DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1T and Scn8a

DIOPT Version :9

Sequence 1:NP_001259267.1 Gene:Ca-alpha1T / 31550 FlyBaseID:FBgn0264386 Length:3218 Species:Drosophila melanogaster
Sequence 2:XP_017172001.1 Gene:Scn8a / 20273 MGIID:103169 Length:1988 Species:Mus musculus


Alignment Length:2670 Identity:535/2670 - (20%)
Similarity:945/2670 - (35%) Gaps:955/2670 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   244 NGSCSSDDGDSSHTSSSSSSSSSGEPNLPYPGFPEISIRA---------LTQYT----------- 288
            :||...||.||....:|...:....|.: |...|:..:..         |||.|           
Mouse    41 DGSHREDDEDSKPKPNSDLEAGKSLPFI-YGDIPQGLVAVPLEDFDPYYLTQKTFVVLNRGKTLF 104

  Fly   289 -----------RP----RNWCLMLITNPWFERVSILVILLNCITLGMYQPCVDDACVTNRCKILQ 338
                       .|    |...:.::.:..|..:.:..||.||:.:....|             .:
Mouse   105 RFSATPALYILSPFNLIRRIAIKILIHSVFSMIIMCTILTNCVFMTFSNP-------------PE 156

  Fly   339 IFDDIIFAF---FALEMTIKMVAMGICGKN-TYLADSWNRLDFFIVLAGLLEYVMHVENL-NLTA 398
            ...::.:.|   :..|..:|::|.|.|... |:|.|.||.|||.::   ::.||....:| |::|
Mouse   157 WSKNVEYTFTGIYTFESLVKIIARGFCIDGFTFLRDPWNWLDFSVI---MMAYVTEFVDLGNVSA 218

  Fly   399 IRTIRVLRPLRAINRIPSMRILVMLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWEGILRQRCSL 463
            :||.||||.|:.|:.||.::.:|..|:.::..|.:|::|..|...:|.:||:||:.|.||.:|  
Mouse   219 LRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKC-- 281

  Fly   464 MRTEGMVYPLTVPEVYRVRVRVNSLSQYYEFSKDQDYICSTPNDSGMHLCGNFPPYRIGSLVCNE 528
                 :|:|:...|.|     :.:.::.:::   ::||   .|.:..::.    |..:..|:|. 
Mouse   282 -----VVWPINFNESY-----LENGTRGFDW---EEYI---NNKTNFYMV----PGMLEPLLCG- 325

  Fly   529 EAKLFDFNEPTNTSCVNWNQYYTTCKQSGENPFQGTISFDNIGMAWVAIFLVISLEGWTDIMYYV 593
                   |......|....|    |.::|.||..|..|||....|::|:|.:::.:.|.::....
Mouse   326 -------NSSDAGQCPEGFQ----CMKAGRNPNYGYTSFDTFSWAFLALFRLMTQDYWENLYQLT 379

  Fly   594 QDAHSFWDWIYFVLLIVIGSFFMINLCLVVIATQFSETKKREMERMRQERARYTSTSTLASSTNN 658
            ..|......|:|||:|.:|||:::||.|.|:|..:.|..:..:|...|:.|.:            
Mouse   380 LRAAGKTYMIFFVLVIFVGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEF------------ 432

  Fly   659 SEPATCYAEIVKYIAHLWRRFKRRMLKKYRLYKYQRQQRKEGLLPNADNLTFSPSRIKCHHPKCP 723
                                  :.||:  :|.|.|.:.:...:..:|..::              
Mouse   433 ----------------------KAMLE--QLKKQQEEAQAAAMATSAGTVS-------------- 459

  Fly   724 KYSNRKPSSIQDQMITVMVPLNSASNNINNNNNNNSNSSNHNGSGNHTAAGGGNNNNNNNNNNAA 788
                  ..:|:::                          ..:|.|:..:                
Mouse   460 ------EDAIEEE--------------------------GEDGVGSPRS---------------- 476

  Fly   789 SCTTVALVNGINGSAASVTMSSAHHQQHQLLQHQQQQHQNQQQQQQQQQHSSSDNTEQSLAPDGL 853
                       :...:.::..||..:::      :::.:.|::..:.::....:...:|.:.||:
Mouse   477 -----------SSELSKLSSKSAKERRN------RRKKRKQKELSEGEEKGDPEKVFKSESEDGM 524

