Protein Alignment Ca-alpha1T and cacna1c

DIOPT Version :9

• Sequence 1: NP_001259267.1
• Gene: Ca-alpha1T / 31550
• FlyBaseID: FBgn0264386
• Length: 3218
• Species: Drosophila melanogaster
• Sequence 2: XP_012814814.1
• Gene: cacna1c / 100488055
• XenbaseID: XB-GENE-991126
• Length: 2196
• Species: Xenopus tropicalis
• Alignment Length: 3182
• Identity: 611/3182 - (19%)
• Similarity: 962/3182 - (30%)
• Gaps: 1497/3182 - (47%)

  Fly   206 SGASSLSDAAAATAAGRSRSRGGGRTGGAVSSSTGSSCNGSCSSDDGDSSHTSSSSSSSSSGEPN 270
            |..::||..||..||.:::..      ||.:::|.|:.:.:.......|......:::::.
 Frog    73 SPGAALSWQAAIDAARQAKLM------GAAANATISTVSSTQRKRQQYSKQKKQGTTTATR---- 127

  Fly   271 LPYPGFPEISIRALTQYTRPRNWCLMLITNPWFERVSILVILLNCITLGMYQPC-VDDACVTNRC 334
                  |..::..||.....|..|:.::....||.:.:|.|..||:.|.:|.|. .||:..||
 Frog   128 ------PPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAVYIPFPEDDSNATN-- 184

  Fly   335 KILQIFDDIIFAFFALEMTIKMVAMGIC-GKNTYLADSWNRLDFFIVLAGLLEYVMHV------- 391
            ..|:..:.:....|.:|..:|::|.|:. ..|.||.:.||.|||.||:.||...::..
 Frog   185 SNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGG 249

  Fly   392 -------ENLNLTAIRTIRVLRPLRAINRIPSMRILVMLLLDTLPMLGNVLLLCFFVFFIFGIIG 449
                   ...::.|:|..|||||||.::.:||:::::..::..:..|.::.||..||..|:.|||
 Frog   250 SAIGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIG 314

  Fly   450 VQLWEGILRQRCSLMRTEGMVYPLT--VPEVYRVRVRVNSLSQYYEFSKDQDYICSTPNDSGMHL 512
            ::|:.|.:.:.|         |.||  .|:|               .::::...|:..:::|.|
 Frog   315 LELFMGKMHKTC---------YYLTNGYPDV---------------LTEEEPSPCALESNNGRH- 354

  Fly   513 CGNFPPYRIGSLVCNEEAKLFDFNEPTNTSCVNWNQYYTTCKQSGENPFQGTISFDNIGMAWVAI 577
                                          |.|.    |.|:.....|..|..:|||...|.:.:
 Frog   355 ------------------------------CPNG----TLCRSGWVGPKHGITNFDNFAFAMLTV 385

  Fly   578 FLVISLEGWTDIMYYVQDAHSF-WDWIYFVLLIVIGSFFMINLCLVVIATQFSETKKREMERMRQ 641
            |..|::|||||::|::|||..: ...:|||.|::.||||::||.|.|::.:||  |:||..:.|.
 Frog   386 FQCITMEGWTDVLYWMQDAMGYELPCVYFVSLVIFGSFFVLNLVLGVLSGEFS--KEREKAKARG 448

  Fly   642 ERARYTSTSTLASSTNNSEPATCYAEIVKYIAHLWRRFKRRMLKKYRLYKYQRQQRKEGLLPNAD 706
            :                                         .:|.|    ::||.:|.|....|
 Frog   449 D-----------------------------------------FQKLR----EKQQLEEDLKGYLD 468

  Fly   707 NLTFSPSRIKCHHPKCPKYSNRKPSSIQDQMITVMVPLNSASNNINNNNNNNSNSSNHNGSGNHT 771
            .:|
 Frog   469 WIT-------------------------------------------------------------- 471

  Fly   772 AAGGGNNNNNNNNNNAASCTTVALVNGINGSAASVTMSSAHHQQHQLLQHQQQQHQNQQQQQQQQ 836
                                                                      |.:....
 Frog   472 ----------------------------------------------------------QAEDIDP 478

  Fly   837 QHSSSDNTEQSLAPDGLPRSSSLKKSTAHHQLKPEGSAAEQKTILLKFPQQMIDSEQLILQLGNL 901
            ::...|..|:.      ||:.|:
 Frog   479 ENEDEDIDEEK------PRNMSM------------------------------------------ 495

  Fly   902 GKSHPCTSGFLSPPTSASRRPSVMFNEYVLLHTPPALNADPATAGTTTTVAPTVATVAGTAAAAA 966
                         |||.:.                ::|.|
 Frog   496 -------------PTSETE----------------SVNTD------------------------- 506

