DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1T and Scn9a

DIOPT Version :9

Sequence 1:NP_001259267.1 Gene:Ca-alpha1T / 31550 FlyBaseID:FBgn0264386 Length:3218 Species:Drosophila melanogaster
Sequence 2:NP_001277603.1 Gene:Scn9a / 20274 MGIID:107636 Length:1984 Species:Mus musculus


Alignment Length:2605 Identity:550/2605 - (21%)
Similarity:946/2605 - (36%) Gaps:949/2605 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   284 LTQYTRPRNWCLMLITNPWFERVSILVILLNCITLGMYQPCVDDACVTNRCKILQIFDDIIFAFF 348
            |:.::..|...:.::.:..|..:.:..||.|||.:.|..|       .:..|.::.....|:.| 
Mouse   109 LSPFSPLRRISIKILVHSLFSMLIMCTILTNCIFMTMSNP-------PDWTKNVEYTFTGIYTF- 165

  Fly   349 ALEMTIKMVAMGIC-GKNTYLADSWNRLDF-FIVLAGLLEYVMHVENL-NLTAIRTIRVLRPLRA 410
              |..||::|.|.| |:.|:|.|.||.||| .||.|.|.|:|    || |::|:||.||||.|:.
Mouse   166 --ESLIKILARGFCVGEFTFLRDPWNWLDFVVIVFAYLTEFV----NLGNVSALRTFRVLRALKT 224

  Fly   411 INRIPSMRILVMLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWEGILRQRC---SLMRTEGMVYP 472
            |:.||.::.:|..|:.::..|.:|::|..|...:|.:||:||:.|.|:.:|   .|.:.|     
Mouse   225 ISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRKDLEQNE----- 284

  Fly   473 LTVPEVYRVRVRVNSLSQYY---EFSKDQDYICSTPNDSGMHLCGNFPPYRIGSLVCNEEAKLFD 534
             |:..:.........|.:|:   |.|||. .:|....|||.               |        
Mouse   285 -TLESIMSTAESEEELKRYFYYLEGSKDA-LLCGFSTDSGQ---------------C-------- 324

  Fly   535 FNEPTNTSCVNWNQYYTTCKQSGENPFQGTISFDNIGMAWVAIFLVISLEGWTDIMYYVQDAHSF 599
               |....||.          :|.||..|..|||..|.|::|:|.:::.:.|.::......|...
Mouse   325 ---PEGYECVT----------AGRNPDYGYTSFDTFGWAFLALFRLMTQDYWENLYQQTLRAAGK 376

  Fly   600 WDWIYFVLLIVIGSFFMINLCLVVIATQFSETKKREMERMRQERARYTSTSTLASSTNNSEPATC 664
            ...|:||::|.:|||::|||.|.|:|..:.|..:..:|..:|:...:                  
Mouse   377 TYMIFFVVVIFLGSFYLINLILAVVAMAYEEQNQANIEEAKQKELEF------------------ 423

  Fly   665 YAEIVKYIAHLWRRFKRRMLKKYRLYKYQRQQRKEGLLPNADNLTFSPSRIKCHHPKCPKYSNRK 729
                            ::||.:.:    :.|:..|.:                            
Mouse   424 ----------------QQMLDRLK----KEQEEAEAI---------------------------- 440

  Fly   730 PSSIQDQMITVMVPLNSASNNINNNNNNNSNSSNHNGSGNHTAAGGGNNNNNNNNNNAASCTTVA 794
                                                      ||.            ||..|:: 
Mouse   441 ------------------------------------------AAA------------AAEYTSL- 450

  Fly   795 LVNGINGSAASVTMSSAHHQQHQLLQHQQQQHQNQQQQQQQQQHSSSD-NTEQSLAPDGLPRSSS 858
                  |.:..:.:|.:..:..:|.....::.:|::::::|:..|..: ..::.|:..|  ...|
Mouse   451 ------GRSRIMGLSESSSETSRLSSKSAKERRNRRKKKKQKLSSGEEKGDDEKLSKSG--SEES 507

  Fly   859 LKKSTAHHQLKPEGSAAEQKTILLKFPQQMIDSEQLILQLGNLGKSHPCTSGFLSPPTSASRRPS 923
            ::|.:.|..::....|.|::                                             
Mouse   508 IRKKSFHLGVEGHHRAREKR--------------------------------------------- 527

