DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ca-alpha1T and Scn1a

DIOPT Version :9

Sequence 1:NP_001259267.1 Gene:Ca-alpha1T / 31550 FlyBaseID:FBgn0264386 Length:3218 Species:Drosophila melanogaster
Sequence 2:NP_001300926.1 Gene:Scn1a / 20265 MGIID:98246 Length:2009 Species:Mus musculus


Alignment Length:2618 Identity:547/2618 - (20%)
Similarity:945/2618 - (36%) Gaps:949/2618 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   284 LTQYTRPRNWCLMLITNPWFERVSILVILLNCITLGMYQPCVDDACVTNRCKILQIFDDIIFAFF 348
            ||.:...|...:.::.:..|..:.:..||.||:.:.|..|       .:..|.::.....|:.| 
Mouse   111 LTPFNPLRKIAIKILVHSLFSMLIMCTILTNCVFMTMSNP-------PDWTKNVEYTFTGIYTF- 167

  Fly   349 ALEMTIKMVAMGICGKN-TYLADSWNRLDFFIVLAGLLEYVMHVENL-NLTAIRTIRVLRPLRAI 411
              |..||::|.|.|.:: |:|.|.||.|||.::   ...||....:| |::|:||.||||.|:.|
Mouse   168 --ESLIKIIARGFCLEDFTFLRDPWNWLDFTVI---TFAYVTEFVDLGNVSALRTFRVLRALKTI 227

  Fly   412 NRIPSMRILVMLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWEGILRQRCSLMRTEGMVYPLTVP 476
            :.||.::.:|..|:.::..|.:|::|..|...:|.:||:||:.|.||.:|       :.:|.|..
Mouse   228 SVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKC-------VQWPPTNA 285

  Fly   477 EVYRVRVRVNSLSQY---------YEFSKDQDYICSTPNDSGMHLCGNFPPYRIGSLVCNEEAKL 532
            .:....:..|....|         :||.. :.||    .||..|.   |....:.:|:|...:  
Mouse   286 SLEEHSIEKNITMDYNGTLVNETVFEFDW-KSYI----QDSRYHY---FLEGVLDALLCGNSS-- 340

  Fly   533 FDFNE-PTNTSCVNWNQYYTTCKQSGENPFQGTISFDNIGMAWVAIFLVISLEGWTDIMYYVQDA 596
             |..: |....||          ::|.||..|..|||....|::::|.:::.:.|.::......|
Mouse   341 -DAGQCPEGYMCV----------KAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRA 394

  Fly   597 HSFWDWIYFVLLIVIGSFFMINLCLVVIATQFSETKKREMERMRQERARYTSTSTLASSTNNSEP 661
            ......|:|||:|.:|||::|||.|.|:|..:.|..:..:|...|:.|.:               
Mouse   395 AGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEF--------------- 444

  Fly   662 ATCYAEIVKYIAHLWRRFKRRMLKKYRLYKYQRQQRKEGLLPNADNLTFSPSRIKCHHPKCPKYS 726
                               ::||::   .|.|::..::.....|..                  .
Mouse   445 -------------------QQMLEQ---LKKQQEAAQQAAATTASE------------------H 469

  Fly   727 NRKPSSIQDQMITVMVPLNSASNNINNNNNNNSNSSNHNGSGNHTAAGGGNNNNNNNNNNAASCT 791
            :|:||                                        |||..:::::          
Mouse   470 SREPS----------------------------------------AAGRLSDSSS---------- 484

  Fly   792 TVALVNGINGSAASVTMSSAHHQQHQLLQHQQQQHQNQQQQQQQQQHSSSDNTEQSLAPDGLPRS 856
                      .|:.::..||..::::..:.:|::....:::...:.|.|  .:|.|:...|.   
Mouse   485 ----------EASKLSSKSAKERRNRRKKRKQKEQSGGEEKDDDEFHKS--ESEDSIRRKGF--- 534

  Fly   857 SSLKKSTAHHQLKPEGSAAEQKTILLKFPQQMIDSEQLILQLGNLGKSHPCTSGFLSPPTSASRR 921
                      :...||:.       |.:.::.....|.:|.:          .|.|..|...|| 
Mouse   535 ----------RFSIEGNR-------LTYEKRYSSPHQSLLSI----------RGSLFSPRRNSR- 571

