DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1T and Cacna1c

DIOPT Version :9

Sequence 1:NP_001259267.1 Gene:Ca-alpha1T / 31550 FlyBaseID:FBgn0264386 Length:3218 Species:Drosophila melanogaster
Sequence 2:NP_036649.2 Gene:Cacna1c / 24239 RGDID:2245 Length:2170 Species:Rattus norvegicus


Alignment Length:3309 Identity:636/3309 - (19%)
Similarity:980/3309 - (29%) Gaps:1550/3309 - (46%)


- Green bases have known domain annotations that are detailed below.


  Fly   209 SSLSDAAAATAAGRSRSRG--GGRTGGAVSSSTGSSCNGSCSSDDGDSSHTSSSSSSSSSGEPNL 271
            ::||..||..||.:::..|  |..|...|||:.............|.::.|.             
  Rat    78 AALSWQAAIDAARQAKLMGSAGNATISTVSSTQRKRQQYGKPKKQGGTTATR------------- 129

  Fly   272 PYPGFPEISIRALTQYTRPRNWCLMLITNPWFERVSILVILLNCITLGMYQPC-VDDACVTNRCK 335
                 |..::..||.....|..|:.::....||.:.:|.|..||:.|.:|.|. .||:..||  .
  Rat   130 -----PPRALLCLTLKNPIRRACISIVEWKSFEIIILLTIFANCVALAIYIPFPEDDSNATN--S 187

  Fly   336 ILQIFDDIIFAFFALEMTIKMVAMGIC-GKNTYLADSWNRLDFFIVLAGL----LEYVMHVENLN 395
            .|:..:.:....|.:|..:|::|.|:. ..|.||.:.||.|||.||:.||    ||.....:..|
  Rat   188 NLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGAN 252

  Fly   396 ----------LTAIRTIRVLRPLRAINRIPSMRILVMLLLDTLPMLGNVLLLCFFVFFIFGIIGV 450
                      :.|:|..|||||||.::.:||:::::..::..:..|.::.||..||..|:.|||:
  Rat   253 ALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 317

  Fly   451 QLWEGILRQRCSLMRTEGMVYPLTVPEVYRVRVRVNSLSQYYEFSKDQDYICSTPNDSGMHLCGN 515
            :|:.|.:.:.|  ...||::   .||                  :::....|:.....|      
  Rat   318 ELFMGKMHKTC--YNQEGII---DVP------------------AEEDPSPCALETGHG------ 353

  Fly   516 FPPYRIGSLVCNEEAKLFDFNEPTNTSCVNWNQYYTTCKQSGENPFQGTISFDNIGMAWVAIFLV 580
                                     ..|.|.    |.||...:.|..|..:|||...|.:.:|..
  Rat   354 -------------------------RQCQNG----TVCKPGWDGPKHGITNFDNFAFAMLTVFQC 389

  Fly   581 ISLEGWTDIMYYVQDAHSF-WDWIYFVLLIVIGSFFMINLCLVVIATQFSETKKREMERMRQERA 644
            |::|||||::|::|||..: ..|:|||.|::.||||::||.|.|::.:||  |:||..:.|.:  
  Rat   390 ITMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFS--KEREKAKARGD-- 450

  Fly   645 RYTSTSTLASSTNNSEPATCYAEIVKYIAHLWRRFKRRMLKKYRLYKYQRQQRKEGLLPNADNLT 709
                                                   .:|.|    ::||.:|.|        
  Rat   451 ---------------------------------------FQKLR----EKQQLEEDL-------- 464

  Fly   710 FSPSRIKCHHPKCPKYSNRKPSSIQDQMITVMVPLNSASNNINNNNNNNSNSSNHNGSGNHTAAG 774
                                                                             
  Rat   465 ----------------------------------------------------------------- 464

  Fly   775 GGNNNNNNNNNNAASCTTVALVNGINGSAASVTMSSAHHQQHQLLQHQQQQHQNQQQQQQQQQHS 839
                                                                             
  Rat   465 ----------------------------------------------------------------- 464

  Fly   840 SSDNTEQSLAPDGLPRSSSLKKSTAHHQLKPEGSAAEQKTILLKFPQQMIDSEQLILQLGNLGKS 904
                                                                             
  Rat   465 ----------------------------------------------------------------- 464

  Fly   905 HPCTSGFLSPPTSASRRPSVMFNEYVLLHTPPALNADPATAGTTTTVAPTVATVAGTAAAAAAAA 969
                .|:|                                                         
  Rat   465 ----KGYL--------------------------------------------------------- 468

