DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1T and cacna1b

DIOPT Version :9

Sequence 1:NP_001259267.1 Gene:Ca-alpha1T / 31550 FlyBaseID:FBgn0264386 Length:3218 Species:Drosophila melanogaster
Sequence 2:XP_031746887.1 Gene:cacna1b / 100489231 -ID:- Length:2250 Species:Xenopus tropicalis


Alignment Length:3075 Identity:638/3075 - (20%)
Similarity:1038/3075 - (33%) Gaps:1162/3075 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   348 FALEMTIKMVAMG-ICGKNTYLADSWNRLDFFIVLAGLLEYVMHVENLNLTAIRTIRVLRPLRAI 411
            |..|..||::|:| :..|.:||.:.||.:||.:||.|:|  .....:.:|..:|.:||||||:.:
 Frog    13 FCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGIL--ATAGTDFDLRTLRAVRVLRPLKLV 75

  Fly   412 NRIPSMRILVMLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWEGILRQRCSLMRTEGMVYPLTVP 476
            :.|||:::::..::..:..|..:.||.||...:|.|||::.:.|...:.|               
 Frog    76 SGIPSLQVVLKSIMKAMVPLLQIGLLLFFAIVMFAIIGLEFYMGKFHKAC--------------- 125

  Fly   477 EVYRVRVRVNSLSQYYEFSKDQDYICSTPNDSGMHLCGNFPPYRIGSLVCNEEAKLFDFNEPTNT 541
                             ||.|.|      ...|...||..||.|:                    
 Frog   126 -----------------FSDDSD------EPVGDFPCGEEPPARL-------------------- 147

  Fly   542 SCVNWNQYYTTCKQSGENPFQGTISFDNIGMAWVAIFLVISLEGWTDIMYYVQDAHSF-WDWIYF 605
             |.|.    |.|:...:.|..|..:||||..|.:.:|..|::||||||:|...||..: |:|:||
 Frog   148 -CENG----TFCRVYWKGPNFGITNFDNILFAVLTVFQCITMEGWTDILYNTNDAVGYMWNWLYF 207

  Fly   606 VLLIVIGSFFMINLCLVVIATQFSETKKREMERMRQERARYTSTSTLASSTNNSEPATCYAEIVK 670
            :.||::|||||:||.|.|::.:|:    :|.||:...||                          
 Frog   208 IPLIIVGSFFMLNLVLGVLSGEFA----KERERVENRRA-------------------------- 242

  Fly   671 YIAHLWRRFKRRMLKKYRLYKYQRQQRKEGLLPNADNLTFSPSRIKCHHPKCPKYSNRKPSSIQD 735
                              ..|.:|||:.|                                    
 Frog   243 ------------------FLKLRRQQQIE------------------------------------ 253

  Fly   736 QMITVMVPLNSASNNINNNNNNNSNSSNHNGSGNHTAAGGGNNNNNNNNNNAASCTTVALVNGIN 800
                                                                         ..:|
 Frog   254 -------------------------------------------------------------RELN 257

  Fly   801 GSAASVTMSSAHHQQHQLLQHQQQQHQNQQQQQQQQQHSSSDNTEQSLAPDGLPRSSSLKKSTAH 865
            |....:.                        :.::...:..|...:..:|..:.:.:::|||   
 Frog   258 GYLEWIF------------------------KAEEVMLAEEDKNAEEKSPLDVLKRATIKKS--- 295

  Fly   866 HQLKPEGSAAEQKTILLKFPQQMIDSEQLILQLGNLGKSHPCTSGFLSPPTSASRRPSVMFNEYV 930
                               ...:|.:|:        |..|                    ||:  
 Frog   296 -------------------KNDLIHAEE--------GDDH--------------------FND-- 311

  Fly   931 LLHTPPALNADPATAGTTTTVAPTVATVAGTAAAAAAAAATGSGSGNNNHQNGGASGGAGTGGTT 995
                                                                             
 Frog   312 ----------------------------------------------------------------- 311

  Fly   996 EKSNIFSTEKMTQAGDGSIWQVNLPQTIGTIANPYADCSELGIHDAMTCQELLAFSVAFSAALPT 1060
                                       |.::.:|:|                             
 Frog   312 ---------------------------ICSVGSPFA----------------------------- 320

