Protein Alignment Ca-alpha1T and unc-2

DIOPT Version :9

• Sequence 1: NP_001259267.1
• Gene: Ca-alpha1T / 31550
• FlyBaseID: FBgn0264386
• Length: 3218
• Species: Drosophila melanogaster
• Sequence 2: NP_001355464.1
• Gene: unc-2 / 180570
• WormBaseID: WBGene00006742
• Length: 2171
• Species: Caenorhabditis elegans
• Alignment Length: 3303
• Identity: 582/3303 - (17%)
• Similarity: 954/3303 - (28%)
• Gaps: 1535/3303 - (46%)

  Fly    13 TTTTTQSATSATSTAATSAAAAAARNGQRRRVAAATEGCNSNIGNSNSKLSSNTTTNTTKRVSQM 77
            |.:..:..||||||      .:|.::|.        |....||..|....||.|:|     :.:.
 Worm    23 TPSHRKPKTSATST------YSAEKSGD--------ESVTINIEFSYRSQSSGTST-----LQKN 68

  Fly    78 HSNEEPPMTVIVDGGGGSNVSVSGGSSHRRGSQRLRKTSSSSANAKSASANP------------T 130
            ....|||.                       |:|..:..:|:..|....|.|            .
 Worm    69 RKPSEPPK-----------------------SKRSSRDDNSNGYAGYEDATPRPSIDFPTAVIEA 110

  Fly   131 ERTSSGQRSSHRQTSNASDGGGSSRRRYQGKEHHDRRDRQDRQDR--QDRQERSDRHERR--DRR 191
            .|.:|....|..::.:|.:...||.|    .||.:.|........  .|.::.|..|.||  |..
 Worm   111 ARRASVLGRSAAESLSAQEAASSSER----GEHTNSRSPSTSYSSCIDDERKFSSPHRRRVVDVS 171

  Fly   192 DEQQAARRRTGRRHSGASSLSDAAAATAAGRSRSRGGGRTGGAVSSSTGSSCNGSCSSDDGDSSH 256
            |.:..|...|  |...||....:.:..||..:|......:|..|..:|.|| |.....
 Worm   172 DHKTCALLMT--RMKEASRQLPSPSQLAAEEARREQKAESGTFVRKTTLSS-NAPVKE------- 226

  Fly   257 TSSSSSSSSSGEPNLPYPGFPEISIRALTQYTRPRNWCLMLITNPWFERVSILVILLNCITLGMY 321
             ...||.....|.|:         ||        ||...::...| ||...:|.|:.||:.|.|.
 Worm   227 -KGPSSLFIFAEDNI---------IR--------RNAKAIIEWGP-FEYFILLTIIGNCVVLSME 272

  Fly   322 Q--PCVDDACVTNRCKILQIFDDIIFAFFALEMTIKMVAMGIC-GKNTYLADSWNRLDFFIVLAG 383
            |  |..|...::   :.|:..:......|.||..:|::|.|.. .|.:||...||.:||.:|::|
 Worm   273 QHLPKNDKKALS---EWLERTEPYFMGIFCLECVLKVIAFGFALHKGSYLRSGWNIMDFIVVVSG 334

  Fly   384 LLEYV----------MHVENLNLTAIRTIRVLRPLRAINRIPSMRILVMLLLDTLPMLGNVLLLC 438
            ::..:          ..|::::|..:|.:||||||:.::.|||:::::..:|..:..|..:.||.
 Worm   335 VVTMLPFSPATQTANQPVDSVDLRTLRAVRVLRPLKLVSGIPSLQVVLKSILCAMAPLLQIGLLV 399

  Fly   439 FFVFFIFGIIGVQLWEGILRQRCSLMRTEGMVYPLTVPEVYRVRVRVNSLSQYYEFSKDQDYICS 503
            .|...||.|||::.:.|.....|                 |..|..:.::|:
 Worm   400 LFAIIIFAIIGLEFYSGAFHSAC-----------------YNERGEIENVSE------------- 434