  Fly   970 ATGSGSGNNNHQNGGASGGAGTGGTTEKSNIFSTEKMTQAGDGSIWQVNLPQTIGTIANPYADCS 1034
                                              :.:|||.|                       
  Rat   469 ----------------------------------DWITQAED----------------------- 476

  Fly  1035 ELGIHDAMTCQELLAFSVAFSAALPTGQSTLESFYTSLARCDPHTAEALRAHHKPR--SVPTGQN 1097
                                                    .||...:......|||  |:||.:.
  Rat   477 ----------------------------------------IDPENEDEGMDEDKPRNMSMPTSET 501

  Fly  1098 QTTPGAEGATVMVASTAGDTGQTLQPSTVSAVVGGTIDSHAANHRRKEHHQQSHHHHNNNNTTSH 1162
            ::.                        ....|.||.|:                           
  Rat   502 ESV------------------------NTENVAGGDIE--------------------------- 515

  Fly  1163 SRNYRSRQGQGNSRMREPRAPTGNYMEDYACCYDLYQNALSPLDERPRQRSPTTRCLISVYRCMS 1227
            ..|..:|.....|:.:..|                                        .:|..:
  Rat   516 GENCGARLAHRISKSKFSR----------------------------------------YWRRWN 540

  Fly  1228 RVCSWIRRYIRRLVEHKYFQQGILLAILINTLSMGIEYHNQPPELTAIVETSNVVFSGIFAVEML 1292
            |.|   ||..|..|:...|...::..:.:|||::..|::|||..||.:.:|:|.....:|..|||
  Rat   541 RFC---RRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPHWLTEVQDTANKALLALFTAEML 602

  Fly  1293 LKVVAEGPFRYIANGFNVFDGIIV---ILSAIEICQTFMGNGTGGGGSGLSVLRTFRLLRILKLV 1354
            ||:.:.|...|..:.||.||..||   ||..|.:....|      ...|:||||..|||||.|:.
  Rat   603 LKMYSLGLQAYFVSLFNRFDCFIVCGGILETILVETKIM------SPLGISVLRCVRLLRIFKIT 661

  Fly  1355 RFMPNLRRQLFVMLRTMDNVAVFFSLLVLFIFIFSILGMYLFGGKFCKFLDESGLERECTCPEII 1419
            |:..:|...:..:|.::.::|....||.|||.|||:|||.||||||                   
  Rat   662 RYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF------------------- 707

  Fly  1420 SRHPQCECDRKHFNNILWATVTVFQILTQEDWNVVLFNGM------EKTSHWAALYFVALMTFGN 1478
             ...:.:..|..|:|...:.:|||||||.||||.|:::|:      ........:||:.|...||
  Rat   708 -NFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGN 771

  Fly  1479 YVLFNLLVAILVEGF-------SSERNERREREQRELVKKLREETLAENYSDGMYDESRSEADSS 1536
            |:|.|:.:||.|:..       |:::.|..|:|:::|.                           
  Rat   772 YILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLA--------------------------- 809

  Fly  1537 TTNDSYYEVRNRWRSAEDVRKLQDSVELIIEAKSNMHRQRLLQPTHDYQINELPASSAAPSASGT 1601
                                                   |...|....::.|.||          
  Rat   810 ---------------------------------------RTASPEKKQEVMEKPA---------- 825

  Fly  1602 SGASAPGDRERDRDRDRDRERDRDRDRERDREAGGGGKEEGAQHAKPRGGLKKTYSIKERRSEAP 1666
                                                                    ::|.:.|..
  Rat   826 --------------------------------------------------------VEESKEEKI 834

  Fly  1667 RLSKIRLARDPPIITTTAATPQDSPSTTLEPGMSFRQWGDMEPPSPPSPSLLRPPNIFTGGQRSL 1731
            .|..|             ....:||.||                                     
  Rat   835 ELKSI-------------TADGESPPTT------------------------------------- 849

