Protein Alignment Ca-alpha1T and egl-19

DIOPT Version :9

• Sequence 1: NP_001259267.1
• Gene: Ca-alpha1T / 31550
• FlyBaseID: FBgn0264386
• Length: 3218
• Species: Drosophila melanogaster
• Sequence 2: NP_001023079.1
• Gene: egl-19 / 177513
• WormBaseID: WBGene00001187
• Length: 1877
• Species: Caenorhabditis elegans
• Alignment Length: 3134
• Identity: 585/3134 - (18%)
• Similarity: 921/3134 - (29%)
• Gaps: 1550/3134 - (49%)

  Fly   192 DEQQAARRRTGRRHSGASSLSDAAAATAAGRSRSRGGGRTGGAVSSSTGSSCNGSCSSDDGDSSH 256
            ||:|||.....|......:|..|.||
 Worm    13 DEEQAAADEQERTDLWQQTLQAAVAA--------------------------------------- 38

  Fly   257 TSSSSSSSSSGEPNLPYP-------GFPEISIRALTQYTRPRNWCLMLITNPWFERVSILVILLN 314
              |||..::...|....|       ...|.|:..|:.....|..|:.::....||.:.:.:|..|
 Worm    39 --SSSQDATKKRPAQRKPLRQTNVVERSERSLLCLSLNNPIRKLCISIVEWKPFEFLILFMICAN 101

  Fly   315 CITLGMYQPC-VDDACVTNRCKILQIFDDIIFAFFALEMTIKMVAMG-ICGKNTYLADSWNRLDF 377
            ||.|.:|||. ..|:...|  .:|:..:.:....|.:|..:|:|||| :...:.||.::||.|||
 Worm   102 CIALAIYQPYPAQDSDYKN--TLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDF 164

  Fly   378 FIVLAGLLEYV---MHVENLNLTAIRTIRVLRPLRAINRIPSMRILVMLLLDTLPMLGNVLLLCF 439
            .||:.||:..:   |.::..::.|:|..|||||||.::.:||:::::..:|..:..|.::.||..
 Worm   165 IIVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVL 229

  Fly   440 FVFFIFGIIGVQLWEGILRQRCSLMRTEGMVYPLTVPEVYRVRVRVNSLSQYYEFSKDQDYICST 504
            ||..|:.|||::|:.|.|...|        :.|.|           ..|:|     ||.. .|.|
 Worm   230 FVILIYAIIGLELFCGKLHSTC--------IDPAT-----------GQLAQ-----KDPT-PCGT 269

  Fly   505 PNDSGMHLCGNFPPYRIGSLVCNEEAKLFDFNEPTNTSC---VNWNQYYTTCKQSGENPFQGTIS 566
            ..:.....|                       :|:::..   |.|.   .:...:...|..|..:
 Worm   270 DTEGSAFKC-----------------------QPSDSLTNMGVRWE---CSSNTTWPGPNNGITN 308

  Fly   567 FDNIGMAWVAIFLVISLEGWTDIMYYVQDA-HSFWDWIYFVLLIVIGSFFMINLCLVVIATQFSE 630
            |||.|:|.:.:|..:|||||||:||:|.|| ...|.|||||.|:::||||::||.|.|::.:||
 Worm   309 FDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLVLGVLSGEFS- 372

  Fly   631 TKKREMERMRQERARYTSTSTLASSTNNSEPATCYAEIVKYIAHLWRRFKRRMLKKYRLYKYQRQ 695
             |:||..|                                         .|.:.:|:|    ::|
 Worm   373 -KEREKAR-----------------------------------------ARGLFQKFR----EKQ 391

  Fly   696 QRKEGLLPNADNLTFSPSRIKCHHPKCPKYSNRKPSSIQDQMITVMVPLNSASNNINNNNNNNSN 760
            |.:|.|....|.:|
 Worm   392 QLEEDLKGYLDWIT--------------------------------------------------- 405

  Fly   761 SSNHNGSGNHTAAGGGNNNNNNNNNNAASCTTVALVNGINGSAASVTMSSAHHQQHQLLQHQQQQ 825
                                                                       |.:..:
 Worm   406 -----------------------------------------------------------QAEDIE 411

  Fly   826 HQNQQQQQQQQQHSSSDNTEQSLAPDGLPRSSSLKKSTAHHQLKPEGSAAEQKTILLKFPQQMID 890
            ..|:.:|:.:
 Worm   412 PVNEDEQEDE------------------------------------------------------- 421

  Fly   891 SEQLILQLGNLGKSHPCTSGFLSPPTSASRRPSVMFNEYVLLHTPPALNADPATAGTTTTVAPTV 955
                                                                          |..
 Worm   422 --------------------------------------------------------------PVA 424

