Protein Alignment Ca-alpha1T and Cacna1c

DIOPT Version :10

• Sequence 1: NP_001259267.1
• Gene: Ca-alpha1T / 31550
• FlyBaseID: FBgn0264386
• Length: 3218
• Species: Drosophila melanogaster
• Sequence 2: XP_036021662.1
• Gene: Cacna1c / 12288
• MGIID: 103013
• Length: 2245
• Species: Mus musculus
• Alignment Length: 3350
• Identity: 647/3350 - (19%)
• Similarity: 1005/3350 - (30%)
• Gaps: 1557/3350 - (46%)

  Fly   209 SSLSDAAAATAAGRSRSRG--GGRTGGAVSSSTGSSCNGSCSSDDGDSSHTSSSSSSSSSGEPNL 271
            ::||..||..||.:::..|  |..|...|||:.............|.::.|.
Mouse    78 AALSWQAAIDAARQAKLMGSAGNATISTVSSTQRKRQQYGKPKKQGGTTATR------------- 129

  Fly   272 PYPGFPEISIRALTQYTRPRNWCLMLITNPWFERVSILVILLNCITLGMYQPC-VDDACVTNRCK 335
                 |..::..||.....|..|:.::....||.:.:|.|..||:.|.:|.|. .||:..||  .
Mouse   130 -----PPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATN--S 187

  Fly   336 ILQIFDDIIFAFFALEMTIKMVAMGIC-GKNTYLADSWNRLDFFIVLAGL----LEYVMHVENLN 395
            .|:..:.:....|.:|..:|::|.|:. ..|.||.:.||.|||.||:.||    ||.....:..|
Mouse   188 NLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGAN 252

  Fly   396 ----------LTAIRTIRVLRPLRAINRIPSMRILVMLLLDTLPMLGNVLLLCFFVFFIFGIIGV 450
                      :.|:|..|||||||.::.:||:::::..::..:..|.::.||..||..|:.|||:
Mouse   253 ALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 317

  Fly   451 QLWEGILRQRCSLMRTEGMVYPLTVPEVYRVRVRVNSLSQYYEFSKDQDYICSTPNDSGMHLCGN 515
            :|:.|.:.:.|  ...||::   .||                  :::....|:.....|
Mouse   318 ELFMGKMHKTC--YNQEGII---DVP------------------AEEDPSPCALETGHG------ 353

  Fly   516 FPPYRIGSLVCNEEAKLFDFNEPTNTSCVNWNQYYTTCKQSGENPFQGTISFDNIGMAWVAIFLV 580
                                     ..|.|.    |.||...:.|..|..:|||...|.:.:|..
Mouse   354 -------------------------RQCQNG----TVCKPGWDGPKHGITNFDNFAFAMLTVFQC 389

  Fly   581 ISLEGWTDIMYYVQDAHSF-WDWIYFVLLIVIGSFFMINLCLVVIATQFSETKKREMERMRQERA 644
            |::|||||::|::|||..: ..|:|||.|::.||||::||.|.|::.:||  |:||..:.|.:
Mouse   390 ITMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFS--KEREKAKARGD-- 450

  Fly   645 RYTSTSTLASSTNNSEPATCYAEIVKYIAHLWRRFKRRMLKKYRLYKYQRQQRKEGLLPNADNLT 709
                                                   .:|.|    ::||.:|.|....|.:|
Mouse   451 ---------------------------------------FQKLR----EKQQLEEDLKGYLDWIT 472

  Fly   710 FSPSRIKCHHPKCPKYSNRKPSSIQDQMITVMVPLNSASNNINNNNNNNSNSSNHNGSGNHTAAG 774
                                                                             
Mouse   473 ----------------------------------------------------------------- 472

  Fly   775 GGNNNNNNNNNNAASCTTVALVNGINGSAASVTMSSAHHQQHQLLQHQQQQHQNQQQQQQQQQHS 839
                                                                        |.:..
Mouse   473 ------------------------------------------------------------QAEDI 477