  Fly  1732 DEGIPSIDLIPPSPVLSHKPLNILNASQLGVGMGGGVPSTAGSSSSMHSVIIDDISKSSSSTAAA 1796
                                                            .:.:||:..|.:     
  Rat   850 ------------------------------------------------KINMDDLQPSEN----- 861

  Fly  1797 TPIYVPTISSTADAQSQSHSLNDVSVGSSPGGEIPATGMSRNANTGASTSGSSSSERLPLAPPPQ 1861
                                 .|.|..|:|                 .|:|              
  Rat   862 ---------------------EDKSPHSNP-----------------DTAG-------------- 874

  Fly  1862 QGSFKQRLRRGSSKKRRASALALATDDNPARRTLDNQARRTQDEEEEQQQLNNGGDNSCLLRNSN 1926
                                                      :|:||:.::              
  Rat   875 ------------------------------------------EEDEEEPEM-------------- 883

  Fly  1927 AVVSGSSSGTKETNRLSPQNSIRRLSNTLSIGSGPVGSRRASACIFNSQVYQNLNQPPKLRPGSG 1991
                                              |||                    |:.||   
  Rat   884 ----------------------------------PVG--------------------PRPRP--- 891

  Fly  1992 QRRMSSIELAFSKTSHLNLHNLEANRKSLSYTNSKMDLDKWNKSYGNLNEPDNMLQQYMEARDKR 2056
                                                                             
  Rat   892 ----------------------------------------------------------------- 891

  Fly  2057 KNSISHYNLKKRLEEKELQQLQQLHQQQLLQQRQDSFSSTTQQQQQQLQQHRLSKDQQQLAMQPH 2121
                                |.:||                                        
  Rat   892 --------------------LSELH---------------------------------------- 896

  Fly  2122 SMVPGGGERYSKLKMLIEQLTPKHFTTEREDYSLYIFPEDNRFRQICTWFVNQKWFDNVVLLFIA 2186
                           |.|:..|.     .|..:.:||..:||||..|...||...|.|::|.||.
  Rat   897 ---------------LKEKAVPM-----PEASAFFIFSPNNRFRLQCHRIVNDTIFTNLILFFIL 941

  Fly  2187 LNCITLAMERPNIPPSSTERLFLATANYVFTVVFTVEMFIKVVATGMFYGHDAYFTSGWNIMDGS 2251
            |:.|:||.|.| :..:|.....|...:.|||.:||:|:.:|:.|.|.|....::..:.:||:|..
  Rat   942 LSSISLAAEDP-VQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLL 1005

  Fly  2252 LVTISIIDLLMSLISESSPRIFGILRVFRLLRSLRPLRVINRAPGLKLVVQTLLSSLRPIGNIVL 2316
            :|::|:|    |...:||  ...::::.|:||.|||||.||||.|||.|||.:..::|.|||||:
  Rat  1006 VVSVSLI----SFGIQSS--AINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVI 1064

  Fly  2317 ICCTFFIIFGILGVQLFKGTFYYCEGENIKGVRNADECRRIPGNV-----------------WTN 2364
            :......:|..:|||||||..|.|...:   .:...||:   ||.                 |.|
  Rat  1065 VTTLLQFMFACIGVQLFKGKLYTCSDSS---KQTEAECK---GNYITYKDGEVDHPIIQPRSWEN 1123

  Fly  2365 RKYNFDDLGKALMSLFVLSSRDGWVNIMYTGLDAVGVDQQPIVNYNEWRLLYFIAFILLVGFFVL 2429
            .|::||::..|:|:||.:|:.:||..::|..:|:...|:.||.||.....::||.:|:::.||::
  Rat  1124 SKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMM 1188

  Fly  2430 NMFVGVVVENFHRCREEQEKEEKIRRAAKRALQMEKKRRRMHEPPYYTNYSPTRMFV----HN-- 2488
            |:|||.|:..|   :|:.|:|.|       ..:::|.:|:..|  |.....|.|.::    |.  
  Rat  1189 NIFVGFVIVTF---QEQGEQEYK-------NCELDKNQRQCVE--YALKARPLRRYIPKNQHQYK 1241

  Fly  2489 ---VVTSKYFDLAIAAVIGLNVVTMAMEYYKMPSGLKYALKIFNYFFTAVFILEANMKLVALGWK 2550
               ||.|.||:..:..:|.||.:.:||::|......|.|:.|.|..||.:|.:|..:||:|...|
  Rat  1242 VWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPK 1306

