DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1T and cacna1f

DIOPT Version :9

Sequence 1:NP_001259267.1 Gene:Ca-alpha1T / 31550 FlyBaseID:FBgn0264386 Length:3218 Species:Drosophila melanogaster
Sequence 2:XP_031747315.1 Gene:cacna1f / 100485906 XenbaseID:XB-GENE-1013840 Length:2034 Species:Xenopus tropicalis


Alignment Length:3135 Identity:608/3135 - (19%)
Similarity:935/3135 - (29%) Gaps:1535/3135 - (48%)


- Green bases have known domain annotations that are detailed below.


  Fly   211 LSDAAAATAAGRSRSRGGGRTGGAVSSSTGSSCNGSCSSDDGDSSHTSSSSSSSSSGEPNLPYPG 275
            ::.|.||.|..|....||....|.      .:.|.:.||.........|...:..:|..:.    
 Frog    24 MASAEAALACWRYSMDGGPMMNGT------DTLNSTASSQAQKKRQYHSKHKNQGTGGVHR---- 78

  Fly   276 FPEISIRALTQYTRPRNWCLMLITNP----------W--FERVSILVILLNCITLGMYQPC-VDD 327
                |.|||        :||.| :||          |  |:.:.::.|..||:.||:|.|. .||
 Frog    79 ----SPRAL--------FCLYL-SNPIRRACISIVEWKPFDILILMTIFANCVALGVYIPFPEDD 130

  Fly   328 ACVTNRCKILQIFDDIIFAFFALEMTIKMVAMG-ICGKNTYLADSWNRLDFFIVLAGL----LEY 387
            :.:.|.  .|:..:.|....|.:|..:|::|.| :...:.|:.:.||.|||.||:.||    ||.
 Frog   131 SNIANH--NLEQVEYIFLIIFTVESFLKIIAYGLVLHPSAYIRNGWNLLDFVIVVIGLFSVILEQ 193

  Fly   388 VMHVE-----------NLNLTAIRTIRVLRPLRAINRIPSMRILVMLLLDTLPMLGNVLLLCFFV 441
            ..|.:           ..::.|:|..|||||||.::.:||:.|::..::..:..|.::.||..||
 Frog   194 FSHKQGDAHHMSGKPGGFDVKALRAFRVLRPLRLVSGVPSLHIVLNSIMKAMVPLLHIALLVLFV 258

  Fly   442 FFIFGIIGVQLWEGILRQRCSLMRTEGMVYPLTVPEVYRVRVRVNSLSQYYEFSKDQDYICSTPN 506
            ..|:.|||::|:.|.:.:.|                                             
 Frog   259 IIIYAIIGLELFIGRMHKTC--------------------------------------------- 278

  Fly   507 DSGMHLCGNFPPYRIGSLVCNEEAKLFDFNEPT-------NTSCVNWNQYYTTCKQSGENPFQGT 564
                        :.|||.:.:||       ||.       ...|:..|   |.|:...|.|..|.
 Frog   279 ------------FYIGSDLVSEE-------EPAPCAFSGHGRECLLNN---TECRGKWEGPNGGI 321

  Fly   565 ISFDNIGMAWVAIFLVISLEGWTDIMYYVQDAHSF-WDWIYFVLLIVIGSFFMINLCLVVIATQF 628
            .:|||...|.:.:|..|::|||||::|::|||..: ..|:|||.|::.||||::||.|.|::.:|
 Frog   322 TNFDNFFFAMLTVFQCITMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEF 386

  Fly   629 SETKKREMERMRQERARYTSTSTLASSTNNSEPATCYAEIVKYIAHLWRRFKRRMLKKYRLYKYQ 693
            |  |:||..:.|.:                                         .:|.|    :
 Frog   387 S--KEREKAKARGD-----------------------------------------FQKLR----E 404

