DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1T and Scn4a

DIOPT Version :9

Sequence 1:NP_001259267.1 Gene:Ca-alpha1T / 31550 FlyBaseID:FBgn0264386 Length:3218 Species:Drosophila melanogaster
Sequence 2:NP_573462.2 Gene:Scn4a / 110880 MGIID:98250 Length:1841 Species:Mus musculus


Alignment Length:2908 Identity:548/2908 - (18%)
Similarity:899/2908 - (30%) Gaps:1292/2908 - (44%)


- Green bases have known domain annotations that are detailed below.


  Fly   284 LTQYTRPRNWCLMLITNPWFERVSILVILLNCITLGMYQPCVDDACVTNRCKILQIFDDIIFAF- 347
            |:.::..|...:.::.:..|....::.||.||:.:.|..|       .:..|      |:.:.| 
Mouse   114 LSPFSIVRRVAIKVLIHALFSMFIMITILTNCVFMTMSNP-------PSWSK------DVEYTFT 165

  Fly   348 --FALEMTIKMVAMGICGKN-TYLADSWNRLDFFIVLAGLLEYVMHVENL-NLTAIRTIRVLRPL 408
              :..|..|||:|.|.|..: |:|.|.||.|||.::   .:.||....:| |::|:||.||||.|
Mouse   166 GIYTFESLIKMLARGFCIDDFTFLRDPWNWLDFSVI---TMAYVTEFVDLGNISALRTFRVLRAL 227

  Fly   409 RAINRIPSMRILVMLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWEGILRQRC------------ 461
            :.|..||.::.:|..|:.::..|.:|::|..|...:|.::|:||:.|.|||:|            
Mouse   228 KTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMGNLRQKCVRWPPPMNDTNT 292

  Fly   462 ------------------------SLMRTEGMVYPLTVP-EVYRVRVRVNSLSQYYEFSKDQD-Y 500
                                    :....|..|...|.. |.|     :|....:|......| .
Mouse   293 TWYGNDTWYGNDTWYGNDTWYGNDTWNSQESWVSNSTFDWEAY-----INDEGNFYFLEGSNDAL 352

  Fly   501 ICSTPNDSGMHLCGNFPPYRIGSLVCNEEAKLFDFNEPTNTSCVNWNQYYTTCKQSGENPFQGTI 565
            :|...:|:| |              |.|..:                     |.::|.||..|..
Mouse   353 LCGNSSDAG-H--------------CPEGYE---------------------CMKAGRNPNYGYT 381

  Fly   566 SFDNIGMAWVAIFLVISLEGWTDIMYYVQDAHSFWDWIYFVLLIVIGSFFMINLCLVVIATQFSE 630
            |:|....|::|:|.:::.:.|.::......|......|:||::|.:|||::|||.|.|:|..::|
Mouse   382 SYDTFSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMIFFVVIIFLGSFYLINLILAVVAMAYAE 446

  Fly   631 TKKREMERMRQERARYTSTSTLASSTNNSEPATCYAEIVKYIAHLWRRFKRRMLKKYRLYKYQRQ 695
            ..:                :|||......|..                  ::||:|::       
Mouse   447 QNE----------------ATLAEDQEKEEEF------------------QQMLEKFK------- 470

  Fly   696 QRKEGLLPNADNLTFSPSRIKCHHPKCPKYSNRKPSSIQDQMITVMVPLNSASNNINNNNNNNSN 760
                                                                             
Mouse   471 ----------------------------------------------------------------- 470

  Fly   761 SSNHNGSGNHTAAGGGNNNNNNNNNNAASCTTVALVNGINGSAASVTMSSAHHQQHQLLQHQQQQ 825
                                                                            :
Mouse   471 ----------------------------------------------------------------K 471

  Fly   826 HQNQQQQQQQQQHSSSDNTEQSLAPDGLPRSSSLKKSTAHHQLKPEGSAAEQKTILLKFPQQMID 890
            ||.:.::.:..|  :.:..|::   ||.|.          |.....||               :|
Mouse   472 HQEELEKAKAAQ--ALEGGEEA---DGDPT----------HSKDCNGS---------------LD 506

  Fly   891 SEQLILQLGNLGKSHPCTSGFLSPPTSASRRPSVMFNEYVLLHTPPALNADPATAGTTTTVAPTV 955
                             |||...||     |||                                
Mouse   507 -----------------TSGEKGPP-----RPS-------------------------------- 517

  Fly   956 ATVAGTAAAAAAAAATGSGSGNNNHQNGGASGGAGTGGTTEKSNIFSTEKMTQAGDGSIWQVNLP 1020
                                                                             
Mouse   518 ----------------------------------------------------------------- 517