  Fly   854 PRSSSLKKSTAHHQLKPEGSAAEQKTILLKFPQQMIDSEQLILQLGNLGKSHPCTSGFLSPPTSA 918
            .|.:                                                     |..|....
Mouse   525 RRKA-----------------------------------------------------FRLPDNRI 536

  Fly   919 SRRPSVMFNEYVLLHTPPALNADPATAGTTTTVAPTVATVAGTAAAAAAAAATGSGSGNNNHQNG 983
            .|:.|:|....:.:...|.|                                       :.|.: 
Mouse   537 GRKFSIMNQSLLSIPGSPFL---------------------------------------SRHNS- 561

  Fly   984 GASGGAGTGGTTEKSNIFSTEKMTQAGD-GSIWQVNLPQTIGTIANPYADCSELGIHDAMTCQEL 1047
                         ||:|||.....:..| ||             .|.:||.....:.::...::.
Mouse   562 -------------KSSIFSFRGPGRFRDPGS-------------ENEFADDEHSTVEESEGRRDS 600

  Fly  1048 LAFSVAFSAALPTGQSTLESFYTSLARCDPHTA--EALRAHHKPRSVPTGQNQTTPGAEGATVMV 1110
            |     |.......:.:..|.|:..::|...:.  .:||     |||   :..:|....|...::
Mouse   601 L-----FIPIRARERRSSYSGYSGYSQCSRSSRIFPSLR-----RSV---KRNSTVDCNGVVSLI 652

  Fly  1111 ASTAGDTGQTLQPSTVSAVVGGTIDSHAANHRRKEHHQQSHHHHNNNNTTSHSRNYRSRQGQGNS 1175
            .  .|.....|.|..       .||..|.:....|...:.....:...:.....:| .|:.:.||
Mouse   653 G--PGSHIGRLLPEV-------KIDKAATDSATTEVEIKKKGPGSLLVSMEQLASY-GRKDRINS 707

  Fly  1176 RMREPRAPTGNYMEDYACCYDLYQNALSPLDERPRQRSPTTRCLISVYRCMSRVCSW-------- 1232
            .|   ...|...:|:              |:|..|:..|   |.   |:..:....|        
Mouse   708 IM---SVVTNTLVEE--------------LEESQRKCPP---CW---YKFANTFLIWECHPYWIK 749

  Fly  1233 IRRYIRRLVEHKYFQQGILLAILINTLSMGIEYHNQPPELTAIVETSNVVFSGIFAVEMLLKVVA 1297
            ::..:..:|...:....|.:.|::|||.|.:|:|...|:...::...|:||:|||..||.||::|
Mouse   750 LKEIVNLIVMDPFVDLAITICIVLNTLFMAMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIA 814

  Fly  1298 EGPFRYIANGFNVFDGIIVILSAIEICQTFMGNGTGGGGSGLSVLRTFRLLRILKLVRFMPNLRR 1362
            ..|:.|...|:|:|||.||.||.:|:....:        .||||||:|||||:.||.:..|.|..
Mouse   815 MDPYYYFQEGWNIFDGFIVSLSLMELGLADV--------EGLSVLRSFRLLRVFKLAKSWPTLNM 871

  Fly  1363 QLFVMLRTMDNVAVFFSLLVLFIFIFSILGMYLFGGKFCKFLDESGLERECTCPEIISRHPQCEC 1427
            .:.::..::..:.....:|.:.:|||:::||.|||..:          :||.|.  ||:  :|:.
Mouse   872 LIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSY----------KECVCK--ISQ--ECKL 922

  Fly  1428 DRKHFNNILWATVTVFQILTQEDWNVVLFNGMEKTSH-WAALYFVALMTFGNYVLFNLLVAILVE 1491
            .|.|.|:...:.:.||::|..| |...:::.||.... ...:.|:.:|..||.|:.||.:|:|:.
Mouse   923 PRWHMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQAMCLIVFMMVMVIGNLVVLNLFLALLLS 986

  Fly  1492 GFSSERNERREREQRELVKKLREETLAENYSDGMYDESRSEADSSTTNDSYYEVRNRWRSAEDVR 1556
            .||:                   :.||....||                             ::.
Mouse   987 SFSA-------------------DNLAATDDDG-----------------------------EMN 1003

  Fly  1557 KLQDSVELIIEAKSNMHRQRLLQPTHDYQINELPASSAAPSASGTSGASAPGDRERDRDRDRDRE 1621
            .||.||..|                                                        
Mouse  1004 NLQISVIRI-------------------------------------------------------- 1012

