DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1T and cacna1c

DIOPT Version :9

Sequence 1:NP_001259267.1 Gene:Ca-alpha1T / 31550 FlyBaseID:FBgn0264386 Length:3218 Species:Drosophila melanogaster
Sequence 2:XP_021330579.1 Gene:cacna1c / 170581 ZFINID:ZDB-GENE-020129-1 Length:2202 Species:Danio rerio


Alignment Length:3244 Identity:613/3244 - (18%)
Similarity:960/3244 - (29%) Gaps:1563/3244 - (48%)


- Green bases have known domain annotations that are detailed below.


  Fly   184 RHERRDRRDEQQAARRRTGRRHSGASSLSDAAAATAAGRSRSRGGGRTGGAVSSSTGSSCNGSCS 248
            :|||.:...|.:...:....|..|.:.:                  |.||:..||...:...|.:
Zfish    12 KHERLEEEVEVRFKGKLVSERELGYTHV------------------RPGGSNYSSPSLAPVPSLN 58

  Fly   249 SDDGDSSHTSSSSSSSSSGEPNLPYPGFP---------------------EISIRALTQ-----Y 287
            .|:    |.............::|.||.|                     .||..:.||     |
Zfish    59 EDE----HVGGGGGVLGLAPEHIPTPGAPLSWQAAIDAARQAKLMGTTGAPISTASSTQRKRQHY 119

  Fly   288 TRPRN-------------WCLMLITNP----------W--FERVSILVILLNCITLGMYQPC-VD 326
            |:|:.             .||.| .||          |  ||.:.::.|..||:.|.:|.|. .|
Zfish   120 TKPKKQASTASTRPPRALLCLTL-KNPIRRACINIVEWKPFEIIILMTIFANCVALAVYIPFPED 183

  Fly   327 DACVTNRCKILQIFDDIIFAFFALEMTIKMVAMG-ICGKNTYLADSWNRLDFFIVLAGLLEYVMH 390
            |:..||  ..|:..:.:....|.:|..:|::|.| :|..|.||.:.||.|||.||:.||...::.
Zfish   184 DSNATN--SNLERVEYLFLIIFTVEAFLKVIAYGLLCHPNAYLRNGWNLLDFIIVVVGLFSAILE 246

  Fly   391 --------------VENLNLTAIRTIRVLRPLRAINRIPSMRILVMLLLDTLPMLGNVLLLCFFV 441
                          ....::.|:|..|||||||.::.:||:::::..::..:..|.::.||..||
Zfish   247 QATKGDGGTSMGGKAAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFV 311

  Fly   442 FFIFGIIGVQLWEGILRQRCSLMRT--EGMVYPLTVPEVYRVRVRVNSLSQYYEFSKDQDYICST 504
            ..|:.|||::|:.|.:.:.|...:.  :|.:                        ::::...|:.
Zfish   312 IIIYAIIGLELFMGKMHRTCFFYKDGHKGHI------------------------AEEKPAPCAP 352

  Fly   505 PNDSGMHLCGNFPPYRIGSLVCNEEAKLFDFNEPTNTSCVNWNQYYTTCKQSGENPFQGTISFDN 569
            .:..|.|              |:          |.|         .|.|....|.|..|..:|||
Zfish   353 SSAHGRH--------------CS----------PPN---------ITQCMMGWEGPNDGITNFDN 384

  Fly   570 IGMAWVAIFLVISLEGWTDIMYYVQDAHSF-WDWIYFVLLIVIGSFFMINLCLVVIATQFSETKK 633
            ...|.:.:|..|::|||||::|::|||..: ..|:|||.|::.||||::||.|.|::.:||  |:
Zfish   385 FAFAMLTVFQCITMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFS--KE 447

  Fly   634 REMERMRQERARYTSTSTLASSTNNSEPATCYAEIVKYIAHLWRRFKRRMLKKYRLYKYQRQQRK 698
            ||..:.|.:                                         .:|.|    ::||.:
Zfish   448 REKAKARGD-----------------------------------------FQKLR----EKQQLE 467

