DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1T and Cacna1b

DIOPT Version :9

Sequence 1:NP_001259267.1 Gene:Ca-alpha1T / 31550 FlyBaseID:FBgn0264386 Length:3218 Species:Drosophila melanogaster
Sequence 2:XP_006497689.1 Gene:Cacna1b / 12287 MGIID:88296 Length:2351 Species:Mus musculus


Alignment Length:3271 Identity:688/3271 - (21%)
Similarity:1071/3271 - (32%) Gaps:1280/3271 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly   228 GGRTGGAVSSSTGSSCNGSCSSDDGDSSHTSSSSSSSSSGEPNLPYPGFPEISIRALTQYTRPRN 292
            |||.||     ||.          |:.:....:..:...|:..|| ||...:..:::.|..|   
Mouse     9 GGRYGG-----TGG----------GERARGGGAGGAGGPGQGGLP-PGQRVLYKQSIAQRAR--- 54

  Fly   293 WCLMLITNP--------------------------------W--FERVSILVILLNCITLGMYQ- 322
              .|.:.||                                |  ||.:.:..|:.|||.|.:.| 
Mouse    55 --TMALYNPIPVKQNCFTVNRSLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQH 117

  Fly   323 -PCVDDACVTNRCKILQIFDDIIFAFFALEMTIKMVAMG-ICGKNTYLADSWNRLDFFIVLAGLL 385
             |..|...::.|   |...:......|..|..||::|:| :..|.:||.:.||.:||.:||.|:|
Mouse   118 LPDGDKTPMSER---LDDTEPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGIL 179

  Fly   386 EYVMHVENLNLTAIRTIRVLRPLRAINRIPSMRILVMLLLDTLPMLGNVLLLCFFVFFIFGIIGV 450
              .....:.:|..:|.:||||||:.::.|||:::::..::..:..|..:.||.||...:|.|||:
Mouse   180 --ATAGTDFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGL 242

  Fly   451 QLWEGILRQRCSLMRTEGMVYPLTVPEVYRVRVRVNSLSQYYEFSKDQDYICSTPNDSGMHLCGN 515
            :.:.|...:.|                              :..|.|.:.:...|       ||.
Mouse   243 EFYMGKFHKAC------------------------------FPNSTDTEPVGDFP-------CGK 270

  Fly   516 FPPYRIGSLVCNEEAKLFDFNEPTNTSCVNWNQYYTTCKQSGENPFQGTISFDNIGMAWVAIFLV 580
            .||.|    .|:.:                     |.|::....|..|..:||||..|.:.:|..
Mouse   271 DPPAR----QCDGD---------------------TECREYWPGPNFGITNFDNILFAILTVFQC 310

  Fly   581 ISLEGWTDIMYYVQD-AHSFWDWIYFVLLIVIGSFFMINLCLVVIATQFSETKKREMERMRQERA 644
            |::||||||:|...| |.:.|:|:||:.||:||||||:||.|.|::.:|:    :|.||:...||
Mouse   311 ITMEGWTDILYNTNDAAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFA----KERERVENRRA 371

  Fly   645 RYTSTSTLASSTNNSEPATCYAEIVKYIAHLWRRFKRRMLKKYRLYKYQRQQRKEGLLPNADNLT 709
                                                        ..|.:|||:.|..|.......
Mouse   372 --------------------------------------------FLKLRRQQQIERELNGYLEWI 392

  Fly   710 FSPSRIKCHHPKCPKYSNRKPSSIQDQMITVMVPLNSASNNINNNNNNNSNSSNHNGSGNHTAAG 774
            |....:                                                           
Mouse   393 FKAEEV----------------------------------------------------------- 398

  Fly   775 GGNNNNNNNNNNAASCTTVALVNGINGSAASVTMSSAHHQQHQLLQHQQQQHQNQQQQQQQQQHS 839
                                                                             
Mouse   399 ----------------------------------------------------------------- 398

  Fly   840 SSDNTEQSLAPDGLPRSSSLKKSTAHHQLKPEGSAAEQKTILLKFPQQMIDSEQLILQLGNLGKS 904
                                       .|..|...||:|                          
Mouse   399 ---------------------------MLAEEDKNAEEK-------------------------- 410

