DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1T and scn5a

DIOPT Version :9

Sequence 1:NP_001259267.1 Gene:Ca-alpha1T / 31550 FlyBaseID:FBgn0264386 Length:3218 Species:Drosophila melanogaster
Sequence 2:XP_031760488.1 Gene:scn5a / 100485924 XenbaseID:XB-GENE-6037407 Length:1989 Species:Xenopus tropicalis


Alignment Length:2621 Identity:546/2621 - (20%)
Similarity:916/2621 - (34%) Gaps:1010/2621 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly   291 RNWCLMLITNPWFERVSILVILLNCITLGMYQPCVDDACVTNRCKILQIFDDIIFAFFALEMTIK 355
            |...:.::.:..|....:..||.||:.:.|          ::....|:..:......:..|..||
 Frog   120 RRASIKILVHSLFSMFIMCTILTNCVFMAM----------SDSSAWLKYVEYTFTGIYTFESMIK 174

  Fly   356 MVAMGICGKN-TYLADSWNRLDF-FIVLAGLLEYVMHVENLNLTAIRTIRVLRPLRAINRIPSMR 418
            ::|.|.|.|. |:|.|.||.||| .||:|...|:   |:..|::|:||.||||.|:.|:.||.::
 Frog   175 ILARGFCLKPFTFLRDPWNWLDFSVIVMAYATEF---VDLGNVSALRTFRVLRALKTISVIPGLK 236

  Fly   419 ILVMLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWEGILRQRCSLMRTEGMVYPLTVPEV-YRVR 482
            .:|..|:.::..|.:|::|..|...:|.:.|:||:.|.|:|:|             |.:: |...
 Frog   237 TIVGALIQSVRKLADVMILTVFCLSVFALTGLQLFMGHLKQKC-------------VRDLDYFNA 288

  Fly   483 VRVNSL--------SQYYEFSKDQDYICSTPNDSGMHLCGNFPPYRIGSLVCNEEAKLFD-FNEP 538
            .|:..|        |.|..|..|...|..........||||          .::..|..| |   
 Frog   289 TRMGMLDWSNESMWSSYEAFISDPANIYHKDGAKDALLCGN----------SSDAGKCPDGF--- 340

  Fly   539 TNTSCVNWNQYYTTCKQSGENPFQGTISFDNIGMAWVAIFLVISLEGWTDIMYYVQDAHSFWDWI 603
                         .|.::|.||..|..|||..|.|::::|.:::.:.|.::......|......|
 Frog   341 -------------ICMKTGRNPNYGYTSFDTFGWAFLSLFRLMTQDYWENLYQQTLRAAGKTYMI 392

  Fly   604 YFVLLIVIGSFFMINLCLVVIATQF----------SETKKRE----MERMRQERARYTSTSTLAS 654
            :||.:|.:|||:::||.|.|:|..:          :|.|:||    ||::::|:....|....|:
 Frog   393 FFVFVIFLGSFYLVNLILAVVAMAYEEQNQATIAEAEAKEREFQQAMEQLKKEQEALASKGPDAA 457

  Fly   655 STNNSEPATCYAEIVKYIAHLWRRFKRRMLKKYRLYKY------------QRQQRKEGLLPNADN 707
            |.::.|.:...::..|.     ||.:|:..|.....:|            :...||..:|    .
 Frog   458 SHSSCEMSPFSSKSAKE-----RRNRRKKKKSSETEEYGEDMKPPRGEMDEESLRKMSIL----G 513

  Fly   708 LTFSPSRIKCHHPKCPKYSNRKPSSIQDQMITVMVPLNSASNNINNNNNNNSNSSNHNGSGNHTA 772
            :.|.|                                                     |||....
 Frog   514 IGFGP-----------------------------------------------------GSGKRRI 525

  Fly   773 AGGGNNNNNNNNNNAASCTTVALVNGINGSAASVTMSSAHHQQHQLLQHQQQQHQNQQQQQQQQQ 837
            :.|...|....|.:..|.|..|                                       ..:.
 Frog   526 SQGSIFNFRFRNRDLCSETEFA---------------------------------------DDEV 551

  Fly   838 HSSSDNTEQSLAPDGLPRSSSLKKSTAHHQLKPEGSAAEQKTILLKFPQQMIDSEQLILQLGNLG 902
            .::||....||.   :||:.  ::.:...|..|                         |...|  
 Frog   552 SNASDGHRGSLL---VPRAG--RRQSTQSQTSP-------------------------LSFAN-- 584