  Fly   699 EGLLPNADNLTFSPSRIKCHHPKCPKYSNRKPSSIQDQMITVMVPLNSASNNINNNNNNNSNSSN 763
            |.|                                                              
Zfish   468 EDL-------------------------------------------------------------- 470

  Fly   764 HNGSGNHTAAGGGNNNNNNNNNNAASCTTVALVNGINGSAASVTMSSAHHQQHQLLQHQQQQHQN 828
                                                                             
Zfish   471 ----------------------------------------------------------------- 470

  Fly   829 QQQQQQQQQHSSSDNTEQSLAPDGLPRSSSLKKSTAHHQLKPEGSAAEQKTILLKFPQQMIDSEQ 893
                                                                             
Zfish   471 ----------------------------------------------------------------- 470

  Fly   894 LILQLGNLGKSHPCTSGFLSPPTSASRRPSVMFNEYVLLHTPPALNADPATAGTTTTVAPTVATV 958
                           .|:|                                              
Zfish   471 ---------------KGYL---------------------------------------------- 474

  Fly   959 AGTAAAAAAAAATGSGSGNNNHQNGGASGGAGTGGTTEKSNIFSTEKMTQAGDGSIWQVNLPQTI 1023
                                                         :.:|||.|            
Zfish   475 ---------------------------------------------DWITQAED------------ 482

  Fly  1024 GTIANPYADCSELGIHDAMTCQELLAFSVAFSAALPTGQSTLESFYTSLARCDPHTAEALRAHHK 1088
                                                               .||...:......|
Zfish   483 ---------------------------------------------------IDPENDDEGLDDDK 496

  Fly  1089 PRSVPTGQNQTTPGAEGATVMVASTAGDTGQTLQPSTVSAVVGGTIDSHAANHRRKEHHQQSHHH 1153
            ||      |.:.|.:|..:|                                             
Zfish   497 PR------NLSMPASENESV--------------------------------------------- 510

  Fly  1154 HNNNNTTSHSRNYRSRQGQGNSRMREPRAPTGNYMEDYACCYDLYQNALSPLDERPRQRSPTTRC 1218
             |.:|                       ||.|: ||...||              .|..:..::.
Zfish   511 -NTDN-----------------------APAGD-MEGETCC--------------TRMANRISKS 536

  Fly  1219 LISVY-RCMSRVCSWIRRYIRRLVEHKYFQQGILLAILINTLSMGIEYHNQPPELTAIVETSNVV 1282
            ..|.| |..:|:|   ||..|..|:...|...::..:.:|||::..|:|.||..||.:.:.:|.|
Zfish   537 KFSRYSRRWNRLC---RRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHHQQPEWLTNVQDIANKV 598

  Fly  1283 FSGIFAVEMLLKVVAEGPFRYIANGFNVFDGIIV---ILSAIEICQTFMGNGTGGGGSGLSVLRT 1344
            ...:|..|||||:.:.|...|..:.||.||..:|   ||..|.:....|      ...|:||||.
Zfish   599 LLALFTGEMLLKMYSLGLQAYFVSLFNRFDSFVVCGGILETILVETKIM------SPLGISVLRC 657

  Fly  1345 FRLLRILKLVRFMPNLRRQLFVMLRTMDNVAVFFSLLVLFIFIFSILGMYLFGGKFCKFLDESGL 1409
            .|||||.|:.|:..:|...:..:|.::.::|....||.|||.|||:|||.||||||  ..||:  
Zfish   658 VRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF--NFDET-- 718

  Fly  1410 ERECTCPEIISRHPQCECDRKHFNNILWATVTVFQILTQEDWNVVLFNGM------EKTSHWAAL 1468
                              .|..|:|...:.:|||||||.||||.|:::|:      ........:
Zfish   719 ------------------RRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCI 765

