DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1T and scn2a

DIOPT Version :9

Sequence 1:NP_001259267.1 Gene:Ca-alpha1T / 31550 FlyBaseID:FBgn0264386 Length:3218 Species:Drosophila melanogaster
Sequence 2:XP_031749252.1 Gene:scn2a / 100486750 XenbaseID:XB-GENE-6447552 Length:1970 Species:Xenopus tropicalis


Alignment Length:2585 Identity:536/2585 - (20%)
Similarity:922/2585 - (35%) Gaps:963/2585 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   284 LTQYTRPRNWCLMLITNPWFERVSILVILLNCITLGMYQPCVDDACVTNRCKILQIFDDIIFAF- 347
            ||.:...|...:.::.:..|..:.:..||.||:.:.:..|             .:...::.:.| 
 Frog   111 LTPFNPVRQAAIKILVHSLFNMLIMCTILTNCVFMTLSNP-------------PEWTKNVEYTFT 162

  Fly   348 --FALEMTIKMVAMGIC-GKNTYLADSWNRLDFFIVLAGLLEYVMHVENL-NLTAIRTIRVLRPL 408
              :.||..||::|.|.| .|.|:|.|.||.|||.::   :|.||....|| |::|:||.||||.|
 Frog   163 GIYTLESLIKILARGFCLEKFTFLRDPWNWLDFSVI---VLAYVTEFVNLGNVSALRTFRVLRAL 224

  Fly   409 RAINRIPSMRILVMLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWEGILRQRCSLMRTEGMVYPL 473
            :.|:.||.::.:|..|:.::..|.:|::|..|...:|.:||:||:.|.||.:|       :::| 
 Frog   225 KTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGHLRNKC-------LLWP- 281

  Fly   474 TVPEVYRVRVRVN-----SLSQYYEFSKDQD-YICSTPNDSGMHLCGNFPPYRIGSLVCNEEAKL 532
                 |...|.::     :.|.:|:....:| .:|...:|:|.               |.|.   
 Frog   282 -----YNSSVDISLYEHFNESLFYKLENQKDPLVCGNSSDTGK---------------CPEG--- 323

  Fly   533 FDFNEPTNTSCVNWNQYYTTCKQSGENPFQGTISFDNIGMAWVAIFLVISLEGWTDIMYYVQDAH 597
                              ..|.::|.||..|..|||....|::::|.:::.:.|.::......|.
 Frog   324 ------------------YVCVKAGRNPNYGYTSFDTFNWAFLSLFRLMTQDCWENLYQLTLRAA 370

  Fly   598 SFWDWIYFVLLIVIGSFFMINLCLVVIATQFSETKKREMERMRQERARYTSTSTLASSTNNSEPA 662
            .....|:|||:|.:|||:::||.|.|:|..:.|..:..:|...|:.|.:                
 Frog   371 GKTYMIFFVLVIFLGSFYLVNLILAVVAMAYEEQNQATIEEAVQKEAEF---------------- 419

  Fly   663 TCYAEIVKYIAHLWRRFKRRMLKKYRLYKYQRQQRKEGLLPNADNLTFSPSRIKCHHPKCPKYSN 727
                               :.|||        ||.:...|..|....|..|              
 Frog   420 -------------------QRLKK--------QQEEAQALAAAVADVFGES-------------- 443

  Fly   728 RKPSSIQDQMITVMVPLNSASNNINNNNNNNSNSSNHNGSGNHTAAGGGNNNNNNNNNNAASCTT 792
                    |.::..|.|..||                                        .|::
 Frog   444 --------QELSEEVGLEDAS----------------------------------------ECSS 460

  Fly   793 VALVNGINGSAASVTMSSAHHQQHQLLQHQQQQHQNQQQQQQQQQHSSSDNTEQSLAPDGL---- 853
                     :.:.::..||..:::...|.:|..|.:.|::..:::...| .:|.|:...||    
 Frog   461 ---------TVSKLSSKSAKERRNWRKQRKQVAHCDGQEKGDKEKCYKS-GSEDSIKRKGLNFTR 515

  Fly   854 --PRSSSLKKSTAHHQ--LKPEGSAAEQKTILLKFPQQMIDSEQLILQLGNLGKSHPCTSGFLSP 914
              .|....:||:..||  |..:|                                          
 Frog   516 EGRRLEEYRKSSMPHQSLLSIQG------------------------------------------ 538

