DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1T and Scn3a

DIOPT Version :9

Sequence 1:NP_001259267.1 Gene:Ca-alpha1T / 31550 FlyBaseID:FBgn0264386 Length:3218 Species:Drosophila melanogaster
Sequence 2:NP_001342095.1 Gene:Scn3a / 20269 MGIID:98249 Length:1996 Species:Mus musculus


Alignment Length:2612 Identity:546/2612 - (20%)
Similarity:940/2612 - (35%) Gaps:951/2612 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   284 LTQYTRPRNWCLMLITNPWFERVSILVILLNCITLGMYQPCVDDACVTNRCKILQIFDDIIFAFF 348
            ||.....|...:.::.:..|..:.:..||.||:.:.:..|       .:..|.::.....|:.| 
Mouse   111 LTPLNPVRKIAIKILVHSLFSMLIMCTILTNCVFMTLSNP-------PDWTKNVEYTFTGIYTF- 167

  Fly   349 ALEMTIKMVAMGICGKN-TYLADSWNRLDFFIVLAGLLEYVMHVENL-NLTAIRTIRVLRPLRAI 411
              |..||::|.|.|.:: |:|.|.||.|||.::   ::.||....:| |::|:||.||||.|:.|
Mouse   168 --ESLIKILARGFCLEDFTFLRDPWNWLDFSVI---VMAYVTEFVDLGNVSALRTFRVLRALKTI 227

  Fly   412 NRIPSMRILVMLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWEGILRQRCSLMRTEGMVYPLTVP 476
            :.||.::.:|..|:.::..|.:|::|..|...:|.:||:||:.|.||.:|       :.:|   |
Mouse   228 SVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKC-------LQWP---P 282

  Fly   477 EVYRVRVRVNSLSQYYEFSKD---------------QDYICSTPNDSGMH---------LCGNFP 517
            ......:...|   |:..:.|               :|||.   :||..:         ||||  
Mouse   283 SDSAFEINTTS---YFNGTMDSNGTFVNVTMSTFNWKDYIA---DDSHFYVLDGQKDPLLCGN-- 339

  Fly   518 PYRIGSLVCNEEAKLFDFNE-PTNTSCVNWNQYYTTCKQSGENPFQGTISFDNIGMAWVAIFLVI 581
                ||          |..: |....||          ::|.||..|..|||....|::::|.::
Mouse   340 ----GS----------DAGQCPEGYICV----------KAGRNPNYGYTSFDTFSWAFLSLFRLM 380

  Fly   582 SLEGWTDIMYYVQDAHSFWDWIYFVLLIVIGSFFMINLCLVVIATQFSETKKREMERMRQERARY 646
            :.:.|.::......|......|:|||:|.:|||:::||.|.|:|..:.|..:..:|...|:.|.:
Mouse   381 TQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEF 445

  Fly   647 TSTSTLASSTNNSEPATCYAEIVKYIAHLWRRFKRRMLKKYRLYKYQRQQRKEGLLPNADNLTFS 711
                                              ::||::   .|.|:::.:.....:|.:..||
Mouse   446 ----------------------------------QQMLEQ---LKKQQEEAQAVAAASAASRDFS 473

  Fly   712 PSRIKCHHPKCPKYSNRKPSSIQDQMITVMVPLNSASNNINNNNNNNSNSSNHNGSGNHTAAGGG 776
                                                                             
Mouse   474 ----------------------------------------------------------------- 473

  Fly   777 NNNNNNNNNNAASCTTVALVNGINGSAASVTMSSAHHQQHQLLQHQQQQHQNQQQQQQQQQHSSS 841
                                 ||.|....:..||   :..:|.....::.:|::::::|::|...
Mouse   474 ---------------------GIGGLGELLESSS---EASKLSSKSAKEWRNRRKKRRQREHLEG 514

  Fly   842 DNTEQSLAPDGLPRSSSLKKSTAHHQLKPEGSAAEQKTILLKFPQQMIDSEQLILQLGNLGKSHP 906
            ::                         :|||.         :||:.  :||..:           
Mouse   515 NH-------------------------RPEGD---------RFPKS--ESEDSV----------- 532