  Fly   956 ATVAGTAAAAAAAAATGSGSGNNNHQNGGASGGAGTGGTTEKSNIFSTEKMTQAGDGSIWQVNLP 1020
            .||.|                                           |:..:.|:..:
 Worm   425 QTVVG-------------------------------------------EEADEEGEERV------ 440

  Fly  1021 QTIGTIANPYADCSELGIHDAMTCQELLAFSVAFSAALPTGQSTLESFYTSLARCDPHTAEALRA 1085
                                                                             
 Worm   441 ----------------------------------------------------------------- 440

  Fly  1086 HHKPRSVPTGQNQTTPGAEGATVMVASTAGDTGQTLQPSTVSAVVGGTIDSHAANHRRKEHHQQS 1150
                                             :.::||           ..||..:|.|.
 Worm   441 ---------------------------------EDVRPS-----------KWAARMKRLEK---- 457

  Fly  1151 HHHHNNNNTTSHSRNYRSRQGQGNSRMREPRAPTGNYMEDYACCYDLYQNALSPLDERPRQRSPT 1215
                                                                             
 Worm   458 ----------------------------------------------------------------- 457

  Fly  1216 TRCLISVYRCMSRVCSWIRRYIRRLVEHKYFQQGILLAILINTLSMGIEYHNQPPELTAIVETSN 1280
                      ::|.|   ||..||||:.:.|...::|.:|:|||.:..|::.|...|......:|
 Worm   458 ----------LNRRC---RRACRRLVKSQTFYWLVILLVLLNTLVLTSEHYGQSEWLDHFQTMAN 509

  Fly  1281 VVFSGIFAVEMLLKVVAEGPFRYIANGFNVFDGIIVILSAIEICQTFMGNGTGGGGSGLSVLRTF 1345
            :.|..:|::|||||:.:.|...|..:.||.||..:||.|.:|....:.....   ..|:||||:.
 Worm   510 LFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYFDLMK---PLGVSVLRSA 571

  Fly  1346 RLLRILKLVRFMPNLRRQLFVMLRTMDNVAVFFSLLVLFIFIFSILGMYLFGGKFCKFLDESGLE 1410
            |||||.|:.::..:||..:..:|.::.::.....||.|||.||::|||.:|||||
 Worm   572 RLLRIFKVTKYWTSLRNLVSSLLNSLRSIISLLLLLFLFIVIFALLGMQVFGGKF---------- 626

  Fly  1411 RECTCPEIISRHPQCECDRKHFNNILWATVTVFQILTQEDWNVVLFNGMEKTSHWAAL------Y 1469
                     :.:||....|.:|:..:.|.:|||||||.||||.|:::|:|.......|      |
 Worm   627 ---------NFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGIESFGGVGTLGVIVCIY 682

  Fly  1470 FVALMTFGNYVLFNLLVAILVEGFS---SERNERREREQRELVKKLREETLAENYSDGMYDESRS 1531
            ::.|...|||:|.|:.:||.|:..:   |..|..:|.||:|:..:               ||...
 Worm   683 YIVLFICGNYILLNVFLAIAVDNLADADSLTNAEKEEEQQEIEGE---------------DEEFE 732

  Fly  1532 EADSSTTNDSYYEVRNRWRSAEDVRKLQDSVELIIEAKSNMHRQRLLQPTHDYQINELPASSAAP 1596
            |
 Worm   733 E---------------------------------------------------------------- 733

  Fly  1597 SASGTSGASAPGDRERDRDRDRDRERDRDRDRERDREAGGGGKEEGAQHA--KPRGGLKKTYSIK 1659
                                                     |::||.:|.  :|.|..:.|.:..
 Worm   734 -----------------------------------------GEDEGEEHGMDEPEGDEEMTSARP 757

  Fly  1660 ERRSEAPRLSKIRLARDPPIITTTAATPQDSPSTTLEPGMSFRQWGDMEPPSPPSPSLLRPPNIF 1724
            .|.||.|..|.::                                     |.|.:.||.
 Worm   758 RRMSEVPAASTVK-------------------------------------PIPKASSLF------ 779

  Fly  1725 TGGQRSLDEGIPSIDLIPPSPVLSHKPLNILNASQLGVGMGGGVPSTAGSSSSMHSVIIDDISKS 1789
                                 :|||
 Worm   780 ---------------------ILSH---------------------------------------- 783

