Protein Alignment Ca-alpha1T and cacna1h

DIOPT Version :9

• Sequence 1: NP_001259267.1
• Gene: Ca-alpha1T / 31550
• FlyBaseID: FBgn0264386
• Length: 3218
• Species: Drosophila melanogaster
• Sequence 2: XP_031748783.1
• Gene: cacna1h / 100494894
• XenbaseID: XB-GENE-6042121
• Length: 2460
• Species: Xenopus tropicalis
• Alignment Length: 3056
• Identity: 1087/3056 - (35%)
• Similarity: 1410/3056 - (46%)
• Gaps: 955/3056 - (31%)

  Fly   232 GGAVSSSTGSSCNGSCSSDDGDSSHTSSSSSSSSSGEPNLPYPGFPEISIRALTQYTRPRNWCLM 296
            |.|..|:.||..:|      |.|.........|..|| .:|||.........|:|.||||||||.
 Frog    38 GNAEKSALGSLGSG------GSSGRGREQGMGSEEGE-QVPYPALAPTVFFCLSQTTRPRNWCLR 95

  Fly   297 LITNPWFERVSILVILLNCITLGMYQPCVDDACVTNRCKILQIFDDIIFAFFALEMTIKMVAMGI 361
            |:.|||||.||:|||||||:||||:|||.|..|::.||.||:.||..||||||:||.|||||:||
 Frog    96 LVCNPWFEHVSMLVILLNCVTLGMFQPCEDTNCMSERCNILEAFDGFIFAFFAVEMVIKMVALGI 160

  Fly   362 CGKNTYLADSWNRLDFFIVLAGLLEYVMHVENLNLTAIRTIRVLRPLRAINRIPSMRILVMLLLD 426
            .|:..||.|:||.||||||:||:|||.:...|::|:||||:|||||||||||:|||||||.||||
 Frog   161 FGQKCYLGDTWNWLDFFIVMAGMLEYSLDGHNVSLSAIRTVRVLRPLRAINRVPSMRILVTLLLD 225

  Fly   427 TLPMLGNVLLLCFFVFFIFGIIGVQLWEGILRQRCSLMRTEGMVYPLTVPEVYRVRVRVNSLSQY 491
            |||||||||||||||||||||:|||||.|:||.||.:.....|.|..|            .|..|
 Frog   226 TLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFMDTNFVMSYNFT------------PLRPY 278

  Fly   492 YEF--SKDQDYICSTPNDSGMHLCGNFPPYRIGSLVCNEEAKLFDFNEPTNTSCVNWNQYYTTCK 554
            |:.  ::|..||||:..|:||..|.:.||    .:.|: .....||  |:..||||.||||..||
 Frog   279 YQVDDAEDNPYICSSNRDNGMLKCQDIPP----KMDCS-HVYYSDF--PSRNSCVNINQYYNVCK 336

  Fly   555 QSGENPFQGTISFDNIGMAWVAIFLVISLEGWTDIMYYVQDAHSFWDWIYFVLLIVIGSFFMINL 619
            ....||.:|.|:|||||.||:|||.||:||||.||||||.|||||:::|||:|||::||||||||
 Frog   337 PGEFNPHKGAINFDNIGYAWIAIFQVITLEGWVDIMYYVMDAHSFYNFIYFILLIIVGSFFMINL 401

  Fly   620 CLVVIATQFSETKKREMERMRQERARYTST-STLASSTNNSEPATCYAEIVKYIAHLWRRFKRRM 683
            |||||||||||||:||.:.|:::||||.|. ||:||.   |||.:||.|::|||.|::|:.|||.
 Frog   402 CLVVIATQFSETKQRENQLMQEQRARYLSNDSTIASF---SEPGSCYEELLKYICHIFRKVKRRT 463

  Fly   684 LKKYRLYKYQRQQRKEGLLPNADNLTFSPSRIKCHHPKCPKYSNRKPSSIQDQMITVMVPLNSAS 748
            |   |||...:.:|::.:.||
 Frog   464 L---RLYNNWQNKRRKKVQPN-------------------------------------------- 481

