DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1T and scn1a

DIOPT Version :9

Sequence 1:NP_001259267.1 Gene:Ca-alpha1T / 31550 FlyBaseID:FBgn0264386 Length:3218 Species:Drosophila melanogaster
Sequence 2:XP_012826731.2 Gene:scn1a / 100488621 XenbaseID:XB-GENE-978019 Length:2020 Species:Xenopus tropicalis


Alignment Length:2610 Identity:544/2610 - (20%)
Similarity:933/2610 - (35%) Gaps:968/2610 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   284 LTQYTRPRNWCLMLITNPWFERVSILVILLNCITLGMYQPCVDDACVTNRCKILQIFDDIIFAF- 347
            ||.:...|...:.::.:..|..:.:..||.||:.:.|..|             .:...::.:.| 
 Frog   112 LTPFNPLRKVAIKVLVHSLFSMLIMCTILTNCVFMTMSNP-------------PEWTKNVEYTFT 163

  Fly   348 --FALEMTIKMVAMGIC-GKNTYLADSWNRLDFFIVLAGLLEYVMHVENL-NLTAIRTIRVLRPL 408
              :..|..||::|.|.| .|.|:|.|.||.|||.::   ::.||....|| |::|:||.||||.|
 Frog   164 GIYTFESLIKILARGFCLEKFTFLRDPWNWLDFSVI---VMAYVTEFVNLGNVSALRTFRVLRAL 225

  Fly   409 RAINRIPSMRILVMLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWEGILRQRCSLMRTEGMVYP- 472
            :.|:.||.::.:|..|:.::..|.:|::|..|...:|.:||:||:.|.||.:|       :.:| 
 Frog   226 KTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGHLRNKC-------LQWPP 283

  Fly   473 ------LTVPEVYRVRVRV--------NSLSQYYEFSKDQDYICSTPNDSGMHLCGNFPPYRIGS 523
                  :.:|.:....:.:        ||...:.|:..|:::...........||||    ...|
 Frog   284 IDYFPLINIPPILNGTMNIHDPFGNTTNSTFDWEEYITDKNHFYKLEGQKDFLLCGN----SSDS 344

  Fly   524 LVCNEEAKLFDFNEPTNTSCVNWNQYYTTCKQSGENPFQGTISFDNIGMAWVAIFLVISLEGWTD 588
            ..|           |....||          ::|:||..|..|||....|::::|.:::.:.|.:
 Frog   345 GQC-----------PKGYICV----------KTGKNPNYGYTSFDTFSWAFLSLFRLMTQDYWEN 388

  Fly   589 IMYYVQDAHSFWDWIYFVLLIVIGSFFMINLCLVVIATQFSETKKREMERMRQERARYTSTSTLA 653
            :......|......|:|||:|.:|||:::||.|.|:|..:.|..:..:|...|:.|.:       
 Frog   389 LYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEF------- 446

  Fly   654 SSTNNSEPATCYAEIVKYIAHLWRRFKRRMLKKYRLYKYQRQQRKEGLLPNADNLTFSPSRIKCH 718
                                       ::||::.:    ::|:..:.....|.|:    ||    
 Frog   447 ---------------------------QQMLEQLK----KQQEEAQAAAVAALNM----SR---- 472

  Fly   719 HPKCPKYSNRKPSSIQDQMITVMVPLNSASNNINNNNNNNSNSSNHNGSGNHTAAGGGNNNNNNN 783
                 :||......          ||:.:|:                                  
 Frog   473 -----EYSEDGGFG----------PLSESSS---------------------------------- 488

  Fly   784 NNNAASCTTVALVNGINGSAASVTMSSAHHQQHQLLQHQQQQHQNQQQQQQQQQHSSSDNTEQSL 848
                              .|:.::..||        :.::.:.:.::|::..:::...|:     
 Frog   489 ------------------EASKLSSKSA--------KDRRNRKKKRKQKELGEEYEKGDD----- 522

  Fly   849 APDGLPRSSSLKKSTAHHQLKPEGSAAEQKTILLKFPQQMIDSEQLILQLGNLGKSHPCTSGFLS 913
                    ....||.:...:|.:|.....:...|.:..:.....|.:|.:          .|.|.
 Frog   523 --------EKFPKSESETSIKRKGFRFSIEGNRLTYENKFSSPHQSLLSI----------RGSLF 569