  Fly   967 AAAATGSGSGNNNHQNGGASGGAGTGGTTEKSNIFSTEKMTQAGDGSIWQVNLPQTIGTIANPYA 1031
                                 ..|:|...|:|
 Frog   507 ---------------------NVGSGDVEEES--------------------------------- 517

  Fly  1032 DCSELGIHDAMTCQELLAFSVAFSAALPTGQSTLESFYTSLARCDPHTAEALRAHHKPRSVPTGQ 1096
                        |...||..:
 Frog   518 ------------CGVRLAHRI-------------------------------------------- 526

  Fly  1097 NQTTPGAEGATVMVASTAGDTGQTLQPSTVSAVVGGTIDSHAANHRRKEHHQQSHHHHNNNNTTS 1161
                                                                             
 Frog   527 ----------------------------------------------------------------- 526

  Fly  1162 HSRNYRSRQGQGNSRMREPRAPTGNYMEDYACCYDLYQNALSPLDERPRQRSPTTRCLISVYRCM 1226
             |::..||                                                    .:|..
 Frog   527 -SKSKFSR----------------------------------------------------YWRRW 538

  Fly  1227 SRVCSWIRRYIRRLVEHKYFQQGILLAILINTLSMGIEYHNQPPELTAIVETSNVVFSGIFAVEM 1291
            :|.|   ||..|..|:...|...::..:.:|||::..|::|||..||.:.:|:|.|...:|..||
 Frog   539 NRFC---RRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPDWLTEVQDTANKVLLALFTAEM 600

  Fly  1292 LLKVVAEGPFRYIANGFNVFDGIIV---ILSAIEICQTFMGNGTGGGGSGLSVLRTFRLLRILKL 1353
            |||:.:.|...|..:.||.||..||   ||..|.:....|      ...|:||||..|||||.|:
 Frog   601 LLKMYSLGLQAYFVSLFNRFDCFIVCGGILETILVETRIM------SPLGISVLRCVRLLRIFKI 659

  Fly  1354 VRFMPNLRRQLFVMLRTMDNVAVFFSLLVLFIFIFSILGMYLFGGKFCKFLDESGLERECTCPEI 1418
            .|:..:|...:..:|.::.::|....||.|||.|||:|||.||||||             ...|:
 Frog   660 TRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF-------------NFDEM 711

  Fly  1419 ISRHPQCECDRKHFNNILWATVTVFQILTQEDWNVVLFNGM------EKTSHWAALYFVALMTFG 1477
            ::|       |..|:|...|.:|||||||.||||.|:::|:      ........:||:.|...|
 Frog   712 LTR-------RSTFDNFPQALLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICG 769

  Fly  1478 NYVLFNLLVAILVEGF-------SSERNERREREQRELVKKLREETLAENYSDGMYDESRSEADS 1535
            ||:|.|:.:||.|:..       |:::.|..|:|:::|.:....|...||.|.|
 Frog   770 NYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQENESLG----------- 823

  Fly  1536 STTNDSYYEVRNRWRSAEDVRKLQDSVELIIEAKSNMHRQRLLQPTHDYQINELPASSAAPSASG 1600
                                                                    .|..|:.
 Frog   824 --------------------------------------------------------KSPVPAV-- 830

  Fly  1601 TSGASAPGDRERDRDRDRDRERDRDRDRERDREAGGGGKEEGAQHAKPRGGLKKTYSIKERRSEA 1665
                                        |.::|
 Frog   831 ----------------------------EENKE-------------------------------- 835

  Fly  1666 PRLSKIRLARDPPIITTTAATPQDSPSTTLEPGMSFRQWGDMEPPSPPSPSLLRPPNIFTGGQRS 1730
                ||.|.
 Frog   836 ----KIELK-------------------------------------------------------- 840

  Fly  1731 LDEGIPSIDLIPPSPVLSHKPLNILNASQLGVGMGGGVPSTAGSSSSMHSVIIDDISKSSSSTAA 1795
                                                                             
 Frog   841 ----------------------------------------------------------------- 840

  Fly  1796 ATPIYVPTISSTADAQSQSHSLNDVSVGSSPGGEIPATGMSRNANTGASTSGSSSSERLPLAPPP 1860
                     :.|||             |.||            .||..|....|::|.....|.|
 Frog   841 ---------AITAD-------------GESP------------PNTKISVEEFSTNENEEKTPYP 871

  Fly  1861 QQGSFKQRLRRGSSKKRRASALALATDDNPARRTLDNQARRTQDEEEEQQQLNNGGDNSCLLRNS 1925
                                    ::::.|.            :||||:.::
 Frog   872 ------------------------SSNETPG------------EEEEEEPEM------------- 887

