DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1T and Cacna1c

DIOPT Version :9

Sequence 1:NP_001259267.1 Gene:Ca-alpha1T / 31550 FlyBaseID:FBgn0264386 Length:3218 Species:Drosophila melanogaster
Sequence 2:XP_036021662.1 Gene:Cacna1c / 12288 MGIID:103013 Length:2245 Species:Mus musculus


Alignment Length:3350 Identity:647/3350 - (19%)
Similarity:1005/3350 - (30%) Gaps:1557/3350 - (46%)


- Green bases have known domain annotations that are detailed below.


  Fly   209 SSLSDAAAATAAGRSRSRG--GGRTGGAVSSSTGSSCNGSCSSDDGDSSHTSSSSSSSSSGEPNL 271
            ::||..||..||.:::..|  |..|...|||:.............|.::.|.             
Mouse    78 AALSWQAAIDAARQAKLMGSAGNATISTVSSTQRKRQQYGKPKKQGGTTATR------------- 129

  Fly   272 PYPGFPEISIRALTQYTRPRNWCLMLITNPWFERVSILVILLNCITLGMYQPC-VDDACVTNRCK 335
                 |..::..||.....|..|:.::....||.:.:|.|..||:.|.:|.|. .||:..||  .
Mouse   130 -----PPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATN--S 187

  Fly   336 ILQIFDDIIFAFFALEMTIKMVAMGIC-GKNTYLADSWNRLDFFIVLAGL----LEYVMHVENLN 395
            .|:..:.:....|.:|..:|::|.|:. ..|.||.:.||.|||.||:.||    ||.....:..|
Mouse   188 NLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGAN 252

  Fly   396 ----------LTAIRTIRVLRPLRAINRIPSMRILVMLLLDTLPMLGNVLLLCFFVFFIFGIIGV 450
                      :.|:|..|||||||.::.:||:::::..::..:..|.::.||..||..|:.|||:
Mouse   253 ALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 317

  Fly   451 QLWEGILRQRCSLMRTEGMVYPLTVPEVYRVRVRVNSLSQYYEFSKDQDYICSTPNDSGMHLCGN 515
            :|:.|.:.:.|  ...||::   .||                  :::....|:.....|      
Mouse   318 ELFMGKMHKTC--YNQEGII---DVP------------------AEEDPSPCALETGHG------ 353

  Fly   516 FPPYRIGSLVCNEEAKLFDFNEPTNTSCVNWNQYYTTCKQSGENPFQGTISFDNIGMAWVAIFLV 580
                                     ..|.|.    |.||...:.|..|..:|||...|.:.:|..
Mouse   354 -------------------------RQCQNG----TVCKPGWDGPKHGITNFDNFAFAMLTVFQC 389

  Fly   581 ISLEGWTDIMYYVQDAHSF-WDWIYFVLLIVIGSFFMINLCLVVIATQFSETKKREMERMRQERA 644
            |::|||||::|::|||..: ..|:|||.|::.||||::||.|.|::.:||  |:||..:.|.:  
Mouse   390 ITMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFS--KEREKAKARGD-- 450

  Fly   645 RYTSTSTLASSTNNSEPATCYAEIVKYIAHLWRRFKRRMLKKYRLYKYQRQQRKEGLLPNADNLT 709
                                                   .:|.|    ::||.:|.|....|.:|
Mouse   451 ---------------------------------------FQKLR----EKQQLEEDLKGYLDWIT 472

  Fly   710 FSPSRIKCHHPKCPKYSNRKPSSIQDQMITVMVPLNSASNNINNNNNNNSNSSNHNGSGNHTAAG 774
                                                                             
Mouse   473 ----------------------------------------------------------------- 472

  Fly   775 GGNNNNNNNNNNAASCTTVALVNGINGSAASVTMSSAHHQQHQLLQHQQQQHQNQQQQQQQQQHS 839
                                                                        |.:..
Mouse   473 ------------------------------------------------------------QAEDI 477