  Fly   504 TPNDSGMHLCGNFPPYRIGSLVCNEEAKLFDFNEPTNTSCVNWNQYYTTCKQSGENPFQGTISFD 568
                              ..:.|.        |:.:.....|.:...|||.|....|..|..|||
 Worm   435 ------------------RPMPCT--------NKTSPMGVYNCDVKGTTCLQKWIGPNYGITSFD 473

  Fly   569 NIGMAWVAIFLVISLEGWTDIMYYVQDA-HSFWDWIYFVLLIVIGSFFMINLCLVVIATQFSETK 632
            |||.|.:.:|..|::||||.:|||..|: .|.::|.||:.|||:|||||:||.|.|::.:|:
 Worm   474 NIGFAMITVFQCITMEGWTTVMYYTNDSLGSTYNWAYFIPLIVLGSFFMLNLVLGVLSGEFA--- 535

  Fly   633 KREMERMRQERARYTSTSTLASSTNNSEPATCYAEIVKYIAHLWRRFKRRMLKKYRLYKYQRQQR 697
             :|.||:...|                                            ...|.:|||:
 Worm   536 -KERERVENRR--------------------------------------------EFLKLRRQQQ 555

  Fly   698 KEGLLPNADNLTFSPSRIKCHHPKCPKYSNRKPSSIQDQMITVMVPLNSASNNINNNNNNNSNSS 762
            .|
 Worm   556 IE--------------------------------------------------------------- 557

  Fly   763 NHNGSGNHTAAGGGNNNNNNNNNNAASCTTVALVNGINGSAASVTMSSAHHQQHQLLQHQQQQHQ 827
                                              ..:||
 Worm   558 ----------------------------------RELNG-------------------------- 562

  Fly   828 NQQQQQQQQQHSSSDNTEQSLAPDGLPRSSSLKKSTAHHQLKPEGSAAEQKTILLKFPQQMIDSE 892
                                                                    :.:.::.:|
 Worm   563 --------------------------------------------------------YLEWILTAE 571

  Fly   893 QLILQLGNLGKSHPCTSGFLSPPTSASRRPSVMFNEYVLLHTPPALNADPATAGTTTTVAPTVAT 957
            ::||:
 Worm   572 EVILK------------------------------------------------------------ 576

  Fly   958 VAGTAAAAAAAAATGSGSGNNNHQNGGASGGAGTGGTTEKSNIFSTEKMTQAGDGSIWQVNLPQT 1022
                                             ...|||:......|...:|.:..:.|.:..|:
 Worm   577 ---------------------------------EDRTTEEEKAAIMEARRRAANKKLKQASKQQS 608

  Fly  1023 IGTIANPYADCSELGIHDAMTCQELLAFSVAFSAALPTGQSTLESFYTSLARCDPHTAEALRAHH 1087
            ..|..:...|                             :..:|..|..
 Worm   609 TETEEDFEED-----------------------------EDEMEEEYVD---------------- 628

  Fly  1088 KPRSVPTGQNQTTPGAEGATVMVASTAGDTGQTLQPSTVSAVVGGTIDSHAANHRRKEHHQQSHH 1152
                                                      .|||::...|..:::
 Worm   629 ------------------------------------------EGGTVEDEFAERKKR-------- 643

  Fly  1153 HHNNNNTTSHSRNYRSRQGQGNSRMREPRAPTGNYMEDYACCYDLYQNALSPLDERPRQRSPTTR 1217
                                                   .||:.
 Worm   644 ---------------------------------------GCCHS--------------------- 648

  Fly  1218 CLISVYRCMSRVCSWIRRYIRRLVEHKYFQQGILLAILINTLSMGIEYHNQPPELTAIVETSNVV 1282
                    :.:....:|..||.:|:.:.|...::..:.:||..:..|::.||...|..::.:..|
 Worm   649 --------VGKFIKQLRIQIRIMVKTQIFYWSVITLVFLNTCCVASEHYGQPQWFTDFLKYAEFV 705

  Fly  1283 FSGIFAVEMLLKVVAEGPFRYIANGFNVFDGIIVILSAIEI--CQTFMGNGTGGGGSGLSVLRTF 1345
            |.|||.||||||:.|.|...|.|:.||.||.::::.||.|:  .:.:      ||..|:||:|..
 Worm   706 FLGIFVVEMLLKLFAMGSRTYFASKFNRFDCVVIVGSAAEVIWAEVY------GGSFGISVMRAL 764

