DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1T and Cacna1a

DIOPT Version :9

Sequence 1:NP_001259267.1 Gene:Ca-alpha1T / 31550 FlyBaseID:FBgn0264386 Length:3218 Species:Drosophila melanogaster
Sequence 2:XP_006530650.1 Gene:Cacna1a / 12286 MGIID:109482 Length:2464 Species:Mus musculus


Alignment Length:3301 Identity:701/3301 - (21%)
Similarity:1078/3301 - (32%) Gaps:1278/3301 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly   130 TERTSSG-QRSSHRQTSNASDGG--GSSRRRYQGKEHHDRRDRQDRQDRQDRQERSDRHERRDRR 191
            |:.|.:| .|:.|...|....|.  |.:.:|..|...|       |......|........:.||
Mouse    28 TDCTLAGSSRTLHVPWSQQMSGSLEGPTLKRRGGVVDH-------RDVILAHQAHKMHSTPQARR 85

  Fly   192 DEQQAAR---RRTGRRHSGASSLSDAAAAT--AAGRSRSRGGGRTGGAVSSSTGSSCNGSCSSDD 251
            .|.:.||   ...||..:|......||...  ||| .|..||.|.||                  
Mouse    86 KEWEMARFGDEMPGRYGAGGGGSGPAAGVVVGAAG-GRGAGGSRQGG------------------ 131

  Fly   252 GDSSHTSSSSSSSSSGEPNLPYPGFPEISIRALTQYTRP---------RNWCLML---------- 297
                                 .||...:..:::.|..|.         |..||.:          
Mouse   132 ---------------------QPGAQRMYKQSMAQRARTMALYNPIPVRQNCLTVNRSLFLFSED 175

  Fly   298 ---------ITN-PWFERVSILVILLNCITLGMYQPCVDDACVTNRCKILQIFDD---IIFAFFA 349
                     ||. |.||.:.:..|:.|||.|.:.|...||    ::..:.:..||   .....|.
Mouse   176 NVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDD----DKTPMSERLDDTEPYFIGIFC 236

  Fly   350 LEMTIKMVAMGIC-GKNTYLADSWNRLDFFIVLAGLLEYVMHVENLNLTAIRTIRVLRPLRAINR 413
            .|..||:||:|.. .|.:||.:.||.:||.:||.|:|..|  ....:|..:|.:||||||:.::.
Mouse   237 FEAGIKIVALGFAFHKGSYLRNGWNVMDFVVVLTGILATV--GTEFDLRTLRAVRVLRPLKLVSG 299

  Fly   414 IPSMRILVMLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWEGILRQRCSLMRTEGMVYPLTVPEV 478
            |||:::::..::..:..|..:.||.||...||.|||::.:.|.....|....|:.:......|  
Mouse   300 IPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQGESPAP-- 362

  Fly   479 YRVRVRVNSLSQYYEFSKDQDYICSTPNDSGMHLCGNFPPYRIGSLVCNEEAKLFDFNEPTNTSC 543
                                              ||.                    .||..| |
Mouse   363 ----------------------------------CGT--------------------EEPART-C 372

  Fly   544 VNWNQYYTTCKQSGENPFQGTISFDNIGMAWVAIFLVISLEGWTDIMYYVQDAH-SFWDWIYFVL 607
            .|.    |.|:...|.|..|...||||..|.:.:|..|::|||||::|...||. :.|:|:||:.
Mouse   373 PNG----TKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLYFIP 433

  Fly   608 LIVIGSFFMINLCLVVIATQFSETKKREMERMRQERARYTSTSTLASSTNNSEPATCYAEIVKYI 672
            ||:||||||:||.|.|::.:|:    :|.||:...||                            
Mouse   434 LIIIGSFFMLNLVLGVLSGEFA----KERERVENRRA---------------------------- 466

  Fly   673 AHLWRRFKRRMLKKYRLYKYQRQQRKEGLLPNADNLTFSPSRIKCHHPKCPKYSNRKPSSIQDQM 737
                            ..|.:|||:.|                                      
Mouse   467 ----------------FLKLRRQQQIE-------------------------------------- 477

