DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1T and scn3a

DIOPT Version :9

Sequence 1:NP_001259267.1 Gene:Ca-alpha1T / 31550 FlyBaseID:FBgn0264386 Length:3218 Species:Drosophila melanogaster
Sequence 2:XP_012826714.1 Gene:scn3a / 100125099 XenbaseID:XB-GENE-5812330 Length:2019 Species:Xenopus tropicalis


Alignment Length:2591 Identity:541/2591 - (20%)
Similarity:918/2591 - (35%) Gaps:935/2591 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   284 LTQYTRPRNWCLMLITNPWFERVSILVILLNCITLGMYQPCVDDACVTNRCKILQIFDDIIFAF- 347
            ||.:...|...:.::.:..|..:.:..||.||..:.|..|             .:...::.:.| 
 Frog   113 LTPFNPLRRISIKILVHSLFSMLIMCTILTNCFFMTMSNP-------------PEWTKNVEYTFT 164

  Fly   348 --FALEMTIKMVAMGICGKN-TYLADSWNRLDFFIVLAGLLEYVMHVENL-NLTAIRTIRVLRPL 408
              :..|..:|::|.|.|.:: |:|.|.||.|||.::   ::.||....:| |::|:||.||||.|
 Frog   165 GIYTFESLVKILARGFCLESFTFLRDPWNWLDFSVI---VMAYVTEFVDLGNVSALRTFRVLRAL 226

  Fly   409 RAINRIPSMRILVMLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWEGILRQRCSLMRTEGMVYPL 473
            :.|:.||.::.:|..|:.::..|.:|::|..|...:|.:||:||:.|.||.:|.....|   |..
 Frog   227 KTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGHLRNKCVRWPPE---YEP 288

  Fly   474 TVPEVYR------VRVRVNSLSQYYEFSKDQDYICSTPNDSGMHLCGNFPPYRIGSLVCNEEAKL 532
            .:...:.      :.|.:|..::       ::||....|       ..|.|....:|:|.     
 Frog   289 NITSYFNETAGLYINVTLNPFNR-------EEYILEETN-------FYFLPGTRDALLCG----- 334

  Fly   533 FDFNEPTNTSCVNWNQYYTTCKQSGENPFQGTISFDNIGMAWVAIFLVISLEGWTDIMYYVQDAH 597
                   |:|..........|.::|.||..|..|||....|::::|.:::.:.|.::......|.
 Frog   335 -------NSSDAGQCPKGYVCLKTGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAA 392

  Fly   598 SFWDWIYFVLLIVIGSFFMINLCLVVIATQFSETKKREMERMRQERARYTSTSTLASSTNNSEPA 662
            .....|:|||:|.:|||::|||.|.|:|..:.|..:..:|...|:.|.:                
 Frog   393 GKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEF---------------- 441

  Fly   663 TCYAEIVKYIAHLWRRFKRRMLKKYRLYKYQRQQRKEGLLPNADNLTFSPSRIKCHHPKCPKYSN 727
                                .|...:|.|:|.:.:...|...    |...||         ::| 
 Frog   442 --------------------QLMMEQLKKHQEEIQAAALAAE----TMDGSR---------EFS- 472

  Fly   728 RKPSSIQDQMITVMVPLNSASNNINNNNNNNSNSSNHNGSGNHTAAGGGNNNNNNNNNNAASCTT 792
                                                 .|:|.     ||.:.:::          
 Frog   473 -------------------------------------GGTGY-----GGLSESSS---------- 485

  Fly   793 VALVNGINGSAASVTMSSAHHQQHQLLQHQQQQHQNQQQQQQQQQHSSSDNTEQSLAPDGL---- 853
                     .|:..:..||..::::..:.:|::....::...::.|.|:  :|.|:...|.    
 Frog   486 ---------EASKPSSKSAKERRNRRKKRKQKEQGEDEKADDEKFHKSA--SETSIKRKGFRFSI 539

  Fly   854 --PRSSSLKKSTAHHQ--LKPEGSAAEQKTILLKFPQQMIDSEQLILQLGNLGKSHPCTSGFLSP 914
              .|.:..||.::.||  |...||        |.||::  ||...:......||.....:.|...
 Frog   540 EGNRLTYEKKYSSPHQSRLSFRGS--------LFFPRR--DSRASLCSFRGRGKDVGSENDFADD 594