  Fly  1021 QTIGTIANPYADCS-ELGIHDAMTCQELLAFSVAFSAALPTGQSTLESFYTSLARCDPHTAEALR 1084
                        || |..|.|||  :||                                     
Mouse   518 ------------CSAESAISDAM--EEL------------------------------------- 531

  Fly  1085 AHHKPRSVPTGQNQTTPGAEGATVMVASTAGDTGQTLQPSTVSAVVGGTIDSHAANHRRKEHHQQ 1149
                                                                       :|.|| 
Mouse   532 -----------------------------------------------------------EEAHQ- 536

  Fly  1150 SHHHHNNNNTTSHSRNYRSRQGQGNSRMREPRAPTGNYMEDYACCYDLYQNALSPLDERPRQRSP 1214
                                                                             
Mouse   537 ----------------------------------------------------------------- 536

  Fly  1215 TTRCLISVYRCMSRVCSW--------IRRYIRRLVEHKYFQQGILLAILINTLSMGIEYHNQPPE 1271
              :|....|:|..:|..|        .:..|..:|...:...||.:.|::|||.|.:|::.....
Mouse   537 --KCPPWWYKCAHKVLIWNCCAPWVKFKHIILLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEH 599

  Fly  1272 LTAIVETSNVVFSGIFAVEMLLKVVAEGPFRYIANGFNVFDGIIVILSAIEICQTFMGNGTGGGG 1336
            ...::...|:||:|||..||:||::|..|:.|...|:|:||..||.||.:|:....:        
Mouse   600 FDNVLSVGNLVFTGIFTAEMVLKLIAMDPYEYFQQGWNIFDSFIVTLSLVELGLANV-------- 656

  Fly  1337 SGLSVLRTFRLLRILKLVRFMPNLRRQLFVMLRTMDNVAVFFSLLVLFIFIFSILGMYLFGGKFC 1401
            .||||||:|||||:.||.:..|.|...:.::..::..:.....:|.:.:|||:::||.|||..: 
Mouse   657 QGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSY- 720

  Fly  1402 KFLDESGLERECTCPEIISRHPQCECDRKHFNNILWATVTVFQILTQEDWNVVLFNGMEKTSHWA 1466
                     :||.| :|.|   .|...|.|.::...:.:.||:||..| |...:::.||......
Mouse   721 ---------KECVC-KIAS---DCSLPRWHMHDFFHSFLIVFRILCGE-WIETMWDCMEVAGQAM 771

  Fly  1467 AL-YFVALMTFGNYVLFNLLVAILVEGFSSERNERREREQRELVKKLREETLAENYSDGMYDESR 1530
            .| .|:.:|..||.|:.||.:|:|:..||                                    
Mouse   772 CLTVFLMVMVIGNLVVLNLFLALLLSSFS------------------------------------ 800

  Fly  1531 SEADSSTTNDSYYEVRN--------RWRSAEDVRKLQDSVELIIEAKSNMHRQRLLQPTHD--YQ 1585
              |||...:|...|:.|        :|..|                   ..:..||...|.  ..
Mouse   801 --ADSLAASDEDGEMNNLQIAIGRIKWGIA-------------------FAKTFLLGLLHGKILS 844

  Fly  1586 INELPASSAAPSASGTSGASAPGDRERDRDRDRDRERDRDRDRERDREAGGGGKEEGAQHAKPRG 1650
            :.::..|...|..:|.:|.|.|.|.:::                                ..|..
Mouse   845 LKDIMLSLGEPGGAGENGESPPEDEKKE--------------------------------PPPED 877

  Fly  1651 GLKKTYSIKERRSEAPRLSKIRLARDPPIITTTAATPQDSPSTTLEPGMSFRQWGDMEPPSPPSP 1715
            |.|:                   .:|..|:.....|  |.|.:::|                   
Mouse   878 GNKE-------------------LKDNHILNHVGLT--DGPRSSIE------------------- 902

  Fly  1716 SLLRPPNIFTGGQRSLDEGIPSIDLIPPSPVLSHKPLNILNASQLGVGMGGGVPSTAGSSSSMHS 1780
                                           :.|  ||.:|...|                    
Mouse   903 -------------------------------MDH--LNFINNPYL-------------------- 914

  Fly  1781 VIIDDISKSSSSTAAATPIYVPTISSTADAQSQSHSLNDVSVGSSPGGEIPATGMSRNANTGAST 1845
                             .|:||..|..:|.:..:....|                         |
Mouse   915 -----------------TIHVPIASEESDLEMPTEEETD-------------------------T 937