  Fly  1061 GQSTLESFYTSLARCDPHTAEALRAHHKPRSVPTGQNQTTPGAEGATVMVASTAGDTGQTLQPST 1125
             :|:|:|                           |:|::                          
 Frog   321 -RSSLKS---------------------------GKNES-------------------------- 331

  Fly  1126 VSAVVGGTIDSHAANHRRKEHHQQSHHHHNNNNTTSHSRNYRSRQGQGNSRMREPRAPTGNYMED 1190
                        ::..||||                                             
 Frog   332 ------------SSYLRRKE--------------------------------------------- 339

  Fly  1191 YACCYDLYQNALSPLDERPRQRSPTTRCLISVYRCMSRVCSWIRRYIRRLVEHKYFQQGILLAIL 1255
                                                    ...|.:|||:|:.:.|...:|..:.
 Frog   340 ----------------------------------------KMFRFFIRRMVKAQSFYWFVLCVVA 364

  Fly  1256 INTLSMGIEYHNQPPELTAIVETSNVVFSGIFAVEMLLKVVAEGPFRYIANGFNVFDGIIVILSA 1320
            :|||.:.|.::|||..||..:..:..||.|:|..||.||:...||..|..:.||.||..:::.|.
 Frog   365 LNTLCVAIVHYNQPQWLTEALYYAEFVFLGLFLTEMSLKMYGLGPRNYFHSSFNCFDFGVIVGSI 429

  Fly  1321 IEICQTFMGNGTGGGGSGLSVLRTFRLLRILKLVRFMPNLRRQLFVMLRTMDNVAVFFSLLVLFI 1385
            .|:....:..||   ..|:||||..|||||.|:.::..:||..:..:|.:|.::.....||.|||
 Frog   430 FEVIWAAVKPGT---SFGISVLRALRLLRIFKVTKYWNSLRNLVVSLLNSMKSIVSLLFLLFLFI 491

  Fly  1386 FIFSILGMYLFGGKFCKFLDESGLERECTCPEIISRHPQCECDRKHFNNILWATVTVFQILTQED 1450
            .:|::|||.||||:|  :.:|                   |....:|:....|.:|||||||.||
 Frog   492 VVFALLGMQLFGGQF--YFEE-------------------ETRNTNFDTFPTAILTVFQILTGED 535

  Fly  1451 WNVVLFNGME-----KTSHWAALYFVALMTFGNYVLFNLLVAILVEGFSSERNERREREQRELVK 1510
            ||:|::.|:|     ....::.:||:.|..||||.|.|:.:||.|:..::.:...::.|:.|   
 Frog   536 WNLVMYFGIESQGGVSKGMFSCIYFIILTLFGNYTLLNVFLAIAVDNLANAQELTKDEEEME--- 597

  Fly  1511 KLREETLAENYSDGMYDESRSEADSSTTNDSYYEVR---NRWRSAEDVRKLQDSV-ELIIEAKSN 1571
            :...:.||...:..:.:.|...|.:.:......:.:   :|..|..:|.....|| ..:|:    
 Frog   598 EATNQKLALQKAKEVAEVSPMSAANLSITAFVKQTQGAISRSSSVSNVNSPDPSVCSAVIK---- 658

  Fly  1572 MHRQRLLQPTHDYQINELPASSA----APSASGTSGASAPGDRERDRDRDRDRERDRDRDRERDR 1632
                           .:|||..:    |||.:....|..|..::.........|:...:.|:.:.
 Frog   659 ---------------TQLPAYPSAWELAPSCARHLHAMDPCKQQNSTKCRSVWEQRTSQIRKHNF 708

  Fly  1633 EAGGGGKEEGAQHAKPRGGLKKTYSIKERRSEAPRLSKIRLARDPPIITTTAATPQDSPSTTLEP 1697
            .|   ..|......:|...|:...::..|       ..::...|.|::    ..||||..|  :.
 Frog   709 RA---SCEALYSELEPEDRLRYATTLHLR-------PDMKSHMDRPLL----VEPQDSTET--KD 757