  Fly  1926 NAVVSGSSSGTKETNRLSPQNSIRRLSNTLSIGSGPVGSRRASACIFNSQVYQNLNQPPKLRPGS 1990
                                               |||                    |:.||
 Frog   888 -----------------------------------PVG--------------------PRPRP-- 895

  Fly  1991 GQRRMSSIELAFSKTSHLNLHNLEANRKSLSYTNSKMDLDKWNKSYGNLNEPDNMLQQYMEARDK 2055
                                                                             
 Frog   896 ----------------------------------------------------------------- 895

  Fly  2056 RKNSISHYNLKKRLEEKELQQLQQLHQQQLLQQRQDSFSSTTQQQQQQLQQHRLSKDQQQLAMQP 2120
                                 |.:||                              .:::.|..|
 Frog   896 ---------------------LSELH------------------------------IKEKAAPMP 909

  Fly  2121 HSMVPGGGERYSKLKMLIEQLTPKHFTTEREDYSLYIFPEDNRFRQICTWFVNQKWFDNVVLLFI 2185
                                          |..:.::|..|||||..|...||...|.|::|.||
 Frog   910 ------------------------------EASAFFVFRSDNRFRVHCHRIVNNNIFTNLILFFI 944

  Fly  2186 ALNCITLAMERPNIPPSSTERL-------------------FLATANYVFTVVFTVEMFIKVVAT 2231
            .|:.|:||.|.|....|...::                   .|..|:||||.:||:|:.:|:.|.
 Frog   945 LLSSISLAAEDPVRHNSFRNQVLFYFDIVFTAIFTVEIVLKILGNADYVFTSIFTLEIILKMTAY 1009

  Fly  2232 GMFYGHDAYFTSGWNIMDGSLVTISIIDLLMSLISESSPRIFGILRVFRLLRSLRPLRVINRAPG 2296
            |.|....::..:.:||:|..:|::|:|    |...:||  ...::::.|:||.|||||.||||.|
 Frog  1010 GAFLHKGSFCRNYFNILDLLVVSVSLI----SFGIQSS--AINVVKILRVLRVLRPLRAINRAKG 1068

  Fly  2297 LKLVVQTLLSSLRPIGNIVLICCTFFIIFGILGVQLFKGTFYYCEGENIKGVRNADECR------ 2355
            ||.|||.:..::|.|||||::......:|..:|||||||..|.|...:  .:..| ||:
 Frog  1069 LKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYSCTDSS--KITEA-ECKGKYITY 1130

  Fly  2356 --------RIPGNVWTNRKYNFDDLGKALMSLFVLSSRDGWVNIMYTGLDAVGVDQQPIVNYNEW 2412
                    .|....|.|.|::||::..|:|:||.:|:.:||..::|..:|:...|..||.|:...
 Frog  1131 KDGDVSQPMIVDRSWENSKFDFDNVLSAMMALFTVSTFEGWPELLYRAIDSHTEDVGPIYNHRVE 1195

  Fly  2413 RLLYFIAFILLVGFFVLNMFVGVVVENFHRCREEQEKEEKIRRAAKRALQMEKKRRRMHEPPYYT 2477
            ..::||.:|:::.||::|:|||.|:..|....|::.|..::.:..::.::...|.|.:.
 Frog  1196 ISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLR------ 1254

  Fly  2478 NYSPTRMF---VHNVVTSKYFDLAIAAVIGLNVVTMAMEYYKMPSGLKYALKIFNYFFTAVFILE 2539
            .|.|...:   |..||.|.||:..:..:|.||.:.:||::|......|.|:.|.|..||.:|.:|
 Frog  1255 RYIPKNQYQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCSFKEAMNILNMLFTGLFTVE 1319

  Fly  2540 ANMKLVALGWKLYLKDRWNQLDVGIVLLSIVGIVLEELETNTH--------------------QI 2584
            ..:||:|...|.|..|.||..|..||:.|:|.::|.  |||.:                    .|
 Frog  1320 MILKLIAFKPKGYFSDPWNVFDFLIVIGSVVDVILS--ETNHYFCDAWNTFDALIVVGSIVDIAI 1382

  Fly  2585 IPINP-----------------TIIRVMRVLRIARVLKLLKMANGIRALLDTVM---QALPQVGN 2629
            ..:||                 ..|...|:.|:.|::|||....|||.||.|.:   ||||.|
 Frog  1383 TELNPGEHAQCSSSMNVEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYV-- 1445