  Fly  1846 SGSSSSERLPLAPPPQQGSFKQRLRRGSSKKRRASALALATDDNPARRTLDNQARRTQDEEEEQQ 1910
            .......:.||.|          |..|:      |::....|..|           .:::.|||.
Mouse   938 FSEPEDIKKPLQP----------LYDGN------SSVCSTADYKP-----------PEEDPEEQA 975

  Fly  1911 QLNNGGD--NSCLLRNSNAVVSGSSSGTKETNRLSPQNSIRRLSNTLSIGSGPVGSRRASACIFN 1973
            :.|..|:  ..|.                                             ..||:..
Mouse   976 EENPEGELPEECF---------------------------------------------TEACVKR 995

  Fly  1974 SQ-VYQNLNQPPKLRPGSGQRRMSSIELAFSKTSHLNLHNLEANRKSLSYTNSKMDLDKWNKSYG 2037
            .. :|.:::|                                                       
Mouse   996 CPCLYVDISQ------------------------------------------------------- 1005

  Fly  2038 NLNEPDNMLQQYMEARDKRKNSISHYNLKKRLEEKELQQLQQLHQQQLLQQRQDSFSSTTQQQQQ 2102
                                                                             
Mouse  1006 ----------------------------------------------------------------- 1005

  Fly  2103 QLQQHRLSKDQQQLAMQPHSMVPGGGERYSKLKMLIEQLTPKHFTTEREDYSLYIFPEDNRFRQI 2167
                                   |.|:.:..|                              |:.
Mouse  1006 -----------------------GRGKMWWTL------------------------------RRA 1017

  Fly  2168 CTWFVNQKWFDNVVLLFIALNCITLAMERPNIPPSSTERLFLATANYVFTVVFTVEMFIKVVATG 2232
            |...|...||:..::..|.|:...||.|...|......:..|..|:.|||.:|.:||.:|.||  
Mouse  1018 CFKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRRVIQTILEYADKVFTYIFILEMLLKWVA-- 1080

  Fly  2233 MFYGHDAYFTSGWNIMDGSLVTISIIDLLMSLISESSPRIFGILRVFRLLRSLRPLRVINRAPGL 2297
              ||...|||:.|..:|..:|.:|||.|:.:.:..|.   .|.::..|.||:|||||.::|..|:
Mouse  1081 --YGFKVYFTNAWCWLDFLIVDVSIISLVANWLGYSE---LGPIKSLRTLRALRPLRALSRFEGM 1140

  Fly  2298 KLVVQTLLSSLRPIGNIVLICCTFFIIFGILGVQLFKGTFYYC------EGENIKGVRNADECRR 2356
            ::||..||.::..|.|::|:|..|::||.|:||.||.|.||||      |..:|..|.|..||..
Mouse  1141 RVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYYCINTTTSERFDISVVNNKSECES 1205

  Fly  2357 I--PGNV-WTNRKYNFDDLGKALMSLFVLSSRDGWVNIMYTGLDAVGVDQQPIVNYNEWRLLYFI 2418
            :  .|.| |.|.|.|:|::|...:||..:::..||::|||..:|:...::||....|.:..|||:
Mouse  1206 LMYTGQVRWMNVKVNYDNVGLGYLSLLQVATFKGWMDIMYAAVDSREKEEQPDYEVNLYMYLYFV 1270

  Fly  2419 AFILLVGFFVLNMFVGVVVENFHRCREE--------QEKEEKIRRAAKRALQMEKKRRRMHEPPY 2475
            .||:...||.||:|:||:::||::.:::        .|:::|...|.|: |..:|.::.:..|  
Mouse  1271 IFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGKDIFMTEEQKKYYNAMKK-LGSKKPQKPIPRP-- 1332

  Fly  2476 YTNYSPTRMFVHNVVTSKYFDLAIAAVIGLNVVTMAMEYYKMPSGLKY-ALKIFNYFFTAVFILE 2539
               .:..:..|::.||.:.||::|..:|.||:|||.:|.... |.||. .|...|..|..||..|
Mouse  1333 ---QNKIQGMVYDFVTKQVFDISIMILICLNMVTMMVETDDQ-SQLKVDILYNINMVFIIVFTGE 1393

  Fly  2540 ANMKLVALGWKLYLKDRWNQLDVGIVLLSIVGIVLEELETNTHQIIPINPTIIRVMRVLRIARVL 2604
            ..:|:.||. ..|....||..|..:|:|||||:.|.:|    .|...::||:.||:|:.||.|||
Mouse  1394 CVLKMFALR-HYYFTIGWNIFDFVVVILSIVGLALSDL----IQKYFVSPTLFRVIRLARIGRVL 1453