  Fly   915 PTSASRRPSVMFNEYVLLHTPPALNADPATAGTTTTVAPTVATVAGTAAAAAAAAATGSGSGNNN 979
            |..:.||.|                                                        
 Frog   539 PVFSPRRNS-------------------------------------------------------- 547

  Fly   980 HQNGGASGGAGTGGTTEKSNIFSTEKMTQAGDGSIWQVNLPQTIGTIANPYADCSELGIHDAMTC 1044
                             |::|||.:  .:|.|           :|: .|.:||            
 Frog   548 -----------------KTSIFSFK--DRAKD-----------VGS-ENDFAD------------ 569

  Fly  1045 QELLAFSVAFSAALPTGQSTLESFYTSLARCDPHTAEALRAHHKPRSVPTGQNQTTPGAEGATVM 1109
                           ..:||.|..    :|.||   ..:...|:.|   ...|.:........:.
 Frog   570 ---------------DERSTFEED----SRRDP---LFVPGRHRAR---RNSNISQTSRSSRILP 609

  Fly  1110 VASTAGDTGQTLQPSTVSAVVGGTIDSHAANHRRKEHHQQSHHHHNNNNTTSHSRNYRSRQGQGN 1174
            :.|..|....|:..:.|.::|||   |.|......|            .||:.:           
 Frog   610 LLSMNGKMHSTVDCNGVVSLVGG---SSAPIGLFPE------------GTTTET----------- 648

  Fly  1175 SRMREPRAPTGNYMEDYACCYDLYQ----------------NALSPLDERPRQRSPT-----TRC 1218
            .|.|.|        ..|....||.:                |.:..|.| .|::.|:     ..|
 Frog   649 DRKRRP--------SSYKISMDLMEDPSLRQRAQSIASILTNTMEELQE-SRRKCPSCWYKFANC 704

  Fly  1219 LISVYRCMSRVCSW--IRRYIRRLVEHKYFQQGILLAILINTLSMGIEYHNQPPELTAIVETSNV 1281
            .: ::.|..   :|  ::|.::.:|...:....|.::|::||:.|.:|:.:..|...:::.|.|.
 Frog   705 FL-IWDCCE---AWLKVKRIVKLIVMDPFVDLAITISIVLNTIFMAVEHAHMTPYFISVLTTGNQ 765

  Fly  1282 VFSGIFAVEMLLKVVAEGPFRYIANGFNVFDGIIVILSAIEICQTFMGNGTGGGGSGLSVLRTFR 1346
            ||:|||..||:||::|..|:.|...|:|:|||:||.||.:|:       |....| |.||||:||
 Frog   766 VFTGIFTAEMVLKLIALDPYYYFQEGWNIFDGLIVSLSLMEL-------GLSSTG-GFSVLRSFR 822

  Fly  1347 LLRILKLVRFMPNLRRQLFVMLRTMDNVAVFFSLLVLFIFIFSILGMYLFGGKFCKFLDESGLER 1411
            |||:.||.:..|.|.:.:.::..::..:.....:|.:.:|||:::||.|||..:          :
 Frog   823 LLRVFKLAKSWPTLNKLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSY----------K 877

  Fly  1412 ECTCPEIISRHPQCECDRKHFNNILWATVTVFQILTQEDWNVVLFNGMEKTSH-WAALYFVALMT 1475
            ||.|.  |:.:  ||..|.|.|:...:.:.||::|..| |...:::.||.... ...|.|:.:|.
 Frog   878 ECVCK--IAEN--CELPRWHMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQSMCLLVFMLVMV 937

  Fly  1476 FGNYVLFNLLVAILVEGFSSERNERREREQRELVKKLREETLAENYSDGMYDESRSEADSSTTND 1540
            .||.|:.||.:|:|:..|||:..                                    |:|..|
 Frog   938 IGNLVVLNLFLALLLSSFSSDNL------------------------------------SATDED 966

  Fly  1541 SYYEVRNRWRSAEDVRKLQDSVELIIEAKSNMHRQRLLQPTHDYQINELPASSAAPSASGTSGAS 1605
            |  |:.|...:...:::...|.::|:.   ....:..||...|  |||.......|   |.:...
 Frog   967 S--EINNIQIAVGRIQRGVASGKIILR---EFFEKLFLQKQKD--INETKQLEETP---GKNDTC 1021

