DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ca-alpha1T and cacna1hb

DIOPT Version :9

Sequence 1:	NP_001259267.1	Gene:	Ca-alpha1T / 31550	FlyBaseID:	FBgn0264386	Length:	3218	Species:	Drosophila melanogaster
Sequence 2:	XP_021331616.1	Gene:	cacna1hb / 100007317	ZFINID:	ZDB-GENE-090312-128	Length:	2102	Species:	Danio rerio

Alignment Length:	2968	Identity:	1021/2968 - (34%)
Similarity:	1355/2968 - (45%)	Gaps:	953/2968 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   308 ILVILLNCITLGMYQPCVDDACVTNRCKILQIFDDIIFAFFALEMTIKMVAMGICGKNTYLADSW 372
            :|||||||:||||:|||.|..|.|:||.|||.|||.||||||:||.:||||:|:.|...||.|:|
Zfish     1 MLVILLNCVTLGMFQPCQDLECHTDRCSILQAFDDFIFAFFAVEMVVKMVALGVFGPKCYLGDTW 65

  Fly   373 NRLDFFIVLAGLLEYVMHVENLNLTAIRTIRVLRPLRAINRIPSMRILVMLLLDTLPMLGNVLLL 437
            ||||.|||:||:|||.:...|::.:||||:|||||||||||:|||||||.|||||||||||||||
Zfish    66 NRLDLFIVMAGMLEYSLDGHNVSFSAIRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLL 130

  Fly   438 CFFVFFIFGIIGVQLWEGILRQRCSLMRTEGMVYPLTVPEVYRVRVRVNSLSQYYEFSKDQD--Y 500
            ||||||||||:|||||.|:||.||.......|:|.::           .|:|:||...:..|  :
Zfish   131 CFFVFFIFGIVGVQLWAGLLRNRCFFDNNIRMLYNVS-----------GSVSEYYRVDETDDIPF 184

  Fly   501 ICSTPNDSGMHLCGNFPPYRIGSLVCN---EEAKLFDFNEPTNTSCVNWNQYYTTCKQSGENPFQ 562
            ||||..::||..|.|.|..|:....|.   :......|.|..:..|||||.||.||..|..||..
Zfish   185 ICSTNRENGMLRCSNVPKRRVAGADCELTADNVTELVFKEAPHHGCVNWNLYYNTCNASEHNPHN 249

  Fly   563 GTISFDNIGMAWVAIFLVISLEGWTDIMYYVQDAHSFWDWIYFVLLIVIGSFFMINLCLVVIATQ 627
            |.|:|||||.||:|||.||:||||.||||||.|||||:::|||:.||::||||||||||||||||
Zfish   250 GAINFDNIGYAWIAIFQVITLEGWADIMYYVMDAHSFYNFIYFIFLIIVGSFFMINLCLVVIATQ 314

  Fly   628 FSETKKREMERMRQERARYTST-STLASSTNNSEPATCYAEIVKYIAHLWRRFKRRMLKKYRLYK 691
            |||||:||.:.|:::|||:.|. |||||.   :||.:||.|::||:||:.|:..|.:::.|
Zfish   315 FSETKQRENQLMQEQRARFRSNESTLASL---AEPGSCYEEMLKYLAHVCRKLWRHVVRIY---- 372

  Fly   692 YQRQQRKEGLLPNADNLTFSPSRIKCHHPKCPKYSNRKPSSIQDQMITVMVPLNSASNNINNNNN 756
                    |.|                   |||  .||..:.....::|
Zfish   373 --------GDL-------------------CPK--RRKGVANPGTSLSV---------------- 392

  Fly   757 NNSNSSNHNGSGNHTAAGGGNNNNNNNNNNAASCTTVALVNGINGSAASVTMSSAHHQQHQLLQH 821
                              ||.|...::|......|...:::              :|..|
Zfish   393 ------------------GGTNGYWSDNGTKMGPTQYCMLH--------------YHHPH----- 420