  Fly  1469 YFVALMTFGNYVLFNLLVAILVEGF-------SSERNERREREQRELVKKLREETLAENYSDGMY 1526
            ||:.|...|||:|.|:.:||.|:..       |:::.|..|:|:::|.:....|....:....:.
Zfish   766 YFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKRQNSEKPPLE 830

  Fly  1527 DESRSEADSSTTNDSYYEVRNRWRSAEDVRKLQDSVELIIEAKSNMHRQRLLQPTHDYQINELPA 1591
            ||.:.|.                                ||.||                     
Zfish   831 DEKKEEK--------------------------------IELKS--------------------- 842

  Fly  1592 SSAAPSASGTSGASAPGDRERDRDRDRDRERDRDRDRERDREAGGGGKEEGAQHAKPRGGLKKTY 1656
                                                                             
Zfish   843 ----------------------------------------------------------------- 842

  Fly  1657 SIKERRSEAPRLSKIRLARDPPIITTTAATPQDSPSTTLEPGMSFRQWGDMEPPSPPSPSLLRPP 1721
                                   ||:...||                                  
Zfish   843 -----------------------ITSDGETP---------------------------------- 850

  Fly  1722 NIFTGGQRSLDEGIPSIDLIPPSPVLSHKPLNILNASQLGVGMGGGVPSTAGSSSSMHSVIIDDI 1786
                                                                             
Zfish   851 ----------------------------------------------------------------- 850

  Fly  1787 SKSSSSTAAATPIYVPTISSTADAQSQSHSLNDVSVGSSPGGEIPATGMSRNANTGASTSGSSSS 1851
                    .||.|.:...:...:.:...:.:||.     |.||                      
Zfish   851 --------TATKINIDEYTGEDNEEKNPYPVNDF-----PAGE---------------------- 880

  Fly  1852 ERLPLAPPPQQGSFKQRLRRGSSKKRRASALALATDDNPARRTLDNQARRTQDEEEEQQQLNNGG 1916
                                                                |:|||.:.     
Zfish   881 ----------------------------------------------------DDEEEPEM----- 888

  Fly  1917 DNSCLLRNSNAVVSGSSSGTKETNRLSPQNSIRRLSNTLSIGSGPVGSRRASACIFNSQVYQNLN 1981
                                                        |||                  
Zfish   889 --------------------------------------------PVG------------------ 891

  Fly  1982 QPPKLRPGSGQRRMSSIELAFSKTSHLNLHNLEANRKSLSYTNSKMDLDKWNKSYGNLNEPDNML 2046
              |:.||                     |.:::...|::....:|                    
Zfish   892 --PRPRP---------------------LSDIQLKEKAVPMPQAK-------------------- 913

  Fly  2047 QQYMEARDKRKNSISHYNLKKRLEEKELQQLQQLHQQQLLQQRQDSFSSTTQQQQQQLQQHRLSK 2111
                                                                             
Zfish   914 ----------------------------------------------------------------- 913

  Fly  2112 DQQQLAMQPHSMVPGGGERYSKLKMLIEQLTPKHFTTEREDYSLYIFPEDNRFRQICTWFVNQKW 2176
                                                      :.:||...|:||.:|...||...
Zfish   914 ------------------------------------------AFFIFSPSNKFRVLCHKIVNHNI 936

  Fly  2177 FDNVVLLFIALNCITLAMERPNIPPSSTERLFLATANYVFTVVFTVEMFIKVVATGMFYGHDAYF 2241
            |.|::|.||.|:.|:||.|.| :...|.....|..|:||||.:||:|:.:|:.|.|.|....::.
Zfish   937 FTNLILFFILLSSISLAAEDP-VKNDSFRNQILGYADYVFTGIFTIEIILKMTAYGAFLHKGSFC 1000

