DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1T and cacna1a

DIOPT Version :9

Sequence 1:NP_001259267.1 Gene:Ca-alpha1T / 31550 FlyBaseID:FBgn0264386 Length:3218 Species:Drosophila melanogaster
Sequence 2:XP_031755311.1 Gene:cacna1a / 100492135 XenbaseID:XB-GENE-1013831 Length:2302 Species:Xenopus tropicalis


Alignment Length:3216 Identity:651/3216 - (20%)
Similarity:1051/3216 - (32%) Gaps:1246/3216 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly   308 ILVILLNCITLGMYQ--PCVDDACVTNRCKILQIFDDIIFAFFALEMTIKMVAMGIC-GKNTYLA 369
            :..|:.|||.|.|.|  |..|...::.|   |...:......|..|..||::|:|.. .|.:||.
 Frog     3 LATIIANCIVLAMEQHLPVGDKTPMSER---LDDTEPYFIGIFCFETGIKIIALGFAFHKGSYLR 64

  Fly   370 DSWNRLDFFIVLAGLL-----EYVMHVENLNLTAIRTIRVLRPLRAINRIPSMRILVMLLLDTLP 429
            :.||.:||.:||:|::     |:       :|..:|.:||||||:.::.|||:::::..::..:.
 Frog    65 NGWNIMDFVVVLSGIVASTGPEF-------DLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMI 122

  Fly   430 MLGNVLLLCFFVFFIFGIIGVQLWEGILRQRCSLMRTEGMVYPLTVPEVYRVRVRVNSLSQYYEF 494
            .|..:.||.||...||.|||:..:.|.....|..|..|.:                         
 Frog   123 PLLQIGLLLFFAILIFAIIGLDFYIGKFHTSCYDMAGEDI------------------------- 162

  Fly   495 SKDQDYICSTPNDSGMHLCGNFPPYRIGSLVCNEEAKLFDFNEPTNTSCVN-WNQYYTTCKQSGE 558
              .::.:|.  |||....|                        |.||.|:: |           |
 Frog   163 --REEVLCG--NDSSSRRC------------------------PENTQCLSKW-----------E 188

  Fly   559 NPFQGTISFDNIGMAWVAIFLVISLEGWTDIMYYVQDAH-SFWDWIYFVLLIVIGSFFMINLCLV 622
            .|..|...||||..|.:.:|..|::||||||:||..|.. |.::|:||:.||:||||||:||.|.
 Frog   189 GPNNGITQFDNILFAILTVFQCITMEGWTDILYYSNDVFGSAFNWLYFIPLIIIGSFFMLNLVLG 253

  Fly   623 VIATQFSETKKREMERMRQERARYTSTSTLASSTNNSEPATCYAEIVKYIAHLWRRFKRRMLKKY 687
            |::.:|:    :|.||:...||                                           
 Frog   254 VLSGEFA----KERERVENRRA------------------------------------------- 271

  Fly   688 RLYKYQRQQRKEGLLPNADNLTFSPSRIKCHHPKCPKYSNRKPSSIQDQMITVMVPLNSASNNIN 752
             ..|.:|||:.|                                                     
 Frog   272 -FMKLRRQQQIE----------------------------------------------------- 282

  Fly   753 NNNNNNSNSSNHNGSGNHTAAGGGNNNNNNNNNNAASCTTVALVNGING-----SAASVTMSSAH 812
                                                        ..:||     |.|.|.::   
 Frog   283 --------------------------------------------RELNGYMEWISKAEVILA--- 300

  Fly   813 HQQHQLLQHQQQQHQNQQQQQQQQQHSSSDNTEQSLAPDGLPRSSSLKKSTAHHQLKPEGSAAEQ 877
                                      ....:.||.|..||                         
 Frog   301 --------------------------EDDSDIEQRLPYDG------------------------- 314

  Fly   878 KTILLKFPQQMIDSEQLILQLGNLGKSHPCTSGFLSPPTSASRRPSVMFNEYVLLHTPPALNADP 942
                                                    |.|||::..|               
 Frog   315 ----------------------------------------ALRRPTIKKN--------------- 324

