Protein Alignment Ca-alpha1T and Cacna1h

DIOPT Version :9

• Sequence 1: NP_001259267.1
• Gene: Ca-alpha1T / 31550
• FlyBaseID: FBgn0264386
• Length: 3218
• Species: Drosophila melanogaster
• Sequence 2: XP_008765754.2
• Gene: Cacna1h / 114862
• RGDID: 68943
• Length: 2370
• Species: Rattus norvegicus
• Alignment Length: 3117
• Identity: 1090/3117 - (34%)
• Similarity: 1424/3117 - (45%)
• Gaps: 999/3117 - (32%)

  Fly   207 GASSLSDAAAATAAGRS------RSRGGGRTGGAVSSSTGSSCNGSCSSDDGDSSHTSSSSSSSS 265
            |||..:.||...|:..|      ..:||..:|.....|.|:.|.....:|:
  Rat    16 GASPPAPAAPVRASPASPGAPGREEQGGSGSGVLAPESPGTECGADLGADE-------------- 66

  Fly   266 SGEPNLPYPGFPEISIRALTQYTRPRNWCLMLITNPWFERVSILVILLNCITLGMYQPCVDDACV 330
              |..:|||.........|.|.||||:|||.|:.|||||.:|:|||:|||:||||::||.|..|.
  Rat    67 --EQPVPYPALAATVFFCLGQTTRPRSWCLRLVCNPWFEHISMLVIMLNCVTLGMFRPCEDVECR 129

  Fly   331 TNRCKILQIFDDIIFAFFALEMTIKMVAMGICGKNTYLADSWNRLDFFIVLAGLLEYVMHVENLN 395
            :.||.||:.|||.||||||:||.|||||:|:.|:..||.|:|||||||||:||::||.:...|::
  Rat   130 SERCSILEAFDDFIFAFFAVEMVIKMVALGLFGQKCYLGDTWNRLDFFIVMAGMMEYSLDGHNVS 194

  Fly   396 LTAIRTIRVLRPLRAINRIPSMRILVMLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWEGILRQR 460
            |:||||:|||||||||||:|||||||.|||||||||||||||||||||||||:|||||.|:||.|
  Rat   195 LSAIRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 259

  Fly   461 CSL----MRTEGMVYPLTVPEVYRVRVRVNSLSQYY--EFSKDQDYICSTPNDSGMHLCGNFPPY 519
            |.|    :|...:.:                |..||  |..::..:|||:..|:||..|.:.|..
  Rat   260 CFLDSAFVRNNNLTF----------------LRPYYQTEEGEENPFICSSRRDNGMQKCSHIPSR 308

  Fly   520 RIGSLVC--NEEAKLFDFNEPT-------NTSCVNWNQYYTTCKQSGENPFQGTISFDNIGMAWV 575
            |...:.|  ..||    :.:|.       ..:|:||||||..|:....||..|.|:|||||.||:
  Rat   309 RELRVQCTLGWEA----YGQPQAEDGGAGRNACINWNQYYNVCRSGEFNPHNGAINFDNIGYAWI 369

  Fly   576 AIFLVISLEGWTDIMYYVQDAHSFWDWIYFVLLIVIGSFFMINLCLVVIATQFSETKKREMERMR 640
            |||.||:||||.||||||.|||||:::|||:|||::|||||||||||||||||||||:||.:.||
  Rat   370 AIFQVITLEGWVDIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRENQLMR 434

  Fly   641 QERARYTST-STLASSTNNSEPATCYAEIVKYIAHLWRRFKRRMLKKYRLYKYQRQQRKEGLLPN 704
            ::||||.|. |||||.   |||.:||.|::||:.|::|:.|||.|:.|.  ::|.:.||:
  Rat   435 EQRARYLSNDSTLASF---SEPGSCYEELLKYVGHIFRKVKRRSLRLYA--RWQSRWRKK----- 489

  Fly   705 ADNLTFSPSRIKCHHPKCPKYSNRKPSSIQDQMITVMVPLNSASNNINNNNNNNSNSSNHNGSGN 769
                 ..||  ...|.:.|   .|:|                                  ..:|.
  Rat   490 -----VDPS--STVHGQGP---GRRP----------------------------------RRAGR 510