  Fly   694 RQQRKEGLLPNADNLTFSPSRIKCHHPKCPKYSNRKPSSIQDQMITVMVPLNSASNNINNNNNNN 758
            :||.:|.|....|.:|                                                 
 Frog   405 KQQMEEDLKGYLDWIT------------------------------------------------- 420

  Fly   759 SNSSNHNGSGNHTAAGGGNNNNNNNNNNAASCTTVALVNGINGSAASVTMSSAHHQQHQLLQHQQ 823
                                                                             
 Frog   421 ----------------------------------------------------------------- 420

  Fly   824 QQHQNQQQQQQQQQHSSSDNTEQSLAPDGLPRSSSLKKSTAHHQLKPEGSAAEQKTILLKFPQQM 888
                                ..:.|.||                                   |.
 Frog   421 --------------------QAEDLEPD-----------------------------------QE 430

  Fly   889 IDSEQLILQLGNLGKSHPCTSGFLSPPTSASRRPSVMFNEYVLLHTPPALNADPATAGTTTTVAP 953
            |..|:..|.|.::               :..|:..:.:    |||.                   
 Frog   431 IRDERHRLSLADI---------------TGRRKRRLQW----LLHA------------------- 457

  Fly   954 TVATVAGTAAAAAAAAATGSGSGNNNHQNGGASGGAGTGGTTEKSNIFSTEKMTQAGDGSIWQVN 1018
                                     ||                     |||..|           
 Frog   458 -------------------------NH---------------------STETHT----------- 465

  Fly  1019 LPQTIGTIANPYADCSELGIHDAMTCQELLAFSVAFSAALPTGQSTLESFYTSLARCDPHTAEAL 1083
                                                  :||..::|                   
 Frog   466 --------------------------------------SLPASETT------------------- 473

  Fly  1084 RAHHKPRSVPTGQNQTTPGAEGATVMVASTAGDTGQTLQPSTVSAVVGGTIDSHAANHRRKEHHQ 1148
                   ||.| :|                                    ||...||        
 Frog   474 -------SVNT-EN------------------------------------IDEEHAN-------- 486

  Fly  1149 QSHHHHNNNNTTSHSRNYRSRQGQGNSRMREPRAPTGNYMEDYACCYDLYQNALSPLDERPRQRS 1213
                                                        ||                   
 Frog   487 --------------------------------------------CC------------------- 488

  Fly  1214 PTTRCL--ISVYRCMSRVCSW---IRRYIRRLVEHKYFQQGILLAILINTLSMGIEYHNQPPELT 1273
              .|||  :|...|..::..|   .||..|..|:...|...:||.:.:|||::..|::.||..||
 Frog   489 --ARCLSKLSQTGCCRKIRRWNRAFRRKCRLAVKSVTFYWMVLLLVFLNTLTIASEHYQQPDWLT 551

  Fly  1274 AIVETSNVVFSGIFAVEMLLKVVAEGPFRYIANGFNVFDGIIV---ILSAIEICQTFMGNGTGGG 1335
            .|...:|.|...:|.:|||||:.:.|...|..:.||.||..:|   ||..:.:....|      .
 Frog   552 EIQAYANKVLLSLFTLEMLLKMYSLGLHAYFVSFFNRFDCFVVCGGILETVLVEFDIM------S 610

  Fly  1336 GSGLSVLRTFRLLRILKLVRFMPNLRRQLFVMLRTMDNVAVFFSLLVLFIFIFSILGMYLFGGKF 1400
            ..|:||||..|||||.|:.|...:|...:..:|.:|.::|....||.|||.|||:|||.||||||
 Frog   611 PLGISVLRCVRLLRIFKVTRHWASLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKF 675

  Fly  1401 CKFLDESGLERECTCPEIISRHPQCECDRKHFNNILWATVTVFQILTQEDWNVVLFNGMEK---- 1461
              ..||:                  :..|..|:....|.:|||||||.||||.|:::|:..    
 Frog   676 --NFDET------------------QTKRSTFDTFPQALLTVFQILTGEDWNAVMYDGIMAYGGP 720