  Fly   903 KSHPCTSGFLSPPTSASRRPSVMFNEYVLLHTPPALNADPATAGTTTTVAPTVATVAGTAAAAAA 967
                 |.|:..   :..|..||..|..|.|                                   
 Frog   585 -----TPGYTQ---NGKRNSSVDCNGVVSL----------------------------------- 606

  Fly   968 AAATGSGSGNNNHQNGGASGGAGTGGTTEKSNIFSTEKMTQAGDGSIWQVNLPQTIGTIANPYAD 1032
                              .|||||     .||                    |.:.|.:..|...
 Frog   607 ------------------VGGAGT-----YSN--------------------PTSPGGLLLPAVI 628

  Fly  1033 CSELGIHDAMTCQELLAFSVAFSAALPTGQSTLESFYTSLARCDPHTAEALRAHHKPRSVPTGQN 1097
            ..:.|               |...|.||   .||     |:|.                      
 Frog   629 VEKSG---------------AEENASPT---DLE-----LSRM---------------------- 648

  Fly  1098 QTTPGAEGATVMVASTAGDTGQTLQPSTVSAVVGGTIDSHAANHRRKEHHQQSHHHHNNNNTTSH 1162
                                 |.|.|..:|.                |:..|........:|.| 
 Frog   649 ---------------------QLLMPHALSV----------------EYVDQPFQRQRAVSTVS- 675

  Fly  1163 SRNYRSRQGQGNSRMREPRAPTGNYMEDYACCYDLYQNALSPLDERPRQRSPTTRC------LIS 1221
                                              :..|||..|:| .||:.|.  |      ...
 Frog   676 ----------------------------------VLTNALEELEE-SRQKCPP--CWNHFAQSYL 703

  Fly  1222 VYRCMSRVCS-W--IRRYIRRLVEHKYFQQGILLAILINTLSMGIEYHNQPPELTAIVETSNVVF 1283
            ::.|    || |  |:..::.:|...:....|.:.|::|||.|.:|::...||...::...|.||
 Frog   704 IWDC----CSLWLDIKDGVKFVVMDPFIDLTITICIVLNTLFMALEHYKMTPEFEYMLSVGNYVF 764

  Fly  1284 SGIFAVEMLLKVVAEGPFRYIANGFNVFDGIIVILSAIEICQTFMGNGTGGGGSGLSVLRTFRLL 1348
            :|||..||:.|::|..|:.|...|:|:||.|||.||.:|:|...|||        |||||:||||
 Frog   765 TGIFTAEMVFKIIALDPYYYFQQGWNIFDSIIVCLSLMELCLASMGN--------LSVLRSFRLL 821

  Fly  1349 RILKLVRFMPNLRRQLFVMLRTMDNVAVFFSLLVLFIFIFSILGMYLFGGKFCKFLDESGLEREC 1413
            |:.||.:..|.|...:.::..::..:.....:|.:.:|||:::|:.|||..:.          ||
 Frog   822 RVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGVQLFGRNYF----------EC 876

  Fly  1414 TCPEIISRHPQCECDRKHFNNILWATVTVFQILTQEDWNVVLFNGMEKTSH-WAALYFVALMTFG 1477
            .|.  ||  .:|:..|.|.::...:.:.||::|..| |...:::.||.... ...|.|:.:|..|
 Frog   877 VCK--IS--AECKLPRWHMHDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQPLCILVFMLVMVIG 936

  Fly  1478 NYVLFNLLVAILVEGFSSERNERREREQRELVKKLREETLAENYSDGMYDESRSEADSSTTNDSY 1542
            |.|:.||.:|:|:..||                       |:|.|                    
 Frog   937 NLVVLNLFLALLLSSFS-----------------------ADNLS-------------------- 958

  Fly  1543 YEVRNRWRSAEDVRKLQDSVELIIEAKSNMHRQRLLQPTHDYQINELPASSAAPSASGTSGASAP 1607
                                                .|..|.::|.|                  
 Frog   959 ------------------------------------APDEDGEMNNL------------------ 969

  Fly  1608 GDRERDRDRDRDRERDRDRDRERDREAGGGGKEEGAQHAKPRGGLKKTYSIKERRSEAPRLSKIR 1672
                                                                          :|.
 Frog   970 --------------------------------------------------------------QIA 972

