DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1T and Scn11a

DIOPT Version :9

Sequence 1:NP_001259267.1 Gene:Ca-alpha1T / 31550 FlyBaseID:FBgn0264386 Length:3218 Species:Drosophila melanogaster
Sequence 2:XP_017168851.1 Gene:Scn11a / 24046 MGIID:1345149 Length:1782 Species:Mus musculus


Alignment Length:2563 Identity:489/2563 - (19%)
Similarity:844/2563 - (32%) Gaps:1056/2563 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly   291 RNWCLMLITNPWFERVSILVILLNCITLGMYQPCVDDACVTNRCKILQIFDDIIFAFFALEMTIK 355
            |::.:.:..:..|....|..:::||:.:. ....||....:|      |.:.:....:.||..||
Mouse   136 RSFMIRISVHSVFSMFIICTVIINCMFMA-NNSSVDSRPSSN------IPEYVFIGIYVLEAVIK 193

  Fly   356 MVAMG-ICGKNTYLADSWNRLDFFIVLAGLLEYVMHVENLNLTAIRTIRVLRPLRAINRIPSMRI 419
            ::|.| |..:.:||.|.||.|||.::...:....:..:..||:.:||.||||.|:||:.|..:::
Mouse   194 ILARGFIVDEFSYLRDPWNWLDFIVIGTAIAPCFLGNKVNNLSTLRTFRVLRALKAISVISGLKV 258

  Fly   420 LVMLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWEGILRQRCSLMRTEGMVYPLTVPEVYRVRVR 484
            :|..||.::..|.:|::|..|...||.::|.||:.|||.|:|                 .:....
Mouse   259 IVGALLRSVKKLVDVMVLTLFCLSIFALVGQQLFMGILSQKC-----------------IKDDCG 306

  Fly   485 VNSLSQYYEFSKD---QDYICSTPNDSGMHLCGNFPPYRIGSLVCNEEAKLFDFNEPTNTSCVNW 546
            .|:.|....|.|:   :|:|          :|||:    :|...|.:.                 
Mouse   307 PNAFSNKDCFVKENDSEDFI----------MCGNW----LGRRSCPDG----------------- 340

  Fly   547 NQYYTTCKQSGENPFQGTISFDNIGMAWVAIFLVISLEGWTDIMYYVQDAHSFWDWIYFVLLIVI 611
                :||.::..||.....:||:.|.:::|:|.|::.:.|..:...:......:...:||::|.:
Mouse   341 ----STCNKTTFNPDYNYTNFDSFGWSFLAMFRVMTQDSWEKLYRQILRTSGIYFVFFFVVVIFL 401

  Fly   612 GSFFMINLCLVVIATQFSETKKREMERMRQERARYTSTSTLASSTNNSEPATCYAEIVKYIAHLW 676
            |||:::||.|.|:...:.|..:                 .:|:.|...|                
Mouse   402 GSFYLLNLTLAVVTMAYEEQNR-----------------NVAAETEAKE---------------- 433

  Fly   677 RRFKRRMLKKYRLYKYQRQQRKEGLLP-NADNLTFSPSRIKCHHPKCPKY---SNRKPSSIQDQM 737
                    |.::..:...::.||.|:. ..|..:.:..:.....||..|:   ..||...::   
Mouse   434 --------KMFQEAQQLLREEKEALVAMGIDRTSLNSLQASSFSPKKRKFFGSKTRKSFFMR--- 487

  Fly   738 ITVMVPLNSASNNINNNNNNNSNSSNHNGSGNHTAAGGGNNNNNNNNNNAASCTTVALVNGINGS 802
                                          |:.||....:::.::.:.|.               
Mouse   488 ------------------------------GSKTARASASDSEDDASKNP--------------- 507

  Fly   803 AASVTMSSAHHQQHQLLQHQQQQHQNQQQQQQQQQHSSSDNTEQSLAPDGLPRSSSLKKSTAHHQ 867
                          |||:..::..||                                       
Mouse   508 --------------QLLEQTKRLSQN--------------------------------------- 519

  Fly   868 LKPEGSAAEQKTILLKFPQQMIDSEQLILQLGNLGKSHPCTSGFLSPPTSASRRPSVMFNEYVLL 932
                                                                 .|..:|:|:|  
Mouse   520 -----------------------------------------------------LPVELFDEHV-- 529