  Fly   915 PTSA-----SRRPSVMFNEYVLLHTPPALNADPATAGTTTTVAPTVATVAGTAAAAAAAAATGSG 974
            ..|.     |||.|        |..|                                       
 Frog   595 EHSTFEDNESRRGS--------LFVP--------------------------------------- 612

  Fly   975 SGNNNHQNGGASGGAGTGGTTEKSNIFSTEKMTQAGDGSIWQVNLPQTIGTIANPYADCSELGIH 1039
                 |::          |....|||..|.|.::         .||                   
 Frog   613 -----HRH----------GERRNSNISQTSKASR---------TLP------------------- 634

  Fly  1040 DAMTCQELLAFSVAFSAALPTGQSTLESFYTSLARCDPHTAEALRAHHKPRSVPTGQNQTTPGAE 1104
                             .||.                                 .|:..:|....
 Frog   635 -----------------VLPV---------------------------------NGKMHSTVDCN 649

  Fly  1105 GATVMVASTAGDTGQT--LQPSTVSAVVGGTIDSHAANHRRKEHHQQSHHHHNNNNTTSHSRNYR 1167
            |...::...:|.|...  |.|..:       ||..|::             .|..||.:..|  :
 Frog   650 GVVSLLGGPSGPTSPAGLLLPEVI-------IDKPASD-------------DNGTNTENELR--K 692

  Fly  1168 SRQGQGNSRMREPRAPTGNYMEDYACCYDLYQNALS----------PLDERPRQRSPTTRCLISV 1222
            .|....:..|        :::||..    |.|.|||          .|:|...:..|......:.
 Frog   693 RRLSSYHVSM--------DFLEDPI----LRQRALSIASNLTNTMEELEESREKCPPCWNKFANT 745

  Fly  1223 YRCMSRVCSW--IRRYIRRLVEHKYFQQGILLAILINTLSMGIEYHNQPPELTAIVETSNVVFSG 1285
            |.......||  |:..:..:|...:....|.:.|::|||.|.:|::....|....:...|:||:|
 Frog   746 YLIWDCSDSWLKIKHVVNLIVMDPFVDLAITICIVLNTLFMAMEHYPITDEFAGALNVGNLVFTG 810

  Fly  1286 IFAVEMLLKVVAEGPFRYIANGFNVFDGIIVILSAIEICQTFMGNGTGGGGSGLSVLRTFRLLRI 1350
            ||..||:.|::|..|:.|...|:|:|||:||.||.:|:..:.:        .||||||:|||||:
 Frog   811 IFTAEMVFKLIALDPYYYFQVGWNIFDGVIVSLSLMELGLSDV--------EGLSVLRSFRLLRV 867

  Fly  1351 LKLVRFMPNLRRQLFVMLRTMDNVAVFFSLLVLFIFIFSILGMYLFGGKFCKFLDESGLERECTC 1415
            .||.:..|.|...:.::..::..:.....:|.:.:|||:::||.|||..:          :||.|
 Frog   868 FKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSY----------KECVC 922

  Fly  1416 ---PEIISRHPQCECDRKHFNNILWATVTVFQILTQEDWNVVLFNGMEKTSHWAAL-YFVALMTF 1476
               |:      .||..|.|.|:...:.:.||::|..| |...:::.||.......| .|:.:|..
 Frog   923 KIAPD------DCELPRWHMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQAMCLTVFMMVMVI 980

  Fly  1477 GNYVLFNLLVAILVEGFSSERNERREREQRELVKKLREETLAENYSDGMYDESRSEADSSTTNDS 1541
            ||.|:.||.:|:|:..|||                   :.||                 :|.:|:
 Frog   981 GNLVVLNLFLALLLSSFSS-------------------DNLA-----------------ATEDDN 1009

  Fly  1542 YYEVRNRWRSAEDVRKLQDSVELIIEAKSNMHRQRLLQPTHDYQINELPASSAAPSASGTSGASA 1606
                        ::..||.:|       :.||                                 
 Frog  1010 ------------EMNNLQIAV-------ARMH--------------------------------- 1022