  Fly  1698 GMSFRQWGDMEPPSPPSPSLLRP-PNIFTGGQRSLDEGIPSIDLIPPSPVLSHKPLNILNASQLG 1761
            |          .|..|:|:.:.| |.:.|                .||....|:..:        
 Frog   758 G----------SPDAPAPNEIEPVPGVTT----------------EPSARKQHRHRD-------- 788

  Fly  1762 VGMGGGVPSTAGSSSSMHSVIIDDISKSSSSTAAATPIYVPTISSTADAQSQSHSLNDVSVGSSP 1826
                .|.|:..|..:..|:      ..|.|             :...:.|.|..|.:....||..
 Frog   789 ----RGEPNGGGRENGNHN------GDSGS-------------NDREERQRQHRSRSKEEDGSKE 830

  Fly  1827 GGEIPATGMSRNANTGASTSGSSSSERLPLAPPPQQGSFKQRLRRGSSKKRRASALALATDDNPA 1891
            .|                                 :|...:...||....||||     .:|...
 Frog   831 TG---------------------------------RGERNRSQERGKRHHRRAS-----PEDGTE 857

  Fly  1892 RRTLDNQARRTQDEEEEQQ------QLNNGGDNSCLLRNSNAVVSGSSSGTKE---TNRLSPQNS 1947
            |   :::..||.....::|      |..:||...   |.|.....||.||.:|   |||      
 Frog   858 R---EHRRHRTHRHSADRQGKEGNGQPPSGGKGE---RKSRHRGGGSRSGNREGEGTNR------ 910

  Fly  1948 IRRLSNTLSIGSGPVGSRRASACIFNSQVYQNLNQPPKLRPGSGQRRMSSIELAFSKTSHLNLHN 2012
                      |:|                 :|..:||:.|                   |.|.| 
 Frog   911 ----------GTG-----------------ENGEEPPRSR-------------------HRNRH- 928

  Fly  2013 LEANRKSLSYTNSKMDLDKWNKSYGNLNEPDNMLQQYMEARDKRKNSISHYNLKKRLEEKELQQL 2077
                 |:||             :|...::.:|        :|.......|.|.:.| |.:...:|
 Frog   929 -----KALS-------------TYDTEDKKEN--------KDGESAEKEHRNHRPR-ENRNESEL 966

  Fly  2078 QQLHQQQLLQQRQDSFSSTTQQQQQQLQQHRLSKDQQ---------------QLAMQPHSMVPGG 2127
            .....|||.:|.:|:      ..|:.:.:..|...::               :.|:.|.:.|...
 Frog   967 PPGGLQQLAEQPEDA------DNQKNVNRMALPHPERSSTINIPVTITAPPGESAVIPINNVDFD 1025

  Fly  2128 GERYSKLKMLIEQLT---PKHFTTEREDYSLYIFPEDNRFRQICTWFVNQKWFDNVVLLFIALNC 2189
            |:...| |.:.:.||   ||......   |::||...|..|::|.:.||.::|:.|:|:.|||:.
 Frog  1026 GKSEEK-KEMEDDLTKNGPKQILPYS---SMFIFSTTNPVRRLCHYIVNLRYFEMVILVVIALSS 1086

  Fly  2190 ITLAMERPNIPPSSTERLFLATANYVFTVVFTVEMFIKVVATGMFYGHDAYFTSGWNIMD----- 2249
            |.||.|.| :...:.....|...:|:||.|||.||.||::..|:.....:||...|||:|     
 Frog  1087 IALAAEDP-VQADAPRNDVLKYMDYIFTGVFTFEMVIKMIDLGLLLHSGSYFRDLWNILDFIVVS 1150

