DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1T and Scn5a

DIOPT Version :9

Sequence 1:NP_001259267.1 Gene:Ca-alpha1T / 31550 FlyBaseID:FBgn0264386 Length:3218 Species:Drosophila melanogaster
Sequence 2:XP_006512056.1 Gene:Scn5a / 20271 MGIID:98251 Length:2085 Species:Mus musculus


Alignment Length:2615 Identity:551/2615 - (21%)
Similarity:933/2615 - (35%) Gaps:949/2615 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   280 SIRALTQYTRPRNWCLMLITNPWFERVSILVILLNCITLGMYQPCVDDACVTNRCKILQIFDDII 344
            ::..|:.:...|...:.::.:..|..:.:..||.||:.:..:.|       ....|.::.....|
Mouse   175 ALYVLSPFHPVRRAAVKILVHSLFSMLIMCTILTNCVFMAQHDP-------PPWTKYVEYTFTAI 232

  Fly   345 FAFFALEMTIKMVAMGIC-GKNTYLADSWNRLDF-FIVLAGLLEYVMHVENLNLTAIRTIRVLRP 407
            :.|   |..:|::|.|.| ...|:|.|.||.||| .||:|...|:   |:..|::|:||.||||.
Mouse   233 YTF---ESLVKILARGFCLHAFTFLRDPWNWLDFSVIVMAYTTEF---VDLGNVSALRTFRVLRA 291

  Fly   408 LRAINRIPSMRILVMLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWEGILRQRC----------- 461
            |:.|:.|..::.:|..|:.::..|.:|::|..|...:|.:||:||:.|.||.:|           
Mouse   292 LKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTELNGTN 356

  Fly   462 SLMRTEGMVYPLTVPEVYRVRVRVNSLSQYYEFSKDQDYICSTPNDSGMHLCGNFPPYRIGSLVC 526
            ..:..:|:|:              |||..|  .:...:|:... ..:.:.||||    ...:..|
Mouse   357 GSVEADGIVW--------------NSLDVY--LNDPANYLLKN-GTTDVLLCGN----SSDAGTC 400

  Fly   527 NEEAKLFDFNEPTNTSCVNWNQYYTTCKQSGENPFQGTISFDNIGMAWVAIFLVISLEGWTDIMY 591
            .|..:                     |.::||||..|..|||:...|::|:|.:::.:.|..:  
Mouse   401 PEGYR---------------------CLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERL-- 442

  Fly   592 YVQDAHSFWD--WIYFVLLIVIGSFFMINLCLVVIATQFSETKKREMERMRQERARYTSTSTLAS 654
            |.|...|...  .|:|:|:|.:|||:::||.|.|:|..:.|..:                :|:| 
Mouse   443 YQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQ----------------ATIA- 490

  Fly   655 STNNSEPATCYAEIVKYIAHLWRRFKR--RMLKKYRLYKYQRQQRKEGL-LPNADNLTFSPSRIK 716
            .|...|                :||:.  .||||          ..|.| :...|.:    ||  
Mouse   491 ETEEKE----------------KRFQEAMEMLKK----------EHEALTIRGVDTV----SR-- 523

  Fly   717 CHHPKCPKYSNRKPSSIQDQMITVMVPLNSASNNINNNNNNNSNSSNHNGSGNHTAAGGGNN-NN 780
                          ||::      |.||...:|:...:......||.       |..||.:. ..
Mouse   524 --------------SSLE------MSPLAPVTNHERRSKRRKRLSSG-------TEDGGDDRLPK 561

  Fly   781 NNNNNNAASCTTVALVNGINGSAASVTMSSAHHQQHQLLQHQQQQHQNQQQQQQQQQHSSSDNTE 845
            :::.:...:...::|.:|::.::..                                        
Mouse   562 SDSEDGPRALNQLSLTHGLSRTSMR---------------------------------------- 586

  Fly   846 QSLAPDGLPRSSSLKKSTAHHQLKPEGSAAEQKTILLKFPQQMIDSEQLILQLGNLGKSHPCTSG 910
                    ||||  :.|....:.:.:||.|:           ..|.|.     ...|:|....:.
Mouse   587 --------PRSS--RGSIFTFRRRDQGSEAD-----------FADDEN-----STAGESESHRTS 625