  Fly  2242 TSGWNIMDGSLVTISIIDLLMSLISESSPRIFGILRVFRLLRSLRPLRVINRAPGLKLVVQTLLS 2306
            .:.:||:|  ||.:| :.|:.|.|..|:   ..::::.|:||.|||||.||||.|||.|||.:..
Zfish  1001 RNYFNILD--LVVVS-VSLISSGIQSSA---INVVKILRVLRVLRPLRAINRAKGLKHVVQCVFV 1059

  Fly  2307 SLRPIGNIVLICCTFFIIFGILGVQLFKGTFYYCEGENIKGVRNADECRRI-----PGNV----- 2361
            ::|.|||||::......:|..:|||||||.|:||...:   .:...|||..     .|||     
Zfish  1060 AIRTIGNIVIVTSLLQFMFACIGVQLFKGKFFYCTDTS---KQTQAECRGAYILYKDGNVGKPEK 1121

  Fly  2362 ----WTNRKYNFDDLGKALMSLFVLSSRDGWVNIMYTGLDAVGVDQQPIVNYNEWRLLYFIAFIL 2422
                |.|..:||||:.:.:|:||.:|:.:||..::|..:|:...|..||.||.....::||.:|:
Zfish  1122 AQRSWENSDFNFDDVLQGMMALFAVSTFEGWPGLLYRAIDSHAEDVGPIYNYRVVISIFFIIYII 1186

  Fly  2423 LVGFFVLNMFVGVVVENFHRCREEQ----EKEEKIRRAAKRALQMEKKRRRMHEPPYYTNYSPTR 2483
            ::.||::|:|||.|:..|....|::    |.::..|:..:.||:....||.:.:.||  .|.   
Zfish  1187 IIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNPY--QYK--- 1246

  Fly  2484 MFVHNVVTSKYFDLAIAAVIGLNVVTMAMEYYKMPSGLKYALKIFNYFFTAVFILEANMKLVALG 2548
              |..||.|.||:..:..:|.||.:.:||:::........|:.|.|..||.:|.:|..:||:|..
Zfish  1247 --VWYVVNSTYFEYLMFTLILLNTICLAMQHHGQSQSFNKAMNILNMLFTGLFTVEMILKLIAFK 1309

  Fly  2549 WKLYLKDRWNQLDVGIVLLSIVGIVLEELE------------------TNTHQIIPINPTIIRVM 2595
            .:.|..|.||..|..||:.||:.::|.|:.                  .||.....|:.|..|:.
Zfish  1310 PRGYFSDPWNVFDFLIVIGSIIDVILSEINPADPSSSPPSSVVRPMGLQNTEDNARISITFFRLF 1374

  Fly  2596 RVLRIARVLKLLKMANGIRALLDTVM---QALPQVGNLGLLFFLLFFIFAALGVELFGRLECSDE 2657
            ||:|:   :|||....|||.||.|.:   ||||.|   .||..:||||:|.:|:::||::...|.
Zfish  1375 RVMRL---VKLLSRGEGIRTLLWTFIKSFQALPYV---ALLIVMLFFIYAVIGMQMFGKIALRDN 1433

  Fly  2658 IPCQGLGEHAHFANFGMAFLTLFRVATGDNWNGIMKDTLRDNCDDAADCVRNCCVS-------SV 2715
               ..:..:.:|..|..|.|.|||.|||:.|..||.     .|.....|.:...::       |.
Zfish  1434 ---SQINRNNNFQTFPQAVLLLFRCATGEAWQEIML-----ACSPNRPCEKGSEINHSSEDCGSH 1490

  Fly  2716 IAPIFFVIFVLMAQFVLVNVVVAVLM---------------KHLEESHKQMEDELDME------- 2758
            .|..:||.|.::..|:::|:.|||:|               .||:| .|::..|.|.|       
Zfish  1491 FAIFYFVSFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDE-FKRIWAEYDPEAKGRIKH 1554