  Fly   770 HTAAGGGNNNNNNNNNNAASCTTVALVNGINGSAASVTMSSAHHQQHQLLQHQQQQHQNQQQQQQ 834
            .||                                     |.||    |:.|....|.:
  Rat   511 RTA-------------------------------------SVHH----LVYHHHHHHHH------ 528

  Fly   835 QQQHSSSDNTEQSLAPDGLPRSSSLKKSTAHHQLKPEGSAAEQKTILLKFPQQMIDSEQLILQLG 899
             ..|.|          .|.||..|           ||..|.:.:.:....|.
  Rat   529 -HYHFS----------HGGPRRPS-----------PEPGAGDNRLVRACAPP------------- 558

  Fly   900 NLGKSHPCTSGFLSPPTSASRRPSVMFNEYVLLHTPP-------ALNADPATAG--TTTTVAPTV 955
                         |||:..              |.||       ..:||....|  ....||.::
  Rat   559 -------------SPPSPG--------------HGPPDSESVHSIYHADCHVEGPQERARVAHSI 596

  Fly   956 ATVAGTAAAAAAAAATGSG---------SGNNNHQNGGAS-----GGAGTGGTTEKSNIFSTEKM 1006
            ||      ||:...|:|.|         ||..|.:.|.:|     .|||..|..
  Rat   597 AT------AASLKLASGLGTMNYPTILPSGTVNSKGGTSSRPKGLRGAGAPGAA----------- 644

  Fly  1007 TQAGDGSIWQVNLPQTIGTIANPYAD----CSELGIHDAMTCQELLAFSVAFSAALPTGQS-TLE 1066
                      |:.|.::|: ..||..    ..|.|:..|.:  .|...||  ...||:.|: ||.
  Rat   645 ----------VHSPLSLGS-PRPYEKIQHVVGEQGLGRASS--HLSGLSV--PCPLPSPQAGTLT 694

  Fly  1067 SFYTSLARCDPHTAEALRAHHKPRSVPTGQNQTTPGAEGATVMVASTAGDTGQTLQPSTVSAVVG 1131
               ..|..| |:.|.||.               .|..|    ...|.:||       |....|..
  Rat   695 ---CELKSC-PYCASALE---------------DPEFE----FSGSESGD-------SDAHGVYE 729

  Fly  1132 GTIDSHAANHRRKEHHQQSHHHHNNNNTTSHSRNYRSRQGQGNSRMREPRAPTGNYMEDYACCYD 1196
            .|.|....:.|  :..||.|    ...|..|| |.|.|     :.:|:...|.|
  Rat   730 FTQDVRHGDCR--DPVQQPH----EVGTPGHS-NERRR-----TPLRKASQPGG----------- 771

  Fly  1197 LYQNALSPLDERPRQRSPTTRCLISVYRCMSRVCSWIRRYIRRLVEHKYFQQGILLAILINTLSM 1261
                                         :..:.:.....:||:|:.|||.:||:.|||:|||||
  Rat   772 -----------------------------IGHLWASFSGKLRRIVDSKYFNRGIMAAILVNTLSM 807

  Fly  1262 GIEYHNQPPELTAIVETSNVVFSGIFAVEMLLKVVAEGPFRYIANGFNVFDGIIVILSAIEICQT 1326
            |:|||.||.|||..:|.||:||:.:||:|||||::|.||..||.|.:|:||||:|::|..||
  Rat   808 GVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLACGPLGYIRNPYNIFDGIVVVISVWEI--- 869

  Fly  1327 FMGNGTGGGGSGLSVLRTFRLLRILKLVRFMPNLRRQLFVMLRTMDNVAVFFSLLVLFIFIFSIL 1391
                 .|....||||||||||||:||||||:|.|||||.|::|||||||.|..||:|||||||||
  Rat   870 -----VGQADGGLSVLRTFRLLRVLKLVRFLPALRRQLVVLMRTMDNVATFCMLLMLFIFIFSIL 929