  Fly  2250 GSLVTISIIDLLMSLISESSPRIFGILRVFRLLRSLRPLRVINRAPGLKLVVQTLLSSLRPIGNI 2314
            |:||..:    ..|.:..:..:....::..|:||.||||:.|.|.|.||.|...:::||:.:.||
 Frog  1151 GALVAFA----FSSFVGGNKGKDLNTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNI 1211

  Fly  2315 VLICCTFFIIFGILGVQLFKGTFYYCEGENIKGVRNADECR-----------RIPGNVWTNRKYN 2368
            :::...|..||.::.||||||.|:||..|: |.:..  :||           |.....|...:::
 Frog  1212 LIVYMLFMFIFAVVAVQLFKGKFFYCTDES-KDLEK--DCRGEYLNYENNDVRAQAREWKKYEFH 1273

  Fly  2369 FDDLGKALMSLFVLSSRDGWVNIMYTGLDAVGVDQQPIVNYNEWRLLYFIAFILLVGFFVLNMFV 2433
            :|::..||::||.:|:.:||.|::...:||...||.|...:.....::::.:.::..||.:|:||
 Frog  1274 YDNVLWALLTLFTVSTGEGWPNVLKHSVDATYEDQGPTPGFRMEISIFYVVYFVVFPFFFVNIFV 1338

  Fly  2434 GVVVENFHRCREEQEKEEKIRRAAKRALQMEKKRR-----RMHEPPYYTNYSP--TRMFVHNV-- 2489
            .:::..|      ||:.:|:....    .:||..|     .:...| .|.|.|  .:.|.:.:  
 Frog  1339 ALIIITF------QEQGDKVMSEC----SLEKNERACIDFAISAKP-LTRYMPQNRQSFQYKMWR 1392

  Fly  2490 -VTSKYFDLAIAAVIGLNVVTMAMEYYKMPSGLKYALKIFNYFFTAVFILEANMKLVALGWKLYL 2553
             |.|..|:..|..:|.||.:.:.|::|..|...:..||..|..||::|.||..:|::|.|...|.
 Frog  1393 FVVSPPFEYFIMVMIALNTIVLMMKFYGAPQTYEDMLKCLNIIFTSMFSLECILKIIAFGVLNYF 1457

  Fly  2554 KDRWNQLDVGIVLLSIVGIVLEELETNTHQIIPINPTIIRVMRVLRIARVLKLLKMANGIRALLD 2618
            :|.||..|...||.||..|::.|: .:|...|.::     .:|:.|.||::|||:....||.||.
 Frog  1458 RDAWNVFDFVTVLGSITDILVTEI-ADTENFINLS-----FLRLFRAARLIKLLRQGYTIRILLW 1516

  Fly  2619 TVMQALPQVGNLGLLFFLLFFIFAALGVELFGRLECSDEIPCQGLGEHAHFANFGMAFLTLFRVA 2683
            |.:|:...:..:.||..:||||:|.:|:::||.:..||:   ..:..|.:|..|..|.:.|||.|
 Frog  1517 TFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIALSDD---SSINRHNNFRTFFQALMLLFRSA 1578

  Fly  2684 TGDNWNGIMKDTLRDN-CDDAADCVRNCCVSSVIAPIFFVIFVLMAQFVLVNVVVAVLM------ 2741
            ||:.|:.||...|.:. ||..:...:..| .|..|..:||.|:.:..|:::|:.|||:|      
 Frog  1579 TGEGWHEIMLSCLSNRPCDPRSGNTKEEC-GSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYL 1642

  Fly  2742 ---------KHLEE----------------SHKQMED---------------------------- 2753
                     .||:|                .:|.|.:                            
 Frog  1643 TRDSSILGPHHLDEFIRVWAEYDPAACCRIHYKDMYNLLRVIAPPLGLGKRCPSRVAYKRLVRMN 1707

  Fly  2754 ----ELDMEVELERELVREQEFAQEQKL---------CQQLAEAQSKAAA--------------- 2790
                :.|:.|.....|:.....|.:.||         |.  ||.:.:.::               
 Frog  1708 MPISDTDLTVHFTSTLMALIRTALDIKLASGGIKQHECD--AELRKEVSSVWPNLSQKTLDLLVP 1770