  Fly  2551 LYLKDRWNQLDVGIVLLSIVGIVLEELETNTH-QIIP---------INPTIIRVMRVLRIARVLK 2605
            .|..|.||..|..||:.|||.|.:.|:....| |..|         |:.|..|:.||:|:   :|
  Rat  1307 HYFCDAWNTFDALIVVGSIVDIAITEVHPAEHTQCSPSMSAEENSRISITFFRLFRVMRL---VK 1368

  Fly  2606 LLKMANGIRALLDTVM---QALPQVGNLGLLFFLLFFIFAALGVELFGRLECSDEIPCQGLGEHA 2667
            ||....|||.||.|.:   ||||.|   .||..:||||:|.:|:::||::..:|...   :..:.
  Rat  1369 LLSRGEGIRTLLWTFIKSFQALPYV---ALLIVMLFFIYAVIGMQVFGKIALNDTTE---INRNN 1427

  Fly  2668 HFANFGMAFLTLFRVATGDNWNGIMKDTLRDNCDDAADCV-----------RNCCVSSVIAPIFF 2721
            :|..|..|.|.|||.|||:.|..||.     .|.....|.           ...|.|| .|..:|
  Rat  1428 NFQTFPQAVLLLFRCATGEAWQDIML-----ACMPGKKCAPESEPSNSTEGETPCGSS-FAVFYF 1486

  Fly  2722 VIFVLMAQFVLVNVVVAVLM---------------KHLEESHKQMEDELDME----------VEL 2761
            :.|.::..|:::|:.|||:|               .||:| .|::..|.|.|          |.|
  Rat  1487 ISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDE-FKRIWAEYDPEAKGRIKHLDVVTL 1550

  Fly  2762 ERELVREQEFAQEQKLCQQLAEAQSKAAAPPRPL------------------------------- 2795
            .|.:.....|.   |||.... |..:..:...||                               
  Rat  1551 LRRIQPPLGFG---KLCPHRV-ACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGNLEQA 1611

  Fly  2796 -----AKVKSLPKNFIYSTPSLDKKFPAVSG-----------------------------VNNPS 2826
                 |.:|.:.|.  .|...||:..|....                             |..||
  Rat  1612 NEELRAIIKKIWKR--TSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGKPS 1674

  Fly  2827 LTSSAATNLN---------QVATAGSGG---------AAPGAVPAGS-------GAGPRRQTVQY 2866
            ..::.:....         ::..|.||.         |...||.|.|       ..|.....|.|
  Rat  1675 QRNALSLQAGLRTLHDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVSY 1739

  Fly  2867 FQQP-----PQSML---------GGLSLAE---------MGGTLTPQ-----------------A 2891
            :|..     ||:..         .|.:.|:         :..|.||.                 |
  Rat  1740 YQSDSRSNFPQTFATQRPLHINKTGNNQADTESPSHEKLVDSTFTPSSYSSTGSNANINNANNTA 1804

  Fly  2892 LGARLGEPFG--------GGGGNKSGPR---RQSYWQINPIR------KRGVLSKERSLDE--QA 2937
            || |...|.|        .|.|....|.   :::.|:::..|      :...:|::...||  .:
  Rat  1805 LG-RFPHPAGYSSTVSTVEGHGPPLSPAVRVQEAAWKLSSKRCHSRESQGATVSQDMFPDETRSS 1868

  Fly  2938 IRRRN-----LEAKRTSCDSLPWGGD---ALDCRRGTIFESLESDGGGVGGGGSGG--GGGGLGG 2992
            :|...     .|....|.|.|.:..|   .|.|        ||.|...:.......  ....||.
  Rat  1869 VRLSEEVEYCSEPSLLSTDILSYQDDENRQLTC--------LEEDKREIQPSPKRSFLRSASLGR 1925

  Fly  2993 GVSYDLRSV-RSADVGHSEMDGDVS------LSVV--SALVPSVTTPL----------PPPLSLP 3038
            ..|:.|..: |..|.|     ||:|      |.:|  .||..:..:||          |.|...|
  Rat  1926 RASFHLECLKRQKDQG-----GDISQKTALPLHLVHHQALAVAGLSPLLQRSHSPSTFPRPRPTP 1985