  Fly   738 ITVMVPLNSASNNINNNNNNNSNSSNHNGSGNHTAAGGGNNNNNNNNNNAASCTTVALVNGING- 801
                                                                       ..:|| 
Mouse   478 -----------------------------------------------------------RELNGY 483

  Fly   802 -----SAASVTMSSAHHQQHQLLQHQQQQHQNQQQQQQQQQHSSSDNTEQSLAPDGLPRSSSLKK 861
                 .|..|.::                   :.:...:|:|...         .|..|.::|||
Mouse   484 MEWISKAEEVILA-------------------EDETDVEQRHPFD---------VGALRRATLKK 520

  Fly   862 STAHHQLKPEGSAAEQKTILLKFPQQMIDSEQLILQLGNLGKSHPCTSGFLSPPTSASRRPSVMF 926
            |               ||.||. |::..|                                    
Mouse   521 S---------------KTDLLN-PEEAED------------------------------------ 533

  Fly   927 NEYVLLHTPPALNADPATAGTTTTVAPTVATVAGTAAAAAAAAATGSGSGNNNHQNGGASGGAGT 991
                                                                             
Mouse   534 ----------------------------------------------------------------- 533

  Fly   992 GGTTEKSNIFSTEKMTQAGDGSIWQVNLPQTIGTIANPYADCSELGIHDAMTCQELLAFSVAFSA 1056
                            |..|           |.::.:|:|                         
Mouse   534 ----------------QLAD-----------IASVGSPFA------------------------- 546

  Fly  1057 ALPTGQSTLESFYTSLARCDPHTAEALRAHHKPRSVPTGQNQTTPGAEGATVMVASTAGDTGQTL 1121
                                       ||..|...:                             
Mouse   547 ---------------------------RASIKSAKL----------------------------- 555

  Fly  1122 QPSTVSAVVGGTIDSHAANHRRKEHHQQSHHHHNNNNTTSHSRNYRSRQGQGNSRMREPRAPTGN 1186
                                              .|:|..|.:..|                   
Mouse   556 ----------------------------------ENSTFFHKKERR------------------- 567

  Fly  1187 YMEDYACCYDLYQNALSPLDERPRQRSPTTRCLISVYRCMSRVCSWIRRYIRRLVEHKYFQQGIL 1251
                                                          :|.||||:|:.:.|...:|
Mouse   568 ----------------------------------------------MRFYIRRMVKTQAFYWTVL 586

  Fly  1252 LAILINTLSMGIEYHNQPPELTAIVETSNVVFSGIFAVEMLLKVVAEGPFRYIANGFNVFDGIIV 1316
            ..:.:|||.:.|.::|||..|:..:..:..:|.|:|..||.:|:...|...|..:.||.||..::
Mouse   587 SLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVI 651

  Fly  1317 ILSAIEICQTFMGNGTGGGGSGLSVLRTFRLLRILKLVRFMPNLRRQLFVMLRTMDNVAVFFSLL 1381
            |.|..|:....:..||   ..|:||||..|||||.|:.::..:||..:..:|.:|.::.....||
Mouse   652 IGSIFEVIWAVIKPGT---SFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLL 713

  Fly  1382 VLFIFIFSILGMYLFGGKFCKFLDESGLERECTCPEIISRHPQCECDRKHFNNILWATVTVFQIL 1446
            .|||.:|::|||.||||:|  ..||.      |.|             .:|:....|.:||||||
Mouse   714 FLFIVVFALLGMQLFGGQF--NFDEG------TPP-------------TNFDTFPAAIMTVFQIL 757

  Fly  1447 TQEDWNVVLFNGMEKTSHWA-----ALYFVALMTFGNYVLFNLLVAILVEGFSS-------ERNE 1499
            |.||||.|:::|::......     ::||:.|..||||.|.|:.:||.|:..::       |:.|
Mouse   758 TGEDWNEVMYDGIKSQGGVQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEE 822

  Fly  1500 RREREQRELVKKLRE-----ETLAENYSDGMYDESRSEADSSTTNDS-----------------Y 1542
            .....|:..::|.:|     ...|.|.|..:.::.:::..:.:..:.                 |
Mouse   823 EEAANQKLALQKAKEVAEVSPLSAANMSIAVKEQQKNQKPTKSVWEQRTSEMRKQNLLASREALY 887