  Fly  1392 GMYLFGGKFCKFLDESGLERECTCPEIISRHPQCECDRKHFNNILWATVTVFQILTQEDWNVVLF 1456
            ||:|||.||....|...     |.|           |||:|:::|||.||||||||||||||||:
  Rat   930 GMHLFGCKFSLKTDSGD-----TVP-----------DRKNFDSLLWAIVTVFQILTQEDWNVVLY 978

  Fly  1457 NGMEKTSHWAALYFVALMTFGNYVLFNLLVAILVEGFSSERNERREREQRELVKKLREETLAENY 1521
            |||..||.|||||||||||||||||||||||||||||.:|.
  Rat   979 NGMASTSSWAALYFVALMTFGNYVLFNLLVAILVEGFQAEG------------------------ 1019

  Fly  1522 SDGMYDESRSEADSSTTNDSYYEVRNRWRSAEDVRKLQDSVELIIEAKSNMHRQRLLQPTHDYQI 1586
                 |.:||:.|...|:.         :...|..||:|                 |:.|
  Rat  1020 -----DATRSDTDEDKTST---------QLEGDFDKLRD-----------------LRAT----- 1048

  Fly  1587 NELPASSAAPSASGTSGASAPGDRERDRDRDRDRERDRDRDRERDREAGGGGKEEGAQHAKPRGG 1651
             |:...|.|.:.:|                                            |.:.||.
  Rat  1049 -EMKMYSLAVTPNG--------------------------------------------HLEGRGS 1068

  Fly  1652 LKKTYSIKERRSEAPRLSKIRLARDPPIITTTAATPQDSPSTTLEPGMSFRQWGDMEPPSPPSPS 1716
            |                       .||:||.|||||..:|.::
  Rat  1069 L-----------------------PPPLITHTAATPMPTPKSS---------------------- 1088

  Fly  1717 LLRPPNIFTGGQRSLDEGIPSIDLIPPSPVLSHKPLNILNASQLGVGMGGGVPSTAGSSSSMHSV 1781
                               |::|       ::|..|:                |...||.|:...
  Rat  1089 -------------------PNLD-------VAHALLD----------------SRRSSSGSVDPQ 1111

  Fly  1782 IIDDISKSSSSTAAATPIYVPTISSTADAQSQSHSLNDVSVGSSPGGEIPATGMSRNANTGASTS 1846
            :.|..|.:|..::..||                                          .|.:::
  Rat  1112 LGDQKSLASLRSSPCTP------------------------------------------WGPNSA 1134

  Fly  1847 GSSSSERLPLAPPPQQGSFKQRLRRGSSKKRRASALALATDDNPARRTLDNQARRTQDEEEEQQQ 1911
            |||           ::.|:.. |.|..|.|||:..       ......|..:.:.:.|:|.|..
  Rat  1135 GSS-----------RRSSWNS-LGRAPSLKRRSQC-------GERESLLSGEGKGSTDDEAEDS- 1179

  Fly  1912 LNNGGDNSCLLRNSNAVVSGSSSGTKETNRLSPQNSIRRLSNTLSIGSGPVGSRRASACIFNSQV 1976
                       |.|.....|:|.|.:.|    |......|.:..::...|   .|.:|.:
  Rat  1180 -----------RPSTGTHPGASPGPRAT----PLRRAESLDHRSTLDLCP---PRPAALL----- 1221

  Fly  1977 YQNLNQPPKLRPGSGQRRMSSIELAFSKTSHLNLHNLEANRKSLSYTNSKMDLDKWNKSYGNLNE 2041
                  |.|....:||.      :|......|.:
  Rat  1222 ------PTKFHDCNGQM------VALPSEFFLRI------------------------------- 1243

  Fly  2042 PDNMLQQYMEARDKRKNSISHYNLKKRLEEKELQQLQQLHQQQLLQQRQDSFSSTTQQQQQQLQQ 2106
                        |..|...:.::     ::.|.....:||:
  Rat  1244 ------------DSHKEDAAEFD-----DDIEDSCCFRLHK------------------------ 1267