  Fly   840 SSDNTEQSLAPDGLPRSSSLKKSTAHHQLKPEGSAAEQKTILLKFPQQMIDSEQLILQLGNLGKS 904
            ..:|.::.:..|                 ||
Mouse   478 DPENEDEGMDED-----------------KP---------------------------------- 491

  Fly   905 HPCTSGFLSPPTSASRRPSVMFNEYVLLHTPPALNADPATAGTTTTVAPTVATVAGTAAAAAAAA 969
                                                                             
Mouse   492 ----------------------------------------------------------------- 491

  Fly   970 ATGSGSGNNNHQNGGASGGAGTGGTTEKSNIFSTEKMTQAGDGSIWQVNLPQTIGTIANPYADCS 1034
                       :|.||..
Mouse   492 -----------RNRGAPA----------------------------------------------- 498

  Fly  1035 ELGIHDAMTCQELLAFSVAFSAALPTGQSTLESFYTSLARCDPHTAEALRAHHKPRSVPTGQNQT 1099
              |:||    |:...|: .||                      |:.|.    |.  |:||.:.::
Mouse   499 --GLHD----QKKGKFA-WFS----------------------HSTET----HV--SMPTSETES 528

  Fly  1100 TPGAEGATVMVASTAGDTGQTLQPSTVSAVVGGTIDSHAANHRRKEHHQQSHHHHNNNNTTSHSR 1164
            .                        ....|.||.|:                           ..
Mouse   529 V------------------------NTENVAGGDIE---------------------------GE 542

  Fly  1165 NYRSRQGQGNSRMREPRAPTGNYMEDYACCYDLYQNALSPLDERPRQRSPTTRCLISVYRCMSRV 1229
            |..:|.....|:.:..|                                        .:|..:|.
Mouse   543 NCGARLAHRISKSKFSR----------------------------------------YWRRWNRF 567

  Fly  1230 CSWIRRYIRRLVEHKYFQQGILLAILINTLSMGIEYHNQPPELTAIVETSNVVFSGIFAVEMLLK 1294
            |   ||..|..|:...|...::..:.:|||::..|::|||..||.:.:|:|.....:|..|||||
Mouse   568 C---RRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPHWLTEVQDTANKALLALFTAEMLLK 629

  Fly  1295 VVAEGPFRYIANGFNVFDGIIV---ILSAIEICQTFMGNGTGGGGSGLSVLRTFRLLRILKLVRF 1356
            :.:.|...|..:.||.||..||   ||..|.:....|      ...|:||||..|||||.|:.|:
Mouse   630 MYSLGLQAYFVSLFNRFDCFIVCGGILETILVETKIM------SPLGISVLRCVRLLRIFKITRY 688

  Fly  1357 MPNLRRQLFVMLRTMDNVAVFFSLLVLFIFIFSILGMYLFGGKFCKFLDESGLERECTCPEIISR 1421
            ..:|...:..:|.::.::|....||.|||.|||:|||.||||||                    .
Mouse   689 WNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF--------------------N 733

  Fly  1422 HPQCECDRKHFNNILWATVTVFQILTQEDWNVVLFNGM------EKTSHWAALYFVALMTFGNYV 1480
            ..:.:..|..|:|...:.:|||||||.||||.|:::|:      ........:||:.|...|||:
Mouse   734 FDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYI 798

  Fly  1481 LFNLLVAILVEGF-------SSERNERREREQRELVKKLREETLAENYSDGMYDESRSEADSSTT 1538
            |.|:.:||.|:..       |:::.|..|:|:::|.:
Mouse   799 LLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLAR---------------------------- 835

  Fly  1539 NDSYYEVRNRWRSAEDVRKLQDSVELIIEAKSNMHRQRLLQPTHDYQINELPASSAAPSASGTSG 1603
                                                               ||.:|:|
Mouse   836 ---------------------------------------------------PARTASP------- 842