  Fly   911 FLSP-PTSASRRPSVMFNEYVLLHTPPALNADPATAGTTTTVAPTVATVAGTAAAAAAAAATGSG 974
            .|.| |.   ||||..                                                 
Mouse   626 LLVPWPL---RRPSTQ------------------------------------------------- 638

  Fly   975 SGNNNHQNGGASGGAGTGGTTEKSNIFSTEKMTQAGDGSIWQVNLPQTIGTIANPYADC----SE 1035
                         |....||:...::.:.::                      |...||    |.
Mouse   639 -------------GQPGFGTSAPGHVLNGKR----------------------NSTVDCNGVVSL 668

  Fly  1036 LGIHDAMTCQELLAFSVAFSAALPTGQSTLESFYTSLARCDPHTAEALRAHHKPRSVPTGQNQTT 1100
            ||..|                                       |||                |:
Mouse   669 LGAGD---------------------------------------AEA----------------TS 678

  Fly  1101 PGAEGATVMVASTAGDTGQTLQPSTVSAVVGGTIDSHAANHRRKEHHQQSHHHHNNNNTTSHSRN 1165
            ||:.....:|.....||      :|.|...||                                 
Mouse   679 PGSHLLRPIVLDRPPDT------TTPSEEPGG--------------------------------- 704

  Fly  1166 YRSRQGQGNSRMREPRAPTGNYMEDYAC------CYDLYQNALSPLDERPRQRSPTTRCLISVYR 1224
                     .:|..|:||..:..|:...      ...:..:||..|:|..|:..|........|.
Mouse   705 ---------PQMLTPQAPCADGFEEPGARQRALSAVSVLTSALEELEESHRKCPPCWNRFAQHYL 760

  Fly  1225 CMSRVCSW--IRRYIRRLVEHKYFQQGILLAILINTLSMGIEYHNQPPELTAIVETSNVVFSGIF 1287
            .......|  |::.::.:|...:....|.:.|::|||.|.:|::|...|...:::..|:||:|||
Mouse   761 IWECCPLWMSIKQKVKFVVMDPFADLTITMCIVLNTLFMALEHYNMTAEFEEMLQVGNLVFTGIF 825

  Fly  1288 AVEMLLKVVAEGPFRYIANGFNVFDGIIVILSAIEICQTFMGNGTGGGGSGLSVLRTFRLLRILK 1352
            ..||..|::|..|:.|...|:|:||.||||||.:|:..:.|||        |||||:|||||:.|
Mouse   826 TAEMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMGN--------LSVLRSFRLLRVFK 882

  Fly  1353 LVRFMPNLRRQLFVMLRTMDNVAVFFSLLVLFIFIFSILGMYLFGGKFCKF---LDESGLERECT 1414
            |.:..|.|...:.::..::..:.....:|.:.:|||:::||.|||..:.:.   :.:|||     
Mouse   883 LAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRHRISDSGL----- 942

  Fly  1415 CPEIISRHPQCECDRKHFNNILWATVTVFQILTQEDWNVVLFNGMEKTSH-WAALYFVALMTFGN 1478
                        ..|.|..:...|.:.:|:||..| |...:::.||.:.. ...|.|:.:|..||
Mouse   943 ------------LPRWHMMDFFHAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGN 994

  Fly  1479 YVLFNLLVAILVEGFSSERNERREREQRELVKKLREETLAENYSDGMYDESRSEADSSTTNDSYY 1543
            .|:.||.:|:|:..||::                                               
Mouse   995 LVVLNLFLALLLSSFSAD----------------------------------------------- 1012

  Fly  1544 EVRNRWRSAEDVRKLQDSVELIIEAKSNMHRQRLLQPTHDYQINELPASSAAPSASGTSGASAPG 1608
                                            .|..|..|.::|.|..:.|.             
Mouse  1013 --------------------------------NLTAPDEDGEMNNLQLALAR------------- 1032

  Fly  1609 DRERDRDRDRDRERDRDRDRERDREAGGGGKEEGAQHAKPRGGLKKTY----SIKERRSEAPRLS 1669
                                          .:.|.:..|     :.|:    .:..||.:.|   
Mouse  1033 ------------------------------IQRGLRFVK-----RTTWDFCCGLLRRRPKKP--- 1059