  Fly   905 HPCTSGFLSPPTSASRRPSVMFNEYVLLHTPPALNADPATAGTTTTVAPTVATVAGTAAAAAAAA 969
                    ||..:..:|.:...:...|:|                                    
Mouse   411 --------SPLDAVLKRAATKKSRNDLIH------------------------------------ 431

  Fly   970 ATGSGSGNNNHQNGGASGGAGTGGTTEKSNIFSTEKMTQAGDGSIWQVNLPQTIGTIANPYADCS 1034
                                                   |.:|....|:|    ..:.:|:|   
Mouse   432 ---------------------------------------AEEGEDRFVDL----CAVGSPFA--- 450

  Fly  1035 ELGIHDAMTCQELLAFSVAFSAALPTGQSTLESFYTSLARCDPHTAEALRAHHKPRSVPTGQNQT 1099
                                .|:|.:|::...|::                              
Mouse   451 --------------------RASLKSGKTESSSYF------------------------------ 465

  Fly  1100 TPGAEGATVMVASTAGDTGQTLQPSTVSAVVGGTIDSHAANHRRKEHHQQSHHHHNNNNTTSHSR 1164
                                                      ||||                   
Mouse   466 ------------------------------------------RRKE------------------- 469

  Fly  1165 NYRSRQGQGNSRMREPRAPTGNYMEDYACCYDLYQNALSPLDERPRQRSPTTRCLISVYRCMSRV 1229
                                                                             
Mouse   470 ----------------------------------------------------------------- 469

  Fly  1230 CSWIRRYIRRLVEHKYFQQGILLAILINTLSMGIEYHNQPPELTAIVETSNVVFSGIFAVEMLLK 1294
             ...|.:|||:|:.:.|...:|..:.:|||.:.:.::|||..||..:..:..||.|:|..||.||
Mouse   470 -KMFRFFIRRMVKAQSFYWVVLCVVALNTLCVAMVHYNQPQRLTTALYFAEFVFLGLFLTEMSLK 533

  Fly  1295 VVAEGPFRYIANGFNVFDGIIVILSAIEICQTFMGNGTGGGGSGLSVLRTFRLLRILKLVRFMPN 1359
            :...||..|..:.||.||..:::.|..|:....:..||   ..|:||||..|||||.|:.::..:
Mouse   534 MYGLGPRSYFRSSFNCFDFGVIVGSIFEVVWAAIKPGT---SFGISVLRALRLLRIFKVTKYWNS 595

  Fly  1360 LRRQLFVMLRTMDNVAVFFSLLVLFIFIFSILGMYLFGGKFCKFLDESGLERECTCPEIISRHPQ 1424
            ||..:..:|.:|.::.....||.|||.:|::|||.||||:| .|.||:                 
Mouse   596 LRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQF-NFQDET----------------- 642

  Fly  1425 CECDRKHFNNILWATVTVFQILTQEDWNVVLFNGME-----KTSHWAALYFVALMTFGNYVLFNL 1484
               ...:|:....|.:|||||||.||||.|:::|:|     ....:::.||:.|..||||.|.|:
Mouse   643 ---PTTNFDTFPAAILTVFQILTGEDWNAVMYHGIESQGGVSKGMFSSFYFIVLTLFGNYTLLNV 704

  Fly  1485 LVAILVEGFSSERNERREREQRE-------LVKKLRE-----ETLAENYSDGMYDE------SRS 1531
            .:||.|:..::.:...::.|:.|       .::|.:|     ...|.|.|...:.:      |||
Mouse   705 FLAIAVDNLANAQELTKDEEEMEEAANQKLALQKAKEVAEVSPMSAANISIAAFVKQTRGTVSRS 769

  Fly  1532 EADSSTTN---DSYYEVRNRWRSAEDVRKLQD---SVELII-------------------EAKSN 1571
            .:.||..:   .:..:.|:.|.......:||:   |.|.:.                   :.|::
Mouse   770 SSVSSVNSPRQQNSAKARSVWEQRASQLRLQNLRASCEALYSEMDPEERLRYASTRHVRPDMKTH 834