  Fly  1462 --TSHWAALYFVALMTFGNYVLFNLLVAILVEGFSSERNERREREQRELVKKLREETLAENYSDG 1524
              ......:||:.|...|||:|.|:.:||.|                            :|.:||
 Frog   721 FFPGMLVCVYFIILFICGNYILLNVFLAIAV----------------------------DNLADG 757

  Fly  1525 MYDESRSEADSSTTNDSYYEVRNRWRSAEDVRKLQDSVELIIEAKSNMHRQRLLQPTHDYQINEL 1589
                     |:..:.|.  :|.|:     ..:|.::||::                         
 Frog   758 ---------DNINSKDK--KVNNK-----SEKKDENSVKV------------------------- 781

  Fly  1590 PASSAAPSASGTSGASAPGDRERDRDRDRDRERDRDRDRERDREAGGGGKEEGAQHAKPRGGLKK 1654
                             |.:.|.:..                       :|||            
 Frog   782 -----------------PCEEENENQ-----------------------EEEG------------ 794

  Fly  1655 TYSIKERRSEAPRLSKIRLARDPPIITTTAATPQDSPSTTLEPGMSFRQWGDMEPPSPPSPSLLR 1719
                    |||                                                      
 Frog   795 --------SEA------------------------------------------------------ 797

  Fly  1720 PPNIFTGGQRSLDEGIPSIDLIPPSPVLSHKPLNILNASQLGVGMGGGVPSTAGSSSSMHSVIID 1784
                                                                             
 Frog   798 ----------------------------------------------------------------- 797

  Fly  1785 DISKSSSSTAAATPIYVPTISSTADAQSQSHSLNDVSVGSSPGGEIPATGMSRNANTGASTSGSS 1849
                                                                             
 Frog   798 ----------------------------------------------------------------- 797

  Fly  1850 SSERLPLAPPPQQGSFKQRLRRGSSKKRRASALALATDDNPARRTLDNQARRTQDEEEEQQQLNN 1914
                                                                  .||||..:   
 Frog   798 ------------------------------------------------------SEEEEDDE--- 805

  Fly  1915 GGDNSCLLRNSNAVVSGSSSGTKETNRLSPQNSIRRLSNTLSIGSGPVGSRRASACIFNSQVYQN 1979
                                                       ||.|                  
 Frog   806 -------------------------------------------GSLP------------------ 809

  Fly  1980 LNQPPKLRPGSGQRRMSSIELAFSKTSHLNLHNLEANRKSLSYTNSKMDLDKWNKSYGNLNEPDN 2044
                                     .|||                                    
 Frog   810 -------------------------ESHL------------------------------------ 813

  Fly  2045 MLQQYMEARDKRKNSISHYNLKKRLEEKELQQLQQLHQQQLLQQRQDSFSSTTQQQQQQLQQHRL 2109
                     ||    |:.:..|    ||.|.                                  
 Frog   814 ---------DK----IADFAPK----EKVLP---------------------------------- 827

  Fly  2110 SKDQQQLAMQPHSMVPGGGERYSKLKMLIEQLTPKHFTTEREDYSLYIFPEDNRFRQICTWFVNQ 2174
                          :|.|.                         :.:|....|..|..|...::.
 Frog   828 --------------IPEGS-------------------------AFFILSNTNLLRVGCHKLIHH 853

  Fly  2175 KWFDNVVLLFIALNCITLAMERPNIPPSSTERLFLATANYVFTVVFTVEMFIKVVATGMFYGHDA 2239
            ..|.|::|:||.|:.|:||.|.| |...|.....|...:|.||.:||||:.:|:.|.|.|. |..
 Frog   854 HIFTNLILVFIILSSISLAAEDP-IRAHSFRNHILGYFDYAFTSIFTVEILLKMTAYGAFL-HKG 916

