DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1T and cacna1s

DIOPT Version :9

Sequence 1:NP_001259267.1 Gene:Ca-alpha1T / 31550 FlyBaseID:FBgn0264386 Length:3218 Species:Drosophila melanogaster
Sequence 2:XP_031752682.1 Gene:cacna1s / 100485035 XenbaseID:XB-GENE-5823874 Length:1689 Species:Xenopus tropicalis


Alignment Length:2580 Identity:496/2580 - (19%)
Similarity:782/2580 - (30%) Gaps:1257/2580 - (48%)


- Green bases have known domain annotations that are detailed below.


  Fly   254 SSHTSSSSSSSSSGEPNLPYPGFPEISIRALTQYTRPRNWCLMLITNPWFERVSILVILLNCITL 318
            |..|....:.....:|.:|....|..|:..|......|..|:.::....||.:.:|.|..|||.|
 Frog     4 SGTTMEEGTQKKKKKPLVPPSPRPPRSLFCLGLQNPFRKSCINIVEWKPFEMIILLTIFANCIAL 68

  Fly   319 GMYQPCVDDACVTNRCK-ILQIFDDIIFAFFALEMTIKMVAMG-ICGKNTYLADSWNRLDFFIVL 381
            .:|.|..:|.  ||... ||:..:.|....|.:|..:|:||.| |...:.||.:.||.|||.||.
 Frog    69 AIYLPMPEDD--TNSVNTILEKIEYIFLFIFTIEAALKIVAYGFILHSDAYLRNCWNILDFTIVS 131

  Fly   382 AGL----LEYVMHVENL--------NLTAIRTIRVLRPLRAINRIPSMRILVMLLLDTLPMLGNV 434
            .||    ||.:..|:.:        |:.|:|..|||||||.::.:||:::::..::..:..|.::
 Frog   132 VGLFTIVLEQINKVQGVTAPGGTGFNVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHI 196

  Fly   435 LLLCFFVFFIFGIIGVQLWEGILRQRCSLMRTEGMVYPLTVPEVYRVRVRVNSLSQYYEFSKDQD 499
            .||..|:..|:.|:|.:|:.|.:.:.|                             ||   |..|
 Frog   197 ALLVLFMIIIYAIVGKELFSGKMHKTC-----------------------------YY---KATD 229

  Fly   500 YICSTPNDSGMHLCGNFPPYRIGSLVCNEEAKLFDFNEPTNTS------CVNWNQYYTTCKQSGE 558
            .|.:....|                             |.:|:      .:|.::    |:....
 Frog   230 VIATVEKPS-----------------------------PCSTTGQGRQCAINGSE----CRGWWP 261

  Fly   559 NPFQGTISFDNIGMAWVAIFLVISLEGWTDIMYYVQDA-HSFWDWIYFVLLIVIGSFFMINLCLV 622
            .|..|...|||.|.|.:.::..|::||||:::|:|.|| .:.|.|||||.||::||||::||.|.
 Frog   262 GPNNGITHFDNFGFAMLTVYQCITMEGWTEVLYWVNDAIGNEWPWIYFVSLILLGSFFVLNLVLG 326

  Fly   623 VIATQFSETKKREMERMRQERARYTSTSTLASSTNNSEPATCYAEIVKYIAHLWRRFKRRMLKKY 687
            |::.:|  ||:||..:                                         .|...:|.
 Frog   327 VLSGEF--TKEREKAK-----------------------------------------SRGAFQKL 348

  Fly   688 RLYKYQRQQRKEGLLPNADNLTFSPSRIKCHHPKCPKYSNRKPSSIQDQMITVMVPLNSASNNIN 752
            |    ::|...|.|....|.:|.:                           .||.|         
 Frog   349 R----EQQAMDEDLRGYLDWITHA---------------------------EVMDP--------- 373