  Fly   914 PPTSASRRPSVMFNEYVLLHTPPALNADPATAGTTTTVAPTVATVAGTAAAAAAAAATGSGSGN- 977
            .|...||.....|..                                        .|...||.| 
 Frog   570 SPRRNSRASLFSFRN----------------------------------------RAKDVGSEND 594

  Fly   978 ----------NNHQNGGASGGAGTGGTTEKSNIFSTEKMTQAGDGSIWQVNLPQTIGTIANPYAD 1032
                      :|....|:.......|....|||      :|....|.....||      ||.   
 Frog   595 FADDEHSTFEDNESRRGSLFVPNRHGERRNSNI------SQVSKSSKTMTVLP------ANG--- 644

  Fly  1033 CSELGIHDAMTCQELLAFSVAFSAALPTGQSTLESFYTSLARCDPHTAEALRAHHKPRSVPTGQN 1097
                .:|..:.|..::  |:....::||.                               |.|  
 Frog   645 ----KMHSTVDCNGVV--SLLGGPSVPTS-------------------------------PVG-- 670

  Fly  1098 QTTPGAEGATVMVASTAGDTGQTLQPSTVSAVVGGTIDSHAANHRRKEHHQQSHHHHNNNNTTSH 1162
                                  .|.|..:       :|..|:               ::|.||:.
 Frog   671 ----------------------LLLPEVI-------VDKPAS---------------DDNGTTTE 691

  Fly  1163 SRNYRSRQGQGNSRMREPRAPTGNYMEDYACCYDLYQNALSPLDERPRQRSPTT----------- 1216
            : ..|.|:                     :.||.:..:.|.  |...|||:.:.           
 Frog   692 T-EIRKRK---------------------SSCYQVPMDLLE--DPTARQRALSVASILTNTVEEL 732

  Fly  1217 -----RCLISVYRCMSRVCSW--------IRRYIRRLVEHKYFQQGILLAILINTLSMGIEYHNQ 1268
                 :|....|:..:....|        ::..::.:|...:....|.:.|::|||.|.:|::..
 Frog   733 EESRQKCPPCWYKFANTFLIWDCCENWLTVKHIVKLIVMDPFVDLAITICIVLNTLFMAMEHYPM 797

  Fly  1269 PPELTAIVETSNVVFSGIFAVEMLLKVVAEGPFRYIANGFNVFDGIIVILSAIEICQTFMGNGTG 1333
            ..|...::...|:||:|||..||:.|::|..|:.|...|:|:||||||.||.:|:....:     
 Frog   798 TKEFNDVLSIGNLVFTGIFTAEMVFKLIALDPYYYFQEGWNIFDGIIVSLSLMELGLANV----- 857

  Fly  1334 GGGSGLSVLRTFRLLRILKLVRFMPNLRRQLFVMLRTMDNVAVFFSLLVLFIFIFSILGMYLFGG 1398
               .||||||:|||||:.||.:..|.|...:.::..::..:.....:|.:.:|||:::||.|||.
 Frog   858 ---EGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGK 919

  Fly  1399 KFCKFLDESGLERECTCPEIISRHPQCECDRKHFNNILWATVTVFQILTQEDWNVVLFNGMEKTS 1463
            .:          :||.|.  |:.:  ||..|.|.|:...:.:.||::|..| |...:::.||...
 Frog   920 SY----------KECVCK--IAEN--CELPRWHMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAG 969

  Fly  1464 H-WAALYFVALMTFGNYVLFNLLVAILVEGFSSERNERREREQRELVKKLREETLAENYSDGMYD 1527
            . ...|.|:.:|..||.|:.||.:|:|:..|||                                
 Frog   970 QSMCLLVFMLVMVIGNLVVLNLFLALLLSSFSS-------------------------------- 1002

  Fly  1528 ESRSEADSSTTNDSYYEVRNRWRSAEDVRKLQDSVELIIEAKSNMHRQRLLQPTHDYQINELPAS 1592
                  |:.|..|...|:.|          ||.:|..|         ||.:    ||        
 Frog  1003 ------DNLTATDDDNEMNN----------LQIAVGRI---------QRGI----DY-------- 1030