  Fly  1543 YEVRNRWRSAEDVRKLQDSVELIIEAKSNMHRQRLLQPTHDYQINELPASSAAPSASGTSGASAP 1607
            .:...||.:.. .|.|:..|      |:::.|..::.|..:.  |.....|.||.      |..|
Mouse   888 GDAAERWPTPY-ARPLRPDV------KTHLDRPLVVDPQENR--NNNTNKSRAPE------ALRP 937

  Fly  1608 GDRERDRDRDRDRERDRDRDRER--DREAGGGGKEEGAQ--HAKPRGGLK-KTYSIKERRSEAPR 1667
            ..|.|:..||.|..|......||  .||...|.:.|..|  ||.||.... ...:.:.:..:|||
Mouse   938 TARPRESARDPDARRAWPGSPERAPGREGPYGRESEPQQREHAPPREHAPWDADTERAKAGDAPR 1002

  Fly  1668 LSKIR-LARDPPIITTTAATPQDSPSTTLEPGMSFRQWGDMEPPSPPSP-SLLRPPNIFTG---- 1726
            ....| :|...|........|.|.|              |..|...|.| ...||.....|    
Mouse  1003 RHTHRPVAEGEPRRHRARRRPGDEP--------------DDRPERRPRPRDATRPARAADGEGDD 1053

  Fly  1727 GQRSL--DEGIPSIDLIPPSPVLSHKPLNILNASQLGVGMGGGVPSTAGSSSSMHSVIIDDISKS 1789
            |:|..  ..|.|:.|    .....|:        :.....|.||| .:|.:.|....|..|:.:.
Mouse  1054 GERKRRHRHGPPAHD----DRERRHR--------RRKENQGSGVP-VSGPNLSTTRPIQQDLGRQ 1105

  Fly  1790 SSSTAAATPIYVPTISSTADAQSQSHSLNDVSVGSSPGGEIPATGMSRNANTGASTSGSSSSERL 1854
            ....|...........:|.:..|...||....:..||            |..|.||:        
Mouse  1106 DLPLAEDLDNMKNNKLATGEPASPHDSLGHSGLPPSP------------AKIGNSTN-------- 1150

  Fly  1855 PLAPPPQQGSFKQRLRRGSSKKRRASALALATDDNPARRTLDNQARRTQDEEEEQQQLNNGGDNS 1919
               |.|                      ||||  ||....    :|||.         ||.|   
Mouse  1151 ---PGP----------------------ALAT--NPQNAA----SRRTP---------NNPG--- 1172

  Fly  1920 CLLRNSNAVVSGSSSGTKETNRLSPQNSIRRLSNTLSIGSGPVGSRRASACIFNSQVYQNLNQPP 1984
                      :.|:.|..:|    |:||:        |.:.|..::..||.......:..:..||
Mouse  1173 ----------NPSNPGPPKT----PENSL--------IVTNPSSTQPNSAKTARKPEHMAVEIPP 1215

  Fly  1985 KLRPGSGQRRMSSIELAFSKTSHLNLHNLEANRKSLSYTNSKMDLDKWNKSYGNLNEPDNMLQQY 2049
            ...|                   ||...::.|:                    |.| ||      
Mouse  1216 ACPP-------------------LNHTVVQVNK--------------------NAN-PD------ 1234

  Fly  2050 MEARDKRKNSISHYNLKKRLEEKELQQLQQLHQQQLLQQRQDSFSSTTQQQQQQLQQHRLSKDQQ 2114
                          .|.|:.|||:        :::.....:|.                      
Mouse  1235 --------------PLPKKEEEKK--------EEEEADPGEDG---------------------- 1255

  Fly  2115 QLAMQPHSMVPGGGERYSKLKMLIEQLTPKHFTTEREDYSLYIFPEDNRFRQICTWFVNQKWFDN 2179
                 |..|.|     ||                     |::|....|..|::|.:.:|.::|:.
Mouse  1256 -----PKPMPP-----YS---------------------SMFILSTTNPLRRLCHYILNLRYFEM 1289