  Fly   753 NNNNNNSNSSNHNGSGNHTAAGGGNNNNNNNNNNAASCTTVALVNGINGSAASVTMSSAHHQQHQ 817
                                                                             
 Frog   374 ----------------------------------------------------------------- 373

  Fly   818 LLQHQQQQHQNQQQQQQQQQHSSSDNTEQSLAPDGLPRSSSLKKSTAHHQLKPEGSAAEQKTILL 882
                                                                             
 Frog   374 ----------------------------------------------------------------- 373

  Fly   883 KFPQQMIDSEQLILQLGNLGKSHPCTSGFLSPPTSASRRPSVMFNEYVLLHTPPALNADPATAGT 947
                   |.||                                                      
 Frog   374 -------DMEQ------------------------------------------------------ 377

  Fly   948 TTTVAPTVATVAGTAAAAAAAAATGSGSGNNNHQNGGASGGAGTGGTTEKSNIFSTEKMTQAGDG 1012
                                                                          |||
 Frog   378 --------------------------------------------------------------GDG 380

  Fly  1013 SIWQVNLPQTIGTIANPYADCSELGIHDAMTCQELLAFSVAFSAALPTGQSTLESFYTSLARCDP 1077
                                                     || .|..|.|..||.|.       
 Frog   381 -----------------------------------------FS-QLEEGCSETESLYE------- 396

  Fly  1078 HTAEALRAHHKPRSVPTGQNQTTPGAEGATVMVASTAGDTGQTLQPSTVSAVVGGTIDSHAANHR 1142
                                     .||....::..                             
 Frog   397 -------------------------LEGINKFISFL----------------------------- 407

  Fly  1143 RKEHHQQSHHHHNNNNTTSHSRNYRSRQGQGNSRMREPRAPTGNYMEDYACCYDLYQNALSPLDE 1207
                 :|..|.|                                                     
 Frog   408 -----KQWRHWH----------------------------------------------------- 414

  Fly  1208 RPRQRSPTTRCLISVYRCMSRVCSWIRRYIRRLVEHKYFQQGILLAILINTLSMGIEYHNQPPEL 1272
                            |.:.|.|       |.||:.::|...::|.||.||:::..|:||||..|
 Frog   415 ----------------RLLRRKC-------RDLVKSRFFYWFVILIILFNTITIATEHHNQPEWL 456

  Fly  1273 TAIVETSNVVFSGIFAVEMLLKVVAEGPFRYIANGFNVFDGIIVILSAIEICQTFMGNGTGGGGS 1337
            |...:.:|.|...:|.:||:||:.|.|...|..:.||.||..:|....:||   .:.:.......
 Frog   457 TKAQDIANQVLLAMFTLEMVLKIYALGFQSYFMSLFNRFDCFVVCTGILEI---LLVSSNIMSPL 518

  Fly  1338 GLSVLRTFRLLRILKLVRFMPNLRRQLFVMLRTMDNVAVFFSLLVLFIFIFSILGMYLFGGKFCK 1402
            |:||||..|||||.|:.|:..:|...:..:|.::.::|....||.||:.||::|||.:||||| .
 Frog   519 GISVLRCIRLLRIFKITRYWTSLNNLVASLLNSVRSIASLLLLLFLFMIIFALLGMQMFGGKF-D 582

  Fly  1403 FLDESGLERECTCPEIISRHPQCECDRKHFNNILWATVTVFQILTQEDWNVVLFNGMEK------ 1461
            |.|                   .|..|..|:|...:.:|||||||.||||.|::||:..      
 Frog   583 FED-------------------TEIRRSTFDNFPQSLITVFQILTGEDWNSVMYNGIMAYGGPTF 628

  Fly  1462 TSHWAALYFVALMTFGNYVLFNLLVAILVEGFSSERNERREREQRELVKKLREETLAENYSDGMY 1526
            ...:..:||:.|...|||:|.|:.:||.|:..                                 
 Frog   629 PGMFVCIYFIILFVCGNYILLNVFLAIAVDNL--------------------------------- 660

  Fly  1527 DESRSEADSSTTNDSYYEVRNRWRSAEDVRKLQDSVELIIEAKSNMHRQRLLQPTHDYQINELPA 1591
                :||::.|:                                                     
 Frog   661 ----AEAENLTS----------------------------------------------------- 668