  Fly   822 QQQQHQNQQQQQQQQQHSSSDNTEQSLAPDGLPRSSSLKKSTAHHQLKPEGSAAEQKTILLKFPQ 886
                           ||..|:..|.....  |.|.:.:.|.|
Zfish   421 ---------------QHYISNGIEMKTLQ--LDRDAHIAKKT----------------------- 445

  Fly   887 QMIDSEQLILQLGN-----LGKSHPCTSGFLSPPTSASRRPSVMFNEYVLLHTPPALNADPATAG 946
                 ..|.|.|.|     ||.::|            :..||.|:
Zfish   446 -----PSLPLALQNLKGLRLGMNYP------------TILPSKMY-------------------- 473

  Fly   947 TTTTVAPTVATVAGTAAAAAAAAATGSGSGNNNHQNGGASGGAGTGGTTEKSNIFSTEKMTQAGD 1011
                                          .|:|..|            .|:..|..
Zfish   474 ------------------------------TNSHARG------------VKAPAFHH-------- 488

  Fly  1012 GSIWQVNLPQTIGTIANPYADCSELGIHDAMTCQELLAFSVAFSAALPTGQSTLESFYTSLARCD 1076
                        |......:.|.  |.||....|                    ...|
Zfish   489 ------------GIYGRKISVCG--GYHDTYKLQ--------------------HGVY------- 512

  Fly  1077 PHTAEALRAHHKPRSVPTGQNQTTPGAEGATVMVASTAGDTGQTLQPSTVSAVVGGTIDSHAANH 1141
            |.|..::....:...| :.|:.:.|        :.:..||              |...||:..:.
Zfish   513 PGTCSSVCVDSRVGLV-SSQSSSCP--------ICAQEGD--------------GVNCDSNGESD 554

  Fly  1142 RRKEHHQQSHHHHNNN----NTTSHSRNYRSRQGQGNSRMREPRAPTGNYMEDYACCYDLYQNAL 1202
            ..|:...........|    ...|..||
Zfish   555 PEKQGPDVGSEQRKTNLDAEEKVSEKRN------------------------------------- 582

  Fly  1203 SPLDERPRQRSPTTRCLISVYRCMSRVCSWIRRYIRRLVEHKYFQQGILLAILINTLSMGIEYHN 1267
                                  |:.....:.|..::|:|:.|||.:||::||||||||||:|||.
Zfish   583 ----------------------CVCMCVHYARAVLKRIVDSKYFNRGIMIAILINTLSMGVEYHE 625

  Fly  1268 QPPELTAIVETSNVVFSGIFAVEMLLKVVAEGPFRYIANGFNVFDGIIVILSAIEICQTFMGNGT 1332
            ||.|||.::|.||:||:.:|.:|||||:.|.|.|.||:|.:|:|||||||:|..||        .
Zfish   626 QPDELTDVLEISNIVFTSLFVLEMLLKLSACGLFDYISNPYNIFDGIIVIISVCEI--------V 682

  Fly  1333 GGGGSGLSVLRTFRLLRILKLVRFMPNLRRQLFVMLRTMDNVAVFFSLLVLFIFIFSILGMYLFG 1397
            |....|.||||||||||:||||||:|.|||||.|:::||||||.|..||:|||||||||||:|||
Zfish   683 GQADGGFSVLRTFRLLRVLKLVRFLPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFG 747

  Fly  1398 GKFCKFLDESGLERECTCPEIISRHPQCECDRKHFNNILWATVTVFQILTQEDWNVVLFNGMEKT 1462
            .||...| |:|        :.:|       |||:|:::|||.||||||||||||||||:|||..|
Zfish   748 CKFTLRL-ENG--------DTVS-------DRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMAST 796

  Fly  1463 SHWAALYFVALMTFGNYVLFNLLVAILVEGFSSERNERREREQRELVKKLREETLAENYSDGMYD 1527
            |.:||||||||||||||||||||||||||||.:|.                             |
Zfish   797 SPYAALYFVALMTFGNYVLFNLLVAILVEGFQAEG-----------------------------D 832