  Fly  2240 YFTSGW-NIMDGSLVTISIID--LLMSLISESSPRIFGILRVFRLLRSLRPLRVINRAPGLKLVV 2301
            .|...| |::|..:|::|:|.  :..|.||        ::::.|:||.|||||.||||.|||.||
 Frog   917 SFCRNWFNLLDLLVVSVSLISFGIHSSAIS--------VVKILRVLRVLRPLRAINRAKGLKHVV 973

  Fly  2302 QTLLSSLRPIGNIVLICCTFFIIFGILGVQLFKGTFYYCEGENIKGVRNADECR----------- 2355
            |.:..::|.||||:::......:|..:|||||||.||.|..|   ..|:.:||:           
 Frog   974 QCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYSCTDE---AKRSPEECKGTFIIYKEGDV 1035

  Fly  2356 ---RIPGNVWTNRKYNFDDLGKALMSLFVLSSRDGWVNIMYTGLDAVGVDQQPIVNYNEWRLLYF 2417
               .:...:|.|..:|||::...:|:||.:|:.:||..::|..:||.|.:..||.||.....::|
 Frog  1036 SHPMVRERIWHNSDFNFDNVLSGMMALFTVSTFEGWPALLYKAIDAYGENVGPIYNYRVEISIFF 1100

  Fly  2418 IAFILLVGFFVLNMFVGVVVENFHRCREEQEKEEKIRRAAKRALQMEKKRRRMHEPPYYTNYSPT 2482
            |.:|:::.||::|:|||.|:..| |.:.|||.:.         .:::|.:|:..|  |.....|.
 Frog  1101 IVYIIIIAFFMMNIFVGFVIITF-RAQGEQEYKN---------CELDKNQRQCVE--YALKAQPL 1153

  Fly  2483 RMFVHN---------VVTSKYFDLAIAAVIGLNVVTMAMEYYKMPSGLKYALKIFNYFFTAVFIL 2538
            |:::..         :|.|..|:..:..:|.||.|.:||::|:......||:.|.|..||.:|.:
 Frog  1154 RLYIPKAKYQYKVWYMVNSTGFEYIMFVLILLNTVALAMQHYEQSKPFNYAMDILNMVFTGLFTV 1218

  Fly  2539 EANMKLVALGWKLYLKDRWNQLDVGIVLLSIVGIVLEELETNTH------QIIPINPTIIRVMRV 2597
            |..:||:|...|.|..|.||..|..||:.|:|.|.:.|:....|      ....|:.|..|:.||
 Frog  1219 EMVLKLMAFRPKHYFCDAWNTFDALIVVGSLVDIAVTEVNNGWHVGESSEDSSRISITFFRLFRV 1283

  Fly  2598 LRIARVLKLLKMANGIRALLDTVM---QALPQVGNLGLLFFLLFFIFAALGVELFGRLECSDEIP 2659
            :|:   :|||....|||.||.|.:   ||||.|   .||..::|||:|.:|::.||::...|   
 Frog  1284 MRL---VKLLSKGEGIRTLLWTFIKSFQALPYV---ALLIAMIFFIYAVIGMQTFGKIAMQD--- 1339

  Fly  2660 CQGLGEHAHFANFGMAFLTLFRVATGDNWNGIMKDTL-RDNCDDAAD--------CVRNCCVSSV 2715
            ...:..:.:|..|..|.|.|||.|||:.|..||..:| ...||..:|        |..|      
 Frog  1340 ASQINRNNNFQTFPQAVLLLFRCATGEAWQDIMLASLPGKRCDSESDFGPGEEFTCGSN------ 1398

  Fly  2716 IAPIFFVIFVLMAQFVLVNVVVAVLM---------------KHLEESHKQMEDELDME------- 2758
            .|.::|:.|.::..|:::|:.|||:|               .||:| .|::..|.|.|       
 Frog  1399 FAIVYFISFFMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDE-FKRIWSEYDPEAKGRIKH 1462