  Fly   749 NNINNNNNNNSNSSNHNGSGNHTAAGGGNNNNNNNNNNAASCTTVALVNGINGSAASVTMSSAHH 813
                         ||.|..|.|                 ..|..              .::|.||
 Frog   482 -------------SNTNSQGRH-----------------RKCKR--------------RITSIHH 502

  Fly   814 QQHQLLQHQQQQHQNQQQQQQQQQHSSSDNTEQSLAPDGLPRSSSLKKSTAHHQLKPEGSAAEQK 878
                |:.|....|.:       ..|.|:.      :|.| ||||            ||....|.|
 Frog   503 ----LIHHHHHHHHH-------HYHISNG------SPRG-PRSS------------PEICDVEMK 537

  Fly   879 TILLKFPQQMIDSEQLILQLGNLGKSHPCTSGFLSPPTSASRRPSVMFNEYV--LLHTPPALNAD 941
            .        |....||.|                 ||.|.|.:.....:|.|  :.|....|.|.
 Frog   538 I--------MKPKNQLRL-----------------PPASPSLQSMSPNSEAVHSIYHADCHLEAP 577

  Fly   942 PATAGTTTTVAPTVATVAGTAAAAAAAAATGSGSGNNNHQNGGASGGAGTGGTTEKSNIFSTEKM 1006
            ...:..::..:..:...||.                 ||.|
 Frog   578 QRKSSKSSNASSNIKLNAGL-----------------NHSN------------------------ 601

  Fly  1007 TQAGDGSIWQVNLPQTIGTIANPYADCS-ELGIHDAMTCQELLAFSVAFSAALPTGQSTLESFYT 1070
                      :|.|..:.:.||..:..: ..|..:......||:..|:..|         :||..
 Frog   602 ----------MNYPTIMPSQANKTSPATLPKGKRNGSNAVSLLSSPVSMKA---------DSFGK 647

  Fly  1071 SLARCDPH----TAEALRAHHKPRSVPTGQNQTTPGAEGATVMVASTAGDTGQTLQPSTVSAVVG 1131
            :......|    ::..|.....|.|:|:.                          |||.:...:.
 Frog   648 TNHLVGEHGLCRSSSKLSGLSVPCSLPSP--------------------------QPSPLLCEIQ 686

  Fly  1132 GTIDSHAAN---HRRKEHHQQSHHHHNNNNTTSHSRNYRSRQGQGNSRMREPRAPTGNYMEDYAC 1193
            ..  .:.||   :...|.........::|.....:::.  |:|....::::.|
 Frog   687 NC--PYCANLLENPDLELSDSESCESDSNGVYEFTQDL--RRGDQRDQVQKGR------------ 735

  Fly  1194 CYDLYQNALSPLDERPRQRSPTTRCLISVYRCMSRVCSW----IRRYIRRLVEHKYFQQGILLAI 1254
                      .|..:|::.:       .||      ..|    :|  ::|:|:.|||.:||::||
 Frog   736 ----------KLKTKPKEAN-------KVY------LLWEEFTVR--LKRIVDSKYFNRGIMIAI 775

  Fly  1255 LINTLSMGIEYHNQPPELTAIVETSNVVFSGIFAVEMLLKVVAEGPFRYIANGFNVFDGIIVILS 1319
            ||||||||||||.||.|||..:|.||:||:.:||:|||||::|.|.|:||.|.:|:||||||::|
 Frog   776 LINTLSMGIEYHEQPEELTNALEISNIVFTSMFALEMLLKLLAFGIFQYIKNPYNIFDGIIVVIS 840

  Fly  1320 AIEICQTFMGNGTGGGGSGLSVLRTFRLLRILKLVRFMPNLRRQLFVMLRTMDNVAVFFSLLVLF 1384
            ..||    :|...|    ||||||||||||:||||||||.|||||.|:::||||||.|..||:||
 Frog   841 VWEI----IGQSDG----GLSVLRTFRLLRVLKLVRFMPALRRQLVVLVKTMDNVATFCMLLMLF 897