  Fly   922 PSVMFNEYVLLHTPPALNADPATAGTTTTVAPTVATVAGTAAAAAAAAATGSGSGNNNHQNGGAS 986
                                                   |:..:....|...||.|:        
Mouse   572 ---------------------------------------TSLFSFRGRAKDVGSEND-------- 589

  Fly   987 GGAGTGGTTEKSNIFSTEKMTQAGDGSIWQVNLPQTIGTIANPYADCSELGIHDAMTCQELLAFS 1051
                                                       :||.......|           
Mouse   590 -------------------------------------------FADDEHSTFED----------- 600

  Fly  1052 VAFSAALPTGQSTLESFYTSLARCDPHTAEALRAHHKPRSVPTGQNQTTPGAEGATVMVASTAGD 1116
                     .:|..:|.:..            |.|.:.|:  :..:||:..:....|..|:  |.
Mouse   601 ---------NESRRDSLFVP------------RRHGERRN--SNLSQTSRSSRMLAVFPAN--GK 640

  Fly  1117 TGQTLQPSTVSAVVGG---------------TIDSHAANHRRKEHHQQSHHHHNNNNTTSHSRNY 1166
            ...|:..:.|.::|||               .||..|.               ::|.||:.:...
Mouse   641 MHSTVDCNGVVSLVGGPSVPTSPVGQLLPEVIIDKPAT---------------DDNGTTTETEMR 690

  Fly  1167 RSRQGQGNSRMREPRAPTGNYMEDYA------CCYDLYQNALSPLDERPRQRSPTTRC------L 1219
            :.|....:..|        :::||.:      ....:..|.:..|:| .||:.|.  |      :
Mouse   691 KRRSSSFHVSM--------DFLEDPSQRQRAMSIASILTNTVEELEE-SRQKCPP--CWYKFSNI 744

  Fly  1220 ISVYRCMSRVCSW--IRRYIRRLVEHKYFQQGILLAILINTLSMGIEYHNQPPELTAIVETSNVV 1282
            ..::.|..   .|  ::..:..:|...:....|.:.|::|||.|.:|::........::...|:|
Mouse   745 FLIWDCSP---YWLKVKHIVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEHFNHVLTVGNLV 806

  Fly  1283 FSGIFAVEMLLKVVAEGPFRYIANGFNVFDGIIVILSAIEICQTFMGNGTGGGGSGLSVLRTFRL 1347
            |:|||..||.||::|..|:.|...|:|:|||.||.||.:|:....:        .||||||:|||
Mouse   807 FTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVELGLANV--------EGLSVLRSFRL 863

  Fly  1348 LRILKLVRFMPNLRRQLFVMLRTMDNVAVFFSLLVLFIFIFSILGMYLFGGKFCKFLDESGLERE 1412
            ||:.||.:..|.|...:.::..::..:.....:|.:.:|||:::||.|||..:          ::
Mouse   864 LRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSY----------KD 918

  Fly  1413 CTCPEIISRHPQCECDRKHFNNILWATVTVFQILTQEDWNVVLFNGMEKTSHWAAL-YFVALMTF 1476
            |.| :|.:   .|:..|.|.|:...:.:.||::|..| |...:::.||.......| .|:.:|..
Mouse   919 CVC-KIAT---DCKLPRWHMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQAMCLTVFMMVMVI 978

  Fly  1477 GNYVLFNLLVAILVEGFSSERNERREREQRELVKKLREETLAENYSDGMYDESRSEADSSTTNDS 1541
            ||.|:.||.:|:|:..||                                      ||:....|.
Mouse   979 GNLVVLNLFLALLLSSFS--------------------------------------ADNLAATDD 1005

  Fly  1542 YYEVRNRWRSAEDVRKLQDSVELIIEAKSNMHRQRLLQPTHDYQINELPASSAAPSASGTSGASA 1606
            ..|:.|          ||.:|:       .||:                                
Mouse  1006 DNEMNN----------LQIAVD-------RMHK-------------------------------- 1021

  Fly  1607 PGDRERDRDRDRDRERDRDRDRERDREAGGGGKEEGAQHAKPRGGLKKTYSIKERRSEAPRLSKI 1671
                                               |..:.|     :|.|...::.         
Mouse  1022 -----------------------------------GIAYVK-----RKIYEFIQQS--------- 1037