  Fly   840 SSDNTEQSLAPDGLPRSSSLKKSTAHHQLKPEGSAAEQKTILLKFPQQMIDSEQLILQLGNLGKS 904
            ..:|.::.:..|                 ||                                  
Mouse   478 DPENEDEGMDED-----------------KP---------------------------------- 491

  Fly   905 HPCTSGFLSPPTSASRRPSVMFNEYVLLHTPPALNADPATAGTTTTVAPTVATVAGTAAAAAAAA 969
                                                                             
Mouse   492 ----------------------------------------------------------------- 491

  Fly   970 ATGSGSGNNNHQNGGASGGAGTGGTTEKSNIFSTEKMTQAGDGSIWQVNLPQTIGTIANPYADCS 1034
                       :|.||..                                               
Mouse   492 -----------RNRGAPA----------------------------------------------- 498

  Fly  1035 ELGIHDAMTCQELLAFSVAFSAALPTGQSTLESFYTSLARCDPHTAEALRAHHKPRSVPTGQNQT 1099
              |:||    |:...|: .||                      |:.|.    |.  |:||.:.::
Mouse   499 --GLHD----QKKGKFA-WFS----------------------HSTET----HV--SMPTSETES 528

  Fly  1100 TPGAEGATVMVASTAGDTGQTLQPSTVSAVVGGTIDSHAANHRRKEHHQQSHHHHNNNNTTSHSR 1164
            .                        ....|.||.|:                           ..
Mouse   529 V------------------------NTENVAGGDIE---------------------------GE 542

  Fly  1165 NYRSRQGQGNSRMREPRAPTGNYMEDYACCYDLYQNALSPLDERPRQRSPTTRCLISVYRCMSRV 1229
            |..:|.....|:.:..|                                        .:|..:|.
Mouse   543 NCGARLAHRISKSKFSR----------------------------------------YWRRWNRF 567

  Fly  1230 CSWIRRYIRRLVEHKYFQQGILLAILINTLSMGIEYHNQPPELTAIVETSNVVFSGIFAVEMLLK 1294
            |   ||..|..|:...|...::..:.:|||::..|::|||..||.:.:|:|.....:|..|||||
Mouse   568 C---RRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPHWLTEVQDTANKALLALFTAEMLLK 629

  Fly  1295 VVAEGPFRYIANGFNVFDGIIV---ILSAIEICQTFMGNGTGGGGSGLSVLRTFRLLRILKLVRF 1356
            :.:.|...|..:.||.||..||   ||..|.:....|      ...|:||||..|||||.|:.|:
Mouse   630 MYSLGLQAYFVSLFNRFDCFIVCGGILETILVETKIM------SPLGISVLRCVRLLRIFKITRY 688

  Fly  1357 MPNLRRQLFVMLRTMDNVAVFFSLLVLFIFIFSILGMYLFGGKFCKFLDESGLERECTCPEIISR 1421
            ..:|...:..:|.::.::|....||.|||.|||:|||.||||||                    .
Mouse   689 WNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF--------------------N 733

  Fly  1422 HPQCECDRKHFNNILWATVTVFQILTQEDWNVVLFNGM------EKTSHWAALYFVALMTFGNYV 1480
            ..:.:..|..|:|...:.:|||||||.||||.|:::|:      ........:||:.|...|||:
Mouse   734 FDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYI 798

  Fly  1481 LFNLLVAILVEGF-------SSERNERREREQRELVKKLREETLAENYSDGMYDESRSEADSSTT 1538
            |.|:.:||.|:..       |:::.|..|:|:::|.:                            
Mouse   799 LLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLAR---------------------------- 835

  Fly  1539 NDSYYEVRNRWRSAEDVRKLQDSVELIIEAKSNMHRQRLLQPTHDYQINELPASSAAPSASGTSG 1603
                                                               ||.:|:|       
Mouse   836 ---------------------------------------------------PARTASP------- 842