  Fly   943 ATAGTTTTVAPTVATVAGTAAAAAAAAATGSGSGNNNHQNGGASGGAGTGGTTEKSNIFSTEKMT 1007
                                                                  |:.:.:.|:..
 Frog   325 ------------------------------------------------------KTELLNAEEGE 335

  Fly  1008 QA-GDGSIWQVNLPQTIGTIANPYADCSELGIHDAMTCQELLAFSVAFSAALPTGQSTLESFYTS 1071
            :| ||           |.::.:|:|                                        
 Frog   336 EAIGD-----------IASVGSPFA---------------------------------------- 349

  Fly  1072 LARCDPHTAEALRAHHKPRSVPTGQNQTTPGAEGATVMVASTAGDTGQTLQPSTVSAVVGGTIDS 1136
                        ||..|...:                                            
 Frog   350 ------------RASIKSAKM-------------------------------------------- 358

  Fly  1137 HAANHRRKEHHQQSHHHHNNNNTTSHSRNYRSRQGQGNSRMREPRAPTGNYMEDYACCYDLYQNA 1201
                               .|::..|.:..|                                  
 Frog   359 -------------------ENSSYMHKKERR---------------------------------- 370

  Fly  1202 LSPLDERPRQRSPTTRCLISVYRCMSRVCSWIRRYIRRLVEHKYFQQGILLAILINTLSMGIEYH 1266
                                           ||..|||:|:.:.|...:|..:.:|||.:.|.::
 Frog   371 -------------------------------IRFLIRRMVKTQAFYWVVLGLVALNTLCVAIVHY 404

  Fly  1267 NQPPELTAIVETSNVVFSGIFAVEMLLKVVAEGPFRYIANGFNVFDGIIVILSAIEICQTFMGNG 1331
            .|...|:..:..:..:|.|:|..||.:|:...|...|..:.||.||..::..|..|:....:..|
 Frog   405 GQDDRLSEFLYYAEFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCAVITGSIFEVVWAMVKPG 469

  Fly  1332 TGGGGSGLSVLRTFRLLRILKLVRFMPNLRRQLFVMLRTMDNVAVFFSLLVLFIFIFSILGMYLF 1396
            |   ..|:||||..|||||.|:.::..:||..:..:|.:|.::.....||.|||.:|::|||.||
 Frog   470 T---SFGISVLRALRLLRIFKVTKYWASLRNLVISLLSSMKSIISLLFLLFLFIVVFALLGMQLF 531

  Fly  1397 GGKFCKFLDESGLERECTCPEIISRHPQCECDRKHFNNILWATVTVFQILTQEDWNVVLFNGME- 1460
            ||:|  ..||                   :....:|:....|.:|||||||.||||.|:::|:: 
 Frog   532 GGQF--NFDE-------------------KTPATNFDTFPAAIMTVFQILTGEDWNAVMYDGIKS 575

  Fly  1461 ----KTSHWAALYFVALMTFGNYVLFNLLVAILVEGFSSERNERREREQRELVKKLREETLAENY 1521
                ||....::||:.|..||||.|.|:.:||.|:..::         .:||.|..:||..|.|.
 Frog   576 QGGVKTGMVFSIYFIILTLFGNYTLLNVFLAIAVDNLAN---------AQELTKDEQEEEEAANQ 631

  Fly  1522 SDGMY--DESRSEADSSTTNDSYYEVRNRWRSAEDVRKLQDSVELIIEAKSNMHRQRLLQPTHDY 1584
            ...|.  .|....:..|.||.|.        :|::.:|.|.:...:.|.::|..|::.|..:.:.
 Frog   632 KLAMQKAKEVAEVSPLSATNMSI--------AAKEQQKNQKTSMSVWEQRTNEIRRQNLMNSREA 688

  Fly  1585 QINEL------PASSAAP----------------SASGTSGASAPGDRERDRDRDRDRERDRD-- 1625
            ..:||      ..|...|                :.:..:..:.||:.....::...::|..|  
 Frog   689 LYSELDPEERWKLSFMRPDVKTHLDRPLVVDPQENRNNNTNKTRPGEGRNPIEQRLSQQRAEDYL 753