  Fly   933 HTPPALNADPATAGTTTTVAPTVATVAGTAAAAAAAAATGSGSGNNNHQNGGASGGAGTGGTTEK 997
                    ||.                                                      
Mouse   530 --------DPL------------------------------------------------------ 532

  Fly   998 SNIFSTEKMTQAGDGSIWQVNLPQTIGTIANPYADCSELGIHDAMTCQELLAFSVAFSAALPTGQ 1062
                                                                             
Mouse   533 ----------------------------------------------------------------- 532

  Fly  1063 STLESFYTSLARCDPHTAEALRAHHKPRSVPTGQNQTTPGAEGATVMVASTAGDTGQTLQPSTVS 1127
                                    |:.|::                               |.||
Mouse   533 ------------------------HRQRAL-------------------------------SAVS 542

  Fly  1128 AVVGGTIDSHAANHRRKEHHQQSHHHHNNNNTTSHSRNYRSRQGQGNSRMREPRAPTGNYMEDYA 1192
            .:   ||..                                   |...:.:||..|.|   ::.|
Mouse   543 IL---TITM-----------------------------------QEQEKSQEPCFPCG---KNLA 566

  Fly  1193 CCYDLYQNALSPLDERPRQRSPTTRCLISVYRCMSRVCSWIRRYIRRLVEHKYFQQGILLAILIN 1257
            ..|.::            :.||...|              |::.::.::...:.:..|.:.|::|
Mouse   567 SKYLVW------------ECSPPWLC--------------IKKVLQTIMTDPFTELAITICIIVN 605

  Fly  1258 TLSMGIEYHNQPPELTAIVETSNVVFSGIFAVEMLLKVVAEGPFRYIANGFNVFDGIIVILSAIE 1322
            |:.:.:|:||....|..|::..|.||:|||..||.||::|..|:.|..:|:|:||.|:.::|..:
Mouse   606 TVFLAMEHHNMDNSLKDILKIGNWVFTGIFIAEMCLKIIALDPYHYFRHGWNIFDSIVALVSLAD 670

  Fly  1323 ICQTFMGNGTGGGGSGLSVLRTFRLLRILKLVRFMPNLRRQLFVMLRTMDNVAVFFSLLVLFIFI 1387
            :....:       ...||.|.:.|:||:.||.:..|.|...:.::..::..:.....:|.:.:||
Mouse   671 VLFHKL-------SKNLSFLASLRVLRVFKLAKSWPTLNTLIKIIGHSVGALGNLTVVLTIVVFI 728

  Fly  1388 FSILGMYLFGGKFCKFLDESGLEREC-TCPEIISRHPQCECDRKHFNNILWATVTVFQILTQEDW 1451
            ||::||.|||.||         .:.| |.||.:.|.        |..:...:.:.||:||..| |
Mouse   729 FSVVGMRLFGAKF---------NKTCSTSPESLRRW--------HMGDFYHSFLVVFRILCGE-W 775

  Fly  1452 NVVLFNGMEKT--SHWAALYFVALMTFGNYVLFNLLVAILVEGFSSERNERREREQRELVKKLRE 1514
            ...::..|::.  |....:.||.:|..|..|:.||.:|:|:..||   ||.::.......:|.:.
Mouse   776 IENMWECMQEMEGSPLCVIVFVLIMVVGKLVVLNLFIALLLNSFS---NEEKDGNPEGETRKTKV 837

  Fly  1515 ETLAENYSDGMYDESRSEADSSTTNDSYYEVRNRWRSAEDVRKLQDSVELIIEAKSNMHRQRLLQ 1579
            :...:.:|...|..:|:                          ||:.      ......||...:
Mouse   838 QLALDRFSRAFYFMARA--------------------------LQNF------CCKRCRRQNSPK 870

  Fly  1580 PTHDYQINELPASSAAPSASGTSGASAPGDRERDRDRDRDRERDRDRDRERDREAGGGGKEEGAQ 1644
            |      ||     |..|.:|.|..:|..|                                   
Mouse   871 P------NE-----ATESFAGESRDTATLD----------------------------------- 889