  Fly  1604 ASAPGDRERDRDRDRDRERDRDRDRERDREAGGGGKEEGAQHAKPRGGLKKTYSIKERRSEAPRL 1668
                                     |:.:|.          ..||        :::|.:.|...|
Mouse   843 -------------------------EKKQEV----------MEKP--------AVEESKEEKIEL 864

  Fly  1669 SKIRLARDPPIITTTAATPQDSPSTTLEPGMSFRQWGDMEPPSPPSPSLLRPPNIFTGGQRSLDE 1733
            ..|             ....:||.||                                       
Mouse   865 KSI-------------TADGESPPTT--------------------------------------- 877

  Fly  1734 GIPSIDLIPPSPVLSHKPLNILNASQLGVGMGGGVPSTAGSSSSMHSVIIDDISKSSSSTAAATP 1798
                                                          .:.:||:..|.:       
Mouse   878 ----------------------------------------------KINMDDLQPSEN------- 889

  Fly  1799 IYVPTISSTADAQSQSHSLNDVSVGSSPGGEIPATGMSRNANTGASTSGSSSSERLPLAPPPQQG 1863
                               .|.|..|:|                 .|:|                
Mouse   890 -------------------EDKSPHSNP-----------------DTAG---------------- 902

  Fly  1864 SFKQRLRRGSSKKRRASALALATDDNPARRTLDNQARRTQDEEEEQQQLNNGGDNSCLLRNSNAV 1928
                                                    :|:||:.::                
Mouse   903 ----------------------------------------EEDEEEPEM---------------- 911

  Fly  1929 VSGSSSGTKETNRLSPQNSIRRLSNTLSIGSGPVGSRRASACIFNSQVYQNLNQPPKLRPGSGQR 1993
                                            |||                    |:.||     
Mouse   912 --------------------------------PVG--------------------PRPRP----- 919

  Fly  1994 RMSSIELAFSKTSHLNLHNLEANRKSLSYTNSKMDLDKWNKSYGNLNEPDNMLQQYMEARDKRKN 2058
                                                                             
Mouse   920 ----------------------------------------------------------------- 919

  Fly  2059 SISHYNLKKRLEEKELQQLQQLHQQQLLQQRQDSFSSTTQQQQQQLQQHRLSKDQQQLAMQPHSM 2123
                              |.:||                                          
Mouse   920 ------------------LSELH------------------------------------------ 924

  Fly  2124 VPGGGERYSKLKMLIEQLTPKHFTTEREDYSLYIFPEDNRFRQICTWFVNQKWFDNVVLLFIALN 2188
                         |.|:..|.     .|..:.:||..:||||..|...||...|.|::|.||.|:
Mouse   925 -------------LKEKAVPM-----PEASAFFIFSPNNRFRLQCHRIVNDTIFTNLILFFILLS 971

  Fly  2189 CITLAMERPNIPPSSTERL-------------------FLATANYVFTVVFTVEMFIKVVATGMF 2234
            .|:||.|.|....|....:                   .|..|:||||.:||:|:.:|:.|.|.|
Mouse   972 SISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKILGNADYVFTSIFTLEIILKMTAYGAF 1036

  Fly  2235 YGHDAYFTSGWNIMDGSLVTISIIDLLMSLISESSPRIFGILRVFRLLRSLRPLRVINRAPGLKL 2299
            ....::..:.:||:|..:|::|:|    |...:||  ...::::.|:||.|||||.||||.|||.
Mouse  1037 LHKGSFCRNYFNILDLLVVSVSLI----SFGIQSS--AINVVKILRVLRVLRPLRAINRAKGLKH 1095

  Fly  2300 VVQTLLSSLRPIGNIVLICCTFFIIFGILGVQLFKGTFYYCEGENIKGVRNADECRRIPGNV--- 2361
            |||.:..::|.|||||::......:|..:|||||||..|.|...:   .:...||:   ||.   
Mouse  1096 VVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSS---KQTEAECK---GNYITY 1154