  Fly  1626 RDRERDREAGGGGKEEGAQHAKPRGGLKKTYSIKERRSEAPRLSKIRLARDPPIITTTAATPQDS 1690
            |.:.|.:|.||.|                 |.:.:.....||:.:..:.||          .||.
 Frog   754 RKQARFQERGGRG-----------------YDMGQEPGRRPRIKEQDIIRD----------GQDL 791

  Fly  1691 PSTTLEPGMSFRQWGDMEPPSPPSPSLLRPPNIFTGGQRSLDEGIPSIDLIPPSPVLSHKPLNIL 1755
                   ||..|. |:|:                 ||.|.           |..|...|:     
 Frog   792 -------GMQDRT-GEMD-----------------GGIRP-----------PQDPHRRHR----- 815

  Fly  1756 NASQLGVGMGGGVPSTAGSSSSMHSVIIDDISKSSSSTAAATPIYVPTISSTADAQSQSH----- 1815
                     |||                   ||.|.|   .:|:      ...|...:.|     
 Frog   816 ---------GGG-------------------SKESRS---GSPL------PRGDGDHRRHRPHRR 843

  Fly  1816 -SLNDVSVGSSPGGEIPATGMSRNANTGASTSGSSSSERLPLAPPPQQGSFKQRLRRG------- 1872
             ..::...|...||             |....|.....|      |:.|....|:|.|       
 Frog   844 TGEDNEDAGGGGGG-------------GGRGGGGGGDRR------PRHGRDGMRVREGGGGESEG 889

  Fly  1873 --SSKKRRASALALATDDNPARRTLDNQARRTQDEEEEQQQLNNGGDNSCLLRNSNAVVSGSSSG 1935
              ..::||....|.:|.::.|:|. |.:.|..:.:|.......:||.|   |..:..:...|   
 Frog   890 PEGERRRRHRHAAQSTYESDAKRD-DRERRHRRRKEPTAPTPGSGGPN---LSTTRPIQDRS--- 947

  Fly  1936 TKETNRLSPQNSIRRLSNTLSI------GSGPVGSRRASACIFNSQVYQNLNQPPKLRPGSGQRR 1994
            .:|.....|:| :..:.||..:      |.|..|...:.|.|.|.....|.|..|   .|:...|
 Frog   948 RQENQNQQPEN-MDNIRNTKLVTSEPPAGGGVGGLNHSPAKIGNHTNCANNNSVP---TGNATPR 1008

  Fly  1995 MSSIELAFSKTSHLNLHNLEANRKSLSYT-NSKMDLDKWNKS--YGNLNEPDNMLQQYMEARDKR 2056
                     :|.|........:....|:| ::..:..|..|:  :..::.|.........|..:.
 Frog  1009 ---------RTPHPTNSGPPPSAPDPSHTFSNPTETAKGTKTTEHTTVDIPPPFPPPVENAIGQA 1064

  Fly  2057 KNSISHYNLKKRLEEKELQQLQQLHQQQLLQQRQDSFSSTTQQQQQQLQQHRLSKDQQQLAMQPH 2121
            ...::...|.|:.:||:.::                                  :|.......|.
 Frog  1065 NKIVAVSPLPKKDDEKKEEE----------------------------------EDDDDGEKGPK 1095

  Fly  2122 SMVPGGGERYSKLKMLIEQLTPKHFTTEREDYSLYIFPEDNRFRQICTWFVNQKWFDNVVLLFIA 2186
            .|.|     ||                     |::|....|..|::|.:.|..::|:..:|:.||
 Frog  1096 PMPP-----YS---------------------SMFILSTTNPLRRLCHYIVTMRYFEMCILMVIA 1134

  Fly  2187 LNCITLAME---RPNIPPSSTERLFLATANYVFTVVFTVEMFIKVVATGMFYGHDAYFTSGWNIM 2248
            ::.|.||.|   :|:.|.::..|.|    :||||.|||.||.||:|..|:.....|||...||.:
 Frog  1135 MSSIALAAEDPVQPDAPRNNVLRYF----DYVFTGVFTFEMVIKMVDLGLILHQGAYFRDLWNFL 1195

  Fly  2249 DGSLVTISIIDLLMSLISE--SSPRIFGILRVFRLLRSLRPLRVINRAPGLKLVVQTLLSSLRPI 2311
            |..:|..:::....|....  |..:....::..|:||.||||:.|.|.|.||.|...:::||:.:
 Frog  1196 DFIVVCGALVAFAFSSNQRGGSKGKDISTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNV 1260