  Fly  1607 PGDRERDRDRDRDRERDRDRDRERDREAGGGGKEEGAQHAKPRGGLKKTYSIKERRSEAPRLSKI 1671
                                              ||..:.|                     .|:
 Frog  1023 ----------------------------------EGIAYVK---------------------RKM 1032

  Fly  1672 RLARDPPIITTTAATPQDSPSTTLEPGMSFRQWGDMEPPSPPSPSLLRPPNIFTGGQRSLDEGIP 1736
            |                           .|.|                  |.|...|::|:|..|
 Frog  1033 R---------------------------EFIQ------------------NAFVKKQKALEETKP 1052

  Fly  1737 SIDLIPPSPVLSHKPLNILNASQLGVGM-------GGGVPSTAGSSSSMHSVIIDDISKSSSSTA 1794
            ..|:      .:.|...|.|.:.:.:..       |....:|:|..||:...|||:....|.   
 Frog  1053 LEDM------QNQKDSCISNHTTVEISKEYDYLKDGNVTTATSGIGSSVEKYIIDESDYMSF--- 1108

  Fly  1795 AATPIYVPTISSTADAQSQSHSLNDVSVGSSPGGEIPATGMSRNANTGASTSGSSSSERLPLAPP 1859
                |:.|:::.|.          .::||.|.         ..|.||...:|.|...|.      
 Frog  1109 ----IHNPSLTVTV----------PIAVGESD---------FENLNTEEFSSESDLEES------ 1144

  Fly  1860 PQQGSFKQRLRRGSSKKRRASALALATDDNPARRTLDNQARRTQDEEEEQQQLNNGGDNSCLLRN 1924
                  |::|...||.:.....:..|.:..|.          .|.|.||.|:.:....:.|:   
 Frog  1145 ------KEKLNSSSSSEGSTVDIRPAGEGEPV----------PQVEVEEFQEPDACFTDGCI--- 1190

  Fly  1925 SNAVVSGSSSGTKETNRLSPQNSIRRLSNTLSIGSGPVGSRRASACIFNSQVYQNLNQPPKLRPG 1989
                                                    ||...|:.:                
 Frog  1191 ----------------------------------------RRFPCCVVD---------------- 1199

  Fly  1990 SGQRRMSSIELAFSKTSHLNLHNLEANRKSLSYTNSKMDLDKWNKSYGNLNEPDNMLQQYMEARD 2054
                           .||                      .|| |.:.||               
 Frog  1200 ---------------VSH----------------------GKW-KQWWNL--------------- 1211

  Fly  2055 KRKNSISHYNLKKRLEEKELQQLQQLHQQQLLQQRQDSFSSTTQQQQQQLQQHRLSKDQQQLAMQ 2119
                                                                             
 Frog  1212 ----------------------------------------------------------------- 1211

  Fly  2120 PHSMVPGGGERYSKLKMLIEQLTPKHFTTEREDYSLYIFPEDNRFRQICTWFVNQKWFDNVVLLF 2184
                                                         |:.|...|...||:..::..
 Frog  1212 ---------------------------------------------RKTCFLIVEHNWFETFIIFM 1231

  Fly  2185 IALNCITLAMERPNIPPSSTERLFLATANYVFTVVFTVEMFIKVVATGMFYGHDAYFTSGWNIMD 2249
            |.::...||.|...|....|.::.|..|:.|||.:|.:||.:|.||    ||...|||:.|..:|
 Frog  1232 ILMSSGALAFEDIYIEQRKTIKIILEYADKVFTYIFILEMLLKWVA----YGFQKYFTNAWCWLD 1292

  Fly  2250 GSLVTISIIDLLMSLISESSPRIFGILRVFRLLRSLRPLRVINRAPGLKLVVQTLLSSLRPIGNI 2314
            ..:|.:|::.|:.:.:..|.   .|.::..|.||:|||||.::|..|:::||..|:.::..|.|:
 Frog  1293 FLIVDVSLVSLIANALGYSE---LGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNV 1354