  Fly  1672 RLARDPPIITTTAATPQDSPSTTLEPGMSFRQWGDMEPPSPPSPSLLRPPNIFTGGQRSLDEGIP 1736
                                                                |...|:.|||   
Mouse  1038 ----------------------------------------------------FVKKQKILDE--- 1047

  Fly  1737 SIDLIPPSPVLSHKPLNILNASQLGVGMG-------GGVPSTAGSSSSMHSVIIDDISKSSSSTA 1794
                |.|...|:::..|.::.....:|..       .|..|..|:.||:...|||:....|....
Mouse  1048 ----IKPLDDLNNRKDNCISNHTTEIGKDLDCLKDVNGTTSGIGTGSSVEKYIIDESDYMSFINN 1108

  Fly  1795 AATPIYVPTISSTADAQSQSHSLNDVSVGSSPGGEIPATGMSRNANTGASTSGSSSSERLPLAPP 1859
            .:..:.||                 ::||.|.         ..|.||...:|.|           
Mouse  1109 PSLTVTVP-----------------IAVGESD---------FENLNTEDFSSES----------- 1136

  Fly  1860 PQQGSFKQRLRRGSSKKRRASALALATDDNPARRTLDNQARRTQDEEEEQQQLNNGGDNSCLLRN 1924
                                                        |.||.:::||..         
Mouse  1137 --------------------------------------------DLEESKEKLNES--------- 1148

  Fly  1925 SNAVVSGSSSGTKETNRLSPQNSIRRLSNTLSIGSGPVGSRRASACIFNSQVYQNLNQPPKLRPG 1989
                 |.||.|                 :|:.||:                       |.:.:| 
Mouse  1149 -----SSSSEG-----------------STVDIGA-----------------------PAEEQP- 1167

  Fly  1990 SGQRRMSSIELAFSKTSHLNLHNLEANRKSLSYTNSKMDLDKWNKSYGNLNEPDNMLQQYMEARD 2054
                                                             :.||:..|        
Mouse  1168 -------------------------------------------------VIEPEETL-------- 1175

  Fly  2055 KRKNSISHYNLKKRLEEKELQQLQQLHQQQLLQQRQDSFSSTTQQQQQQLQQHRLSKDQQQLAMQ 2119
                            |.|                    :..|:...|:.:..::|.::      
Mouse  1176 ----------------EPE--------------------ACFTEGCVQRFKCCQISVEE------ 1198

  Fly  2120 PHSMVPGGGERYSKLKMLIEQLTPKHFTTEREDYSLYIFPEDNRFRQICTWFVNQKWFDNVVLLF 2184
                  |.|:::..|                              |:.|...|...||:..::..
Mouse  1199 ------GRGKQWWNL------------------------------RRTCFRIVEHNWFETFIVFM 1227

  Fly  2185 IALNCITLAMERPNIPPSSTERLFLATANYVFTVVFTVEMFIKVVATGMFYGHDAYFTSGWNIMD 2249
            |.|:...||.|...|....|.:..|..|:.|||.:|.:||.:|.||    ||:..|||:.|..:|
Mouse  1228 ILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYIFILEMLLKWVA----YGYQTYFTNAWCWLD 1288

  Fly  2250 GSLVTISIIDLLMSLISESSPRIFGILRVFRLLRSLRPLRVINRAPGLKLVVQTLLSSLRPIGNI 2314
            ..:|.:|::.|..:.:..|.   .|.::..|.||:|||||.::|..|:::||..||.::..|.|:
Mouse  1289 FLIVDVSLVSLTANALGYSE---LGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNV 1350

  Fly  2315 VLICCTFFIIFGILGVQLFKGTFYYC----EGE--NIKGVRNADEC-RRIPGNV---WTNRKYNF 2369
            :|:|..|::||.|:||.||.|.||:|    .|:  .|..|.|..:| :.|..|.   |.|.|.||
Mouse  1351 LLVCLIFWLIFSIMGVNLFAGKFYHCVNTTTGDIFEISEVNNHSDCLKLIERNETARWKNVKVNF 1415

  Fly  2370 DDLGKALMSLFVLSSRDGWVNIMYTGLDAVGVDQQPIVNYNEWRLLYFIAFILLVGFFVLNMFVG 2434
            |::|...:||..:::..||::|||..:|:..|:.||....:.:..|||:.||:...||.||:|:|
Mouse  1416 DNVGFGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFIG 1480