  Fly  1622 RDRDRDRERDREAGGGGKEEGAQHAKPRGGLKKTYSIKERRSEAPRLSKIRLARDPPIITTTAAT 1686
                              ::|...||     .|.::..:...:                      
Mouse  1013 ------------------KKGVAWAK-----VKVHAFMQAHFK---------------------- 1032

  Fly  1687 PQDSPSTTLEPGMSFRQWGDMEPPSPPSPSLLRPPNIFTGGQRSLDEGIPSIDLIPPSPVLSHKP 1751
                                                     ||..||       :.|...|..|.
Mouse  1033 -----------------------------------------QREADE-------VKPLDELYEKK 1049

  Fly  1752 LNILNASQLGVGM---------GGGVPSTAGSSSSMHSVIIDDISKSSSSTAAATPIYVPTISST 1807
            .|.: |:..||.:         |.|  :|:|..||:...|||:...|..:....| :.||     
Mouse  1050 ANCI-ANHTGVDIHRNGDFQKNGNG--TTSGIGSSVEKYIIDEDHMSFINNPNLT-VRVP----- 1105

  Fly  1808 ADAQSQSHSLNDVSVGSSPGGEIPATGMSRNANTGASTSGSSSSERLPLAPPPQQGSFKQRLRRG 1872
                        ::||.|                                               
Mouse  1106 ------------IAVGES----------------------------------------------- 1111

  Fly  1873 SSKKRRASALALATDDNPARRTLDNQARRTQDEEEEQQQLNNGGDNSCLLRNSNAVVSGSSSGTK 1937
                                   |.:...|:|...|                             
Mouse  1112 -----------------------DFENLNTEDVSSE----------------------------- 1124

  Fly  1938 ETNRLSPQNSIRRLSNTLSIGSGPVGSRRASACIFNSQVYQNLNQPPKLRPGSGQRRMSSIELAF 2002
                                 |.|.|                                       
Mouse  1125 ---------------------SDPEG--------------------------------------- 1129

  Fly  2003 SKTSHLNLHNLEANRKSLSYTNSKMDLDKWNKSYGNLNEPDNMLQQYMEARDKRKNSISHYNLKK 2067
                                  ||..||..:.|.|                       |..::|.
Mouse  1130 ----------------------SKDKLDDTSSSEG-----------------------STIDIKP 1149

  Fly  2068 RLEEKELQQLQQLHQQQLLQQRQDSFSSTTQQQQQQLQQHRLSKDQQQLAMQPHS-MVPGGGERY 2131
            .:||..::|.::.                                     :.|.: ...|..:|:
Mouse  1150 EVEEVPVEQPEEY-------------------------------------LDPDACFTEGCVQRF 1177

  Fly  2132 SKLKMLIEQLTPKHFTTEREDYSLYIFPEDNRFRQICTWFVNQKWFDNVVLLFIALNCITLAMER 2196
            ...::.||:...|         |.:|      .|:.|...|...||:..::..|.|:...||.|.
Mouse  1178 KCCQVNIEEGLGK---------SWWI------LRKTCFLIVEHNWFETFIIFMILLSSGALAFED 1227

  Fly  2197 PNIPPSSTERLFLATANYVFTVVFTVEMFIKVVATGMFYGHDAYFTSGWNIMDGSLVTISIIDLL 2261
            ..|....|.|..|..|:.|||.:|.:||.:|..|    ||...:||:.|..:|..:|.:|::.|:
Mouse  1228 IYIEQRKTIRTILEYADKVFTYIFILEMLLKWTA----YGFVKFFTNAWCWLDFLIVAVSLVSLI 1288

  Fly  2262 MSLISESSPRIFGILRVFRLLRSLRPLRVINRAPGLKLVVQTLLSSLRPIGNIVLICCTFFIIFG 2326
            .:.:..|.   .|.::..|.||:|||||.::|..|:::||..|:.::..|.|::|:|..|::||.
Mouse  1289 ANALGYSE---LGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFS 1350

  Fly  2327 ILGVQLFKGTFYYCEGE------NIKGVRNADECRRI-PGN----VWTNRKYNFDDLGKALMSLF 2380
            |:||.||.|.::||..|      .|..|.|..:|.:: .||    .|.|.|.|||::|...::|.
Mouse  1351 IMGVNLFAGKYHYCFNETSEIRFEIDEVNNKTDCEKLMEGNNTEIRWKNVKINFDNVGAGYLALL 1415