  Fly  1593 SAAPSASGTSGASAPGDRERDRDRDRDRERDRDRDRERDREAGGGGKEEGAQHAKPRGGLKKTYS 1657
                                                                       :|||  
 Frog  1031 -----------------------------------------------------------VKKT-- 1034

  Fly  1658 IKERRSEAPRLSKIRLARDPPIITTTAATPQDSPSTTLEPGMSFRQWGDMEPPSPPSPSLLRPPN 1722
            |:|...:|                                                         
 Frog  1035 IRECIQKA--------------------------------------------------------- 1042

  Fly  1723 IFTGGQRSLDEGIPSIDL--IPPSPVLSHKPLNILNASQLGVGMGGGVPSTAGSSSSMHSVIIDD 1785
             |...|:.|||..|..:|  ...|.:.:|..:.|........|..|   :|:|..||:...|||:
 Frog  1043 -FVKKQKGLDEIKPLEELHNKRESCLFNHNAVEINKVLDYHKGDNG---TTSGVGSSVEKYIIDE 1103

  Fly  1786 ISKSSSSTAAATPIYVPTISSTADAQSQSHSLNDVSVGSSPGGEIPATGMSRNANTGASTSGSSS 1850
            ....|.       |:.|:::.|.          .::||.|.         ..|.||...:|.|  
 Frog  1104 NDYMSF-------IHNPSLTVTV----------PIAVGESD---------FENLNTEDFSSES-- 1140

  Fly  1851 SERLPLAPPPQQGSFKQRLRRGSSKKRRASALALATDDNPARRTLDNQARRTQDEEEEQQQLNNG 1915
                                                                 |.||.:::||  
 Frog  1141 -----------------------------------------------------DLEESKEKLN-- 1150

  Fly  1916 GDNSCLLRNSNAVVSGSSSGTKETNRLSPQNSIRRLSNTLSIGSGPVGSRRASACIFNSQVYQNL 1980
                         ::.||.|                 :|:.|                       
 Frog  1151 -------------MTSSSEG-----------------STVDI----------------------- 1162

  Fly  1981 NQPP-KLRPGSGQRRMSSIELAFSKTSHLNLHNLEANRKSLSYTNSKMDLDKWNKSYGNLNEPDN 2044
             :|| .:..|.|                                                 ||.:
 Frog  1163 -RPPGVVAEGEG-------------------------------------------------EPID 1177

  Fly  2045 MLQQYMEARDKRKNSISHYNLKKRLEEKELQQLQQLHQQQLLQQRQDSFSSTTQQQQQQLQQHRL 2109
                                    :|.:|                                    
 Frog  1178 ------------------------IESEE------------------------------------ 1182

  Fly  2110 SKDQQQLAMQPHSMVPGGGERYSKLKMLIEQLTPKHFTTEREDYSLYIFPEDNR------FRQIC 2168
                   |::|.:....|              ..|.|..      .|:..|:|:      ||:.|
 Frog  1183 -------ALEPDACFTEG--------------CVKRFPI------CYVNIEENKGKLWWTFRKTC 1220

  Fly  2169 TWFVNQKWFDNVVLLFIALNCITLAMERPNIPPSSTERLFLATANYVFTVVFTVEMFIKVVATGM 2233
            ...|...||:..::..|.|:...||.|...|....|.:..|..|:.|||.:|.:||.:|.||   
 Frog  1221 YTIVEHNWFETFIIFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVA--- 1282

  Fly  2234 FYGHDAYFTSGWNIMDGSLVTISIIDLLMSLISESSPRIFGILRVFRLLRSLRPLRVINRAPGLK 2298
             ||...|||:.|..:|..:|.:|::.|:.:.:..|.   .|.::..|.||:|||||.::|..|::
 Frog  1283 -YGFVKYFTNAWCWLDFLIVDVSLVSLVANALGYSE---LGAIKSLRTLRALRPLRALSRFEGMR 1343

  Fly  2299 LVVQTLLSSLRPIGNIVLICCTFFIIFGILGVQLFKGTFYYC----EGENI--KGVRNADECRRI 2357
            :||..|:.::..|.|::|:|..|::||.|:||.||.|.:|:|    .||.:  ..|.|..:|..:
 Frog  1344 VVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKYYHCVNTTTGEMLLDTQVNNRSDCLHL 1408