  Fly  2791 PPRP----LAKV------------------KSLPKNFIYSTPSLDKKFPAVSGVNNPSLTSSAAT 2833
            |.:|    :.||                  :|.|::.:.|.......|..:.....|...|....
 Frog  1771 PHKPDELTVGKVYAALMIFDFYKQNKNNRDQSHPQSGVLSQTGTVSLFQPLKATLEPFGNSKMFI 1835

  Fly  2834 NLNQVATAGSGGAAP------------GAVPAGSG-AGPR------------------RQTVQYF 2867
            .....|:..:||..|            |..||... :.||                  :|:|: .
 Frog  1836 RQKSSASLNNGGLVPDQDMGIRESSSWGTQPATDPFSTPRSTAFQRGHSEEIHAQRNGKQSVE-M 1899

  Fly  2868 QQPPQSMLGG----LSLAEMGGTLTPQALGA----RLGEPFGGGGGNKS----GPRRQSYWQINP 2920
            :|..|::..|    ..|...|..::...|.|    |...|..|.|...|    .|.::|...:.|
 Frog  1900 KQIGQTLSNGGEHPTGLESQGRAVSMPRLAAETHPRSRAPSPGNGYLPSIPDTSPMKRSVSTLTP 1964

  Fly  2921 ----------------------------IRKRGVLSKERS----------LDEQAIRRRNLEAKR 2947
                                        .::|...|.|||          .|.:..|.|:.|.|:
 Frog  1965 PQRAQLYEYSLERVPPERTHQHHHRCHRRKERKQKSTERSPQSEDADAPTRDRKHERGRSQERKQ 2029

  Fly  2948 T-----------SCDSLPWG----GDALDC--RRGTIFESLESDGGGVGGGGSGGGGGGL-GGGV 2994
            .           |||.  :|    |....|  .|.|...:.:.......|.||..|...| ..|.
 Frog  2030 QPPSSSEKQRFYSCDR--YGSRDSGHPRQCDHSRATSPSAGQDHSTHRQGSGSASGSPRLTSSGA 2092

  Fly  2995 SYDLRSVRSADVGHSEMDGDVSLSVVSALVPSVTTPLPPPLSLPIVTPTSTPTPLQLPMPMPMPM 3059
            |...|.:|..                   :|.  |||.|..|:...|..|:|.....|       
 Frog  2093 STPCRGIRRQ-------------------LPQ--TPLTPRPSVTYRTAHSSPVHFGGP------- 2129

  Fly  3060 AHPPPRRPFGWSQSVDQGCLRSNLLL---SVPRSMPPRSRSGSTKQLFKQQALDEDADMDENSLL 3121
            |:.|.|        :.:|....|.||   |...|....:|.||...|..:|..|....:.|.:|.
 Frog  2130 AYSPGR--------LSRGLSEHNTLLYSDSPSHSACTVTRIGSDPYLGPRQDSDSYCPLSEETLT 2186

  Fly  3122 LPTAAGGGSGPGSVAVIASS 3141
            ...|....||..|.....||
 Frog  2187 FEEALASNSGRSSRTSYVSS 2206

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1TNP_001259267.1 Ion_trans 332..636 CDD:278921 87/289 (30%)
Ion_trans 1261..1495 CDD:278921 84/238 (35%)
Ion_trans 2192..2448 CDD:278921 81/271 (30%)
Ion_trans 2510..2728 CDD:278921 74/218 (34%)
cacna1bXP_031746887.1 Ion_trans 9..238 CDD:395416 90/293 (31%)
Ion_trans 352..591 CDD:395416 89/262 (34%)
PRK12678 747..>927 CDD:237171 59/334 (18%)
Ion_trans 1072..1306 CDD:395416 79/241 (33%)
Ion_trans 1396..1647 CDD:395416 86/260 (33%)
GPHH 1656..1709 CDD:407139 3/52 (6%)
Ca_chan_IQ 1721..1795 CDD:400901 11/75 (15%)
PHA03307 1911..>2139 CDD:223039 52/265 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.010

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