  Fly  1645 HAKPRGGLKKTYSIKERRSEAPRLSKIRLARDPPIITTTAATPQDSPSTTLEPGMSFRQWGDMEP 1709
                      |.|.||..||.            .:.|..|..|. :|....|..|......|..|
Mouse   890 ----------TRSWKEYDSEM------------TLYTGQAGAPL-APLAKEEDDMECCGECDASP 931

  Fly  1710 PSPPSPSLLRPPNIFTGGQRSLDEGIPSIDLIPPSPVLSHKPLNILNASQLGVGMGGGVPSTAGS 1774
            .|.||                  |...:.||          ||....           :|     
Mouse   932 TSQPS------------------EEAQACDL----------PLKTKR-----------LP----- 952

  Fly  1775 SSSMHSVIIDDISKSSSSTAAATPIYVPTISSTADAQSQSHSLNDVSVGSSPGGEIPATGMSRNA 1839
            |...|.|.::..|:...:.         ||.|.......:..|::.|                  
Mouse   953 SPDDHGVEMEVFSEEDPNL---------TIQSARKKSDAASMLSECS------------------ 990

  Fly  1840 NTGASTSGSSSSERLPLAPPPQQGSFKQRLRRGSSKKRRASALALATDDNPARRTLDNQARRTQD 1904
                                                                  |:|        
Mouse   991 ------------------------------------------------------TID-------- 993

  Fly  1905 EEEEQQQLNNGGDNSCLLRNSNAVVSGSSSGTKETNRLSPQNSIRRLSNTLSIGSGPVGSRRASA 1969
                   ||:      :.||....||..    |:.:|..|                     :..:
Mouse   994 -------LND------IFRNLQKTVSPQ----KQPDRCFP---------------------KGLS 1020

  Fly  1970 CIFNSQVYQNLNQPPKLRPGSGQRRMSSIELAFSKTSHLNLHNLEANRKSLSYTNSKMDLDKWNK 2034
            |||                            ...||         ..:||           .|  
Mouse  1021 CIF----------------------------LCCKT---------IKKKS-----------PW-- 1035

  Fly  2035 SYGNLNEPDNMLQQYMEARDKRKNSISHYNLKKRLEEKELQQLQQLHQQQLLQQRQDSFSSTTQQ 2099
                                     :..:||:|                                
Mouse  1036 -------------------------VLWWNLRK-------------------------------- 1043

  Fly  2100 QQQQLQQHRLSKDQQQLAMQPHSMVPGGGERYSKLKMLIEQLTPKHFTTEREDYSLYIFPEDNRF 2164
                                                                             
Mouse  1044 ----------------------------------------------------------------- 1043

  Fly  2165 RQICTWFVNQKWFDNVVLLFIALNCITLAMERPNIPP-SSTERLFLATANYVFTVVFTVEMFIKV 2228
              .|...|...||::.::..|.|:...|..|..|:|. ...|:|...|.| :||.:|.:||.:|.
Mouse  1044 --TCYQIVKHSWFESFIIFVILLSSGALIFEDVNLPSRPQVEKLLKCTDN-IFTFIFLLEMILKW 1105

  Fly  2229 VATGMFYGHDAYFTSGWNIMDGSLVTISIIDLLMSLISESSPRIFGILRVFRLLRSLRPLRVINR 2293
            ||    :|...||||.|..:|..:|.:|.:.|      .:.|.    |:.||.||:|||||.:::
Mouse  1106 VA----FGFRKYFTSAWCWLDFLIVVVSGLSL------TNLPN----LKSFRNLRALRPLRALSQ 1156

  Fly  2294 APGLKLVVQTLLSSLRPIGNIVLICCTFFIIFGILGVQLFKGTFYYC-EGE------NIKGVRNA 2351
            ..|:|:||..|:|::..|.|::|:|..|::||.||||..|.|.|..| .|.      |...|.|.
Mouse  1157 FEGMKVVVNALMSAIPAILNVLLVCLIFWLIFCILGVNFFSGKFGRCINGTDINKYFNASNVPNQ 1221