  Fly  2381 VLSSRDGWVNIMYTGLDAVGVDQQPIVNYNEWRLLYFIAFILLVGFFVLNMFVGVVVENFHRCRE 2445
            .:::..||::|||..:|:...|:||....|.:..:||:.||:...||.||:|:||:::||::.::
Mouse  1416 QVATFKGWMDIMYAAVDSRKPDEQPDYEGNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKK 1480

  Fly  2446 E--------QEKEEKIRRAAKRALQMEKKRRRMHEPPYYTNYSPTRMFVHNVVTSKYFDLAIAAV 2502
            :        .|:::|...|.|: |..:|.::.:..|     .:..:..|.:.||.:.||:.|..:
Mouse  1481 KFGGQDIFMTEEQKKYYNAMKK-LGSKKPQKPIPRP-----LNKIQGIVFDFVTQQAFDIVIMML 1539

  Fly  2503 IGLNVVTMAMEYYKMPSGLKYALKIFNYFFTAVFILEANMKLVALGWKLYLKDRWNQLDVGIVLL 2567
            |.||:|||.:|.......::..|...|..|...|..|..:|:.||. ..|....||..|..:|:|
Mouse  1540 ICLNMVTMMVETDTQSKQMENILYWINLVFVIFFTCECVLKMFALR-HYYFTIGWNIFDFVVVIL 1603

  Fly  2568 SIVGIVLEELETNTHQIIPINPTIIRVMRVLRIARVLKLLKMANGIRALLDTVMQALPQVGNLGL 2632
            ||||:.|.::.....    ::||:.||:|:.||.|:|:|:|.|.|||.||..:|.:||.:.|:||
Mouse  1604 SIVGMFLADIIEKYF----VSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGL 1664

  Fly  2633 LFFLLFFIFAALGVELFGRLECSDEIPCQGLGEHAHFANFGMAFLTLFRVATGDNWNGIMKDTLR 2697
            |.||:.|||:..|:..|..::..     .|:.:..:|..||.:.:.||::.|...|:|::...|.
Mouse  1665 LLFLVMFIFSIFGMSNFAYVKHE-----AGIDDMFNFETFGNSMICLFQITTSAGWDGLLLPILN 1724

  Fly  2698 DNCDDAAD------CVRNCCVSSVIAPIFFVIFVLMAQFVLVNVVVAVLMKHL----EESHKQM- 2751
            ...|.:.|      ..:..|.:..:...|||.:::::..::||:.:|:::::.    |||...: 
Mouse  1725 RPPDCSLDKEHPGSGFKGDCGNPSVGIFFFVSYIIISFLIVVNMYIAIILENFSVATEESADPLS 1789

  Fly  2752 EDELDMEVELERELVREQEFAQEQKLCQQLAEAQSKAAAPPRPLAKVKSLPKNFIYSTPSLDKKF 2816
            ||:.:...|:..:.  :.:..|..:.| :||:.......|.|       :||.......::|  .
Mouse  1790 EDDFETFYEIWEKF--DPDATQFIEYC-KLADFADALEHPLR-------VPKPNTIELIAMD--L 1842

  Fly  2817 PAVSG 2821
            |.|||
Mouse  1843 PMVSG 1847

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1TNP_001259267.1 Ion_trans 332..636 CDD:278921 84/308 (27%)
Ion_trans 1261..1495 CDD:278921 77/234 (33%)
Ion_trans 2192..2448 CDD:278921 93/274 (34%)
Ion_trans 2510..2728 CDD:278921 68/223 (30%)
Scn8aXP_017172001.1 Ion_trans 131..421 CDD:366146 90/339 (27%)
Na_trans_cytopl 504..710 CDD:371806 47/350 (13%)
Ion_trans 760..973 CDD:366146 74/235 (31%)
Na_trans_assoc 999..1200 CDD:368948 65/655 (10%)
Ion_trans 1205..1481 CDD:366146 97/282 (34%)
Na_channel_gate 1473..1525 CDD:240441 10/57 (18%)
Ion_trans 1530..1784 CDD:366146 80/263 (30%)
GPHH 1796..1843 CDD:374878 10/58 (17%)
IQ 1902..1923 CDD:197470
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.820

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