  Fly  1670 KIRLARDPPIITTTAATPQDSPSTTLEPGMSFRQWGDMEPPSPPSPSLLRPPNIFTGGQRSLDEG 1734
                        ...||....||..            ..|.|||.|.:.:.|             
Mouse  1060 ------------AALATHSQLPSCI------------AAPRSPPPPEVEKAP------------- 1087

  Fly  1735 IPSIDLIPPSPVLSHKPLNILNASQLGVGMGGGVPSTAGSSSSMHSVIIDDISKSSSSTAAATPI 1799
                                                                             
Mouse  1088 ----------------------------------------------------------------- 1087

  Fly  1800 YVPTISSTADAQSQSHSLNDVSVGSSPGGEIPA---TGMSRNANTGASTSGSSSSERLPLAPPPQ 1861
                                           ||   |....:...|..|.|.:.    |:..|  
Mouse  1088 -------------------------------PARKETRFEEDKRPGQGTPGDTE----PVCVP-- 1115

  Fly  1862 QGSFKQRLRRGSSKKRRASALALATDDNPARRTLDNQARRTQDEEEEQQQLNNGGDNSCLLRNSN 1926
                                :|:|..|...:...:..:..|::||..:||             .:
Mouse  1116 --------------------IAVAESDTDDQEEDEENSLGTEEEESSKQQ-------------ES 1147

  Fly  1927 AVVSGSSSGTKETNRLSPQNSIRRLSNTLSIGSGPVGSRRASACIFNSQVYQNLNQPPKLRPGSG 1991
            .||||.....:|....|      ::|.|.        |..|.|....:...|.....|: .||.|
Mouse  1148 QVVSGGHEPPQEPRAWS------QVSETT--------SSEAEASTSQADWQQEREAEPR-APGCG 1197

  Fly  1992 QRRMSSIELAFSKTSHLNLHNLEANRKSLSYTNSKMDLDKWNKSYGNLNEPDNMLQQYMEARDKR 2056
            :    :.|.::|:.|..::.|             ..||                           
Mouse  1198 E----TPEDSYSEGSTADMTN-------------TADL--------------------------- 1218

  Fly  2057 KNSISHYNLKKRLEEKELQQLQQLHQQQLLQQRQDSFSSTTQQQQQQLQQHRLSKDQQQLAMQPH 2121
                             |:|:..|.:.  ::..:|.|:....::                  .|.
Mouse  1219 -----------------LEQIPDLGED--VKDPEDCFTEGCVRR------------------CPC 1246

  Fly  2122 SMVPGGGERYSKLKMLIEQLTPKHFTTEREDYSLYIFPEDNRFRQICTWFVNQKWFDNVVLLFIA 2186
            .||.                     ||:......:      |.|:.|...|...||:..::..|.
Mouse  1247 CMVD---------------------TTQAPGKVWW------RLRKTCYRIVEHSWFETFIIFMIL 1284

  Fly  2187 LNCITLAMERPNIPPSSTERLFLATANYVFTVVFTVEMFIKVVATGMFYGHDAYFTSGWNIMDGS 2251
            |:...||.|...:....|.::.|..|:.:||.||.:||.:|.||    ||...|||:.|..:|..
Mouse  1285 LSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVA----YGFKKYFTNAWCWLDFL 1345

  Fly  2252 LVTISIIDLLMSLISESSPRIFGILRVFRLLRSLRPLRVINRAPGLKLVVQTLLSSLRPIGNIVL 2316
            :|.:|::.|:.:.:..:.   .|.::..|.||:|||||.::|..|:::||..|:.::..|.|::|
Mouse  1346 IVDVSLVSLVANTLGFAE---MGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLL 1407

  Fly  2317 ICCTFFIIFGILGVQLFKGTFYYC----EGE---NIKGVRNADECR--RIPGNV-WTNRKYNFDD 2371
            :|..|::||.|:||.||.|.|..|    ||:   |...|.|..||.  .:.|.: ||..|.|||:
Mouse  1408 VCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSECESFNVTGELYWTKVKVNFDN 1472