  Fly  1604 ASAPGDRERDRDRDRDRERDRDRDRERDREAGGGGKEEGAQHAKPRGGLKKTYSIKERRSEAPRL 1668
                                     |:.:|.          ..||        :::|.:.|...|
Mouse   843 -------------------------EKKQEV----------MEKP--------AVEESKEEKIEL 864

  Fly  1669 SKIRLARDPPIITTTAATPQDSPSTTLEPGMSFRQWGDMEPPSPPSPSLLRPPNIFTGGQRSLDE 1733
            ..|             ....:||.||
Mouse   865 KSI-------------TADGESPPTT--------------------------------------- 877

  Fly  1734 GIPSIDLIPPSPVLSHKPLNILNASQLGVGMGGGVPSTAGSSSSMHSVIIDDISKSSSSTAAATP 1798
                                                          .:.:||:..|.:
Mouse   878 ----------------------------------------------KINMDDLQPSEN------- 889

  Fly  1799 IYVPTISSTADAQSQSHSLNDVSVGSSPGGEIPATGMSRNANTGASTSGSSSSERLPLAPPPQQG 1863
                               .|.|..|:|                 .|:|
Mouse   890 -------------------EDKSPHSNP-----------------DTAG---------------- 902

  Fly  1864 SFKQRLRRGSSKKRRASALALATDDNPARRTLDNQARRTQDEEEEQQQLNNGGDNSCLLRNSNAV 1928
                                                    :|:||:.::
Mouse   903 ----------------------------------------EEDEEEPEM---------------- 911

  Fly  1929 VSGSSSGTKETNRLSPQNSIRRLSNTLSIGSGPVGSRRASACIFNSQVYQNLNQPPKLRPGSGQR 1993
                                            |||                    |:.||
Mouse   912 --------------------------------PVG--------------------PRPRP----- 919

  Fly  1994 RMSSIELAFSKTSHLNLHNLEANRKSLSYTNSKMDLDKWNKSYGNLNEPDNMLQQYMEARDKRKN 2058
                                                                             
Mouse   920 ----------------------------------------------------------------- 919

  Fly  2059 SISHYNLKKRLEEKELQQLQQLHQQQLLQQRQDSFSSTTQQQQQQLQQHRLSKDQQQLAMQPHSM 2123
                              |.:||
Mouse   920 ------------------LSELH------------------------------------------ 924

  Fly  2124 VPGGGERYSKLKMLIEQLTPKHFTTEREDYSLYIFPEDNRFRQICTWFVNQKWFDNVVLLFIALN 2188
                         |.|:..|.     .|..:.:||..:||||..|...||...|.|::|.||.|:
Mouse   925 -------------LKEKAVPM-----PEASAFFIFSPNNRFRLQCHRIVNDTIFTNLILFFILLS 971

  Fly  2189 CITLAMERPNIPPSSTERL-------------------FLATANYVFTVVFTVEMFIKVVATGMF 2234
            .|:||.|.|....|....:                   .|..|:||||.:||:|:.:|:.|.|.|
Mouse   972 SISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKILGNADYVFTSIFTLEIILKMTAYGAF 1036

  Fly  2235 YGHDAYFTSGWNIMDGSLVTISIIDLLMSLISESSPRIFGILRVFRLLRSLRPLRVINRAPGLKL 2299
            ....::..:.:||:|..:|::|:|    |...:||  ...::::.|:||.|||||.||||.|||.
Mouse  1037 LHKGSFCRNYFNILDLLVVSVSLI----SFGIQSS--AINVVKILRVLRVLRPLRAINRAKGLKH 1095

  Fly  2300 VVQTLLSSLRPIGNIVLICCTFFIIFGILGVQLFKGTFYYCEGENIKGVRNADECRRIPGNV--- 2361
            |||.:..::|.|||||::......:|..:|||||||..|.|...:   .:...||:   ||.
Mouse  1096 VVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSS---KQTEAECK---GNYITY 1154