  Fly  1346 RLLRILKLVRFMPNLRRQLFVMLRTMDNVAVFFSLLVLFIFIFSILGMYLFGGKFCKFLDESGLE 1410
            |||||.||..:..:||..:..::.:|.::.....||.|||.||::|||.||||:|
 Worm   765 RLLRIFKLTSYWVSLRNLVRSLMNSMRSIISLLFLLFLFILIFALLGMQLFGGRF---------- 819

  Fly  1411 RECTCPEIISRHPQCECDRKHFNNILWATVTVFQILTQEDWNVVLFNGMEK-----TSHWA-ALY 1469
                  ...:.||.     .||:....|.:|||||||.||||.|::..:|.     :..|. ::|
 Worm   820 ------NFPTMHPY-----THFDTFPVALITVFQILTGEDWNEVMYLAIESQGGIYSGGWPYSIY 873

  Fly  1470 FVALMTFGNYVLFNLLVAILVEGFSSERNERREREQRELVKKLREET--LAENYSDGMYDESRSE 1532
            |:.|:.||||.|.|:.:||.|:..::.:......|..|...::.||:  |.|.|.:|
 Worm   874 FIVLVLFGNYTLLNVFLAIAVDNLANAQELTAAEEADEKANEIEEESEELDEQYQEG-------- 930

  Fly  1533 ADSSTTNDSYYEVRNRWRSAEDVRKLQDSVELIIEAKSNMHRQRLLQPTHDYQINELPASSAAPS 1597
                                       |...:.:|.|
 Worm   931 ---------------------------DHCTIDMEGK---------------------------- 940

  Fly  1598 ASGTSGASAPGDRERDRDRDRDRERDRDRDRERDREAGGGGKEEGAQHAKPRGGLKKTYSIKERR 1662
                                                                             
 Worm   941 ----------------------------------------------------------------- 940

  Fly  1663 SEAPRLSKIRLARDPPIITTTAATPQDSPSTTLEPGMSFRQWGDMEPPSPPSPSLLRPPNIFTGG 1727
                                ||                    |||
 Worm   941 --------------------TA--------------------GDM-------------------- 945

  Fly  1728 QRSLDEGIPSIDLIPPSPVLSHKPLNILNASQLGVGMGGGVPSTAGSSSSMHSVIIDDISKSSSS 1792
                                                                             
 Worm   946 ----------------------------------------------------------------- 945

  Fly  1793 TAAATPIYVPTISSTADAQSQSHSLNDVSVGSSPGGEIPATGMSRNANTGASTSGSSSSERLPLA 1857
                                                                             
 Worm   946 ----------------------------------------------------------------- 945

  Fly  1858 PPPQQGSFKQRLRRGSSKKRRASALALATDDNPARRTLDNQARRTQDEEEEQQQLNNGGDNSCLL 1922
                                  .|:|.|.||              .|||.|:::...||
 Worm   946 ----------------------CAVARAMDD--------------LDEECEEEESPFGG------ 968

  Fly  1923 RNSNAVVSGSSSGTKETNRLSPQNSIRRLSNTLSIGSGPVGSRRASACIFNSQVYQNLNQPPKLR 1987
                                                                             
 Worm   969 ----------------------------------------------------------------- 968

  Fly  1988 PGSGQRRMSSIELAFSKTSHLNLHNLEANRKSLSYTNSKMDLDKWNKSYGNLNEPDNMLQQYMEA 2052
                                                                             
 Worm   969 ----------------------------------------------------------------- 968

  Fly  2053 RDKRKNSISHYNLKKRLEEKELQQLQQLHQQQLLQQRQDSFSSTTQQQQQQLQQHRLSKDQQQLA 2117
                                                                             
 Worm   969 ----------------------------------------------------------------- 968

  Fly  2118 MQPHSMVPGGGERYSKLKMLIEQLTPKHFTTEREDYSLYIFPEDNRFRQICTWFVNQKWFDNVVL 2182
              |..|||     ||                     |::.....|.||.:....|..|:|:.:|:
 Worm   969 --PKPMVP-----YS---------------------SMFFLSPTNPFRVLIHSIVCTKYFEMMVM 1005