  Fly  1592 SSAAPSASGTSGASAPGDRERDRDRDRDRERDRDRDRERDREAGGGGKEEGAQHAKPRGGLKKTY 1656
                                                               ||.||         
 Frog   669 ---------------------------------------------------AQKAK--------- 673

  Fly  1657 SIKERRSEAPRLSKIRLARDPPIITTTAATPQDSPSTTLEPGMSFRQWGDMEPPSPPSPSLLRPP 1721
             .:||:.:       :|||..|                                           
 Frog   674 -AEERKRK-------KLARAHP------------------------------------------- 687

  Fly  1722 NIFTGGQRSLDEGIPSIDLIPPSPVLSHKPLNILNASQLGV-GMGGGVPSTAGSSSSMHSVIIDD 1785
                  .:|.:|                   .:|.|.:|.: ..|.|:|:||       .:.||:
 Frog   688 ------DKSEEE-------------------KLLLAKKLEMKAKGEGIPTTA-------KLKIDE 720

  Fly  1786 ISKSSSSTAAATPIYVPTISSTADAQSQSHSLNDVSVGSSPGGEIPATGMSRNANTGASTSGSSS 1850
            .                        :|..:.:.|    ..|..:.|.                  
 Frog   721 F------------------------ESNVNEIKD----PYPSADFPG------------------ 739

  Fly  1851 SERLPLAPPPQQGSFKQRLRRGSSKKRRASALALATDDNPARRTLDNQARRTQDEEEEQQQLNNG 1915
                                                                 |:|||:.::   
 Frog   740 -----------------------------------------------------DDEEEEPEI--- 748

  Fly  1916 GDNSCLLRNSNAVVSGSSSGTKETNRLSPQNSIRRLSNTLSIGSGPVGSRRASACIFNSQVYQNL 1980
                                                         |:.                 
 Frog   749 ---------------------------------------------PIS----------------- 751

  Fly  1981 NQPPKLRPGSGQRRMSSIELAFSKTSHLNLHNLEANRKSLSYTNSKMDLDKWNKSYGNLNEPDNM 2045
               |:.||                     |..|:...|::...::.                   
 Frog   752 ---PRPRP---------------------LAELQLKEKAVPMPDAS------------------- 773

  Fly  2046 LQQYMEARDKRKNSISHYNLKKRLEEKELQQLQQLHQQQLLQQRQDSFSSTTQQQQQQLQQHRLS 2110
                                                                             
 Frog   774 ----------------------------------------------------------------- 773

  Fly  2111 KDQQQLAMQPHSMVPGGGERYSKLKMLIEQLTPKHFTTEREDYSLYIFPEDNRFRQICTWFVNQK 2175
                                                       |.:||...|:||.:|...||..
 Frog   774 -------------------------------------------SFFIFGPTNKFRVLCHRIVNAT 795

  Fly  2176 WFDNVVLLFIALNCITLAMERPNIPPSSTERLFLATANYVFTVVFTVEMFIKVVATGMFYGHDAY 2240
            .|.|.:||||.|:.|:||.|.| |.|.|.....||..:||||.:||.|:.:|:...|.|....::
 Frog   796 TFTNFILLFILLSSISLAAEDP-IEPESFRNQILAYFDYVFTAIFTTEIALKMTTYGAFLHKGSF 859

  Fly  2241 FTSGWNIMDGSLVTISIID--LLMSLISESSPRIFGILRVFRLLRSLRPLRVINRAPGLKLVVQT 2303
            ..:.:||:|..:|.:|::.  :..|.||        ::::.|:||.|||||.||||.|||.|||.
 Frog   860 CRNYFNILDLLVVAVSLVSFGIQSSAIS--------VVKILRVLRVLRPLRAINRAKGLKHVVQC 916

  Fly  2304 LLSSLRPIGNIVLICCTFFIIFGILGVQLFKGTFYYCEGENIKGVRNADECR------------- 2355
            :..:::.||||||:......:|..:|||||||.||.|. :..|  ...:|||             
 Frog   917 VFVAIKTIGNIVLVTTLLQFMFSCIGVQLFKGKFYSCT-DTTK--MTEEECRGYFIVAKDGDSTQ 978