  Fly  1528 ESRSEADSSTTNDSYYEVRNRWRSAEDVRKLQDSVELIIEAKSNMHRQRLLQPTHDYQINELPAS 1592
            .|||:.|...::| |.:              :|.:..::.:.:.|..|.|:
Zfish   833 ASRSDTDDDMSSD-YGD--------------EDKLRELLNSGTEMKMQTLM-------------- 868

  Fly  1593 SAAPSASGTSGASAPGDRERDRDRDRDRERDRDRDRERDREAGGGGKEEGAQHAKPRGGLKKTYS 1657
               |.::|                                            |.:||..:
Zfish   869 ---PISNG--------------------------------------------HLEPRASM----- 881

  Fly  1658 IKERRSEAPRLSKIRLARDPPIITTTAATPQDSPSTTLEPGMSFRQWGDMEPPSPPSPSLLRPPN 1722
                               ||  ..|......:|.|.:.                         :
Zfish   882 -------------------PP--NNTHVQFNSTPRTEVS-------------------------H 900

  Fly  1723 IFTGGQRSLDEGIPSIDLIPPSPVLSHKPLNILNASQLGVGMGGGVPSTAGSSSSMHSVIIDDIS 1787
            |::..:|:                                         :.:|:.:|.      .
Zfish   901 IYSQSRRN-----------------------------------------SNTSTELHD------Q 918

  Fly  1788 KSSSSTAAATPIYVPTISSTADAQSQSHSLNDVSVGSSPGGEIPATGMSRNANTGASTSGSSSSE 1852
            :|.||...                |:..|.|  |:|.:|       .:.|.|.:|
Zfish   919 RSLSSLWG----------------SRRSSWN--SLGHAP-------NLLRRAQSG---------- 948

  Fly  1853 RLPLAPPPQQGSFKQRLRRGSSKKRRASALALATDDNPARRTLDNQARRTQDEEEEQQQLNNGGD 1917
                                    .|.|.|:     .|.|.::|:..     .|:|:..|   |.
Zfish   949 ------------------------ERESLLS-----GPGRDSIDDNL-----SEDEKSSL---GG 976

  Fly  1918 NSCLLRNSNAVVSGSSSGTKETNRLSPQNSIRRLSNTLSIGSGPVGSRRASACIFNSQVYQNLNQ 1982
            .|||         ||..                                          :..|.|
Zfish   977 VSCL---------GSFD------------------------------------------FPELLQ 990

  Fly  1983 PPKLRPGSGQRRMSSIELAFSKTSHLNLHNLEANRKSLSYTNSKMDLDKWNKSYGNLNEPDNMLQ 2047
            .|  ||                       .||.|.:          ||....|..|:..|:....
Zfish   991 VP--RP-----------------------YLECNGR----------LDGGYNSSPNITHPEPTST 1020

  Fly  2048 QYMEARDKRKNSISHYNLKKRLEEKELQQLQQLHQQQLLQQRQDSFSSTTQQQQQQLQQHRLSKD 2112
            |..|                                      .|.|.
Zfish  1021 QGAE--------------------------------------DDEFE------------------ 1029

  Fly  2113 QQQLAMQPHSMVPGGGERYSKLKMLIEQLTPKHFTTEREDYSLYIFPEDNRFRQICTWFVNQKWF 2177
                  :...::         ||.|:|...|: :..:.||:|||:|...|.||..|...:..|.|
Zfish  1030 ------ESWCLI---------LKRLLEPYKPQ-WCRDHEDWSLYLFAPQNNFRMRCQKVITHKMF 1078

  Fly  2178 DNVVLLFIALNCITLAMERPNIPPSSTERLFLATANYVFTVVFTVEMFIKVVATGMFYGHDAYFT 2242
            |::||.||..||||:|:|||:|.|.||||:||..:||:|||:|..||.:|||:.|::.|..:|..
Zfish  1079 DHIVLFFIFFNCITIALERPDIQPDSTERIFLKVSNYIFTVIFVAEMTVKVVSLGLYAGPGSYLK 1143