  Fly  2605 KLLKMANGIRALLDTVMQALPQVGNLGLLFFLLFFIFAALGVELFGRLECSDEIPCQGLGEHAHF 2669
            :|::.|.|||.||..:|.:||.:.|:|||.||:.||::..|:..|..::..     .|:.:..:|
Mouse  1454 RLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSNFAYVKKE-----SGIDDMFNF 1513

  Fly  2670 ANFGMAFLTLFRVATGDNWNGIMKDTLRD---NCDDAAD----CVRNCCVSSVIAPIFFVIFVLM 2727
            ..||.:.:.||.:.|...|:|::...|..   :||...:    .::..|.:..|...||..::::
Mouse  1514 ETFGNSIICLFEITTSAGWDGLLNPILNSGPPDCDPTLENPGTNIKGDCGNPSIGICFFCSYIII 1578

  Fly  2728 AQFVLVNVVVAVLMKHL----EESHKQM-EDELDMEVEL-ERELVREQEFAQEQKLCQQLAEAQS 2786
            :..::||:.:|:::::.    |||.:.: ||:.:|..|. |:......:|....:|...:...|.
Mouse  1579 SFLIVVNMYIAIILENFNVATEESSEPLCEDDFEMFYETWEKFDPDATQFIDYSRLSDFVDTLQE 1643

  Fly  2787 --KAAAPPRPLAKVKSLPKNFIYSTPSLDKKFPAVSGVNNPSLTSSAATNLNQVATAGSGGAAPG 2849
              |.|.|    .|:|.:         :||  .|.|.|.....|                      
Mouse  1644 PLKIAKP----NKIKLI---------TLD--LPMVPGDKIHCL---------------------- 1671

  Fly  2850 AVPAGSGAGPRRQTVQYFQQPPQSMLGGLSLAEMGGTLTPQALGARLGEPFGGGGGNKSGPRRQS 2914
                                   .:|..|:...:|.:....||...:.|.|     ..:.|.:.|
Mouse  1672 -----------------------DILFALTKEVLGDSGEMDALKQTMEEKF-----MAANPSKVS 1708

  Fly  2915 YWQINPIRKRG-----VLSKERSLDEQAIRRRNLEAKRTSCDSLPWGGDALDCRRGTIFESL--- 2971
            |..|....||.     .:..:|:.....::|...:|......|....||....:.|.:..::   
Mouse  1709 YEPITTTLKRKQEEVCAIKIQRAYRRHLLQRSVKQASYMYRHSQEGNGDGAPEKEGLLANTMNKM 1773

  Fly  2972 ---ESDGGGVGGGGSGGGGGGLGGGVSYDLRSVRSADVGHSEMDGDVSLSVVSALVPSVTTPLPP 3033
               |.:..||                         ...|..|.|.              |....|
Mouse  1774 YGSEKEDNGV-------------------------QSQGEKEKDS--------------TEDAGP 1799

  Fly  3034 PLSLPIVTPTSTPTPLQLPMPMPMPMAHPPPRRPFGWSQSVDQGCLRS 3081
              :..:..|:|:.|.|..|.|.|.|.:.||.      .|:|..|...|
Mouse  1800 --TTEVTAPSSSDTALTPPPPSPPPPSSPPQ------GQTVRPGVKES 1839

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1TNP_001259267.1 Ion_trans 332..636 CDD:278921 88/346 (25%)
Ion_trans 1261..1495 CDD:278921 75/234 (32%)
Ion_trans 2192..2448 CDD:278921 99/272 (36%)
Ion_trans 2510..2728 CDD:278921 73/225 (32%)
Scn4aNP_573462.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 32..63
I. /evidence=ECO:0000305 113..448 97/390 (25%)
Ion_trans 130..451 CDD:395416 95/393 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 484..522 18/196 (9%)
II. /evidence=ECO:0000305 554..826 90/332 (27%)
Ion_trans 571..784 CDD:395416 73/235 (31%)
Na_trans_assoc 810..1020 CDD:399489 58/640 (9%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 854..896 12/94 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 925..983 16/109 (15%)
III. /evidence=ECO:0000305 1007..1320 112/350 (32%)
Ion_trans 1024..1298 CDD:395416 103/280 (37%)
Na_channel_gate 1290..1342 CDD:240441 10/57 (18%)
Important for rapid channel inactivation. /evidence=ECO:0000250|UniProtKB:P15390 1304..1306 0/1 (0%)
IV. /evidence=ECO:0000305 1329..1627 96/313 (31%)
Ion_trans 1347..1603 CDD:395416 86/266 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1776..1841 22/111 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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