  Fly   924 VMFNEYVLLHTPPALNADPATAGTTTTVAPTVATVAGTAAAAAAAAATGSGSGNNNHQNGGASGG 988
                    |.||   |..|             .::.|:..:|..::.|...|....        |
Mouse   528 --------LSTP---NQSP-------------LSIRGSLFSARRSSRTSLFSFKGR--------G 560

  Fly   989 AGTGGTTEKSNIFSTEKMTQAGD-----GSIWQVNLPQTIGTIANPYADCSELG----------- 1037
            ...|..||    |:.::.:..||     ||::..:.|:     ....::.|:..           
Mouse   561 RDLGSETE----FADDEHSIFGDNESRRGSLFVPHRPR-----ERRSSNISQASRSPPVLPVNGK 616

  Fly  1038 IHDAMTCQELLAFSVAFSA-ALPTGQSTLESFYTSLARCDPHTAEALRAHHKPRSVPTGQNQTTP 1101
            :|.|:.|..:::.....|| .||.||...|                                   
Mouse   617 MHSAVDCNGVVSLVDGPSALMLPNGQLLPE----------------------------------- 646

  Fly  1102 GAEGATVMVASTAGDTGQTLQPSTVSAVVGGTIDSHAANHRRKEHHQQSHHHHNNNNTTSHSRNY 1166
                 .::..:|:.|:|.|                   |..||:....|:....:.....|.|. 
Mouse   647 -----VIIDKATSDDSGTT-------------------NQMRKKRLSSSYFLSEDMLNDPHLRQ- 686

  Fly  1167 RSRQGQGNSRMREPRAPTGNYMEDYACCYDLYQNALSPLDERPRQRSPTTRCLISVYRCMSRV-- 1229
                 :..||.                  .:..|.:..|:| .||:.|..     .||.....  
Mouse   687 -----RAMSRA------------------SILTNTVEELEE-SRQKCPPW-----WYRFAHTFLI 722

  Fly  1230 --CS--WI--RRYIRRLVEHKYFQQGILLAILINTLSMGIEYHNQPPELTAIVETSNVVFSGIFA 1288
              ||  ||  :::|..:|...:....|.:.|::|||.|.:|:|....|...::...|:||:||||
Mouse   723 WNCSPYWIKFKKFIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTDEFKNVLAVGNLVFTGIFA 787

  Fly  1289 VEMLLKVVAEGPFRYIANGFNVFDGIIVILSAIEICQTFMGNGTGGGGSGLSVLRTFRLLRILKL 1353
            .||:||::|..|:.|...|:|:||.:||.||.:|:   |:.:     ..||||||:|||||:.||
Mouse   788 AEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLVEL---FLAD-----VEGLSVLRSFRLLRVFKL 844

  Fly  1354 VRFMPNLRRQLFVMLRTMDNVAVFFSLLVLFIFIFSILGMYLFGGKFCKFLDESGLERECTCPEI 1418
            .:..|.|...:.::..::..:.....:|.:.:|||:::||.|||..:          :||.|   
Mouse   845 AKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSY----------KECVC--- 896

  Fly  1419 ISRHPQCECDRKHFNNILWATVTVFQILTQEDWNVVLFNGMEKTSHWAAL-YFVALMTFGNYVLF 1482
             ..:..|:..|.|.|:...:.:.||::|..| |...:::.||.......| .::.:|..||.|:.
Mouse   897 -KINENCKLPRWHMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLIVYMMVMVIGNLVVL 959

  Fly  1483 NLLVAILVEGFSSERNERREREQRELVKKLREETLAENYSDGMYDESRSEADSSTTNDSYYEVRN 1547
            ||.:|:|:..|||:.           :..:.|:|                               
Mouse   960 NLFLALLLSSFSSDN-----------LTAIEEDT------------------------------- 982

  Fly  1548 RWRSAEDVRKLQDSVELIIEAKSNMHRQRLLQPTHDYQINELPASSAAPSASGTSGASAPGDRER 1612
                  |...||.:|.. |:...|..:|.|.:..       |.:.|..|..|             
Mouse   983 ------DANNLQIAVAR-IKRGINYVKQTLREFI-------LKSFSKKPKGS------------- 1020

  Fly  1613 DRDRDRDRERDRDRDRERDREAGGGGKEEGAQHAKPRGGLKKTYSIKERRSEAPRLSKIRLARDP 1677
                 :|.:|..|.:.:|:.                        .|..|                
Mouse  1021 -----KDTKRTADPNNKREN------------------------YISNR---------------- 1040

