DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ca-alpha1T and Catsper2

DIOPT Version :9

Sequence 1:	NP_001259267.1	Gene:	Ca-alpha1T / 31550	FlyBaseID:	FBgn0264386	Length:	3218	Species:	Drosophila melanogaster
Sequence 2:	NP_694715.2	Gene:	Catsper2 / 212670	MGIID:	2387404	Length:	588	Species:	Mus musculus

Alignment Length:	348	Identity:	81/348 - (23%)
Similarity:	166/348 - (47%)	Gaps:	51/348 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly  2448 EKEEKIRRAAK----------RALQMEKKRRRMHEPPYYTNYSPTRMFVHNVVTSKYFDLAIAAV 2502
            ::|:.:|.:.|          |.| :.:.|.|....|      |..::...|:.|..|...|.::
Mouse    58 DQEQLVRFSIKPRRMGHITHSRRL-LSRLRVRCSRMP------PLSLWAGWVLDSSVFSKFIISL 115

  Fly  2503 IGLNVVTMAMEYYKMPS------GLKYALKIFNYFFTAVFILEANMKLVALGWKLYLKDRWNQLD 2561
            |.||...:.:|...|.|      .:|.||::.::|....||:|..:..:| .:.|:.||.||..|
Mouse   116 IFLNTFVLMVEIELMESTNTALWPVKLALEVADWFILLSFIVEILLMWLA-SFSLFWKDAWNVFD 179

  Fly  2562 VGIVLLSIVGIVLEELETNTHQIIPINPTIIRVMRVLRIARVLKLLKMANGIRALLDTVMQALPQ 2626
            ..:.|||::..::..|.      :|.:...::::||.|:.|.|||......|:.:|..:::||..
Mouse   180 FFVTLLSLLPELVVLLG------VPAHSVWLQLLRVCRVLRSLKLFARFRQIKVILLALVRALKS 238

  Fly  2627 VGNLGLLFFLLFFIFAALGVELFGRLECSDEIPCQGLGEHAHFANFGMAFLTLFRVATGDNWNGI 2691
            :..|.:|..:.|:|||..||..|.....|   ..:||..:..|::...:.:|:|.:.|.|:|..:
Mouse   239 MTFLLMLLLIFFYIFAVTGVYFFREYSRS---TIEGLEYNMFFSDLLNSLVTVFILFTLDHWYAV 300

  Fly  2692 MKDTLRDNCDDAADCVRNCCV---SSVIAPIFFVIFVLMAQFVLVNVVVAVLMKHLEESHKQMED 2753
            ::|..:              |   |.|.:.|:.::::|:...:..|::||:::.:.:....::.:
Mouse   301 LQDIWK--------------VPESSRVFSSIYVILWLLLGSIIFRNIIVAMMVTNFQNIRSELSE 351

  Fly  2754 ELD-MEVELERELVREQEFAQEQ 2775
            |:. :||:.:.::.::|...:.|
Mouse   352 EMSHLEVQYKADMFKQQIIQRRQ 374

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ca-alpha1T	NP_001259267.1	Ion_trans	332..636	CDD:278921
		Ion_trans	1261..1495	CDD:278921
		Ion_trans	2192..2448	CDD:278921	81/348 (23%)
		Ion_trans	2510..2728	CDD:278921	57/226 (25%)
Catsper2	NP_694715.2	Ion_trans	105..350	CDD:366146	66/268 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900