  Fly  1572 MHRQRLLQPTHDYQINELPASSAAPSASGTSGASAPGDRERDRDRDRDR-------ERDRDRDRE 1629
            |.|..:::|..|.....:.:.|.......|..|..|....|.||||:..       |:||....|
Mouse   835 MDRPLVVEPGRDGLRGPVGSKSKPEGTEATESADLPRRHHRHRDRDKTSATAPAGGEQDRTESTE 899

  Fly  1630 RDREAGGGGKEEGAQHAKPRGGLKKTYSIKERRSEAPRLSKIRLARDPPIITTTAATPQDSPSTT 1694
            .      |.:||   .|:||    :::| ||                         ||.......
Mouse   900 T------GAREE---RARPR----RSHS-KE-------------------------TPGADTQVR 925

  Fly  1695 LEPGMSFRQWGDMEPPSPPSPSLLRPPNIFTGGQRSLDEGIPSIDLIPPSPVLSHKPLNILNASQ 1759
            .|......:.|..|..:...|...|                            :|:         
Mouse   926 CERSRRHHRRGSPEEATEREPRRHR----------------------------AHR--------- 953

  Fly  1760 LGVGMGGGVPSTAGSSSSMHSVIIDDISKSSSSTAAATPIYVPTISSTADAQSQSHSLNDVSVGS 1824
                               |:        ..||.....|:.||.....|..:.            
Mouse   954 -------------------HA--------QDSSKEGTAPVLVPKGERRARHRG------------ 979

  Fly  1825 SPGGEIPATGMSRNANTGASTSGSSSSERLP--LAPPPQQGSFKQRLRRGSSKKRRASALALATD 1887
                  |.||.....|....|....:..::|  |.||.::.:.|:                    
Mouse   980 ------PRTGPREAENNEEPTRRHRARHKVPPTLQPPEREAAEKE-------------------- 1018

  Fly  1888 DNPARRTLDNQARRTQDEEEEQQQLNNGGDNSCLLRNSNAVVSGSSSGTKETNRLSPQNSIRRLS 1952
                                                 ||||     .|.|||....|:.....|.
Mouse  1019 -------------------------------------SNAV-----EGDKETRNHQPKEPHCDLE 1041

  Fly  1953 NTLSIGSGPVGSRRASACIFNSQVYQNLNQPPKLRPGSGQR---RMSSIELAFSKTSHLNLHNLE 2014
            .....|.||: ....|.|:      |.:::.|:  ....||   ||.|.....|.|.|:.: .|.
Mouse  1042 AIAVTGVGPL-HMLPSTCL------QKVDEQPE--DADNQRNVTRMGSQPSDPSTTVHVPV-TLT 1096

  Fly  2015 ANRKSLSYTNSKMDLDKWNKSYGNLNEPDNMLQQYMEARDKRKNSISHYNLKKRLEEKELQQLQQ 2079
            ..........|           ||:|     |:...|.             ||..|..::     
Mouse  1097 GPPGETPVVPS-----------GNMN-----LEGQAEG-------------KKEAEADDV----- 1127

  Fly  2080 LHQQQLLQQRQDSFSSTTQQQQQQLQQHRLSKDQQQLAMQPHSMVPGGGERYSKLKMLIEQLTPK 2144
                                                |...|..:||     ||            
Mouse  1128 ------------------------------------LRRGPRPIVP-----YS------------ 1139

  Fly  2145 HFTTEREDYSLYIFPEDNRFRQICTWFVNQKWFDNVVLLFIALNCITLAMERPNIPPSSTERLFL 2209
                     |::.....|..|:.|.:.|..::|:.|:|:.|||:.|.||.|.| :...|.....|
Mouse  1140 ---------SMFCLSPTNLLRRFCHYIVTMRYFEMVILVVIALSSIALAAEDP-VRTDSFRNNAL 1194

  Fly  2210 ATANYVFTVVFTVEMFIKVVATGMFYGHDAYFTSGWNIMD-----GSLVTISIIDLLMSLISESS 2269
            ...:|:||.|||.||.||::..|:.....|||...|||:|     |:||..:    ..|.:..|.
Mouse  1195 KYMDYIFTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFA----FSSFMGGSK 1255