  Fly  2180 VVLLFIALNCITLAME---RPNIPPSSTERLFLATANYVFTVVFTVEMFIKVVATGMFYGHDAYF 2241
            .:|:.||::.|.||.|   :||.|.::..|.|    :||||.|||.||.||::..|:.....|||
Mouse  1290 CILMVIAMSSIALAAEDPVQPNAPRNNVLRYF----DYVFTGVFTFEMVIKMIDLGLVLHQGAYF 1350

  Fly  2242 TSGWNIMD-----GSLVTISIIDLLMSLISESSPRIFGILRVFRLLRSLRPLRVINRAPGLKLVV 2301
            ...|||:|     |:||..:...   |....|..:....::..|:||.||||:.|.|.|.||.|.
Mouse  1351 RDLWNILDFIVVSGALVAFAFTS---STRGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVF 1412

  Fly  2302 QTLLSSLRPIGNIVLICCTFFIIFGILGVQLFKGTFYYCEGENIKGVRNADECR----------- 2355
            ..:::||:.:.||:::...|..||.::.||||||.|::|..|:.:..|   :||           
Mouse  1413 DCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFER---DCRGKYLLYEKNEV 1474

  Fly  2356 RIPGNVWTNRKYNFDDLGKALMSLFVLSSRDGWVNIMYTGLDAVGVDQQPIVNYNEWRLLYFIAF 2420
            :.....|...::::|::..||::||.:|:.:||..::...:||...:|.|...|.....::::.:
Mouse  1475 KARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVY 1539

  Fly  2421 ILLVGFFVLNMFVGVVVENFH----RCREEQEKEEKIRRAAKRALQMEKKRRRMHEPPYYTNYSP 2481
            .::..||.:|:||.:::..|.    :..||...|:..|.....|:..:...|.|.:......|  
Mouse  1540 FVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLEKNERACIDFAISAKPLTRHMPQNKQSFQY-- 1602

  Fly  2482 TRMFVHNVVTSKYFDLAIAAVIGLNVVTMAMEYYKMPSGLKYALKIFNYFFTAVFILEANMKLVA 2546
             ||:  ..|.|..|:..|.|:|.||.:.:.|::|......:.||::||..||::|.||..:|::|
Mouse  1603 -RMW--QFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENALRVFNIVFTSLFSLECVLKVMA 1664

  Fly  2547 LGWKLYLKDRWNQLDVGIVLLSIVGIVLEELETNTHQIIPINPTIIRVMRVLRIARVLKLLKMAN 2611
            .|...|.:|.||..|...||.||..|::.|...      |.|...:..:|:.|.||::|||:...
Mouse  1665 FGILNYFRDAWNIFDFVTVLGSITDILVTEFGN------PNNFINLSFLRLFRAARLIKLLRQGY 1723

  Fly  2612 GIRALLDTVMQALPQVGNLGLLFFLLFFIFAALGVELFGRL------ECSDEIPCQGLGEHAHFA 2670
            .||.||.|.:|:...:..:.||..:||||:|.:|:::||.:      |.|||...| :.||.:|.
Mouse  1724 TIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDGEDEDSDEDEFQ-ITEHNNFR 1787

  Fly  2671 NFGMAFLTLFRVATGDNWNGIMKDTLRDN-CDD-----AADCVRNCCVSSVIAPIFFVIFVLMAQ 2729
            .|..|.:.|||.|||:.|:.||...|... ||.     .|||      .:..|..:||.|:.:..
Mouse  1788 TFFQALMLLFRSATGEAWHNIMLSCLSGKPCDKNSGILTADC------GNEFAYFYFVSFIFLCS 1846

  Fly  2730 FVLVNVVVAVLMKHLEESHKQMEDELDMEVELERELVREQEFAQEQKLCQQL-AEAQSKAAAPPR 2793
            |:::|:.|||:|.:.|                  .|.|:........|.:.: ..|:...||..|
Mouse  1847 FLMLNLFVAVIMDNFE------------------YLTRDSSILGPHHLDEYVRVWAEYDPAACGR 1893