  Fly  2107 HRLSKDQQQLAMQPHSMVPGGGERYSKLKMLIEQLTPKHFTTEREDYSLYIFPEDNRFRQICTWF 2171
                                          ::|...|: :...||.::||:||..||.|..|...
  Rat  1268 ------------------------------VLEPYAPQ-WCRSRESWALYLFPPQNRLRVSCQKV 1301

  Fly  2172 VNQKWFDNVVLLFIALNCITLAMERPNIPPSSTERLFLATANYVFTVVFTVEMFIKVVATGMFYG 2236
            :..|.||:|||:||.|||||:|:|||:|.|.||||.||:.:||:||.:|.|||.:||||.|:.:|
  Rat  1302 IAHKMFDHVVLVFIFLNCITIALERPDIDPGSTERAFLSVSNYIFTAIFVVEMMVKVVALGLLWG 1366

  Fly  2237 HDAYFTSGWNIMDGSLVTISIIDLLMSLISESSPRIFGILRVFRLLRSLRPLRVINRAPGLKLVV 2301
            ..||..|.||::||.||.:|::|:::::.|....:|.|:|||.||||:|||||||:|||||||||
  Rat  1367 EHAYLQSSWNVLDGLLVLVSLVDIIVAMASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVV 1431

  Fly  2302 QTLLSSLRPIGNIVLICCTFFIIFGILGVQLFKGTFYYCEGENIKGVRNADECRRIPGNVWTNRK 2366
            :||:||||||||||||||.|||||||||||||||.||||||.:.:.:....||...... |..||
  Rat  1432 ETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGTDTRNITTKAECHAAHYR-WVRRK 1495

  Fly  2367 YNFDDLGKALMSLFVLSSRDGWVNIMYTGLDAVGVDQQPIVNYNEWRLLYFIAFILLVGFFVLNM 2431
            ||||:||:||||||||||:||||||||.||||||:||||:.|:|.|.|||||:|:|:|.||||||
  Rat  1496 YNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGIDQQPVQNHNPWMLLYFISFLLIVSFFVLNM 1560

  Fly  2432 FVGVVVENFHRCREEQEKEEKIRRAAKRALQMEKKRR------RMHEPPYYTNYSPTRMFVHNVV 2490
            ||||||||||:||:.||.||..||..||..::|::||      .....|||.:||.||..:|::.
  Rat  1561 FVGVVVENFHKCRQHQEAEEARRREEKRLRRLERRRRSTFPNPEAQRRPYYADYSHTRRSIHSLC 1625

  Fly  2491 TSKYFDLAIAAVIGLNVVTMAMEYYKMPSGLKYALKIFNYFFTAVFILEANMKLVALGWKLYLKD 2555
            ||.|.||.|..:|.|||:||:||:|..|..|..|||..||.||.||:.||.:||||.|::.:.||
  Rat  1626 TSHYLDLFITFIICLNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKD 1690

  Fly  2556 RWNQLDVGIVLLSIVGIVLEELETNTHQIIPINPTIIRVMRVLRIARVLKLLKMANGIRALLDTV 2620
            ||||||:.||||||:||.|||:|.|.  .:||||||||:||||||||||||||||.|:|||||||
  Rat  1691 RWNQLDLAIVLLSIMGIALEEIEMNA--ALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTV 1753

  Fly  2621 MQALPQVGNLGLLFFLLFFIFAALGVELFGRLECSDEIPCQGLGEHAHFANFGMAFLTLFRVATG 2685
            :|||||||||||||.|||||:||||||||||||||::.||:||..||.|.||||||||||||:||
  Rat  1754 VQALPQVGNLGLLFMLLFFIYAALGVELFGRLECSEDNPCEGLSRHATFTNFGMAFLTLFRVSTG 1818

  Fly  2686 DNWNGIMKDTLRDNCDDAADCVR--NCCVS--SVIAPIFFVIFVLMAQFVLVNVVVAVLMKHLEE 2746
            ||||||||||||       :|.|  ..|:|  ..::|::||.|||:|||||||||||||||||||
  Rat  1819 DNWNGIMKDTLR-------ECTREDKHCLSYLPALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEE 1876

