  Rat  1091 PYQEPRAWS------QVSETTSSEAGASTSQAD---------WQQEQKTEPQAPGCGE----TPE 1136

  Fly  2000 LAFSKTSHLNLHNLEANRKSLSYTNSKMDLDKWNKSYGNLNEPDNMLQQYMEARDKRKNSISHYN 2064
            .::|:.|..::.|             ..||                                   
  Rat  1137 DSYSEGSTADMTN-------------TADL----------------------------------- 1153

  Fly  2065 LKKRLEEKELQQLQQLHQQQLLQQRQDSFSSTTQQQQQQLQQHRLSKDQQQLAMQPHSMVPGGGE 2129
                     |:|:..|.:.  ::..:|.|:....::                  .|..||.    
  Rat  1154 ---------LEQIPDLGED--VKDPEDCFTEGCVRR------------------CPCCMVD---- 1185

  Fly  2130 RYSKLKMLIEQLTPKHFTTEREDYSLYIFPEDNRFRQICTWFVNQKWFDNVVLLFIALNCITLAM 2194
                             ||:......:      |.|:.|...|...||:..::..|.|:...||.
  Rat  1186 -----------------TTQSPGKVWW------RLRKTCYRIVEHSWFETFIIFMILLSSGALAF 1227

  Fly  2195 ERPNIPPSSTERLFLATANYVFTVVFTVEMFIKVVATGMFYGHDAYFTSGWNIMDGSLVTISIID 2259
            |...:....|.::.|..|:.:||.||.:||.:|.||    ||...|||:.|..:|..:|.:|::.
  Rat  1228 EDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVA----YGFKKYFTNAWCWLDFLIVDVSLVS 1288

  Fly  2260 LLMSLISESSPRIFGILRVFRLLRSLRPLRVINRAPGLKLVVQTLLSSLRPIGNIVLICCTFFII 2324
            |:.:.:..:.   .|.::..|.||:|||||.::|..|:::||..|:.::..|.|::|:|..|::|
  Rat  1289 LVANTLGFAE---MGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLI 1350

  Fly  2325 FGILGVQLFKGTFYYC----EGE---NIKGVRNADECR--RIPGNV-WTNRKYNFDDLGKALMSL 2379
            |.|:||.||.|.|..|    ||:   |...|.|..||.  .:.|.: ||..|.|||::|...::|
  Rat  1351 FSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSECESFNVTGELYWTKVKVNFDNVGAGYLAL 1415

  Fly  2380 FVLSSRDGWVNIMYTGLDAVGVDQQPIVNYNEWRLLYFIAFILLVGFFVLNMFVGVVVENFHRCR 2444
            ..:::..||::|||..:|:.|.::||....|.:..:||:.||:...||.||:|:||:::||::.:
  Rat  1416 LQVATFKGWMDIMYAAVDSRGYEEQPQWEDNLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQK 1480

  Fly  2445 EE--------QEKEEKIRRAAKRALQMEKKRRRMHEPPYYTNYSPTRMFVHNVVTSKYFDLAIAA 2501
            ::        .|:::|...|.|: |..:|.::.:..|     .:..:.|:.::||.:.||:.|..
  Rat  1481 KKLGGQDIFMTEEQKKYYNAMKK-LGSKKPQKPIPRP-----LNKYQGFIFDIVTKQAFDVTIMF 1539

  Fly  2502 VIGLNVVTMAMEY-YKMPSGLKYALKIFNYFFTAVFILEANMKLVALGWKLYLKDRWNQLDVGIV 2565
            :|.||:|||.:|. .:.|..:....|| |..|.|:|..|..:|:.||. ..|..:.||..|..:|
  Rat  1540 LICLNMVTMMVETDDQSPEKVNILAKI-NLLFVAIFTGECIVKMAALR-HYYFTNSWNIFDFVVV 1602

  Fly  2566 LLSIVGIVLEELETNTHQIIPINPTIIRVMRVLRIARVLKLLKMANGIRALLDTVMQALPQVGNL 2630
            :|||||.||.::    .|....:||:.||:|:.||.|:|:|::.|.|||.||..:|.:||.:.|:
  Rat  1603 ILSIVGTVLSDI----IQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNI 1663

  Fly  2631 GLLFFLLFFIFAALGVELFGRLECSDEIPCQGLGEHAHFANFGMAFLTLFRVATGDNWNGIMKDT 2695
            |||.||:.||::..|:..|..::..     .|:.:..:|..|..:.|.||::.|...|:|::...
  Rat  1664 GLLLFLVMFIYSIFGMANFAYVKWE-----AGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPI 1723

  Fly  2696 LRDN---CD---DAADCVRNCCVSSVIAPIFFVIFVLMAQFVLVNVVVAVLMKHL----EESHKQ 2750
            |...   ||   ..::..|..|.|..:..:||..:::::..::||:.:|:::::.    |||.:.
  Rat  1724 LNTGPPYCDPNLPNSNGSRGNCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEP 1788

  Fly  2751 M-EDELDMEVELERELVREQEFAQEQKLCQQLAEAQSKAAAPPRPLAKVKSLPKNFIYSTPSLDK 2814
            : ||:.||..|:..:...|.....|.......|:|.|:    |..:||...:      |..::| 
  Rat  1789 LSEDDFDMFYEIWEKFDPEATQFIEYLALSDFADALSE----PLRIAKPNQI------SLINMD- 1842

  Fly  2815 KFPAVSG 2821
             .|.|||
  Rat  1843 -LPMVSG 1848

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1TNP_001259267.1 Ion_trans 332..636 CDD:278921 89/318 (28%)
Ion_trans 1261..1495 CDD:278921 77/237 (32%)
Ion_trans 2192..2448 CDD:278921 93/273 (34%)
Ion_trans 2510..2728 CDD:278921 72/224 (32%)
Scn5aXP_038936827.1 Ion_trans 131..424 CDD:395416 95/365 (26%)
Na_trans_cytopl 484..668 CDD:403218 56/441 (13%)
Ion_trans 717..930 CDD:395416 74/238 (31%)
Na_trans_assoc 956..1203 CDD:399489 73/590 (12%)
Ion_trans 1207..1482 CDD:395416 97/281 (35%)
Na_channel_gate 1474..1526 CDD:240441 10/57 (18%)
Ion_trans 1531..1785 CDD:395416 84/264 (32%)
GPHH 1797..1844 CDD:407139 11/58 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.820

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