  Fly  2794 -------PLAKVKSLPKNFIYSTPSLDKKFP-------------AVSGVN----NPSLTSSAATN 2834
                   .|.:|.|.|.       .|.||.|             .|:..|    |.:|.:...|.
Mouse  1894 IHYKDMYSLLRVISPPL-------GLGKKCPHRVACKRLLRMDLPVADDNTVHFNSTLMALIRTA 1951

  Fly  2835 LNQVATAGSGGAAPGAVPAGSGAGPRRQTVQYFQQPPQSMLGGLSLAEMGGTLTP-QALGARLGE 2898
            |:              :....|...::|.....::...::...||...:...:|| ::....:|:
Mouse  1952 LD--------------IKIAKGGADKQQMDAELRKEMMAIWPNLSQKTLDLLVTPHKSTDLTVGK 2002

  Fly  2899 PFGGGGGNKSGPRRQSYWQINPIRKRGVLSKERSLDEQAIRRRNLEAKRTSCDSLPWGGDALDCR 2963
            .:       :......|::         .||.:.|  ||:|.   |..||.              
Mouse  2003 IY-------AAMMIMEYYR---------QSKAKKL--QAMRE---EQNRTP-------------- 2032

  Fly  2964 RGTIFESLESDGGGVGGGGSGGG--------GGGLGGGVSYDLRSVRSADVGHSEMDGDVSLSVV 3020
              .:|:.:|.......||.|...        ||||               :.|   :|.:..|  
Mouse  2033 --LMFQRMEPPSPTQEGGPSQNALPSTQLDPGGGL---------------MAH---EGGMKES-- 2075

  Fly  3021 SALVPSVTTPLP---------------PPLSLPIVTPTSTPTPLQ-------------LPM---- 3053
                ||..|...               ||:.:|...|.|....::             |||    
Mouse  2076 ----PSWVTQRAQEMFQKTGTWSPERGPPIDMPNSQPNSQSVEMREMGTDGYSDSEHYLPMEGQT 2136

  Fly  3054 ---PMPMPMAHPPPRRPFGWSQSVDQGCLRSNLLLSVPRSMPPRSRSGST--------------- 3100
               .||...|....||          |..|.|.|.::..:.|.: ||.|.               
Mouse  2137 RAASMPRLPAENQRRR----------GRPRGNDLSTISDTSPMK-RSASVLGPKARRLDDYSLER 2190

  Fly  3101 -----KQLFKQQALDEDADMDENSLLLPTAAGGGSGPGSVAVIASSSLDLPDQSGSSKQILPDIA 3160
                 .|.:.|:..|......|.||...|....|.|         :.|.:..|||.    ||   
Mouse  2191 VPPEENQRYHQRRRDRGHRTSERSLGRYTDVDTGLG---------TDLSMTTQSGD----LP--- 2239

  Fly  3161 LGVSKSDSSDILRIISERRRMDQREQR-----------EPEQDQDNEAEDR 3200
               ||....|       |.|...|:.|           .|..|:|..|::|
Mouse  2240 ---SKDRDQD-------RGRPKDRKHRPHHHHHHHHHHPPAPDRDRYAQER 2280

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1TNP_001259267.1 Ion_trans 332..636 CDD:278921 90/308 (29%)
Ion_trans 1261..1495 CDD:278921 82/238 (34%)
Ion_trans 2192..2448 CDD:278921 86/278 (31%)
Ion_trans 2510..2728 CDD:278921 79/229 (34%)
Cacna1aXP_006530650.1 Ion_trans 188..462 CDD:366146 104/344 (30%)
Ion_trans 579..817 CDD:366146 87/261 (33%)
PHA03247 <895..1277 CDD:223021 119/629 (19%)
Ion_trans 1285..1520 CDD:366146 80/244 (33%)
Ion_trans 1610..1869 CDD:366146 95/289 (33%)
GPHH 1878..1931 CDD:374878 12/59 (20%)
Ca_chan_IQ 1942..2015 CDD:370105 11/102 (11%)
PHA03307 2046..>2460 CDD:223039 61/296 (21%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.820

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