  Fly  1385 IFIFSILGMYLFGGKFCKFLDESGLERECTCPEIISRHPQCECDRKHFNNILWATVTVFQILTQE 1449
            |||||||||:|||.||....|..         |.:.       |||:|:::|||.||||||||||
 Frog   898 IFIFSILGMHLFGCKFTWTADTG---------ETVK-------DRKNFDSLLWAIVTVFQILTQE 946

  Fly  1450 DWNVVLFNGMEKTSHWAALYFVALMTFGNYVLFNLLVAILVEGFSSERNERREREQRELVKKLRE 1514
            |||:||:|||..||.|||||||||||||||||||||||||||||.:|.:..|...:
 Frog   947 DWNMVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILVEGFQAEGDATRSDTE--------- 1002

  Fly  1515 ETLAENYSDGMYDESRSEADSSTTNDSYYEVRNRWRSAEDVRKLQDSVELIIEAKSNMHRQRLLQ 1579
                |:.:.|.:|                         ||:.||:
 Frog  1003 ----EDKASGNFD-------------------------EDLEKLK-------------------- 1018

  Fly  1580 PTHDYQINELPASSAAPSASGTSGASAPGDRERDRDRDRDRERDRDRDRERDREAGGGGKEEGAQ 1644
               :.:..||...|.|.:.:|
 Frog  1019 ---ELRAAELKMYSLAVTPNG-------------------------------------------- 1036

  Fly  1645 HAKPRGGLKKTYSIKERRSEAPRLSKIRLARDPPIITTTAATPQDSPSTTLEPGM-SFRQWGDME 1708
            |..||..:                       .||||..|||||..:|.::  |.| |...:||
 Frog  1037 HLDPRSSM-----------------------PPPIIMRTAATPMPTPKSS--PCMDSSHPFGD-- 1074

  Fly  1709 PPSPPSPSLLRPPNIFTGGQRSLDEGIPSIDLIPPSPVLSHKPLNILNASQLGVGMGGGVPSTAG 1773
                                                                         |...
 Frog  1075 -------------------------------------------------------------SRRE 1078

  Fly  1774 SSSSMHSVIIDDISKSSSSTAAATPIYVPTISSTADAQSQSHSLNDVSVGSSPGGEIPATGMSRN 1838
            ||.|:...|:|..|.:|             :.||                       |.|.....
 Frog  1079 SSVSIDPSIVDQKSLAS-------------LRST-----------------------PCTPWGTY 1107

  Fly  1839 ANTGASTSGSSSSERLPLAPPPQQGSFKQRLRRGSSKKRRASALALATDD-------NPARRTLD 1896
            :|.|:..|..:|..|.|......|...::.|..|..|.        :|||       :||.|.
 Frog  1108 SNWGSRRSSWNSLGRAPSIKKKSQSGERESLLSGEGKG--------STDDDSDDCKSSPAARV-- 1162

  Fly  1897 NQARRTQDEEEEQQQLNNGGDNSCLLRNSNAVVSGSSSGTKETNRLSPQNSIRRLSNTLSIGSGP 1961
                                                              |:.|.:.:|
 Frog  1163 --------------------------------------------------SLHRRAGSL------ 1171

  Fly  1962 VGSRRASACIFNSQVYQNLNQPPKLRPGSGQRRMSSIELAFSKTSHLNLHNLEANRKSLSYTNSK 2026
              ..|.|..|      .:..|.|.||                       |:|..:..::
 Frog  1172 --DTRGSLDI------PDFLQVPTLR-----------------------HSLSVSPLAM------ 1199

  Fly  2027 MDLDKWNKSYGNLNEPDNMLQQYMEARDKRKNSISHYNLKKRLEEKELQQLQQLHQQQLLQQRQD 2091
                              :...|.:...|..:..|  :|..|:|:         |::..|:...|
 Frog  1200 ------------------VPSDYQDCNGKMMHVPS--DLFVRVEK---------HREDPLEYEDD 1235

  Fly  2092 SFSSTTQQQQQQLQQHRLSKDQQQLAMQPHSMVPGGGERYS-KLKMLIEQLTPKHFTTEREDYSL 2155
            ...|                                   |. :::.::|...|....| .||:||
 Frog  1236 IEDS-----------------------------------YCFRIRKMLEPYKPTWCKT-HEDWSL 1264