  Fly  2312 GNIVLICCTFFIIFGILGVQLFKGTFYYCEGENIKGVRNADECR-----------RIPGNVWTNR 2365
            .||:::...|..||.::.||||||.|:||..|:.:..|   :||           :.....|...
 Frog  1261 LNILIVYMLFMFIFAVVAVQLFKGKFFYCTDESKEFQR---DCRGEYLVYDKSEVKAQKREWKKW 1322

  Fly  2366 KYNFDDLGKALMSLFVLSSRDGWVNIMYTGLDAVGVDQQPIVNYNEWRLLYFIAFILLVGFFVLN 2430
            .:::|::..||::||.:|:.:||.:::...:||...||.|...:.....::::.:.::..||.:|
 Frog  1323 PFHYDNVLWALLTLFTVSTGEGWPDVLRHSVDATYEDQGPRPGFRMEMSIFYVVYFVVFPFFFVN 1387

  Fly  2431 MFVGVVVENFH----RCREEQEKEEKIRRAAKRALQMEKKRRRMHEPPYYTNYSPTRMFVHNVVT 2491
            :||.:::..|.    :..||...|:..|.....|:..:...|.|.:......|   ||:  ..|.
 Frog  1388 IFVALIIITFQEQGDKIMEEYSLEKNERACIDFAISAKPLTRHMPQNKQSFQY---RMW--QFVV 1447

  Fly  2492 SKYFDLAIAAVIGLNVVTMAMEYYKMPSGLKYALKIFNYFFTAVFILEANMKLVALGWKLYLKDR 2556
            |..|:..|.|:|.||.:.:.|:::...:..:..||.||..||::|.||..:|::|.|...|.:|.
 Frog  1448 SPPFEYTIMALIALNTIVLMMKFHGSSNTYENVLKTFNMVFTSLFSLECLLKIMAFGAPNYFRDA 1512

  Fly  2557 WNQLDVGIVLLSIVGIVLEELETNTHQIIPINPTIIRVMRVLRIARVLKLLKMANGIRALLDTVM 2621
            ||..|...||.||..||:.||..:.     ||   :..:|:.|.||::|||:....||.||.|.:
 Frog  1513 WNIFDFVTVLGSITDIVVTELWDSI-----IN---LSFLRLFRAARLIKLLRQGYTIRILLWTFV 1569

  Fly  2622 QALPQVGNLGLLFFLLFFIFAALGVELFGRLECSDEIPCQGLGEHAHFANFGMAFLTLFRVATGD 2686
            |:...:..:.||..:||||:|.:|:::||.:...:|.....:.||.:|.||..|.:.|||.|||:
 Frog  1570 QSFKALPYVCLLIAMLFFIYAIIGMQVFGNIALDEEDDDTAITEHNNFRNFFQALMLLFRSATGE 1634

  Fly  2687 NWNGIMKDTLRDN-CDDAADCVRNCCVSSVIAPIFFVIFVLMAQFVLVNVVVAVLM--------- 2741
            .|:.||...|... ||..:......| .|..|..:||.|:.:..|:::|:.|||:|         
 Frog  1635 AWHEIMLSCLSGRPCDVGSGLKEKEC-GSEFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRD 1698

  Fly  2742 ------KHLEE------------------------------------------SHKQM------- 2751
                  .||:|                                          ::|::       
 Frog  1699 SSILGPHHLDEYVRVWAEYDPAAWGRMKYTDLYEMLRLISPPLGLGKKCPARVAYKRLLRMDLPV 1763

  Fly  2752 ----------------------------EDELDMEVELERELVREQEFAQEQKLCQQLAEAQSKA 2788
                                        .|:..|:.:|.:|::.......::.|...:...:|..
 Frog  1764 ADDNTVHFNSTLMALIRTALDIKIAKGGADKQQMDSQLRKEMMAIWPNMSQKTLDLLVTPHKSTD 1828