  Fly  2183 LFIALNCITLAMERPNIPPSSTERLFLATANYVFTVVFTVEMFIKVVATGMFYGHDAYFTSGWNI 2247
            ..|.|:.::||.|.| :...:.....|...:|.||.||..||.:|::..|:.....:|....|||
 Worm  1006 TVICLSSVSLAAEDP-VDEENPRNKVLQYMDYCFTGVFACEMLLKLIDQGILLHPGSYCRDFWNI 1069

  Fly  2248 MDGSLVTISIIDLLMSLISESSPRIFGILRVFRLLRSLRPLRVINRAPGLKLVVQTLLSSLRPIG 2312
            :||.:||.::.....:....|:.:....::..|:||.||||:.|.|.|.||.|...:::||:.:.
 Worm  1070 LDGIVVTCALFAFGFAGTEGSAGKNLNTIKSLRVLRVLRPLKTIKRIPKLKAVFDCVVNSLKNVF 1134

  Fly  2313 NIVLICCTFFIIFGILGVQLFKGTFYYCEGENIKGVR----------NADECRRIPGNVWTNRKY 2367
            ||:::...|..||.::.||||.|.|::|..:|.|...          |.::..|:....|..|.:
 Worm  1135 NILIVYFLFQFIFAVIAVQLFNGKFFFCTDKNRKFANTCHGQFFVYDNQNDPPRVEQREWRLRPF 1199

  Fly  2368 NFDDLGKALMSLFVLSSRDGWVNIMYTGLDAVGVDQQPIVNYNEWRLLYFIAFILLVGFFVLNMF 2432
            |:|:...|:::|||:::.:||..|....:|....||.|...:.....|:::.|.::..||.:|:|
 Worm  1200 NYDNTINAMLTLFVVTTGEGWPGIRQNSMDTTFEDQGPSPFFRVEVALFYVMFFIVFPFFFVNIF 1264

  Fly  2433 VGVVVENFHRCREEQEKEEKIRRAAKRALQ--MEKKRRRMHEPPYYTNYSPTRMFVHNVVTSKYF 2495
            |.:::..|....|.:..|..:.:..|:.:.  :..:.|.:..|   .:.:.|:..:..:|||..|
 Worm  1265 VALIIITFQEQGEAELSEGDLDKNQKQCIDFALNARPRSLFMP---EDKNSTKYRIWRLVTSPPF 1326

  Fly  2496 DLAIAAVIGLNVVTMAMEYYKMPSGLKYALKIFNYFFTAVFILEANMKLVALGWKLYLKDRWNQL 2560
            :..|..:|..|.:.:.|:||..|...:..|::||...||||.:|:.:|::|.|.:.|.:|.||:.
 Worm  1327 EYFIMTMICCNTLILMMKYYNNPLFYEEILRLFNTALTAVFTVESILKILAFGVRNYFRDGWNRF 1391

  Fly  2561 DVGIVLLSIVGIVLEEL--ETNTHQIIPINPTIIRVMRVLRIARVLKLLKMANGIRALLDTVMQA 2623
            |    .:::||.:.:.|  |...|.:      .:..:|:.|.||:::||:....||.||.|.:|:
 Worm  1392 D----FVTVVGSITDALVTEFGGHFV------SLGFLRLFRAARLIRLLQQGYTIRILLWTFVQS 1446

  Fly  2624 LPQVGNLGLLFFLLFFIFAALGVELFGR--LECSDEIPCQGLGEHAHFANFGMAFLTLFRVATGD 2686
            ...:..:.||..:||||:|.:|:::||.  |..:.||     ..|.:|.:|..|.:.|||.|||:
 Worm  1447 FKALPYVCLLIGMLFFIYAIVGMQVFGNIWLNAATEI-----NRHNNFQSFFNAVILLFRCATGE 1506

  Fly  2687 NWNGIMKDTLRDNCDDAADCVR-----------NCCVSSVIAPIFFVIFVLMAQFVLVNVVVAVL 2740
            .|..||...::     ..||.|           ..|.|:| :..:|..||.::.|:::|:.|||:
 Worm  1507 GWQDIMMAAVQ-----GKDCARAGSAEINFEKGQTCGSNV-SYAYFTSFVFLSSFLMLNLFVAVI 1565