  Fly  2270 PRIFGILRVFRLLRSLRPLRVINRAPGLKLVVQTLLSSLRPIGNIVLICCTFFIIFGILGVQLFK 2334
            .:....::..|:||.||||:.|.|.|.||.|...:::||:.:.||:::...|..||.::.|||||
Mouse  1256 GKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFK 1320

  Fly  2335 GTFYYCEGENIKGVRNADECR-----------RIPGNVWTNRKYNFDDLGKALMSLFVLSSRDGW 2388
            |.|:||..|:.:..|   :||           ......|....:::|::..||::||.:|:.:||
Mouse  1321 GKFFYCTDESKELER---DCRGQYLDYEKEEVEAQPRQWKKYDFHYDNVLWALLTLFTVSTGEGW 1382

  Fly  2389 VNIMYTGLDAVGVDQQPIVNYNEWRLLYFIAFILLVGFFVLNMFVGVVVENFHRCREEQEKEEKI 2453
            ..::...:||...:|.|...:.....::::.:.::..||.:|:||.:::..|      ||:.:|:
Mouse  1383 PMVLKHSVDATYEEQGPSPGFRMELSIFYVVYFVVFPFFFVNIFVALIIITF------QEQGDKV 1441

  Fly  2454 RRAAKRALQMEKKRR-----RMHEPPYYTNYSP--TRMFVHNV---VTSKYFDLAIAAVIGLNVV 2508
            ....    .:||..|     .:...| .|.|.|  .:.|.:..   |.|..|:..|.|:|.||.|
Mouse  1442 MSEC----SLEKNERACIDFAISAKP-LTRYMPQNKQSFQYKTWTFVVSPPFEYFIMAMIALNTV 1501

  Fly  2509 TMAMEYYKMPSGLKYALKIFNYFFTAVFILEANMKLVALGWKLYLKDRWNQLDVGIVLLSIVGIV 2573
            .:.|::|..|...:..||..|..||::|.:|..:|::|.|...|.:|.||..|...||.||..|:
Mouse  1502 VLMMKFYDAPYEYELMLKCLNIVFTSMFSMECILKIIAFGVLNYFRDAWNVFDFVTVLGSITDIL 1566

  Fly  2574 LEEL-ETNTHQIIPINPTIIRVMRVLRIARVLKLLKMANGIRALLDTVMQALPQVGNLGLLFFLL 2637
            :.|: |||..    ||   :..:|:.|.||::|||:....||.||.|.:|:...:..:.||..:|
Mouse  1567 VTEIAETNNF----IN---LSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAML 1624

  Fly  2638 FFIFAALGVELFGRLECSDEIPCQGLGEHAHFANFGMAFLTLFRVATGDNWNGIMKDTLRDN-CD 2701
            |||:|.:|:::||.:...|:   ..:..|.:|..|..|.:.|||.|||:.|:.||...|.:. ||
Mouse  1625 FFIYAIIGMQVFGNIALDDD---TSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLGNRACD 1686

  Fly  2702 ---DAADCVRNCCVSSVIAPIFFVIFVLMAQFVLVNVVVAVLM---------------KHLEE-- 2746
               :|::|      .|..|..:||.|:.:..|:::|:.|||:|               .||:|  
Mouse  1687 PHANASEC------GSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEFI 1745

  Fly  2747 --------------SHKQMEDEL--------------------------------DMEVELEREL 2765
                          |:..|.:.|                                ||.|.....|
Mouse  1746 RVWAEYDPAACGRISYNDMFEMLKHMSPPLGLGKKCPARVAYKRLVRMNMPISNEDMTVHFTSTL 1810

  Fly  2766 VREQEFAQEQKLC-----QQLAEAQSK-------AAAPPR------PLAKVKSLPKNFIYST--- 2809
            :.....|.|.||.     |...:|:.:       |..|.:      |..|...:....:|:.   
Mouse  1811 MALIRTALEIKLAPAGTKQHQCDAELRKEISSVWANLPQKTLDLLVPPHKPDEMTVGKVYAALMI 1875