  Fly  1678 PIITTTAATPQDSPSTTLEPGMSFRQWGDMEPPSPPSPSLLRPPNIFTGGQRSLDEGIPSIDLIP 1742
                |.|...:|.                                                    
Mouse  1041 ----TLAEISKDH---------------------------------------------------- 1049

  Fly  1743 PSPVLSHKPLNILNASQLGVGMGGGVPSTAGSSSSMHSVIIDDISKSSSSTAAATPIYVPTISST 1807
                      |.|....          ..:|.|||:....:|:                      
Mouse  1050 ----------NFLKEKD----------KISGFSSSLDKSFMDE---------------------- 1072

  Fly  1808 ADAQSQSHSLN-DVSVGSSPGGEIPATGMSRNANTGASTSGSSSSERLPLAPPPQQGSFKQRLRR 1871
            .|.||..|:.: .|:|..:||     .....|.||...:|.|.|...            |:|..|
Mouse  1073 NDYQSFIHNPSLTVTVPIAPG-----ESDLENMNTEELSSDSDSDYS------------KERRNR 1120

  Fly  1872 GSSKKRRASALALATDDNPARRTLDNQARRTQDEEEEQQQLNNGGDNSCLLRNSNAVVSGSSSGT 1936
            .||.:       .:|.|||.          ..:||.|.:.:|.....:|.               
Mouse  1121 SSSSE-------CSTVDNPL----------PGEEEAEAEPINADEPEACF--------------- 1153

  Fly  1937 KETNRLSPQNSIRRLSNTLSIGSGPVGSRRASACIFNSQVYQNLNQPPKLRPGSGQRRMSSIELA 2001
                                          ...|:                     ||....:: 
Mouse  1154 ------------------------------TDGCV---------------------RRFPCCQV- 1166

  Fly  2002 FSKTSHLNLHNLEANRKSLSYTNSKMDLDKWNKSYGNLNEPDNMLQQYMEARDKRKNSISHYNLK 2066
                      |:::.:..:.:|                                           
Mouse  1167 ----------NIDSGKGKVWWT------------------------------------------- 1178

  Fly  2067 KRLEEKELQQLQQLHQQQLLQQRQDSFSSTTQQQQQQLQQHRLSKDQQQLAMQPHSMVPGGGERY 2131
                                                                             
Mouse  1179 ----------------------------------------------------------------- 1178

  Fly  2132 SKLKMLIEQLTPKHFTTEREDYSLYIFPEDNRFRQICTWFVNQKWFDNVVLLFIALNCITLAMER 2196
                                            .|:.|...|...||::.::|.|.|:...||.|.
Mouse  1179 --------------------------------IRKTCYRIVEHSWFESFIVLMILLSSGALAFED 1211

  Fly  2197 PNIPPSSTERLFLATANYVFTVVFTVEMFIKVVATGMFYGHDAYFTSGWNIMDGSLVTISIIDLL 2261
            ..|....|.::.|..|:.:||.:|.:||.:|.||    ||:..|||:.|..:|..:|.:|::.|:
Mouse  1212 IYIEKKKTIKIILEYADKIFTYIFILEMLLKWVA----YGYKTYFTNAWCWLDFLIVDVSLVTLV 1272

  Fly  2262 MSLISESSPRIFGILRVFRLLRSLRPLRVINRAPGLKLVVQTLLSSLRPIGNIVLICCTFFIIFG 2326
            .:.:..|.   .|.::..|.||:|||||.::|..|:::||..|:.::..|.|::|:|..|::||.
Mouse  1273 ANTLGYSD---LGPIKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFS 1334

  Fly  2327 ILGVQLFKGTFYYC----EGE--NIKGVRNADEC---RRIPGNV-WTNRKYNFDDLGKALMSLFV 2381
            |:||.||.|.||.|    :|.  ::..|.|..||   ..:.||| |.|.|.|||::|...:||..
Mouse  1335 IMGVNLFAGKFYECVNTTDGSRFSVSQVANRSECFALMNVSGNVRWKNLKVNFDNVGLGYLSLLQ 1399