  Fly  1673 LARDPPIITTTAATPQDSPSTTLEPGMSFRQWGDMEPPSPPSPSLLRPPNIFTGGQRSLDEGIPS 1737
            :||                   ::.|:.|.:...::...          |:||.           
 Frog   973 IAR-------------------IQRGIRFVKKAIVDFFC----------NLFTR----------- 997

  Fly  1738 IDLIPPSPVLSHKPLNILNASQLGVGMGGGVPSTAGSSSSMHSVIIDDISKSSSSTAAATPIYVP 1802
                |..|..:.                                      ||:.||         
 Frog   998 ----PDKPAQAF--------------------------------------KSNLST--------- 1011

  Fly  1803 TISSTADAQSQSHSLNDVSVGSSPGGEIPATGMSRNANTGASTSGSSSSERLPLAPPPQQGSFKQ 1867
                      ::.::|::                 |.|...:.|.:.                |:
 Frog  1012 ----------KNQNINNI-----------------NLNNHINMSNTC----------------KE 1033

  Fly  1868 RLRRGSSKKRRASALALATDDNPARRTLDNQARRTQDEEEEQQQLNNGGDNSCLLRNSNAVVSGS 1932
            ..|.|:|                                      .|||    :.:|....|...
 Frog  1034 DFREGNS--------------------------------------TNGG----ISKNGEKYVVSE 1056

  Fly  1933 SSGTKETNRLSPQNSIRRLSNTLSIGSGPVGSRRASACIFNSQVYQNLNQPPKLRPGSGQRRMSS 1997
            |.....:.||                         |.|                           
 Frog  1057 SDDYMTSPRL-------------------------SVC--------------------------- 1069

  Fly  1998 IELAFSKTSHLNLHNLEANRKSLSYTNSKMDLDKWNKSYGNLNEPDNMLQQYMEARDKRKNSISH 2062
            :.:|..: |.:..|  |.:.:|: :|:.::                        :::|:.:||| 
 Frog  1070 VPIALGE-SDVEYH--EEDEQSI-FTDVEI------------------------SKEKQDDSIS- 1105

  Fly  2063 YNLKKRLEEKELQQLQQLHQQQLLQQRQDSFSSTTQQQQQQLQQHRLSKDQQQLAMQPH------ 2121
                 .....:|::.::|.:|  |.:..:.|:.         .:...::|    |.:|.      
 Frog  1106 -----ECSTVDLRKSRELIEQ--LPESSEEFAD---------PEECFTED----ANRPDGTGCLR 1150

  Fly  2122 -------SMVPGGGERYSKLKMLIEQLTPKHFTTEREDYSLYIFPEDNRFRQICTWFVNQKWFDN 2179
                   .:..|.|:.:.||                              |:.|...|...||:.
 Frog  1151 YCSCCRIDITTGAGKIWWKL------------------------------RKTCFKIVEHNWFET 1185

  Fly  2180 VVLLFIALNCITLAMERPNIPPSSTERLFLATANYVFTVVFTVEMFIKVVATGMFYGHDAYFTSG 2244
            .::..|.|:...||.|...|......:..|..|:.|||.||.:||.:|.||    ||...|||:.
 Frog  1186 FIIFMILLSSGALAFEDIYIDQKKVVKTILEYADKVFTYVFVLEMLLKWVA----YGFKKYFTNA 1246

  Fly  2245 WNIMDGSLVTISIIDLLMSLISESSPRIFGILRVFRLLRSLRPLRVINRAPGLKLVVQTLLSSLR 2309
            |..:|..:|.||:..|:::..|:.:   .|.::..|.||:|||||.::|..|:::||..|:.::.
 Frog  1247 WCWLDFFIVDISVACLMVTTFSKGN---VGSVKSLRTLRALRPLRALSRFEGMRVVVNALIGAIP 1308

  Fly  2310 PIGNIVLICCTFFIIFGILGVQLFKGTFYYCEGENIK------GVRNADECRRIPGN--VWTNRK 2366
            .|.|::|:|..|::||.|:||.||.|.|..|.....|      .|.|...|......  .||..|
 Frog  1309 SIMNVLLVCLIFWLIFSIMGVNLFAGKFGKCVNATTKEELSYLTVDNKSMCNDFINTEAYWTKTK 1373