  Fly  1790 SSSTAAATPIYVPTISSTADAQSQSHSLNDVSVGSSPGGEIPATGMSRNANTGASTSGSSSSERL 1854
                                                                             
 Worm   784 ----------------------------------------------------------------- 783

  Fly  1855 PLAPPPQQGSFKQRLRRGSSKKRRASALALATDDNPARRTLDNQARRTQDEEEEQQQLNNGGDNS 1919
                                                                             
 Worm   784 ----------------------------------------------------------------- 783

  Fly  1920 CLLRNSNAVVSGSSSGTKETNRLSPQNSIRRLSNTLSIGSGPVGSRRASACIFNSQVYQNLNQPP 1984
                                                                             
 Worm   784 ----------------------------------------------------------------- 783

  Fly  1985 KLRPGSGQRRMSSIELAFSKTSHLNLHNLEANRKSLSYTNSKMDLDKWNKSYGNLNEPDNMLQQY 2049
                                                  |||
 Worm   784 --------------------------------------TNS------------------------ 786

  Fly  2050 MEARDKRKNSISHYNLKKRLEEKELQQLQQLHQQQLLQQRQDSFSSTTQQQQQQLQQHRLSKDQQ 2114
                                                                             
 Worm   787 ----------------------------------------------------------------- 786

  Fly  2115 QLAMQPHSMVPGGGERYSKLKMLIEQLTPKHFTTEREDYSLYIFPEDNRFRQICTWFVNQKWFDN 2179
                                                             ||..|...||..:|.|
 Worm   787 -------------------------------------------------FRVFCNMVVNHSYFTN 802

  Fly  2180 VVLLFIALNCITLAMERPNIPPSSTERLFLATANYVFTVVFTVEMFIKVVATGMFYGHDAYFTSG 2244
            .||..|.::...||.|.| :..:||..:.|...:|.||.|||||:.:||:..|:.:...::..:.
 Worm   803 AVLFCILVSSAMLAAEDP-LQANSTRNMILNYFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNA 866

  Fly  2245 WNIMDGSLVTISIIDLLMSLISESSPRIFGILRVFRLLRSLRPLRVINRAPGLKLVVQTLLSSLR 2309
            :|::|..:|.:|:...::...:.|      ::::.|:||.|||||.||||.|||.|||.::.:::
 Worm   867 FNLLDILVVAVSLTSFVLRTDAMS------VVKILRVLRVLRPLRAINRAKGLKHVVQCVIVAVK 925

  Fly  2310 PIGNIVLICCTFFIIFGILGVQLFKGTFYY-----------CEGENIKGVRNADECRRI-PGNVW 2362
            .||||:|:......:|.|:|||||||||:.           |.||.|. ..:.|..:.: ...||
 Worm   926 TIGNIMLVTFMLQFMFAIIGVQLFKGTFFLCNDLSKMTEAECRGEYIH-YEDGDPTKPVSKKRVW 989

  Fly  2363 TNRKYNFDDLGKALMSLFVLSSRDGWVNIMYTGLDAVGVDQQPIVNYNEWRLLYFIAFILLVGFF 2427
            :|..:|||::|.|::||||:|:.:||..::|..:|:...|:.||.|..:...|:|||||:::.||
 Worm   990 SNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALFFIAFIIVIAFF 1054

  Fly  2428 VLNMFVGVVVENF----HRCREEQEKEEKIRRAAKRALQMEKKRRRMHEPPYYTNYSPTRMFVHN 2488
            ::|:|||.|:..|    .|..|..|.::..|:..:.||:.:..||          |.|.....:.
 Worm  1055 MMNIFVGFVIVTFQNEGEREYENCELDKNQRKCIEFALKAKPHRR----------YIPRNRLQYR 1109

  Fly  2489 V---VTSKYFDLAIAAVIGLNVVTMAMEYYKMPSGLKYALKIFNYFFTAVFILEANMKLVALGWK 2550
            |   |||:.|:..|..:|.:|.|::|.::|....|.:..|.:||..||.||..||.:|:|||..|
 Worm  1110 VWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPK 1174

  Fly  2551 LYLKDRWNQLDVGIVLLSIVGIVLEELETNTHQIIPINPTIIRVMRVLRIARVLKLLKMANGIRA 2615
            .|:.||||..|:.:|:.|.:.|...:|......:|.||     ..|:.|:.|::|||....|||.
 Worm  1175 NYISDRWNVFDLLVVVGSFIDITYGKLNPGGTNLISIN-----FFRLFRVMRLVKLLSRGEGIRT 1234

  Fly  2616 LLDTVM---QALPQVGNLGLLFFLLFFIFAALGVELFGRLECSDEIPCQGLGEHAHFANFGMAFL 2677
            ||.|.|   ||||.|   .||..|||||:|.:|::.||::...|.   ..:..:.:|.:|..|.|
 Worm  1235 LLWTFMKSFQALPYV---ALLIVLLFFIYAVIGMQFFGKVALDDS---TSIHRNNNFHSFPAAIL 1293