  Fly  1606 APGDRERDRDRDRDRERDRDRDRERDREAGGGGKEEGAQHAKPRGGLKKTYSIKERRSEAPRLSK 1670
            ..|:...:..::::..||.|                                             
 Frog  1022 VLGNAVVEILKEKNDVRDSD--------------------------------------------- 1041

  Fly  1671 IRLARDPPIITTTAATPQDSPSTTLEPGMSFRQWGDMEPPSPPSPSLLRPPNIFTGGQRSLDEGI 1735
                                                                             
 Frog  1042 ----------------------------------------------------------------- 1041

  Fly  1736 PSIDLIPPSPVLSHKPLNILNASQLGVGMGGGVPSTAGSSSSMHSVIIDDISKSSSSTAAATPIY 1800
                                           |:.|..|||          :.||:.:...    |
 Frog  1042 -------------------------------GMTSEIGSS----------VEKSAENEKE----Y 1061

  Fly  1801 VPTISSTADAQSQSHSLNDVSVGSSPGGEIPATGMSRNANTGASTSGSSSSERLPLAPPPQQGSF 1865
            :..|:.|                                         |.:..:|:||       
 Frog  1062 MTVINKT-----------------------------------------SLTVAVPIAP------- 1078

  Fly  1866 KQRLRRGSSKKRRASALALATDDNPARRTLDNQARRTQDEEEEQQQLNNGGDNSCLLRNSNAVVS 1930
                  |.|           ..:||......:::    |.||.::::.               ||
 Frog  1079 ------GES-----------DFENPNTEEFSSES----DPEETKEKIK---------------VS 1107

  Fly  1931 GSSSGTKETNRLSPQNSIRRLSNTLSIGSGPVGSRRASACIFNSQVYQNLNQPPKLRPGSGQRRM 1995
            .||.|                 :|:.|        ||                    ||      
 Frog  1108 SSSEG-----------------STIDI--------RA--------------------PG------ 1121

  Fly  1996 SSIELAFSKTSHLNLHNLEANRKSLSYTNSKMDLDKWNKSYGNLNEPDNMLQQYMEARDKRKNSI 2060
                             :|...:.|.|            .|....:|:...              
 Frog  1122 -----------------VERIEEFLDY------------EYEETFDPEPCF-------------- 1143

  Fly  2061 SHYNLKKRLEEKELQQLQQLHQQQLLQQRQDSFSSTTQQQQQQLQQHRLSKDQQQLAMQPHSMVP 2125
                                        ..|..:|.|..|                         
 Frog  1144 ----------------------------TDDCVASFTCCQ------------------------- 1155

  Fly  2126 GGGERYSKLKMLIEQLTPKHFTTEREDYSLYIFPEDNRFRQICTWFVNQKWFDNVVLLFIALNCI 2190
                      :.||.      .|.|:.::|         |:.|...|...||::.::..|.|:..
 Frog  1156 ----------INIEN------GTGRDWWNL---------RKTCYTIVEHSWFESFIIFMILLSSG 1195

  Fly  2191 TLAMERPNIPPSSTERLFLATANYVFTVVFTVEMFIKVVATGMFYGHDAYFTSGWNIMDGSLVTI 2255
            .||.|...:......:..|..|:.||..:|.:||.:|.||    ||...|||:.|..:|..:|.|
 Frog  1196 ALAFEDIYVEQRRNVKAILEYADKVFAYIFIMEMLLKWVA----YGFIKYFTNAWCWLDFIIVDI 1256

  Fly  2256 SIIDLLMSLISESSPRIFGILRVFRLLRSLRPLRVINRAPGLKLVVQTLLSSLRPIGNIVLICCT 2320
            |::.|:.:.:..|.   .|.::..|.||:|||||.::|..|:::||..|:.::..|.|::|:|..
 Frog  1257 SLVSLIANALGYSE---LGAIKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLI 1318

  Fly  2321 FFIIFGILGVQLFKGTFYYCEGEN------IKGVRNADECRRIPGNV----WTNRKYNFDDLGKA 2375
            |::||.|:||.||.|.||||....      ...|.|..:||......    |.|.|.|||::|..
 Frog  1319 FWLIFSIMGVNLFAGKFYYCVNTTSGVPFPATDVNNYSDCRMYINTTGAARWKNVKVNFDNVGAG 1383