  Fly  2810 --------PSLDKKFPAVSGVN------------------NPSLTSSAATNLNQ-VATAGSGGAA 2847
                    .:.|:...|..|::                  .|::...|...|.| .||:.|.|.|
Mouse  1876 FDFYKQNKTTRDQTHQAPGGLSQMGPVSLFHPLKATLEQTQPAVLRGARVFLRQKSATSLSNGGA 1940

  Fly  2848 PGAVPAG-----SGAGPRRQTVQYFQQPPQSMLGGLSLAEM----GGTLTPQALGARL------- 2896
            .....:|     |....|.|...|..:.|  :..|.| ||:    .|||   |:..::       
Mouse  1941 IQTQESGIKESLSWGTQRTQDALYEARAP--LERGHS-AEIPVGQSGTL---AVDVQMQNMTLRG 1999

  Fly  2897 --GEPFGG---GGGNKSGPRRQSYWQINPIRKRGVLSKERSLDEQAIRRRNLEAKRTSCDSLPWG 2956
              |||..|   .|...|.||..:..|..|    .....:||:...|.|....:...|..|..|..
Mouse  2000 PDGEPQPGLESQGRAASMPRLAAETQPAP----NASPMKRSISTLAPRPHGTQLCSTVLDRPPPS 2060

  Fly  2957 GDALD----C--RRGTIFESLESDGGGVG----GGGSGGGGGGLGGGV-SYDLRSVRSADVGHSE 3010
            ..:..    |  ||.....|||. |..:.    |..|...|.||..|. |...|..|..:.|.|:
Mouse  2061 QASHHHHHRCHRRRDKKQRSLEK-GPSLSVDPEGAPSTAAGPGLPHGEGSTACRRDRKQERGRSQ 2124

  Fly  3011 MDGDVSLSVVS----------------ALVPSVTT-PLPPPLSL---------------PIVTPT 3043
            .....|.|...                .|:||::: |..|..:|               |:::.:
Mouse  2125 ERRQPSSSSSEKQRFYSCDRFGSREPPQLMPSLSSHPTSPTAALEPAPHPQGSGSVNGSPLMSTS 2189

  Fly  3044 STPTP-----LQLPM-PM-PMP-----MAHPPPRRPFGWSQS---------VDQGCLRSNLLL-S 3086
            ...||     .|||. |: |.|     .|:..|.. |...||         :.:|....|.|| .
Mouse  2190 GASTPGRGGRRQLPQTPLTPRPSITYKTANSSPVH-FAEGQSGLPAFSPGRLSRGLSEHNALLQK 2253

  Fly  3087 VPRSMP--PRSRSGSTKQLFKQQALDEDAD---MDENSLLLPTAAGGGSGPGSVAVIASSSLDLP 3146
            .|.|.|  |.||.||...|  .|.||.:|.   :.|::|....|....||..|.....||   |.
Mouse  2254 EPLSQPLAPGSRIGSDPYL--GQRLDSEASAHTLPEDTLTFEEAVATNSGRSSRTSYVSS---LT 2313

  Fly  3147 DQSGSSKQILPD---IALGVS 3164
            .||...::: |:   ..||:|
Mouse  2314 SQSHPLRRV-PNGYHCTLGLS 2333

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1TNP_001259267.1 Ion_trans 332..636 CDD:278921 87/305 (29%)
Ion_trans 1261..1495 CDD:278921 84/238 (35%)
Ion_trans 2192..2448 CDD:278921 81/271 (30%)
Ion_trans 2510..2728 CDD:278921 76/222 (34%)
Cacna1bXP_006497689.1 Ion_trans 94..367 CDD:366146 101/343 (29%)
Ion_trans 482..721 CDD:366146 89/262 (34%)
Granin <936..>1041 CDD:279595 31/248 (13%)
Ion_trans 1161..1395 CDD:366146 80/241 (33%)
Ion_trans 1485..1734 CDD:366146 90/264 (34%)
GPHH 1743..1796 CDD:374878 4/52 (8%)
Ca_chan_IQ 1808..1882 CDD:370105 12/73 (16%)
PHA03307 1959..>2326 CDD:223039 97/384 (25%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.820

Return to query results.
Submit another query.