  Fly   907 CTSGFLSPPTSASRRPSVMFNEYVLLHTPPALNADPATAGTTTTVAPTVATVAGTAAAAAAAAAT 971
                         :|.|.:|          :|:.:| .:|.....:|                  
Mouse   533 -------------KRRSFLF----------SLDGNP-LSGDKKLCSP------------------ 555

  Fly   972 GSGSGNNNHQN-GGASGGAGTGGTTEKSNIFSTEKMTQAGDGSIWQVNLPQTIGTIANPYADCSE 1035
                    ||: ....|...:.....|::|||..  .:|.|           :|: .|.:||...
Mouse   556 --------HQSLLSIRGSLFSPRRNSKTSIFSFR--GRAKD-----------VGS-ENDFADDEH 598

  Fly  1036 LGIHDAMTCQELLAFSVAFSAALPTGQSTLESFYTSLARCDPHTAEALRAHHKPRSVP----TGQ 1096
            ....|:                    :|..:|.:......:...:...:|....|.||    .|:
Mouse   599 STFEDS--------------------ESRRDSLFVPHRPGERRNSNVSQASMSSRMVPGLPANGK 643

  Fly  1097 NQTTPGAEGATVMV---ASTAGDTGQTLQPSTVSAVVGGTIDSHAANHRRKEHHQQSHHHHNNNN 1158
            ..:|....|...:|   ::....||| |.|.       ||........||...:|.|.....:::
Mouse   644 MHSTVDCNGVVSLVGGPSALTSPTGQ-LPPE-------GTTTETEVRKRRLSSYQISMEMLEDSS 700

  Fly  1159 TTSHSRNYRSRQGQGNSRMREPRAPTGNYMEDYACCYDLYQNALSPLDERPRQRSPTTRC----- 1218
                          |..|.....:...|.||:.               |..||:.|.  |     
Mouse   701 --------------GRQRAMSIASILTNTMEEL---------------EESRQKCPP--CWYRFA 734

  Fly  1219 -LISVYRCMSRVCSW--IRRYIRRLVEHKYFQQGILLAILINTLSMGIEYHNQPPELTAIVETSN 1280
             :..::.|..   ||  ::..:..:|...:....|.:.|::|||.|.:|::....:.::::...|
Mouse   735 NVFLIWDCCD---SWLKVKHLVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGN 796

  Fly  1281 VVFSGIFAVEMLLKVVAEGPFRYIANGFNVFDGIIVILSAIEICQTFMGNGTGGGGSGLSVLRTF 1345
            :||:|||..||:||::|..|:.|...|:|:||||||.||.:|:....:        .||||||:|
Mouse   797 LVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMELGLANV--------EGLSVLRSF 853

  Fly  1346 RLLRILKLVRFMPNLRRQLFVMLRTMDNVAVFFSLLVLFIFIFSILGMYLFGGKFCKFLDESGLE 1410
            ||||:.||.:..|.|...:.::..::..:.....:|.:.:|||:::||.|||..:          
Mouse   854 RLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSY---------- 908

  Fly  1411 RECTCPEIISRHPQCECDRKHFNNILWATVTVFQILTQEDWNVVLFNGMEKTSHWAAL-YFVALM 1474
            :||.|    ..:..|:..|.|.|:...:.:.||::|..| |...:::.||.......| .|:.:|
Mouse   909 KECVC----KINEDCKLPRWHMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLIVFMLVM 968

  Fly  1475 TFGNYVLFNLLVAILVEGFSSERNERREREQRELVKKLREETLAENYSDGMYDESRSEADSSTTN 1539
            ..||.|:.||.:|:|:..|||                                      |:....
Mouse   969 VIGNLVVLNLFLALLLSSFSS--------------------------------------DNLAAT 995

  Fly  1540 DSYYEVRNRWRSAEDVRKLQDSVELIIEAKSNMHRQRLLQPTHDYQINELPASSAAPSASGTSGA 1604
            |...|:.|          ||.:|             ..:|...||..|::               
Mouse   996 DDDNEMNN----------LQIAV-------------GRMQKGIDYVKNKI--------------- 1022