  Fly  2759 ---VELERELVREQEFAQEQKLCQQLAEAQSKAAAPPRPLAK---VKSLPKNFIYSTPSLDKKFP 2817
               |.|.|.:.....|.   |||            |.|...|   ..::|.|             
 Frog  1463 LDVVTLLRRIQPPLGFG---KLC------------PHRVACKRLVAMNMPLN------------- 1499

  Fly  2818 AVSGVN-NPSLTSSAATNLNQVATAGSGGAA--------------------PGAVPAGSGAGPRR 2861
            |...|. |.:|.:...|:| ::.|.|:...|                    ...:|.     |..
 Frog  1500 ADGTVTFNATLFALVRTSL-KIKTEGNLETANEELRAVIKKIWKRTKQKILDEVIPP-----PEE 1558

  Fly  2862 QTV------------QYF----QQPPQSMLGGLSL-----AEMGGTLTPQALGARLGEPFGGGGG 2905
            :.|            .||    ::..:.:||..:|     ....|..:.|.||:.:         
 Frog  1559 EEVTVGKFYATFLIQDYFRKFRRRKEKGLLGTENLPCNSTTLQAGLRSLQDLGSEI--------- 1614

  Fly  2906 NKSGPRRQSYWQINPIRKRGVLSKERSLDEQAIRRRNLEAKRTSCDSLPWGGDALDCRRGTIFES 2970
                              |.|:|.|...:|.....|.|..:.:...||        |...|:.::
 Frog  1615 ------------------RRVISTELEEEEDISGFRALGLQVSEDKSL--------CENLTLVQA 1653

  Fly  2971 LES--DGGGVGGGGSGGGGGGLGGGVSYDLRSVRSADVGHSEMDGDVSLSVVSALVPSVTTPLPP 3033
            .|:  .|..|....|      :|||....|...|.:.:.:..:.|    |..|.|||    |.||
 Frog  1654 TENKISGSVVSLTNS------IGGGREEQLPMSRRSSLINRSVGG----SKDSLLVP----PTPP 1704

  Fly  3034 P-LSLPI----------------VTPTSTPTPLQLPMPMPMPMAHPPPRRPFGWSQSVDQGCLRS 3081
            | :|..:                :|||                .|          :..::.....
 Frog  1705 PNVSSSMKRRQMTTRRRSSEGSGITPT----------------VH----------EEEEESAAEH 1743

  Fly  3082 NLLLSVPRSMPPRSRSGSTKQLFKQQALDE----DADMDENSLLLPTAAGGGSGPGSVAVIASSS 3142
            .|     ||.||......:.::.:|.:|:|    .|...|...:||..|   :.|.|..  |:.:
 Frog  1744 EL-----RSRPPSPGYDQSNEIQRQSSLEESQQRSASPQERVKVLPPPA---APPSSFR--ANGT 1798

  Fly  3143 LDLPDQSGSSKQILP 3157
            |:  .::...:::||
 Frog  1799 LE--GRATQRRRLLP 1811

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1TNP_001259267.1 Ion_trans 332..636 CDD:278921 91/327 (28%)
Ion_trans 1261..1495 CDD:278921 86/242 (36%)
Ion_trans 2192..2448 CDD:278921 99/272 (36%)
Ion_trans 2510..2728 CDD:278921 79/235 (34%)
cacna1fXP_031747315.1 Ion_trans 102..394 CDD:395416 103/362 (28%)
Ion_trans 524..756 CDD:395416 93/285 (33%)
Ion_trans 853..1090 CDD:395416 90/249 (36%)
Ion_trans 1175..1435 CDD:395416 90/274 (33%)
GPHH 1444..1497 CDD:407139 15/68 (22%)
Ca_chan_IQ 1508..1579 CDD:400901 11/76 (14%)
CAC1F_C 1602..2031 CDD:407123 58/297 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.010

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