  Fly  2630 LGLLFFLLFFIFAALGVELFGRLECSDEIPCQGLGEHAHFANFGMAFLTLFRVATGDNWNGIMKD 2694
             .||..:||||:|.:|:::||::..:|...   :..:.:|..|..|.|.|||.|||:.|..||..
 Frog  1446 -ALLIVMLFFIYAVIGMQVFGKIALNDTTE---INRNNNFQTFPQAVLLLFRCATGEAWQEIMLA 1506

  Fly  2695 TLRDN-CDDAADCVRNCCVSSVIAPIFFVIFVLMAQFVLVNVVVAVLM---------------KH 2743
            .|... |...::.....|.|| .|..:|:.|.::..|:::|:.|||:|               .|
 Frog  1507 CLPSKPCAPESETSEEKCGSS-FAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHH 1570

  Fly  2744 LEESHKQMEDELDME----------VELERELVREQEFAQEQKLCQQLAEAQSKAAAPPRPL--- 2795
            |:| .|::..|.|.|          |.|.|.:.....|.   |||.... |..:..|...||
 Frog  1571 LDE-FKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFG---KLCPHRV-ACKRLVAMNMPLNSD 1630

  Fly  2796 ------AKVKSLPKN--FIYSTPSLDKKFPAVSGVNNPSLTSSAATNLNQVATAGSGGAAPGAVP 2852
                  |.:.:|.:.  .|.:..:|::....:..:.......::...|:||            ||
 Frog  1631 GTVMFNATLFALVRTSLCIKTDGNLEQANEELRAIIKKIWKRTSMKLLDQV------------VP 1683

  Fly  2853 AGSGAGPRRQTV----------QYFQQPPQSMLGGLSLAEMGGTLTPQALGARLGEPFGGGGGNK 2907
            .   ||....||          :||::..:....||    :|......||..:.|
 Frog  1684 P---AGDDEVTVGKFYATFLIQEYFRKFKKRKEQGL----VGKPSQRNALSLQAG---------- 1731

  Fly  2908 SGPRRQSYWQINPIRKR---GVLSKERSLDEQAIRRRNLEAKRTSCDSLPWGGDALDCRRGTIFE 2969
                .::...|.|..:|   |.|:.|..|| :|::    ||...:.:.             .||.
 Frog  1732 ----LRTLHDIGPEIRRAISGDLTAEEELD-KAMK----EAVSAASED-------------DIFR 1774

  Fly  2970 SLESDGGGVGGGGSGGGGGGLGGGVSYDLRSVRSADVGHSEMDGDVSLSVVSALVPSVTT---PL 3031
            .               .||..|..|.|....||||                   .|...|   ||
 Frog  1775 R---------------AGGLFGNHVGYYQSEVRSA-------------------FPQTFTTQRPL 1805

  Fly  3032 --------PPPLSLP----IVTPTSTPTPLQLPMPMPMPMAHPPPRRPFGWSQS----------- 3073
                    |..|..|    :|..|.||:                     .:|.|
 Frog  1806 HINKTSGGPGDLDSPSHEKLVDSTFTPS---------------------SYSSSGSNANINNANN 1849

  Fly  3074 ---VDQGCLRSNLLLSVPRSMPPRSRS----GSTKQLFKQQALD----EDADMDENSLLLPTAAG 3127
               |...|.||.:.....:|.|..||.    ||...:.:...|.    |:|..||
 Frog  1850 TALVRLPCYRSTVSTVEGQSRPVTSRGSWKLGSKSSVSRDSRLPIICREEASQDE---------- 1904

  Fly  3128 GGSGPGSVAVIASSSLDL------PDQSGSSKQILP---DIALGVSKSDSSDILRIISERRR 3180
              :...|..|..||...|      .|:...|:|:.|   ::..|:..|.....||..|..||
 Frog  1905 --TYDASEEVEYSSEPSLLCSEMFSDRDEESRQLTPSEGEVERGLCPSPKKGFLRSASLGRR 1964

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ca-alpha1T	NP_001259267.1	Ion_trans	332..636	CDD:278921	87/321 (27%)
		Ion_trans	1261..1495	CDD:278921	89/249 (36%)
		Ion_trans	2192..2448	CDD:278921	95/288 (33%)
		Ion_trans	2510..2728	CDD:278921	81/258 (31%)
cacna1c	XP_012814814.1	Ion_trans	169..445	CDD:278921	94/338 (28%)
		Ion_trans	570..793	CDD:278921	89/248 (36%)
		Ion_trans	985..1230	CDD:278921	90/253 (36%)
		Ion_trans	1290..1564	CDD:278921	87/282 (31%)
		GPHH	1572..1635	CDD:293510	16/67 (24%)
		Ca_chan_IQ	1637..1708	CDD:285917	15/85 (18%)
		CAC1F_C	1731..2149	CDD:293490	67/333 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D172471at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920