  Fly  2789 AAPPRPLAKVKSLPKNFIYSTPSLDKKFPAVSGVNN-----------PSLTSSAATNLNQV--AT 2840
            ..    :.|:.:......|...|..|:..|:....|           ||.|......:|.:  :.
 Frog  1829 LT----VGKIYAAMMIMEYYRQSKAKRLQALQEEQNRTPLMFQRMEPPSPTQDGPLGINALPSSQ 1889

  Fly  2841 AGSGGAAPGAV----------------PAGSGAGPRRQTVQYFQQPPQSMLGGLSLAEMGGT--- 2886
            ||..|...|.:                ..|:.:..|.:|.:.....|.|. ..:.:::||..   
 Frog  1890 AGEMGLPEGGMKESQSWMTQRAQQMFQKTGTWSPERARTQENTNSWPNSQ-QSVEMSDMGRDGYS 1953

  Fly  2887 -----LTPQALGARLGEP-----------FGGGGGNKS-----GPRRQSYWQINPIRKRGVLSKE 2930
                 |..:..|.....|           ....|.|.|     .|.::|...:...:.:|:...|
 Frog  1954 DSEQYLVMEGHGRAASMPRLPADNQQRRKTRTRGSNLSTITDGSPMKRSASMLGHSQSKGIRLDE 2018

  Fly  2931 RSLD----EQAIR----RRNLEAKRTSCDSLPWGGDALDCRRGTIFESLESDGGGVGGGGSGGGG 2987
            .||:    |:..|    ||.....|.|..||            |.:..|||              
 Frog  2019 YSLERVTPEEGPRHGHQRRRERGHRVSDRSL------------TRYVDLES-------------- 2057

  Fly  2988 GGLGGGVS--------------------------------------------YDLRSVRSADVGH 3008
             |||..:|                                            |...|.||...|.
 Frog  2058 -GLGTELSTTTQSCDLPTEERGRTRDRKHHHHHHHHHHHHHHHPSTERERLEYGRPSSRSPSTGR 2121

  Fly  3009 ---------SEMDGDVSLSVVSALVPS---------VTTPLPPPLSLPIV-TPTSTPTPLQ---L 3051
                     |.:||....|...|..|.         .|||.|.....|:| .|.|..:|.|   .
 Frog  2122 DYAPHRQGSSSVDGSPVPSTSGASTPRRGRRQLPQLPTTPRPRVTYSPVVRRPASVCSPQQQSLC 2186

  Fly  3052 PMPMPMPMAHP-PPRRPFGWSQSVDQGCLRSNLLLSVPRSMP-------------PRS---RSGS 3099
            .|..|:...:| ...||            .||...||....|             ||:   .||.
 Frog  2187 RMTTPIQRRYPQTENRP------------SSNERRSVNNDSPRSHRHTRGHCTEVPRAGCRHSGP 2239

  Fly  3100 TKQLFKQQALDEDADMDENSLLLPTAAGGGSGPGSVAVIASSSLDLPDQSGSSKQILPDIALGVS 3164
                ::..:.::....|:.|  ..||..||               :|..|...:::....:.|..
 Frog  2240 ----YRDSSFEDPHPCDQRS--SRTAESGG---------------VPPLSPRGRRLPNGYSHGTP 2283

  Fly  3165 KSDSSDILRIISERRRMDQREQREPEQDQDN 3195
            :|..|              |.:|..|.::|:
 Frog  2284 RSTKS--------------RHERYSESEEDD 2300

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1TNP_001259267.1 Ion_trans 332..636 CDD:278921 90/311 (29%)
Ion_trans 1261..1495 CDD:278921 79/238 (33%)
Ion_trans 2192..2448 CDD:278921 84/275 (31%)
Ion_trans 2510..2728 CDD:278921 76/218 (35%)
cacna1aXP_031755311.1 Ion_trans 1..267 CDD:395416 102/341 (30%)
Ion_trans 382..620 CDD:395416 86/270 (32%)
Ion_trans 1123..1358 CDD:395416 78/241 (32%)
Ion_trans 1448..1700 CDD:395416 89/260 (34%)
GPHH 1709..1762 CDD:407139 2/52 (4%)
Ca_chan_IQ 1773..1846 CDD:400901 8/76 (11%)
PHA03307 2112..>2292 CDD:223039 46/226 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.920

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