  Fly  2358 PGNV-WTNRKYNFDDLGKALMSLFVLSSRDGWVNIMYTGLDAVGVDQQPIVNYNEWRLLYFIAFI 2421
            ..:. |.|.|.|||::|...::|..:::..||::|||..:|:..|::||....|.:..|||:.||
 Frog  1409 NESARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRKVEEQPRYEDNLYMYLYFVIFI 1473

  Fly  2422 LLVGFFVLNMFVGVVVENFHRCREE--------QEKEEKIRRAAKRALQMEKKRRRMHEPPYYTN 2478
            :...||.||:|:||:::||::.:::        .|:::|...|.|: |..:|.::.:..||    
 Frog  1474 IFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKK-LGSKKPQKPIPRPP---- 1533

  Fly  2479 YSPTRMFVHNVVTSKYFDLAIAAVIGLNVVTMAMEYYKMPSGLKYALKIFNYFFTAVFILEANMK 2543
             :..:..|.:.||.:.||:.|..:|.||:|||.:|..:....::..|...|..|..:|..|..:|
 Frog  1534 -NKYQGLVFDFVTKQAFDIIIMILICLNMVTMMIETDEQSQDMENNLYWINLVFIILFTGECILK 1597

  Fly  2544 LVALGWKLYLKDRWNQLDVGIVLLSIVGIVLEELETNTHQIIPINPTIIRVMRVLRIARVLKLLK 2608
            :::|. ..|....||..|..:|:|||||:.|.::.....    ::||:.||:|:.||.|:|:|:|
 Frog  1598 IISLR-HYYFTIGWNIFDFVVVILSIVGMFLADMIEKYF----VSPTLFRVIRLARIGRILRLIK 1657

  Fly  2609 MANGIRALLDTVMQALPQVGNLGLLFFLLFFIFAALGVELFGRLECSDEIPCQGLGEHAHFANFG 2673
            .|.|||.||..:|.:||.:.|:|||.||:.||:|..|:..|..::..     .|:.:..:|..||
 Frog  1658 GAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKE-----SGIDDMFNFETFG 1717

  Fly  2674 MAFLTLFRVATGDNWNGIMKDTLRDNCDDAADC----------VRNCCVSSVIAPIFFVIFVLMA 2728
            .:.:.||::.|...|:|::...|...   |.||          |:..|.:..:...|||.:::::
 Frog  1718 NSMICLFQITTSAGWDGLLAPILNSG---APDCDPQMEHPGSSVKGDCGNPSVGIFFFVSYIIIS 1779

  Fly  2729 QFVLVNVVVAVLMKHL----EESHKQM-EDELDMEVEL-ERELVREQEFAQEQKLCQQLAEAQSK 2787
            ..|:||:.:||::::.    |||.:.: ||:.:|..|: |:......:|.:..|| ...|:|.. 
 Frog  1780 FLVVVNMYIAVILENFSVATEESAEPLGEDDFEMFYEVWEKFDPDATQFIEYSKL-SNFADALD- 1842

  Fly  2788 AAAPPRPLAK 2797
               ||..:||
 Frog  1843 ---PPLRIAK 1849

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1TNP_001259267.1 Ion_trans 332..636 CDD:278921 87/323 (27%)
Ion_trans 1261..1495 CDD:278921 77/234 (33%)
Ion_trans 2192..2448 CDD:278921 93/270 (34%)
Ion_trans 2510..2728 CDD:278921 69/227 (30%)
scn1aXP_012826731.2 Ion_trans 128..435 CDD:395416 94/354 (27%)
Na_trans_cytopl 515..723 CDD:403218 53/392 (14%)
Ion_trans 772..985 CDD:395416 74/235 (31%)
Na_trans_assoc 1011..1222 CDD:399489 76/636 (12%)
Ion_trans 1226..1498 CDD:395416 97/278 (35%)
Na_channel_gate 1490..1542 CDD:240441 11/57 (19%)
Ion_trans 1547..1802 CDD:395416 83/267 (31%)
GPHH 1814..1861 CDD:407139 11/41 (27%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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