  Fly  2362 --------------WTNRKYNFDDLGKALMSLFVLSSRDGWVNIMYTGLDAVGVDQQPIVNYNEW 2412
                          |.|.|::||::..|:|:||.:|:.:||..::|..:|:...|:.||.||...
Mouse  1155 KDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVE 1219

  Fly  2413 RLLYFIAFILLVGFFVLNMFVGVVVENFHRCREEQEKEEKIRRAAKRALQMEKKRRRMHEPPYYT 2477
            ..::||.:|:::.||::|:|||.|:..|   :|:.|:|.|       ..:::|.:|:..|  |..
Mouse  1220 ISIFFIIYIIIIAFFMMNIFVGFVIVTF---QEQGEQEYK-------NCELDKNQRQCVE--YAL 1272

  Fly  2478 NYSPTRMFV----HN-----VVTSKYFDLAIAAVIGLNVVTMAMEYYKMPSGLKYALKIFNYFFT 2533
            ...|.|.::    |.     ||.|.||:..:..:|.||.:.:||::|......|.|:.|.|..||
Mouse  1273 KARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFT 1337

  Fly  2534 AVFILEANMKLVALGWKLYLKDRWNQLDVGIVLLSIVGIVLEELETNTH---------------Q 2583
            .:|.:|..:||:|...|.|..|.||..|..||:.||:.::|.  |||.:               .
Mouse  1338 GLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILS--ETNHYFCDAWNTFDALIVVGS 1400

  Fly  2584 IIPI-------------NPTI---------IRVMRVLRIARVLKLLKMANGIRALLDTVM---QA 2623
            |:.|             :|::         |...|:.|:.|::|||....|||.||.|.:   ||
Mouse  1401 IVDIAITEVHPAEHTQCSPSMSAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQA 1465

  Fly  2624 LPQVGNLGLLFFLLFFIFAALGVELFGRLECSDEIPCQGLGEHAHFANFGMAFLTLFRVATGDNW 2688
            ||.|   .||..:||||:|.:|:::||::..:|...   :..:.:|..|..|.|.|||.|||:.|
Mouse  1466 LPYV---ALLIVMLFFIYAVIGMQVFGKIALNDTTE---INRNNNFQTFPQAVLLLFRCATGEAW 1524

  Fly  2689 NGIMKDTLRDNCDDAADCV-----------RNCCVSSVIAPIFFVIFVLMAQFVLVNVVVAVLM- 2741
            ..||.     .|.....|.           ...|.|| .|..:|:.|.::..|:::|:.|||:| 
Mouse  1525 QDIML-----ACMPGKKCAPESEPSNSTEGETPCGSS-FAVFYFISFYMLCAFLIINLFVAVIMD 1583

  Fly  2742 --------------KHLEESHKQMEDELDME----------VELERELVREQEFAQEQKLCQQLA 2782
                          .||:| .|::..|.|.|          |.|.|.:.....|.   |||....
Mouse  1584 NFDYLTRDWSILGPHHLDE-FKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFG---KLCPHRV 1644

  Fly  2783 EAQSKAAAPPRPL------------------------------------AKVKSLPKNFIYSTPS 2811
             |..:..:...||                                    |.:|.:.|.  .|...
Mouse  1645 -ACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGNLEQANEELRAIIKKIWKR--TSMKL 1706

  Fly  2812 LDKKFPAVSG-----------------------------VNNPSLTSSAATNLN---------QV 2838
            ||:..|....                             |..||..::.:....         ::
Mouse  1707 LDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGKPSQRNALSLQAGLRTLHDIGPEI 1771