  Fly  1605 SAPGDRERDRDRDRDRERDRDRDRERDREAGGGGKEEGAQHAKPRGGLKKTYSIKERRSEAPRLS 1669
                                   ||..|:|                                   
Mouse  1023 -----------------------RECFRKA----------------------------------- 1029

  Fly  1670 KIRLARDPPIITTTAATPQDSPSTTLEPGMSFRQWGDMEPPSPPSPSLLRPPNIFTGGQRSLDEG 1734
               ..|.|.:|........||                                     ..|.:.|
Mouse  1030 ---FFRKPKVIEIHEGNKIDS-------------------------------------CMSNNTG 1054

  Fly  1735 IPSIDLIPPSPVLSHKPLNILNASQLGVGMGGGVPSTAGSSSSMHSVIIDDISKSSSSTAAATPI 1799
            :..|.          |.||.|..       |.|..|..|:.||:...:||:....|.....:..:
Mouse  1055 VVEIS----------KELNYLKD-------GNGTTSGVGTGSSVEKYVIDENDYMSFINNPSLTV 1102

  Fly  1800 YVPTISSTADAQSQSHSLNDVSVGSSPGGEIPATGMSRNANTGASTSGSSSSERLPLAPPPQQGS 1864
            .||                 ::||.|.         ..|.||   ...||.||.           
Mouse  1103 TVP-----------------IAVGESD---------FENLNT---EEFSSESEL----------- 1127

  Fly  1865 FKQRLRRGSSKKRRASALALATDDNPARRTLDNQARRTQDEEEEQQQLNNGGDNSCLLRNSNAVV 1929
                                                     ||.:::||               .
Mouse  1128 -----------------------------------------EESKEKLN---------------A 1136

  Fly  1930 SGSSSGTKETNRLSPQNSIRRLSNTLSIGSGPVGSRRASACIFNSQVYQNLNQPPKLRPGSGQRR 1994
            :.||.|                 :|:.:.                        ||  |.|     
Mouse  1137 TSSSEG-----------------STVDVA------------------------PP--REG----- 1153

  Fly  1995 MSSIELAFSKTSHLNLHNLEANRKSLSYTNSKMDLDKWNKSYGNLNEPDNMLQQYMEARDKRKNS 2059
                                                                             
Mouse  1154 ----------------------------------------------------------------- 1153

  Fly  2060 ISHYNLKKRLEEKELQQLQQLHQQQLLQQ---RQDSFSSTTQQQQQQLQQHRLSKDQQQLAMQPH 2121
                      |:.|::..:.|..:....:   ::..|...:.::                     
Mouse  1154 ----------EQAEIEPEEDLKPEACFTEGCIKKFPFCQVSTEE--------------------- 1187

  Fly  2122 SMVPGGGERYSKLKMLIEQLTPKHFTTEREDYSLYIFPEDNRFRQICTWFVNQKWFDNVVLLFIA 2186
                |.|:.:..|                              |:.|...|...||:..::..|.
Mouse  1188 ----GKGKIWWNL------------------------------RKTCYSIVEHNWFETFIVFMIL 1218

  Fly  2187 LNCITLAMERPNIPPSSTERLFLATANYVFTVVFTVEMFIKVVATGMFYGHDAYFTSGWNIMDGS 2251
            |:...||.|...|....|.:..|..|:.|||.:|.:||.:|.||    ||...|||:.|..:|..
Mouse  1219 LSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVA----YGFQTYFTNAWCWLDFL 1279

  Fly  2252 LVTISIIDLLMSLISESSPRIFGILRVFRLLRSLRPLRVINRAPGLKLVVQTLLSSLRPIGNIVL 2316
            :|.:|::.|:.:.:..|.   .|.::..|.||:|||||.::|..|:::||..|:.::..|.|::|
Mouse  1280 IVDVSLVSLVANALGYSE---LGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLL 1341

  Fly  2317 ICCTFFIIFGILGVQLFKGTFYYCEGE------NIKGVRNADECRRIPGNV-WTNRKYNFDDLGK 2374
            :|..|::||.|:||.||.|.||:|...      ::..|.|..:|:.:.... |.|.|.|||::|.
Mouse  1342 VCLIFWLIFSIMGVNLFAGKFYHCVNMTTGSMFDMSEVNNFSDCQALGKQARWKNVKVNFDNVGA 1406