  Fly  2435 VVVENFHRCREE--------QEKEEKIRRAAKRALQMEKKRRRMHEPPYYTNYSPTRMFVHNVVT 2491
            |:::||::.:::        .|:::|...|.|: |..:|.::.:..|.     :..:..|.:.||
Mouse  1481 VIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKK-LGSKKPQKPIPRPG-----NKFQGMVFDFVT 1539

  Fly  2492 SKYFDLAIAAVIGLNVVTMAMEYYKMPSGLKYALKIFNYFFTAVFILEANMKLVALGWKLYLKDR 2556
            .:.||::|..:|.||:|||.:|.......:...|...|..|..:|..|..:||::|. ..|....
Mouse  1540 RQVFDISIMILICLNMVTMMVETDDQSDYVTSILSRINLVFIVLFTGECVLKLISLR-HYYFTIG 1603

  Fly  2557 WNQLDVGIVLLSIVGIVLEELETNTHQIIPINPTIIRVMRVLRIARVLKLLKMANGIRALLDTVM 2621
            ||..|..:|:|||||:.|.||.....    ::||:.||:|:.||.|:|:|:|.|.|||.||..:|
Mouse  1604 WNIFDFVVVILSIVGMFLAELIEKYF----VSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALM 1664

  Fly  2622 QALPQVGNLGLLFFLLFFIFAALGVELFGRLECSDEIPCQGLGEHAHFANFGMAFLTLFRVATGD 2686
            .:||.:.|:|||.||:.||:|..|:..|..::  .|:   |:.:..:|..||.:.:.||::.|..
Mouse  1665 MSLPALFNIGLLLFLVMFIYAIFGMSNFAYVK--REV---GIDDMFNFETFGNSMICLFQITTSA 1724

  Fly  2687 NWNGIMKDTLRD---NCD----DAADCVRNCCVSSVIAPIFFVIFVLMAQFVLVNVVVAVLMKHL 2744
            .|:|::...|..   :||    :....|:..|.:..:...|||.:::::..|:||:.:||::::.
Mouse  1725 GWDGLLAPILNSKPPDCDPNKVNPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENF 1789

  Fly  2745 ----EESHKQM-EDELDMEVEL-ERELVREQEFAQEQKLCQQLAEAQSKAAAPPRPLAKVKSLPK 2803
                |||.:.: ||:.:|..|: |:......:|.:.:||.|..|     |..||      .:||:
Mouse  1790 SVATEESAEPLSEDDFEMFYEVWEKFDPDATQFMEFEKLSQFAA-----ALEPP------LNLPQ 1843

  Fly  2804 NFIYSTPSLDKKFPAVSG 2821
            .......::|  .|.|||
Mouse  1844 PNKLQLIAMD--LPMVSG 1859

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1TNP_001259267.1 Ion_trans 332..636 CDD:278921 91/315 (29%)
Ion_trans 1261..1495 CDD:278921 74/234 (32%)
Ion_trans 2192..2448 CDD:278921 97/273 (36%)
Ion_trans 2510..2728 CDD:278921 72/224 (32%)
Scn1aNP_001300926.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 28..60
I. /evidence=ECO:0000250|UniProtKB:P04774 110..454 107/420 (25%)
Ion_trans 127..433 CDD:366146 98/346 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 455..528 14/152 (9%)
Na_trans_cytopl 510..718 CDD:371806 48/389 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 584..627 13/127 (10%)
II. /evidence=ECO:0000250|UniProtKB:P04774 750..1022 93/419 (22%)
Ion_trans 767..980 CDD:366146 71/235 (30%)
Na_trans_assoc 1006..1213 CDD:368948 67/634 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1129..1163 15/142 (11%)
III. /evidence=ECO:0000250|UniProtKB:P04774 1200..1514 110/351 (31%)
Ion_trans 1217..1492 CDD:366146 101/281 (36%)
Na_channel_gate 1484..1536 CDD:240441 10/57 (18%)
IV. /evidence=ECO:0000250|UniProtKB:P04774 1523..1821 97/312 (31%)
Ion_trans 1540..1796 CDD:366146 86/265 (32%)
S1-S2 loop of repeat IV. /evidence=ECO:0000269|PubMed:27281198 1561..1571 1/9 (11%)
S3b-S4 loop of repeat IV. /evidence=ECO:0000269|PubMed:27281198 1619..1636 5/20 (25%)
GPHH 1808..1855 CDD:374878 13/59 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1984..2009
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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