  Fly  2741 MKHLEESHKQMEDELDMEVELERELVREQEFAQEQKLCQQLAEAQSKAAAPPRPLAKVKSLPKNF 2805
            |           |..|.       |.|:........|                         ..|
 Worm  1566 M-----------DNFDY-------LTRDSSILGPHHL-------------------------DEF 1587

  Fly  2806 IYSTPSLDKKFPAVSGVNNPSLTSSAATNLNQVATAGSGGAAPGAVPAGSGAG-PRRQTVQYFQQ 2869
            |......|   ||.:|    .:..|....:.::.          |.|.|.|.. |.|...::.
 Worm  1588 IRVWADYD---PAATG----RIHYSEMYEMLRIM----------APPVGFGKKCPYRLAYKHL-- 1633

  Fly  2870 PPQSMLGGLSLAEMGGTLTPQALGARLGEPFGGGGGNKSGPRRQSYWQINPIRKRGVLSKERSLD 2934
                :...:.:||.|.......|.|.:.|...                   |:.|.|...:.:.:
 Worm  1634 ----IRMNMPVAEDGTVHFTTTLFALIRESLS-------------------IKMRPVEEMDEADE 1675

  Fly  2935 EQAIRRRN---LEAKRTSCDSLPWGGDALDCRRGT---------IFESLESDGGGVGGGGSGGGG 2987
            |..:..:.   |:||:...|.:......|..::.|         |.|:..:...|...||.|..|
 Worm  1676 ELRLTLKKIWPLKAKKNMVDLVVPPNHELCFQKLTVGKIYAGLLILENYRARKSGTEVGGQGLFG 1740

  Fly  2988 GGLGGGVSYDLRSVRSADVGHSEMDGDVSLSVVSALVPSVTTPLPPPLSLPIVTPTSTPTPLQLP 3052
            |||...|:    :.::|:..||.                 .||.||..:.||:
 Worm  1741 GGLRSLVA----AAKAAESQHSS-----------------HTPQPPEETTPII------------ 1772

  Fly  3053 MPMPMPMAHPPPRRPFGWSQSVDQGCLRSNLLLSVPRSMPPRSRSGSTKQLFKQQALDEDADMDE 3117
                     |...:.|.                    :.|..|..||.:|
 Worm  1773 ---------PQHAQQFS--------------------AAPTMSAQGSLQQ--------------- 1793

  Fly  3118 NSLLLPTAAGGGSGP-----------------GSVAVIASSSLDLP-DQSGSSKQILPDIALGVS 3164
               :..|::|||..|                 |.|..:...|:|.. ::..|:.:.|.|:...:.
 Worm  1794 ---MQGTSSGGGQRPYSLFNSFVDTIKSGKQDGDVTDVQYQSVDQQHEKMNSTGRRLSDMFSKIR 1855

  Fly  3165 KSDSSDILRIISERRRMDQREQREPEQDQDNEAEDRDSD----YKELLLVKSP 3213
            :..|:|                ..|.|.:...|:|..|.    |:.:.....|
 Worm  1856 RGTSAD----------------HNPHQTEHLLAQDNRSPSSPRYRSMARASPP 1892

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ca-alpha1T	NP_001259267.1	Ion_trans	332..636	CDD:278921	86/315 (27%)
		Ion_trans	1261..1495	CDD:278921	88/241 (37%)
		Ion_trans	2192..2448	CDD:278921	78/265 (29%)
		Ion_trans	2510..2728	CDD:278921	72/232 (31%)
unc-2	NP_001355464.1	Ion_trans	254..536	CDD:366146	97/344 (28%)
		Ion_trans	667..904	CDD:366146	91/263 (35%)
		Ion_trans	998..1279	CDD:366146	83/281 (30%)
		Ion_trans	1323..1577	CDD:366146	87/292 (30%)
		GPHH	1586..1639	CDD:374878	13/75 (17%)
		Ca_chan_IQ	1650..1726	CDD:370105	15/94 (16%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D172471at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920