  Fly  2678 TLFRVATGDNWNGIM-----KDTLRDNCDDAAD-----------CVRNCCVSSVIAPIFFVIFVL 2726
            .|||.|||:.|..||     ::.:|  ||..:|           |..|      .|..:|:.|.:
 Worm  1294 VLFRSATGEAWQDIMLSCSDREDVR--CDPMSDDYHKGGLNESRCGNN------FAYPYFISFFM 1350

  Fly  2727 MAQFVLVNVVVAVLM---------------KHLEESHKQMEDELDME----------VELERELV 2766
            :..|:::|:.|||:|               .|||| ..::..|.|.:          |.|.|::.
 Worm  1351 LCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLEE-FVRLWSEYDPDAKGRIKHLDVVTLLRKIS 1414

  Fly  2767 REQEFAQEQKLCQQLAEAQSKAAAPPRPLAKVKSLPKNFIYSTPSLDKKFPAVSGVNNPSLTSSA 2831
            ....|.   |||             |..||..:.:..|...::..        :...|.:|.:..
 Worm  1415 PPLGFG---KLC-------------PHRLACKRLVSMNMPLNSDG--------TVCFNATLFALV 1455

  Fly  2832 ATNLNQVATAGSGGAAPGAV---------------------PAGS----GAGPRRQTV---QYFQ 2868
            .||| ::.|.|:...|...:                     |||.    ..|....|.   .||:
 Worm  1456 RTNL-KIYTEGNIDEANEQLRSAIKRIWKRTHKDLLDEVVPPAGKEDDVTVGKFYATFLIQDYFR 1519

  Fly  2869 --QPPQSMLGGLSLAEMGGTL---TPQALGARLGEPFGGGGGNKSGPRRQSYWQINPIRKR---G 2925
              :..:.|       |..|.|   ||||:..:.|              .::..:|.|..||   |
 Worm  1520 RFKKRKEM-------EAKGVLPAQTPQAMALQAG--------------LRTLHEIGPELKRAISG 1563

  Fly  2926 VLSKERSLDEQAIRRRNLEAKRTSCDSLPWGGDALDCRRGTIFESLESDGGGVGGGGSGGGGGGL 2990
            .|..:.:.||...:.|                     |..::|.:|.....|.|.
 Worm  1564 NLETDFNFDEPEPQHR---------------------RPHSLFNNLVHRLSGAGS---------- 1597

  Fly  2991 GGGVSYDLRSVRSADVGHSEMDGDVSLSVVSALVPSVTTPLPPPLSLPIVTPTSTPTPLQLPMPM 3055
                        .:...|..::..      |.|:|.......|..||  .....:|.|.|:....
 Worm  1598 ------------KSPTEHERIEKG------STLLPFQPRSFSPTHSL--AGAEGSPVPSQMHRGA 1642

  Fly  3056 PMPMAHPPPRRPFGWSQSVDQGCLRSNLLLSVPRSMPPRSRSGSTKQL-----FKQQALDEDADM 3115
            |:             :||:               ::||  .:||.::|     :.....||..|
 Worm  1643 PI-------------NQSI---------------NLPP--VNGSARRLPALPPYANHIHDETDD- 1676

  Fly  3116 DENSLLLPTAAGGGSGPGSVAVIASSSLDLPDQSG---SSKQILPDIALGVSKSDSSDILRIISE 3177
                           ||        ...|..|::|   ||:.::.:..|.|...:....:|....
 Worm  1677 ---------------GP--------RYRDTGDRAGYDQSSRMVVANRNLPVDPDEEEQWMRSGGP 1718

  Fly  3178 RRRMDQREQ--REP 3189
            ..|.|:|..  |||
 Worm  1719 SNRSDRRNPHLREP 1732

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ca-alpha1T	NP_001259267.1	Ion_trans	332..636	CDD:278921	97/311 (31%)
		Ion_trans	1261..1495	CDD:278921	80/242 (33%)
		Ion_trans	2192..2448	CDD:278921	99/271 (37%)
		Ion_trans	2510..2728	CDD:278921	82/236 (35%)
egl-19	NP_001023079.1	Ion_trans	105..379	CDD:278921	103/328 (31%)
		Ion_trans	493..714	CDD:278921	81/242 (33%)
		Ion_trans	815..1074	CDD:278921	97/266 (36%)
		Ion_trans	1134..1376	CDD:278921	88/260 (34%)
		GPHH	1384..1447	CDD:293510	15/87 (17%)
		Ca_chan_IQ	1449..1521	CDD:285917	14/72 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D172471at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920