  Fly  2376 LMSLFVLSSRDGWVNIMYTGLDAVGVDQQPIVNYNEWRLLYFIAFILLVGFFVLNMFVGVVVENF 2440
            .::|..:::..||:.|||..:|:..:::||....|....|||:|||:...||.||:|:||:::||
 Frog  1384 YLALLQVATFKGWMPIMYAAVDSREINEQPKYENNTTMYLYFVAFIIFGSFFTLNLFIGVIIDNF 1448

  Fly  2441 HRCREE--------QEKEEKIRRAAKRALQMEKKRRRMHEPPYYTNYSPTRMFVHNVVTSKYFDL 2497
            ::.:::        .|:::|...|.|: |..:|.::.:..|.     :..:..:.:.||.:.||:
 Frog  1449 NQQKKKLGGQDIFMTEEQKKYYNAMKK-LGSKKPQKPIPRPA-----NCCQGLIFDFVTKQAFDI 1507

  Fly  2498 AIAAVIGLNVVTMAMEYYKMPSGLKYALKIFNYFFTAVFILEANMKLVALGWKLYLKDRWNQLDV 2562
            .|..:|.||:|||.:|.......::..|...|..|..:|..|..:||::|. :.|....||..|:
 Frog  1508 IIMILIFLNMVTMMIETDDQSQEMEMYLYRINAVFIILFTGEFLLKLISLR-QYYFTIGWNIFDL 1571

  Fly  2563 GIVLLSIVGIVLEELETNTHQIIPINPTIIRVMRVLRIARVLKLLKMANGIRALLDTVMQALPQV 2627
            .:|:|||||:.|.::.....    .:||:.||:|:.||.|:|:|:|.|.|||.||..:|.:||.:
 Frog  1572 VVVILSIVGMFLADIIERYF----FSPTLFRVIRLARIGRILRLIKAAKGIRTLLFALMMSLPAL 1632

  Fly  2628 GNLGLLFFLLFFIFAALGVELFGRLECSDEIPCQGLGEHAHFANFGMAFLTLFRVATGDNWNGIM 2692
            .|:|||.||:.||:|..|:..|..::..     .|:.:..:|..||.:.:.||::.|...|:.::
 Frog  1633 FNIGLLLFLVMFIYAIFGMSNFAYVKKQ-----SGIDDMFNFETFGNSMICLFQITTSAGWDLLL 1692

  Fly  2693 KDTLRD---NCDDAAD----CVRNCCVSSVIAPIFFVIFVLMAQFVLVNVVVAVLMKHL----EE 2746
            :..|..   :||..|:    ..:..|.:..:...|||.:::::..::||:.:||::::.    ||
 Frog  1693 EPILNSGEPDCDPNAEHPGSLFKGDCGNPSVGIFFFVSYIIISFLIVVNMYIAVILENFSVATEE 1757

  Fly  2747 SHKQM-EDELDMEVEL-ERELVREQEFAQEQKLCQQLAEAQSKAAAPPRP 2794
            |.:.: ||:.:|..|: |:......:|.:..|| ...|:|.......|:|
 Frog  1758 SAEPLGEDDFEMFYEVWEKFDPSASQFIEYSKL-SDFADALDPPLRVPKP 1806

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1TNP_001259267.1 Ion_trans 332..636 CDD:278921 86/314 (27%)
Ion_trans 1261..1495 CDD:278921 79/234 (34%)
Ion_trans 2192..2448 CDD:278921 92/273 (34%)
Ion_trans 2510..2728 CDD:278921 68/224 (30%)
scn2aXP_031749252.1 Ion_trans 127..408 CDD:395416 92/345 (27%)
Na_trans_cytopl 488..678 CDD:403218 54/390 (14%)
Ion_trans 727..940 CDD:395416 75/235 (32%)
Na_trans_assoc 966..1175 CDD:399489 66/629 (10%)
Ion_trans 1179..1454 CDD:395416 96/281 (34%)
Na_channel_gate 1446..1498 CDD:240441 9/57 (16%)
Ion_trans 1503..1758 CDD:395416 81/264 (31%)
GPHH 1770..1817 CDD:407139 9/38 (24%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
11.000

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