  Fly  2362 --------------WTNRKYNFDDLGKALMSLFVLSSRDGWVNIMYTGLDAVGVDQQPIVNYNEW 2412
                          |.|.|::||::..|:|:||.:|:.:||..::|..:|:...|:.||.||...
Mouse  1155 KDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVE 1219

  Fly  2413 RLLYFIAFILLVGFFVLNMFVGVVVENFHRCREEQEKEEKIRRAAKRALQMEKKRRRMHEPPYYT 2477
            ..::||.:|:::.||::|:|||.|:..|   :|:.|:|.|       ..:::|.:|:..|  |..
Mouse  1220 ISIFFIIYIIIIAFFMMNIFVGFVIVTF---QEQGEQEYK-------NCELDKNQRQCVE--YAL 1272

  Fly  2478 NYSPTRMFV----HN-----VVTSKYFDLAIAAVIGLNVVTMAMEYYKMPSGLKYALKIFNYFFT 2533
            ...|.|.::    |.     ||.|.||:..:..:|.||.:.:||::|......|.|:.|.|..||
Mouse  1273 KARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFT 1337

  Fly  2534 AVFILEANMKLVALGWKLYLKDRWNQLDVGIVLLSIVGIVLEELETNTH---------------Q 2583
            .:|.:|..:||:|...|.|..|.||..|..||:.||:.::|.  |||.:               .
Mouse  1338 GLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILS--ETNHYFCDAWNTFDALIVVGS 1400

  Fly  2584 IIPI-------------NPTI---------IRVMRVLRIARVLKLLKMANGIRALLDTVM---QA 2623
            |:.|             :|::         |...|:.|:.|::|||....|||.||.|.:   ||
Mouse  1401 IVDIAITEVHPAEHTQCSPSMSAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQA 1465

  Fly  2624 LPQVGNLGLLFFLLFFIFAALGVELFGRLECSDEIPCQGLGEHAHFANFGMAFLTLFRVATGDNW 2688
            ||.|   .||..:||||:|.:|:::||::..:|...   :..:.:|..|..|.|.|||.|||:.|
Mouse  1466 LPYV---ALLIVMLFFIYAVIGMQVFGKIALNDTTE---INRNNNFQTFPQAVLLLFRCATGEAW 1524

  Fly  2689 NGIMKDTLRDNCDDAADCV-----------RNCCVSSVIAPIFFVIFVLMAQFVLVNVVVAVLM- 2741
            ..||.     .|.....|.           ...|.|| .|..:|:.|.::..|:::|:.|||:|
Mouse  1525 QDIML-----ACMPGKKCAPESEPSNSTEGETPCGSS-FAVFYFISFYMLCAFLIINLFVAVIMD 1583

  Fly  2742 --------------KHLEESHKQMEDELDME----------VELERELVREQEFAQEQKLCQQLA 2782
                          .||:| .|::..|.|.|          |.|.|.:.....|.   |||....
Mouse  1584 NFDYLTRDWSILGPHHLDE-FKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFG---KLCPHRV 1644

  Fly  2783 EAQSKAAAPPRPL------------------------------------AKVKSLPKNFIYSTPS 2811
             |..:..:...||                                    |.:|.:.|.  .|...
Mouse  1645 -ACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGNLEQANEELRAIIKKIWKR--TSMKL 1706

  Fly  2812 LDKKFPAVSG-----------------------------VNNPSLTSSAATNLN---------QV 2838
            ||:..|....                             |..||..::.:....         ::
Mouse  1707 LDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGKPSQRNALSLQAGLRTLHDIGPEI 1771