  Fly  2315 VLICCTFFIIFGILGVQLFKGTFYYCEGE------NIKGVRNADECRRIPGN----VWTNRKYNF 2369
            :|:|..|::||.|:||.:|.|.:.||...      :...|.|..:|..:...    .|.|.|.||
 Frog  1355 LLVCLIFWLIFSIMGVNMFSGKYGYCVNYTDDVVFDYTIVNNRSQCMDLISENKTARWKNVKVNF 1419

  Fly  2370 DDLGKALMSLFVLSSRDGWVNIMYTGLDAVGVDQQPIVNYNEWRLLYFIAFILLVGFFVLNMFVG 2434
            |::|...::|..:::..||:.|||..:|:...::||....|.:..|||:.||:...||.||:|:|
 Frog  1420 DNVGFGYLALLQVATFKGWMEIMYAAVDSRKQEEQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIG 1484

  Fly  2435 VVVENFHRCREE--------QEKEEKIRRAAKRALQMEKKRRRMHEPPYYTNYSPTRMFVHNVVT 2491
            |:::||::.:::        .|:::|...|.|: |..:|.::.:..|.     :..:..|.:.|:
 Frog  1485 VIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKK-LGSKKPQKPVPRPD-----NKFQGAVFDFVS 1543

  Fly  2492 SKYFDLAIAAVIGLNVVTMAMEYYKMPSGLKYALKIFNYFFTAVFILEANMKLVALGWKLYLKDR 2556
            .:.||:||..:|.||:|||.:|........:..|...|..|..:|..|..:||::|. ..|....
 Frog  1544 KQPFDIAIMILICLNMVTMMIETDDQSIETENNLYWINAVFIVLFTGECVLKLISLR-HYYFTIG 1607

  Fly  2557 WNQLDVGIVLLSIVGIVLEELETNTHQIIPINPTIIRVMRVLRIARVLKLLKMANGIRALLDTVM 2621
            ||..|..:|:|||||:.|.:|.....    ::||:.||:|:.||.|:|:|:|.|.|||.||..:|
 Frog  1608 WNIFDFVVVILSIVGMFLADLIEKYF----VSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALM 1668

  Fly  2622 QALPQVGNLGLLFFLLFFIFAALGVELFGRLECSDEIPCQGLGEHAHFANFGMAFLTLFRVATGD 2686
            .:||.:.|:|||.||:.||:|..|:..|..::..     .|:.:..:|..||.:.:.||::.|..
 Frog  1669 MSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKE-----AGIDDMFNFETFGNSMICLFQITTSA 1728

  Fly  2687 NWNGIMKDTLRD---NCDDAAD----CVRNCCVSSVIAPIFFVIFVLMAQFVLVNVVVAVLMKHL 2744
            .|:|::...|..   :||..|:    .|:..|.:..:...|||.:::::..|:||:.:||::::.
 Frog  1729 GWDGLLAPILNSGAPDCDPKAEHSGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENF 1793

  Fly  2745 ----EESHKQM-EDELDMEVEL-ERELVREQEFAQEQKLCQQLAEAQSKAAAPPRP 2794
                |||.:.: ||:.:|..|: |:......:|.|..|| ...|:|.......|:|
 Frog  1794 SVATEESAEPLGEDDFEMFYEVWEKFDSNATQFIQYVKL-TDFADALDPPLRMPKP 1848

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1TNP_001259267.1 Ion_trans 332..636 CDD:278921 84/314 (27%)
Ion_trans 1261..1495 CDD:278921 76/237 (32%)
Ion_trans 2192..2448 CDD:278921 89/273 (33%)
Ion_trans 2510..2728 CDD:278921 71/224 (32%)
scn3aXP_012826714.1 Ion_trans 151..430 CDD:278921 85/323 (26%)
Na_trans_cytopl 512..627 CDD:288761 33/188 (18%)
Ion_trans 786..982 CDD:278921 68/220 (31%)
Na_trans_assoc 1008..1216 CDD:284034 67/635 (11%)
Ion_trans 1239..1496 CDD:278921 89/263 (34%)
Na_channel_gate 1488..1540 CDD:240441 10/57 (18%)
Ion_trans 1562..1800 CDD:278921 77/247 (31%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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