  Fly  2747 SHKQMEDELDMEVELERELVREQEFAQEQKLCQQLAEAQSKAAAPPRP-LAKVKSLPKNFIYSTP 2810
            |:|:..::.:|:.|:|.|:. :...||.....|..:..:|:...|..| |..|:.:..:.:.|.|
  Rat  1877 SNKEAREDAEMDAEIELEMA-QGSTAQPPPTAQPPSPQESQGTQPDTPNLLVVRKVSVSRMLSLP 1940

  Fly  2811 SLDKKF----PAVSGVNNPSLTSSAATNLNQVATAGSGGAAPGA---VPAGSGAGPRRQTVQYFQ 2868
            :....|    ||.:..::|.......|....|.:|.|....|.|   ||: :.:.|.|.:.....
  Rat  1941 NDSYMFRPVAPAAAPHSHPLQEVEMETYTGPVTSAHSPPLEPRASFQVPS-AASSPARVSDPLCA 2004

  Fly  2869 QPPQSMLGGLSLA-------------------EMGGTLTPQ-------------ALGARLGEP-- 2899
            ..|:.....|||:                   ::||...|.             :.||....|
  Rat  2005 LSPRGTPRSLSLSRILCRQEAMHSESLEGKVDDVGGDSIPDYTEPAENMSTSQASTGAPRSPPCS 2069

  Fly  2900 ------------------------FGGGGGNKSGPRRQSYWQI---------------------N 2919
                                    .||.....:.|..:....|                     :
  Rat  2070 PRPASVRTRKHTFGQRCISSRPPTLGGDEAEAADPADEEVSHITSSAHPWPATEPHSPEASPTAS 2134

  Fly  2920 PIRKRGVLSKER------SLDEQAI--RRRNLEAKRTSCDSLPWG------GD----------AL 2960
            |:  :|.:...|      |:|.|:.  :....:|:|.|...|..|      |:          ||
  Rat  2135 PV--KGTMGSGRDPRRFCSVDAQSFLDKPGRPDAQRWSSVELDNGESHLESGEVRGRASELEPAL 2197

  Fly  2961 DCRRG--------TIFESLESDG-----GGVGGG-----------------------GSGGGGGG 2989
            ..||.        :|....|.:|     ...||.                       |.|.||..
  Rat  2198 GSRRKKKMSPPCISIEPPTEDEGSSRPPAAEGGNTTLRRRTPSCEAALHRDCPEPTEGPGTGGDP 2262

  Fly  2990 LGGGVSYDLRSVRSADV----------------GHSEMDGDVSLSVVSALVPSVTTPLPPPLSLP 3038
            :..|..:...|.|:..:                |...:|.|.|:           ||.|...||.
  Rat  2263 VAKGERWGQASCRAEHLTVPNFAFEPLDMGGPGGDCFLDSDQSV-----------TPEPRVSSLG 2316

  Fly  3039 IVTPTSTPTPLQLPMPMPMPMAHPPPRRPFGWSQSVDQGCLRSNLLLSVPRSMPPRSRSGST 3100
            .:.|....|.|.:|.               |.....:||     |.|:||::  |..:.|||
  Rat  2317 AIVPLILETELSMPS---------------GDCPEKEQG-----LYLTVPQT--PLKKPGST 2356

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ca-alpha1T	NP_001259267.1	Ion_trans	332..636	CDD:278921	183/318 (58%)
		Ion_trans	1261..1495	CDD:278921	149/233 (64%)
		Ion_trans	2192..2448	CDD:278921	168/255 (66%)
		Ion_trans	2510..2728	CDD:278921	150/221 (68%)
Cacna1h	XP_008765754.2	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	438	1.000	Domainoid score	I538
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1649	1.000	Inparanoid score	I73
OMA	1	1.010	-	-		QHG59758
OrthoDB	1	1.010	-	-		D172471at2759
OrthoFinder	1	1.000	-	-		FOG0001656
OrthoInspector	1	1.000	-	-		otm46010
orthoMCL	1	0.900	-	-		OOG6_102692
Panther	1	1.100	-	-	LDO	PTHR10037
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1056
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.880