  Fly  3039 IVTPTSTPTPLQLPMP--------------MPMPMAHPPPRRPFGWSQSVDQGCLRSNLLL--SV 3087
            .|||.|...||| |:|              ...|..|..     .||:.. ..|...:.:.  :.
  Rat  1986 PVTPGSRGRPLQ-PIPTLRLEGAESSEKLNSSFPSIHCS-----SWSEET-TACSGGSSMARRAR 2043

  Fly  3088 PRSMPPRSRSGSTKQLFKQQALDEDADMDENSLLLPTAAGGGSG-----PGSVAVIASSSLDLPD 3147
            |.|:...|::|:..:.|...|         :||:.......|.|     |..:.|......|..|
  Rat  2044 PVSLTVPSQAGAPGRQFHGSA---------SSLVEAVLISEGLGQFAQDPKFIEVTTQELADACD 2099

  Fly  3148 QSGSSKQILPDIAL--GVSKSDSSDILRIISERRRMDQREQREPEQDQDNEAEDRDSDY 3204
            .:....:...|..|  |..:|.:..:|..::         .|:|.||:....||....|
  Rat  2100 MTIEEMENAADNILSGGAQQSPNGTLLPFVN---------CRDPGQDRAVVPEDESCVY 2149

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1TNP_001259267.1 Ion_trans 332..636 CDD:278921 90/319 (28%)
Ion_trans 1261..1495 CDD:278921 85/249 (34%)
Ion_trans 2192..2448 CDD:278921 94/272 (35%)
Ion_trans 2510..2728 CDD:278921 82/241 (34%)
Cacna1cNP_036649.2 Calmodulin-binding. /evidence=ECO:0000250|UniProtKB:Q13936 77..98 7/19 (37%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 104..128 4/23 (17%)
I 141..438 100/356 (28%)
Ion_trans 171..446 CDD:278921 97/336 (29%)
TrbL <232..>321 CDD:294888 28/88 (32%)
Selectivity filter of repeat I. /evidence=ECO:0000250|UniProtKB:P07293 391..394 0/2 (0%)
AID/alpha-interaction domain, mediates interaction with the beta subunit. /evidence=ECO:0000269|PubMed:15170217 458..475 8/314 (3%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 479..511 8/55 (15%)
II 540..786 95/274 (35%)
Ion_trans 571..794 CDD:278921 85/248 (34%)
Selectivity filter of repeat II. /evidence=ECO:0000250|UniProtKB:P07293 734..737 1/2 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 794..891 34/493 (7%)
Interaction with STAC2. /evidence=ECO:0000250|UniProtKB:Q13936 859..906 22/361 (6%)
Ion_trans 947..1206 CDD:278921 95/274 (35%)
Dihydropyridine binding. /evidence=ECO:0000250|UniProtKB:P07293 1119..1208 33/91 (36%)
Selectivity filter of repeat III. /evidence=ECO:0000250|UniProtKB:P07293 1143..1146 0/2 (0%)
IV 1236..1509 97/287 (34%)
Ion_trans 1266..1517 CDD:278921 88/265 (33%)
Selectivity filter of repeat IV. /evidence=ECO:0000250|UniProtKB:P07293 1444..1447 2/2 (100%)
Dihydropyridine binding. /evidence=ECO:0000250|UniProtKB:P07293 1460..1528 16/69 (23%)
Phenylalkylamine binding. /evidence=ECO:0000250|UniProtKB:P07293 1474..1516 12/42 (29%)
GPHH 1525..1588 CDD:293510 15/67 (22%)
Ca_chan_IQ 1590..1661 CDD:285917 7/72 (10%)
Calmodulin-binding. /evidence=ECO:0000250|UniProtKB:Q13936 1641..1674 1/32 (3%)
Important for interaction with STAC1, STAC2 and STAC3. /evidence=ECO:0000250|UniProtKB:P15381 1641..1668 0/26 (0%)
Calmodulin-binding IQ region. /evidence=ECO:0000250|UniProtKB:Q13936 1647..1667 0/19 (0%)
Important for localization in at the junctional membrane. /evidence=ECO:0000250|UniProtKB:P15381 1681..1700 1/18 (6%)
CAC1F_C 1684..2117 CDD:293490 93/462 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1762..1794 5/31 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1971..1999 10/28 (36%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.920

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