  Fly  2156 YIFPEDNRFRQICTWFVNQKWFDNVVLLFIALNCITLAMERPNIPPSSTERLFLATANYVFTVVF 2220
            |:|...|:||.:|...:..|.||:|||:||.|||||:|:|||:|.|:|.||:||:.:||:||.:|
 Frog  1265 YMFSPQNQFRMMCQKVIAHKMFDHVVLVFIFLNCITIALERPDIDPNSLERIFLSVSNYIFTAIF 1329

  Fly  2221 TVEMFIKVVATGMFYGHDAYFTSGWNIMDGSLVTISIIDLLMSLISESSPRIFGILRVFRLLRSL 2285
            .:||.|||||.|...|.:.|..|.||::||.||.:||||:::||.|....:|.|:|||.||||:|
 Frog  1330 VLEMAIKVVALGFVSGENTYLQSSWNVLDGILVFVSIIDIVVSLASAGGAKILGVLRVLRLLRTL 1394

  Fly  2286 RPLRVINRAPGLKLVVQTLLSSLRPIGNIVLICCTFFIIFGILGVQLFKGTFYYCEGENIKGVRN 2350
            ||||||:|||||||||:||:||||||||||||||.|||||||||||||||.||||||...:.:.|
 Frog  1395 RPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGLETRNITN 1459

  Fly  2351 ADECRRIPGNVWTNRKYNFDDLGKALMSLFVLSSRDGWVNIMYTGLDAVGVDQQPIVNYNEWRLL 2415
            ..||.|.... |..||||||:||:||||||||||:||||||||.|||||..|.||:.|:|.|.||
 Frog  1460 RSECTRARYK-WVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVATDVQPVKNHNPWMLL 1523

  Fly  2416 YFIAFILLVGFFVLNMFVGVVVENFHRCREEQEKEEKIRRAAKRALQMEKKRRR----MHEP--- 2473
            |||:|:|:|.||||||||||||||||:||:.||.||..||..||..::|||||.    |.|.
 Frog  1524 YFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLEKKRRSKALYMSEAQRR 1588

  Fly  2474 PYYTNYSPTRMFVHNVVTSKYFDLAIAAVIGLNVVTMAMEYYKMPSGLKYALKIFNYFFTAVFIL 2538
            |||..|||.|:::|.:.||.|.||.|..:|.:||:||:||:|..|..|..|||..||.||.||:.
 Frog  1589 PYYAEYSPARLYIHTMCTSHYLDLFITCIICINVITMSMEHYNQPKSLDEALKYCNYVFTIVFVF 1653

  Fly  2539 EANMKLVALGWKLYLKDRWNQLDVGIVLLSIVGIVLEELETNTHQIIPINPTIIRVMRVLRIARV 2603
            ||..||||.|::.:.||||||||:.||||||:||.|||:|.|..  :||||||||:|||||||||
 Frog  1654 EALFKLVAFGFRRFFKDRWNQLDLAIVLLSIMGITLEEIEINAS--LPINPTIIRIMRVLRIARV 1716

  Fly  2604 LKLLKMANGIRALLDTVMQALPQVGNLGLLFFLLFFIFAALGVELFGRLECSDEIPCQGLGEHAH 2668
            |||||||.|:|||||||:|||||||||||||.|||||:|||||||||:|.|::|.||:||..||.
 Frog  1717 LKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCNEENPCEGLSRHAT 1781

  Fly  2669 FANFGMAFLTLFRVATGDNWNGIMKDTLRD-NCDDAADCVRNCCV-SSVIAPIFFVIFVLMAQFV 2731
            |.||||||||||||:||||||||||||||: |.||     :||.. ..||:|::||.|||:||||
 Frog  1782 FENFGMAFLTLFRVSTGDNWNGIMKDTLRECNSDD-----KNCLTYLPVISPVYFVTFVLIAQFV 1841