  Fly  2839 ATAGSGG---------AAPGAVPAGS-------GAGPRRQTVQYFQQP-----PQSML------- 2875
            ..|.||.         |...||.|.|       ..|.....|.|:|..     ||:..       
Mouse  1772 RRAISGDLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVTYYQSDSRGNFPQTFATQRPLHI 1836

  Fly  2876 --GGLSLAE---------MGGTLTPQ-----------------ALGARLGEPFG--------GGG 2904
              .|.:.|:         :..|.||.                 ||| |...|.|        .|.
Mouse  1837 NKTGNNQADTESPSHEKLVDSTFTPSSYSSTGSNANINNANNTALG-RFPHPAGYSSTVSTVEGH 1900

  Fly  2905 GNKSGPR---RQSYWQINPIR------KRGVLSKERSLDEQAIRRRNLEAK------RTSCDSLP 2954
            |....|.   :::.|:::..|      :...:::|...||....|.:.||:      ..|.|...
Mouse  1901 GPPLSPAVRVQEAAWKLSSKRCHSRESQGATVNQEIFPDETRSVRMSEEAEYCSEPSLLSTDMFS 1965

  Fly  2955 WGGD---ALDCRRGTIFESLESDGGGVGGGGSGGGGGGLGGGVSYDLRSV-RSADVGHSEMDGDV 3015
            :..|   .|.|......|...|.........|      ||...|:.|..: |..|.|     ||:
Mouse  1966 YQEDEHRQLTCPEEDKREIQPSPKRSFLRSAS------LGRRASFHLECLKRQKDQG-----GDI 2019

  Fly  3016 SLS-------------VVSALVPSV-----TTPLPPPLSLPIVTPTSTPTPLQLPMP-------- 3054
            |..             .|:.|.|.:     .|..|.|...|.|||.|...||: |:|        
Mouse  2020 SQKTALPLHLVHHQALAVAGLSPLLQRSHSPTTFPRPCPTPPVTPGSRGRPLR-PIPTLRLEGAE 2083

  Fly  3055 ------MPMPMAHPPPRRPFGWSQSVDQGCLRSNLLL--SVPRSMPPRSRSGSTKQLFKQQALDE 3111
                  ...|..|..     .||:.. ..|..|:.:.  :.|.|:...|::|:..:.|...|   
Mouse  2084 SSEKLNSSFPSIHCS-----SWSEET-TACSGSSSMARRARPVSLTVPSQAGAPGRQFHGSA--- 2139

  Fly  3112 DADMDENSLLLPTAAGGGSG-----PGSVAVIASSSLDLPDQSGSSKQILPDIAL--GVSKSDSS 3169
                  :||:.......|.|     |..:.|......|..|.:....:...|..|  |..:|.:.
Mouse  2140 ------SSLVEAVLISEGLGQFAQDPKFIEVTTQELADACDMTIEEMENAADNILSGGAQQSPNG 2198

  Fly  3170 DILRIISERRRMDQREQREPEQDQDNEAEDRDSDY 3204
            .:|..::         .|:|.||:....||....|
Mouse  2199 TLLPFVN---------CRDPGQDRAVAPEDESCAY 2224

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1TNP_001259267.1 Ion_trans 332..636 CDD:278921 90/319 (28%)
Ion_trans 1261..1495 CDD:278921 85/249 (34%)
Ion_trans 2192..2448 CDD:278921 96/291 (33%)
Ion_trans 2510..2728 CDD:278921 81/268 (30%)
Cacna1cXP_036021662.1 Ion_trans 153..446 CDD:395416 103/354 (29%)
Ion_trans 578..819 CDD:395416 89/266 (33%)
Ion_trans 957..1254 CDD:395416 104/311 (33%)
Ion_trans 1296..1593 CDD:395416 93/310 (30%)
GPHH 1602..1655 CDD:407139 13/57 (23%)
Ca_chan_IQ 1666..1737 CDD:400901 7/72 (10%)
CAC1F_C 1759..2194 CDD:407123 92/462 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.820

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