  Fly  2352 DECRRIPGNVWTNRKYNFDDLGKALMSLFVLSSRDGWVNIMYTGLDAVGVDQQPIVNYNEWRLLY 2416
            .:| .:....|.....|||::|.|.::|..:::..||::||...:|:.|.|:||....|.:..||
Mouse  1222 SQC-LVSNYTWKVPNVNFDNVGNAYLALLQVATYKGWLDIMNAAVDSRGKDEQPAFEANLYAYLY 1285

  Fly  2417 FIAFILLVGFFVLNMFVGVVVENFHRCREE--------QEKEEKIRRAAKRALQMEKKRRRMHEP 2473
            |:.||:...||.||:|:||:::||::.:::        .|:::|...|.|: |..:|.::.:..|
Mouse  1286 FVVFIIFGSFFTLNLFIGVIIDNFNQQQKKISGQDIFMTEEQKKYYNAMKK-LGTKKPQKPIPRP 1349

  Fly  2474 PYYTNYSPTRMFVHNVVTSKYFDLAIAAVIGLNVVTMAMEYYKMPSGLKYALKIFNYFFTAVFIL 2538
                 .:..:.||.::|||:.||:.|..:|..|::.|..|....|:.:|....|.|..|..:|.:
Mouse  1350 -----LNKCQAFVFDLVTSQVFDVIILGLIVTNMIIMMAESEGQPNEVKKIFDILNIVFVVIFTV 1409

  Fly  2539 EANMKLVALGWKLYLKDRWNQLDVGIVLLSIVGIVLEELETNTHQIIPINPTIIRVMRVLRIARV 2603
            |..:|:.||. :.|..:.||..|..:|:|||:..::..||.:  .:.|  ||:.|::|:.||.|:
Mouse  1410 ECLIKVFALR-QHYFTNGWNLFDCVVVVLSIISTLVSGLENS--NVFP--PTLFRIVRLARIGRI 1469

  Fly  2604 LKLLKMANGIRALLDTVMQALPQVGNLGLLFFLLFFIFAALGVELFGRLECSDEIPCQGLGEHAH 2668
            |:|::.|.|||.||..:|.:||.:.|:|||.||:.||:|..|:..|.:::..     .|:.:..:
Mouse  1470 LRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLVMFIYAIFGMNWFSKVKRG-----SGIDDIFN 1529

  Fly  2669 FANFGMAFLTLFRVATGDNWNGIMKDTL--RDNCDDAADCVRNCCVSSVIAPIFFVIFVLMAQFV 2731
            |..|..:.|.||::.|...|:.::...|  :.:|:.::   :..|....||.::||.:::::..:
Mouse  1530 FDTFSGSMLCLFQITTSAGWDALLNPMLESKASCNSSS---QESCQQPQIAIVYFVSYIIISFLI 1591

  Fly  2732 LVNVVVAVLMKHLEESHKQMEDEL---DMEVELERELVREQEFAQEQKLCQQLAEAQSKAAAPPR 2793
            :||:.:||::::...:.::.||.|   |.|:..|    ..::|..|.....|.:.....|.|.|.
Mouse  1592 VVNMYIAVILENFNTATEESEDPLGEDDFEIFYE----IWEKFDPEATQFIQYSSLSDFADALPE 1652

  Fly  2794 PLAKVKSLPKNFIYSTPSLDKKFPAVSG 2821
            ||...|  |..|.:    |....|.|.|
Mouse  1653 PLRVAK--PNRFQF----LMMDLPMVMG 1674

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1TNP_001259267.1 Ion_trans 332..636 CDD:278921 79/307 (26%)
Ion_trans 1261..1495 CDD:278921 70/236 (30%)
Ion_trans 2192..2448 CDD:278921 94/271 (35%)
Ion_trans 2510..2728 CDD:278921 67/219 (31%)
Scn11aXP_017168851.1 Ion_trans 145..424 CDD:366146 85/354 (24%)
Ion_trans 591..825 CDD:366146 77/261 (30%)
Na_trans_assoc 830..1047 CDD:368948 72/662 (11%)
Ion_trans 1051..1315 CDD:366146 98/279 (35%)
Na_channel_gate 1307..1359 CDD:240441 11/57 (19%)
Ion_trans 1363..1612 CDD:366146 77/261 (30%)
GPHH 1623..1670 CDD:374878 13/56 (23%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.820

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