  Fly  2839 ATAGSGG---------AAPGAVPAGS-------GAGPRRQTVQYFQQP-----PQSML------- 2875
            ..|.||.         |...||.|.|       ..|.....|.|:|..     ||:..
Mouse  1772 RRAISGDLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVTYYQSDSRGNFPQTFATQRPLHI 1836

  Fly  2876 --GGLSLAE---------MGGTLTPQ-----------------ALGARLGEPFG--------GGG 2904
              .|.:.|:         :..|.||.                 ||| |...|.|        .|.
Mouse  1837 NKTGNNQADTESPSHEKLVDSTFTPSSYSSTGSNANINNANNTALG-RFPHPAGYSSTVSTVEGH 1900

  Fly  2905 GNKSGPR---RQSYWQINPIR------KRGVLSKERSLDEQAIRRRNLEAK------RTSCDSLP 2954
            |....|.   :::.|:::..|      :...:::|...||....|.:.||:      ..|.|...
Mouse  1901 GPPLSPAVRVQEAAWKLSSKRCHSRESQGATVNQEIFPDETRSVRMSEEAEYCSEPSLLSTDMFS 1965

  Fly  2955 WGGD---ALDCRRGTIFESLESDGGGVGGGGSGGGGGGLGGGVSYDLRSV-RSADVGHSEMDGDV 3015
            :..|   .|.|......|...|.........|      ||...|:.|..: |..|.|     ||:
Mouse  1966 YQEDEHRQLTCPEEDKREIQPSPKRSFLRSAS------LGRRASFHLECLKRQKDQG-----GDI 2019

  Fly  3016 SLS-------------VVSALVPSV-----TTPLPPPLSLPIVTPTSTPTPLQLPMP-------- 3054
            |..             .|:.|.|.:     .|..|.|...|.|||.|...||: |:|
Mouse  2020 SQKTALPLHLVHHQALAVAGLSPLLQRSHSPTTFPRPCPTPPVTPGSRGRPLR-PIPTLRLEGAE 2083

  Fly  3055 ------MPMPMAHPPPRRPFGWSQSVDQGCLRSNLLL--SVPRSMPPRSRSGSTKQLFKQQALDE 3111
                  ...|..|..     .||:.. ..|..|:.:.  :.|.|:...|::|:..:.|...|
Mouse  2084 SSEKLNSSFPSIHCS-----SWSEET-TACSGSSSMARRARPVSLTVPSQAGAPGRQFHGSA--- 2139

  Fly  3112 DADMDENSLLLPTAAGGGSG-----PGSVAVIASSSLDLPDQSGSSKQILPDIAL--GVSKSDSS 3169
                  :||:.......|.|     |..:.|......|..|.:....:...|..|  |..:|.:.
Mouse  2140 ------SSLVEAVLISEGLGQFAQDPKFIEVTTQELADACDMTIEEMENAADNILSGGAQQSPNG 2198

  Fly  3170 DILRIISERRRMDQREQREPEQDQDNEAEDRDSDY 3204
            .:|..::         .|:|.||:....||....|
Mouse  2199 TLLPFVN---------CRDPGQDRAVAPEDESCAY 2224

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ca-alpha1T	NP_001259267.1	Ion_trans	300..636	CDD:459842	102/352 (29%)
		Ion_trans	1243..1495	CDD:459842	89/267 (33%)
		Ion_trans	2175..2448	CDD:459842	103/308 (33%)
		Ion_trans	2492..2728	CDD:459842	87/286 (30%)
Cacna1c	XP_036021662.1	Ion_trans	153..446	CDD:459842	103/354 (29%)
		Ion_trans	578..819	CDD:459842	89/266 (33%)
		Ion_trans	957..1254	CDD:459842	104/311 (33%)
		Ion_trans	1296..1593	CDD:459842	93/310 (30%)
		GPHH	1602..1655	CDD:465306	13/57 (23%)
		Ca_chan_IQ	1665..1739	CDD:462591	7/75 (9%)
		CAC1F_C	1759..2194	CDD:465298	92/462 (20%)