  Fly  2243 SGWNIMDGSLVTISIIDLLMSLISESSPRIFGILRVFRLLRSLRPLRVINRAPGLKLVVQTLLSS 2307
            |.||::||.||.:||:|:|:||.|....||.|||||.||||:|||||||:|||||||||:||::|
Zfish  1144 SSWNVLDGFLVFVSIVDILVSLASSGGNRILGILRVLRLLRTLRPLRVISRAPGLKLVVETLITS 1208

  Fly  2308 LRPIGNIVLICCTFFIIFGILGVQLFKGTFYYCEGENIKGVRNADECRRIPGNVWTNRKYNFDDL 2372
            ||||||||||||.|||:|||||||||||.||:|||.:.:.:.|..||.:.... |..||||||:|
Zfish  1209 LRPIGNIVLICCAFFIVFGILGVQLFKGKFYHCEGFDTRNITNKSECLQAKYK-WIRRKYNFDNL 1272

  Fly  2373 GKALMSLFVLSSRDGWVNIMYTGLDAVGVDQQPIVNYNEWRLLYFIAFILLVGFFVLNMFVGVVV 2437
            |:||||||||||:||||||||.|||||.||||||.|:|.|.|||||:|:|:|.||||||||||||
Zfish  1273 GQALMSLFVLSSKDGWVNIMYDGLDAVAVDQQPIRNHNPWMLLYFISFLLIVSFFVLNMFVGVVV 1337

  Fly  2438 ENFHRCREEQEKEEKIRRAAKRALQMEKKRRRMHEPPYYTNYSPTRMFVHNVVTSKYFDLAIAAV 2502
            ||||:||::||:||..||..||..:||||||:..:.|||.:|||||:::|.:.||.|.||.|..:
Zfish  1338 ENFHKCRQDQEEEEARRREEKRQKRMEKKRRKALQRPYYADYSPTRLYIHTLCTSHYLDLFITII 1402

  Fly  2503 IGLNVVTMAMEYYKMPSGLKYALKIFNYFFTAVFILEANMKLVALGWKLYLKDRWNQLDVGIVLL 2567
            |.:||:||:||:|:.|..|...||..|||||.||::||.:||||.|::.:.|:||||||:.||||
Zfish  1403 IAINVLTMSMEHYRQPKYLDEGLKYCNYFFTLVFVIEAALKLVAFGFRRFFKERWNQLDLAIVLL 1467

  Fly  2568 SIVGIVLEELETNTHQIIPINPTIIRVMRVLRIARVLKLLKMANGIRALLDTVMQALPQVGNLGL 2632
            ||:||.|||::.|..  :||||||||:||||||||||||||||.|:|||||||:|||||||||||
Zfish  1468 SIMGITLEEIDLNAS--LPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGL 1530

  Fly  2633 LFFLLFFIFAALGVELFGRLECSDEIPCQGLGEHAHFANFGMAFLTLFRVATGDNWNGIMKDTLR 2697
            ||.|||||:|||||||||:|:|::|.||:||..||.|.||||||||||||:||||||||||||||
Zfish  1531 LFMLLFFIYAALGVELFGKLDCTEENPCEGLSRHATFQNFGMAFLTLFRVSTGDNWNGIMKDTLR 1595

  Fly  2698 DNCDDAADCVRNCCVS--SVIAPIFFVIFVLMAQFVLVNVVVAVLMKHLEESH--KQMEDELDME 2758
                   :|..:.|:|  .:::|::||.||||||||||||||||||||||||:  .:.|.|:|.|
Zfish  1596 -------ECKNDKCLSYLPLLSPLYFVTFVLMAQFVLVNVVVAVLMKHLEESNIDAREEAEMDAE 1653

  Fly  2759 VELERELVREQEFAQ----------EQKLCQQLAEAQSKAAAPP---------RP-LAKVKSLPK 2803
            ::||.|..|.|..|.          :.|: :.|:..|.|   .|         || ::::.|||.
Zfish  1654 LKLELEAGRRQSTASVGGAAGLEGTDAKI-ETLSHDQGK---DPNYGNFLTVGRPSISRMLSLPN 1714