  Fly  2382 LSSRDGWVNIMYTGLDAVGVDQQPIVNYNEWRLLYFIAFILLVGFFVLNMFVGVVVENFHRCREE 2446
            :::..||::|||..:|:|.|:.|||..||.:..:||:.||:...||.||:|:||:::||::.:::
Mouse  1400 VATFKGWMDIMYAAVDSVNVNAQPIYEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK 1464

  Fly  2447 --------QEKEEKIRRAAKRALQMEKKRRRMHEPPYYTNYSPTRMFVHNVVTSKYFDLAIAAVI 2503
                    .|:::|...|.|: |..:|.::.:..|.     :..:..:.::||::.||:.|..:|
Mouse  1465 LGGQDIFMTEEQKKYYNAMKK-LGSKKPQKPIPRPG-----NKFQGCIFDLVTNQAFDITIMVLI 1523

  Fly  2504 GLNVVTMAMEYYKMPSGLKYALKIFNYFFTAVFILEANMKLVALGWKLYLKDRWNQLDVGIVLLS 2568
            .||:|||.:|.......:.:.|...|..|..:|..|..:||::|. ..|....||..|..:|:||
Mouse  1524 CLNMVTMMVEKEGQTDYMSFVLYWINVVFIILFTGECVLKLISLR-HYYFTVGWNIFDFVVVILS 1587

  Fly  2569 IVGIVLEELETNTHQIIPINPTIIRVMRVLRIARVLKLLKMANGIRALLDTVMQALPQVGNLGLL 2633
            |||:.|.|:.....    ::||:.||:|:.||.|:|:|:|.|.|||.||..:|.:||.:.|:|||
Mouse  1588 IVGMFLAEMIEKYF----VSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLL 1648

  Fly  2634 FFLLFFIFAALGVELFGRLECSDEIPCQGLGEHAHFANFGMAFLTLFRVATGDNWNGIMKDTLRD 2698
            .||:.||:|..|:..|..::..     .|:.:..:|..||.:.:.||::.|...|:|::...|..
Mouse  1649 LFLVMFIYAIFGMSNFAYVKKE-----AGINDMFNFETFGNSMICLFQITTSAGWDGLLAPILNS 1708

  Fly  2699 ---NCD----DAADCVRNCCVSSVIAPIFFVIFVLMAQFVLVNVVVAVLMKHL----EESHKQM- 2751
               :||    .....|...|.:..:...:||.:::::..|:||:.:||::::.    |||.:.: 
Mouse  1709 APPDCDPKKVHPGSSVEGDCGNPSVGIFYFVSYIIISFLVVVNMYIAVILENFSVATEESTEPLS 1773

  Fly  2752 EDELDMEVELERELVREQEFAQEQKLCQQLAEAQSKAAAPPRPLAKVKSLPKNFIYSTPSLDKKF 2816
            ||:.:|..|:..:.  :.:..|..:.| :|::. :.|..||..:||...:      ...::|  .
Mouse  1774 EDDFEMFYEVWEKF--DPDATQFIEFC-KLSDF-AAALDPPLLIAKPNKV------QLIAMD--L 1826

  Fly  2817 PAVSG 2821
            |.|||
Mouse  1827 PMVSG 1831

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1TNP_001259267.1 Ion_trans 332..636 CDD:278921 96/312 (31%)
Ion_trans 1261..1495 CDD:278921 76/234 (32%)
Ion_trans 2192..2448 CDD:278921 99/273 (36%)
Ion_trans 2510..2728 CDD:278921 69/224 (31%)
Scn9aNP_001277603.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 26..55
I. /evidence=ECO:0000305 112..410 105/354 (30%)
Ion_trans 147..410 CDD:278921 97/319 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 458..540 17/152 (11%)
Na_trans_cytopl 487..606 CDD:288761 28/206 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 574..609 6/39 (15%)
II. /evidence=ECO:0000305 725..988 92/333 (28%)
Ion_trans 760..955 CDD:278921 68/217 (31%)
Na_trans_assoc 981..1185 CDD:284034 64/655 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1015..1039 7/65 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1089..1145 20/89 (22%)
III. /evidence=ECO:0000305 1178..1486 112/455 (25%)
Ion_trans 1224..1464 CDD:278921 94/246 (38%)
Na_channel_gate 1456..1508 CDD:240441 9/57 (16%)
IV. /evidence=ECO:0000305 1495..1793 92/314 (29%)
Ion_trans 1530..1768 CDD:278921 75/247 (30%)
GPHH 1780..1835 CDD:293510 14/64 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1933..1984
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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