  Fly  2759 ---VELERELVREQEFAQEQKLCQQLAEAQSKAAAPPRPL-------------AKVKSLPKNFIY 2807
               |.|.|.:.....|.   |||.... |..:..:...||             |.|::..:  |.
Zfish  1555 LDVVTLLRRIQPPLGFG---KLCPHRV-ACKRLVSMNMPLNSDGTVMFNATLFALVRTALR--IK 1613

  Fly  2808 STPSLDKKFPAVSGVNNPSLTSSAATNLNQVATAGSGGAAPGAVPAGSGAGPRRQTV-------- 2864
            :..:|::....:..:.......::...|:||            ||.   ||....||        
Zfish  1614 TEGNLEQANEELRAIVKKIWKRTSMKLLDQV------------VPP---AGDDEVTVGKFYATFL 1663

  Fly  2865 --QYFQQ-------------PPQSMLGGLSLAEMGGTLTPQALGARLGEPFGGGGGNKSGPRRQS 2914
              :||::             ||::     :|:...|..|...:|..:                  
Zfish  1664 IQEYFRKFKKRKEQGLVAKIPPKT-----ALSLQAGLRTLHDMGPEI------------------ 1705

  Fly  2915 YWQINPIRKRGVLSKERSLDEQAIRRRNLEAKRTSCDSLPWGGDALDCRRGTIFESLESDGGGVG 2979
                     |..:|.:.:::|:..|    ..|.|.|.:          ....||....|      
Zfish  1706 ---------RRAISGDLTVEEELER----AMKETVCAA----------SEDDIFRVKRS------ 1741

  Fly  2980 GGGSGGGGGGLGGGVSYDLRSVRSADVGHSEMDGDVSLSVVSALVPSVTTPLP------------ 3032
                   ||..|..|:|           :.:.||.||..      .|.||..|            
Zfish  1742 -------GGLFGNHVNY-----------YHQSDGHVSFP------QSFTTQRPLHISKSGSPGEA 1782

  Fly  3033 -PPLSLPIVTPTSTP-----------------TPLQLPMPMPM----------PMAHPPPRRPFG 3069
             .|....:|..|.||                 |.:....|.|.          |:...|..|| .
Zfish  1783 ESPSHQKLVDSTFTPSSYSSSGSNANINNANNTAIGHRYPKPTVSTVDGQTGPPLTTIPLPRP-T 1846

  Fly  3070 WSQSVDQGC-----LRSNLLLSVPRSMP-PRSRSGSTKQLFKQQALDEDADMDENSLLLPTAAGG 3128
            |.....:.|     :||:   |....:| .|....||.:.:.:..|||   .|:           
Zfish  1847 WCFPNKRSCFYDTFMRSD---SSDSRLPIIRREEASTDETYDETFLDE---RDQ----------- 1894

  Fly  3129 GSGPGSVAVIASSSLDLPDQSGSSKQILPDIALGVSKSDSSDILRIISERRRMDQREQR 3187
                   |:::...|:..|:  .|||:.|.:...|            .|.||..|..:|
Zfish  1895 -------AMLSMDMLEFQDE--ESKQLAPMVEAEV------------GEERRPWQSPRR 1932

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1TNP_001259267.1 Ion_trans 332..636 CDD:278921 87/321 (27%)
Ion_trans 1261..1495 CDD:278921 86/249 (35%)
Ion_trans 2192..2448 CDD:278921 100/273 (37%)
Ion_trans 2510..2728 CDD:278921 76/245 (31%)
cacna1cXP_021330579.1 Ion_trans 156..452 CDD:306908 100/356 (28%)
Ion_trans 559..798 CDD:306908 90/266 (34%)
Ion_trans 934..1211 CDD:306908 107/286 (37%)
Ion_trans 1253..1527 CDD:306908 88/287 (31%)
GPHH 1528..1598 CDD:318993 17/74 (23%)
Ca_chan_IQ 1600..1671 CDD:312334 15/87 (17%)
CAC1F_C 1694..2129 CDD:318975 64/349 (18%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.920

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