  Fly  2367 YNFDDLGKALMSLFVLSSRDGWVNIMYTGLDAVGVDQQPIVNYNEWRLLYFIAFILLVGFFVLNM 2431
            .|||::|...::|..:::..||::|||..:|:..::||||...|::..|||:.||:...||.||:
 Frog  1374 VNFDNVGAGYLALLQVATFKGWMDIMYAAVDSREIEQQPIYEINKYMYLYFVIFIIFGSFFTLNL 1438

  Fly  2432 FVGVVVENFHRCREE--------QEKEEKIRRAAKRALQMEKKRRRMHEPPYYTNYSPTRMFVHN 2488
            |:||:::||::.:::        .|:::|...|.|: |..:|.::.:..|     .:..:.||.:
 Frog  1439 FIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKK-LGSKKPQKPIPRP-----LNKFQGFVFD 1497

  Fly  2489 VVTSKYFDLAIAAVIGLNVVTMAMEYYKMPSGLKYALKIFNYFFTAVFILEANMKLVALGWKLYL 2553
            :||.:.||:.|..:|.||:|||.:|.......::..|...|..|..:|..|..:|::||.: .:.
 Frog  1498 IVTKQAFDIIIMILICLNMVTMMVETDDQSKEIENLLYKINLAFVVLFSGECILKILALRY-YFF 1561

  Fly  2554 KDRWNQLDVGIVLLSIVGIVLEELETNTHQIIPINPTIIRVMRVLRIARVLKLLKMANGIRALLD 2618
            ...||..|..:|:||||||||.::.....    ::||:.||:|:.||.|||:|::.|.|||.||.
 Frog  1562 TIGWNIFDFVVVILSIVGIVLSDIIEKYF----VSPTLFRVIRLARIGRVLRLIRGAKGIRTLLF 1622

  Fly  2619 TVMQALPQVGNLGLLFFLLFFIFAALGVELFGRLECSDEIPCQGLGEHAHFANFGMAFLTLFRVA 2683
            .:|.:||.:.|:|||.||:.||:|..|:..|..::..     .|:.:..:|..||.:.:.||::.
 Frog  1623 ALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKME-----SGIDDMFNFQTFGNSMICLFQIT 1682

  Fly  2684 TGDNWNGIMKDTLRD---NCD-DAAD----CVRNCCVSSVIAPIFFVIFVLMAQFVLVNVVVAVL 2740
            |...|:|::...|..   :|| |.|:    .:.||...|| ...|||.:::::..::||:.:|::
 Frog  1683 TSAGWDGLLNPILNSGPPDCDPDIANPGSPTLGNCGNPSV-GICFFVSYIIISFLIVVNMYIAII 1746

  Fly  2741 MKHL----EESHKQM-EDELDMEVELERELVREQEFAQEQKLCQQLAEAQSKAAAPPRPLAKVKS 2800
            :::.    |||.:.: ||:.:|..|:..:...|........:....|:..|:.....:| .|:|.
 Frog  1747 LENFSVATEESTEPLSEDDFEMFYEVWEKFDPEATQFISYSVLSNFADTLSEPLRIAKP-NKIKL 1810

  Fly  2801 LPKNFIYSTPSLDKKFPAVSG 2821
            :         ::|  .|.|||
 Frog  1811 I---------AMD--LPMVSG 1820

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1TNP_001259267.1 Ion_trans 332..636 CDD:278921 92/329 (28%)
Ion_trans 1261..1495 CDD:278921 78/234 (33%)
Ion_trans 2192..2448 CDD:278921 94/271 (35%)
Ion_trans 2510..2728 CDD:278921 74/225 (33%)
scn5aXP_031760488.1 Ion_trans 129..424 CDD:395416 94/346 (27%)
Na_trans_cytopl 485..675 CDD:403218 59/485 (12%)
Ion_trans 724..937 CDD:395416 75/235 (32%)
Na_trans_assoc 963..1176 CDD:399489 59/599 (10%)
Ion_trans 1180..1453 CDD:395416 98/279 (35%)
Na_channel_gate 1445..1497 CDD:240441 11/57 (19%)
Ion_trans 1502..1757 CDD:395416 86/265 (32%)
GPHH 1769..1816 CDD:407139 8/58 (14%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
22.010

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