  Fly  2372 LGKALMSLFVLSSRDGWVNIMYTGLDAVGVDQQPIVNYNEWRLLYFIAFILLVGFFVLNMFVGVV 2436
            :|...::|..:::..||::|||..:|:.|.::||....|.:..:||:.||:...||.||:|:||:
Mouse  1473 VGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEDNLYMYIYFVVFIIFGSFFTLNLFIGVI 1537

  Fly  2437 VENFHRCREE--------QEKEEKIRRAAKRALQMEKKRRRMHEPPYYTNYSPTRMFVHNVVTSK 2493
            ::||::.:::        .|:::|...|.|: |..:|.::.:..|     .:..:.|:.::||.:
Mouse  1538 IDNFNQQKKKLGGQDIFMTEEQKKYYNAMKK-LGSKKPQKPIPRP-----LNKYQGFIFDIVTKQ 1596

  Fly  2494 YFDLAIAAVIGLNVVTMAMEY-YKMPSGLKYALKIFNYFFTAVFILEANMKLVALGWKLYLKDRW 2557
            .||:.|..:|.||:|||.:|. .:.|..:....|| |..|.|:|..|..:|:.||. ..|..:.|
Mouse  1597 AFDVTIMFLICLNMVTMMVETDDQSPEKVNILAKI-NLLFVAIFTGECIVKMAALR-HYYFTNSW 1659

  Fly  2558 NQLDVGIVLLSIVGIVLEELETNTHQIIPINPTIIRVMRVLRIARVLKLLKMANGIRALLDTVMQ 2622
            |..|..:|:|||||.||.::    .|....:||:.||:|:.||.|:|:|::.|.|||.||..:|.
Mouse  1660 NIFDFVVVILSIVGTVLSDI----IQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMM 1720

  Fly  2623 ALPQVGNLGLLFFLLFFIFAALGVELFGRLECSDEIPCQGLGEHAHFANFGMAFLTLFRVATGDN 2687
            :||.:.|:|||.||:.||::..|:..|..::..     .|:.:..:|..|..:.|.||::.|...
Mouse  1721 SLPALFNIGLLLFLVMFIYSIFGMANFAYVKWE-----AGIDDMFNFQTFANSMLCLFQITTSAG 1780

  Fly  2688 WNGIMKDTLRDN---CD---DAADCVRNCCVSSVIAPIFFVIFVLMAQFVLVNVVVAVLMKHL-- 2744
            |:|::...|...   ||   ..::..|..|.|..:..:||..:::::..::||:.:|:::::.  
Mouse  1781 WDGLLSPILNTGPPYCDPNLPNSNGSRGNCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSV 1845

  Fly  2745 --EESHKQM-EDELDMEVELERELVREQEFAQEQKLCQQLAEAQSKAAAPPRPLAKVKSLPKNFI 2806
              |||.:.: ||:.||..|:..:...|.....|.......|:|.|:    |..:||...:     
Mouse  1846 ATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYLALSDFADALSE----PLRIAKPNQI----- 1901

  Fly  2807 YSTPSLDKKFPAVSG 2821
             |..::|  .|.|||
Mouse  1902 -SLINMD--LPMVSG 1913

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1TNP_001259267.1 Ion_trans 332..636 CDD:278921 89/318 (28%)
Ion_trans 1261..1495 CDD:278921 77/237 (32%)
Ion_trans 2192..2448 CDD:278921 93/273 (34%)
Ion_trans 2510..2728 CDD:278921 72/224 (32%)
Scn5aXP_006512056.1 Ion_trans 195..488 CDD:366146 95/365 (26%)
Na_trans_cytopl 550..732 CDD:371806 52/444 (12%)
Ion_trans 781..994 CDD:366146 74/238 (31%)
Na_trans_assoc 1020..1268 CDD:368948 71/593 (12%)
Ion_trans 1272..1547 CDD:366146 97/281 (35%)
Na_channel_gate 1539..1591 CDD:240441 10/57 (18%)
Ion_trans 1596..1850 CDD:366146 84/264 (32%)
GPHH 1862..1909 CDD:374878 11/58 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.820

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