  Fly  2375 ALMSLFVLSSRDGWVNIMYTGLDAVGVDQQPIVNYNEWRLLYFIAFILLVGFFVLNMFVGVVVEN 2439
            ..::|..:::..||::|||..:|:..|..||:...|.:..|||:.||:...||.||:|:||:::|
Mouse  1407 GYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDN 1471

  Fly  2440 FHRCREE--------QEKEEKIRRAAKRALQMEKKRRRMHEPPYYTNYSPTRMFVHNVVTSKYFD 2496
            |::.:::        .|:::|...|.|: |..:|.::.:..|.     :..:..|.:.||.:.||
Mouse  1472 FNQQKKKFGGQDIFMTEEQKKYYNAMKK-LGSKKPQKPIPRPA-----NKFQGMVFDFVTRQVFD 1530

  Fly  2497 LAIAAVIGLNVVTMAMEYYKMPSGLKYALKIFNYFFTAVFILEANMKLVALGWKLYLKDRWNQLD 2561
            ::|..:|.||:|||.:|.......:...|...|..|..:|..|..:||::|.: .|....||..|
Mouse  1531 ISIMILICLNMVTMMVETDDQSKYMTLVLSRINLVFIVLFTGEFLLKLISLRY-YYFTIGWNIFD 1594

  Fly  2562 VGIVLLSIVGIVLEELETNTHQIIPINPTIIRVMRVLRIARVLKLLKMANGIRALLDTVMQALPQ 2626
            ..:|:|||||:.|.||.....    ::||:.||:|:.||.|:|:|:|.|.|||.||..:|.:||.
Mouse  1595 FVVVILSIVGMFLAELIEKYF----VSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPA 1655

  Fly  2627 VGNLGLLFFLLFFIFAALGVELFGRLECSDEIPCQGLGEHAHFANFGMAFLTLFRVATGDNWNGI 2691
            :.|:|||.||:.||:|..|:..|..::..     .|:.:..:|..||.:.:.||::.|...|:|:
Mouse  1656 LFNIGLLLFLVMFIYAIFGMSNFAYVKKE-----AGIDDMFNFETFGNSMICLFQITTSAGWDGL 1715

  Fly  2692 MKDTLRD---NCDDAA----DCVRNCCVSSVIAPIFFVIFVLMAQFVLVNVVVAVLMKHL----E 2745
            :...|..   :||..|    ..|:..|.:..:...|||.:::::..|:||:.:||::::.    |
Mouse  1716 LAPILNSAPPDCDPDAIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATE 1780

  Fly  2746 ESHKQM-EDELDMEVELERELVREQEFAQEQKLCQQLAEAQSKAAAPPRPLAKVKSLPKNFIYST 2809
            ||.:.: ||:.:|..|:..:.  :.:..|..:.| :|::. :.|..||..:||...:      ..
Mouse  1781 ESAEPLSEDDFEMFYEVWEKF--DPDATQFIEFC-KLSDF-AAALDPPLLIAKPNKV------QL 1835

  Fly  2810 PSLDKKFPAVSG 2821
            .::|  .|.|||
Mouse  1836 IAMD--LPMVSG 1845

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1TNP_001259267.1 Ion_trans 332..636 CDD:278921 92/330 (28%)
Ion_trans 1261..1495 CDD:278921 75/234 (32%)
Ion_trans 2192..2448 CDD:278921 92/270 (34%)
Ion_trans 2510..2728 CDD:278921 72/224 (32%)
Scn3aNP_001342095.1 Ion_trans 127..434 CDD:306908 98/361 (27%)
Na_trans_cytopl 510..697 CDD:314757 50/325 (15%)
Ion_trans 759..972 CDD:306908 72/235 (31%)
Na_trans_assoc 998..1201 CDD:310839 66/629 (10%)
Ion_trans 1206..1478 CDD:306908 96/278 (35%)
Na_channel_gate 1470..1522 CDD:240441 10/57 (18%)
Ion_trans 1526..1782 CDD:306908 86/265 (32%)
GPHH 1786..1849 CDD:318993 17/72 (24%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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