  Fly  2804 N--FIYSTPSLDKKFPAVSGVNNPSLTSSAATNLNQVATAGSGGAAPGA--------VPAGSGAG 2858
            :  .:|....|.......|...:.:|..|:.:...|.:...:....|||        |||.....
Zfish  1715 DSYMLYPIKPLYGSIHERSSKQDCTLPGSSLSLGTQPSEDSAVMQVPGAASQTSLASVPAPRPLN 1779

  Fly  2859 PRRQTVQYF-----QQPPQSMLGGLSLAEMGGTL-------TPQALGARL-GEPFGGGGGNKSGP 2910
            .|.:|...|     ||..:|.....:.|:....|       :...|..:: ..|.||    :|.|
Zfish  1780 QRARTSNAFRGLRRQQAIKSDSIDSTYADSRDALQIPSKPCSSDNLHLKVPSVPIGG----RSAP 1840

  Fly  2911 RRQSYWQINPIRKRGVLSKERSLDEQAIRRRNLEAKRTSCDSLPWGGDALDCRRGTIFESLESDG 2975
            .........|:|.|   :.....:.....:|::..::|:....|.....|:..|.....||...
Zfish  1841 CSPQTSPPPPLRNR---TASVQTNRHVYSQRSIPCRQTAIKPHPDAAVRLNTNRRASRHSLSPH- 1901

  Fly  2976 GGVGGGGSGGGGGGLGGGVSYDLRSVRSADVGHSEMDGDVSLSVVSALVPS--VTTPLPP----- 3033
                           ...:|.|.:|..|..|| :....|.||...:::..:  ::.|..|
Zfish  1902 ---------------HPSLSSDTQSQDSLHVG-APRHQDTSLRKYNSMENNGFLSQPQIPRRHST 1950

  Fly  3034 ----------PLSLPIVTPTSTPTPLQLPMPMPMPMAHPPPRRPFGWSQSVDQGCLRSNLLLSVP 3088
                      |.|   .:.:|:.||.:..|..|.....||..     |:.|.|.|  |::|
Zfish  1951 HGEELRLQQDPSS---SSSSSSHTPKKDKMSPPCISIEPPAE-----SEVVSQEC--SSVL---- 2001

  Fly  3089 RSMPPRSRSGSTKQLFKQQALDEDADMDE----NSLLLPTAAGGGSGPGSVAVIASSSLDLPDQS 3149
                 |.|:.|......:::||.....||    :.|.||..:...|   .|:.::|.|..|.|..
Zfish  2002 -----RRRTPSFDSALPRESLDLPDVQDEPHLPSRLPLPQFSFDQS---DVSSLSSLSELLSDSD 2058

  Fly  3150 GSSKQILPDIALGVSKSDSSDILRIISERRRMDQREQREPEQD 3192
            .|:..|..:...|.:...:...||   ::..:.....|:|..|
Zfish  2059 QSTHSIAHESRSGFAGDAAHSPLR---KKVLVRMASTRDPGND 2098

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ca-alpha1T	NP_001259267.1	Ion_trans	332..636	CDD:278921	184/308 (60%)
		Ion_trans	1261..1495	CDD:278921	148/233 (64%)
		Ion_trans	2192..2448	CDD:278921	171/255 (67%)
		Ion_trans	2510..2728	CDD:278921	145/219 (66%)
cacna1hb	XP_021331616.1	Ion_trans	1..323	CDD:306908	201/332 (61%)
		Ion_trans	601..828	CDD:306908	160/250 (64%)
		Ion_trans	1075..1347	CDD:306908	182/272 (67%)
		Ion_trans	1392..1597	CDD:306908	145/213 (68%)
		Herpes_TAF50	<1739..2026	CDD:308764	65/329 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	421	1.000	Domainoid score	I612
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1560	1.000	Inparanoid score	I88
OMA	1	1.010	-	-		QHG59758
OrthoDB	1	1.010	-	-		D172471at2759
OrthoFinder	1	1.000	-	-		FOG0001656
OrthoInspector	1	1.000	-	-		otm24624
orthoMCL	1	0.900	-	-		OOG6_102692
Panther	1	1.100	-	-	O	PTHR10037
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1056
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.980