  Fly  2356 -RIPGNVWTNRKYNFDDLGKALMSLFVLSSRDGWVNIMYTGLDAVGVDQQPIVNYNEWRLLYFIA 2419
             ::...:||:..::||::...:||||.:|:.:||..::|..:|:...|..||.||.....::||.
 Frog   979 IQLRERIWTHSDFHFDNVLSGMMSLFTISTFEGWPQLLYRAIDSHSEDMGPIYNYRIEIAVFFII 1043

  Fly  2420 FILLVGFFVLNMFVGVVVENFHRCREEQEKEEKIRRAAKRALQMEKKRRRMHEPPYYTNYSPTRM 2484
            :|:|:.||::|:|||.|:..|....|::.|..::.:..::.:|...|.|.:.      .|.|...
 Frog  1044 YIILIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVQYALKARPLR------RYIPKNQ 1102

  Fly  2485 FVHNV---VTSKYFDLAIAAVIGLNVVTMAMEYYKMPSGLKYALKIFNYFFTAVFILEANMKLVA 2546
            ..:.:   |||.||:..:.|:|.||.:::.|::|...:...:...|.|..||.:|.:|..:||.|
 Frog  1103 HQYKIWYLVTSSYFEYLMFALIMLNTISLGMQHYGQTAEFSHLSDILNVAFTGIFTVEMVLKLAA 1167

  Fly  2547 LGWKLYLKDRWNQLDVGIVLLSIVGIVLEELETNTHQIIPINPTIIRV----MRVLRIARVLKLL 2607
            ...|.|..|.||..|..||:.||:.::|.|::|....:.|.:....|:    .|:.|:.|::|||
 Frog  1168 FKAKGYFGDPWNVFDFLIVIGSIIDVILSEIDTPEPVVTPGSEDTSRISITFFRLFRVMRLVKLL 1232

  Fly  2608 KMANGIRALLDTVM---QALPQVGNLGLLFFLLFFIFAALGVELFGRLECSDEIPCQGLGEHAHF 2669
            ....|:|.||.|.:   ||||.|   .||..:||||:|.:|:::||::...|...   :..:.:|
 Frog  1233 SRGEGVRTLLWTFIKSFQALPYV---ALLIVMLFFIYAVIGMQVFGKIAMVDGTQ---INRNNNF 1291

  Fly  2670 ANFGMAFLTLFRVATGDNWNGI-MKDTLRDNCDDAADCV---RNCCVSSVIAPIFFVIFVLMAQF 2730
            ..|..|.|.|||.|||:.|..| :..:....||..:|.:   ...|.:| .|..:|:.|.::..|
 Frog  1292 QTFPQAVLVLFRCATGEAWQEILLACSYGKLCDPKSDFLPGEEYTCGTS-FAYFYFISFYMLCAF 1355

  Fly  2731 VLVNVVVAVLM---------------KHLEESHKQMEDELDMEVE 2760
            :::|:.|||:|               .||:| .|::..|.|.|.:
 Frog  1356 LIINLFVAVIMDNFDYLTRDWSILGPHHLDE-FKRIWAEYDPEAK 1399

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1TNP_001259267.1 Ion_trans 332..636 CDD:278921 93/324 (29%)
Ion_trans 1261..1495 CDD:278921 84/239 (35%)
Ion_trans 2192..2448 CDD:278921 97/271 (36%)
Ion_trans 2510..2728 CDD:278921 73/228 (32%)
cacna1sXP_031752682.1 Ion_trans 50..340 CDD:395416 106/358 (30%)
Ion_trans 427..668 CDD:395416 92/300 (31%)
Ion_trans 794..1071 CDD:395416 105/288 (36%)
Ion_trans 1113..1377 CDD:395416 86/270 (32%)
GPHH 1386..1439 CDD:407139 5/15 (33%)
Ca_chan_IQ 1450..1521 CDD:400901
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.010

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