  Fly  2732 LVNVVVAVLMKHLEESHKQMEDELDMEVELERELVRE----------------QEFAQEQ----- 2775
            ||||||||||||||||:|:.:::.:|:.|:|.|:.|.                .|..|:.
 Frog  1842 LVNVVVAVLMKHLEESNKEAKEDAEMDAEIEMEMSRALTPISGGCTPASDGKGTEGGQDPLKGEL 1906

  Fly  2776 ------KLCQQ-----LAEAQSKAA---------------APPRP-------------------- 2794
                  .:||:     :.|:...||               |.|.|
 Frog  1907 LKQVGGAVCQENVTLVIPESMEGAALLNDAVPACSIYQQQALPLPLQPCVLGHEDGDFQRRDGSG 1971

  Fly  2795 ---LAKVKSLPKNFIYSTPSLDKKFPAVSGVNNPSLTSSAATNLNQVATAGSGGAAPGAVPAGSG 2856
               |..||.:..:.:.|.|:....|       .|.|.:.::..|.:|.|.....      |.||
 Frog  1972 SRNLLAVKKISVSRMLSLPNDSYMF-------RPVLPAKSSYPLQEVETTEDNS------PHGS- 2022

  Fly  2857 AGPRRQTVQYFQQPPQSMLGGLSLAEMGGTLTPQALGARLGEPFGGGGGNKSGPRRQSYWQINPI 2921
                  |.....||..:.    ||..:.....|||                |....|....:..|
 Frog  2023 ------TASLHSQPGDNN----SLLNIPVECQPQA----------------SVSNHQDSADLPKI 2061

  Fly  2922 RKRGVLSKERSLDEQAIRRRNLEAKRTSCDSLPWGGDALDCRRGTIFESLESDGGGVGGGGSGGG 2986
            ......|:..||: :::||:  ||.|  .||:..|||:.|
 Frog  2062 PPPHTSSRSPSLN-RSLRRQ--EAIR--MDSVDQGGDSKD------------------------- 2096

  Fly  2987 GGGLGGGVSYDLRSVRSADVGHSEMDGDVSLSVVSALVPSVTTPLPPPLSLPIVTPTSTPTPLQL 3051
                     .::.|..|..:|                .|||||.:|..|....|:...|
 Frog  2097 ---------LNVESTESLHLG----------------APSVTTLVPNLLCTLNVSLQGT------ 2130

  Fly  3052 PMPMPMPMAHPPPRRPFGWSQSVDQGCLRSNLLLSVPRSMPPRSRSGSTKQLFKQQALDEDADM- 3115
              |...|...|.||.         ...|..|.:.| ..|:|.|..|.|:.....::::.|.:|:
 Frog  2131 --PQSSPRLSPQPRH---------SSVLTHNHVYS-QHSIPSRPSSVSSGNSNPEESMFESSDLA 2183

  Fly  3116 DENSLLLPTAAGGGSGPG-----SVAVIASSSLDLPDQSGSSKQILPDIALGVSKSDSSDILRII 3175
            ||....:.::|....|..     ||:...|.|...|..|.|.|.....::|..|.....|:.:..
 Frog  2184 DEEVSHINSSAKDWRGSSNNRSHSVSPFISQSSSPPPLSPSLKNCNSTVSLAGSSGKDKDLKKFY 2248

  Fly  3176 S 3176
            |
 Frog  2249 S 2249

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ca-alpha1T	NP_001259267.1	Ion_trans	332..636	CDD:278921	187/305 (61%)
		Ion_trans	1261..1495	CDD:278921	150/233 (64%)
		Ion_trans	2192..2448	CDD:278921	170/255 (67%)
		Ion_trans	2510..2728	CDD:278921	151/219 (69%)
cacna1h	XP_031748783.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	417	1.000	Domainoid score	I647
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1574	1.000	Inparanoid score	I86
OMA	1	1.010	-	-		QHG59758
OrthoDB	1	1.010	-	-		D172471at2759
OrthoFinder	1	1.000	-	-		FOG0001656
OrthoInspector	1	1.000	-	-		otm49097
Panther	1	1.100	-	-	LDO	PTHR10037
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8566
SonicParanoid	1	1.000	-	-		X1056
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.110