DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep1 and ECE2

DIOPT Version :9

Sequence 1:	NP_001284925.1	Gene:	Nep1 / 31547	FlyBaseID:	FBgn0029843	Length:	849	Species:	Drosophila melanogaster
Sequence 2:	NP_001093590.1	Gene:	ECE2 / 9718	HGNCID:	13275	Length:	811	Species:	Homo sapiens

Alignment Length:	861	Identity:	314/861 - (36%)
Similarity:	485/861 - (56%)	Gaps:	86/861 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 NAPLEELSATVVSPLLGQQQVQHQAPHQMQQQQQQQQQNKLPTVVFLAPDG-SGGVGIQRGNPAQ 87
            |..|:||.|       |...|:::     :...:.:...:.|.....:||. ..|.|....:|..
Human     2 NVALQELGA-------GSNMVEYK-----RATLRDEDAPETPVEGGASPDAMEVGKGASPFSPGP 54

  Fly    88 GNPGMVTGTGSHSD--WLL--------------------KESQQ----RRRL-LVLAIAFTVLGA 125
             :|||..||...|.  |.:                    |.::|    |.:| ||||.|..:|.|
Human    55 -SPGMTPGTPRSSGLFWRVTCPHLRSISGLCSRTMVGFQKGTRQLLGSRTQLELVLAGASLLLAA 118

  Fly   126 -AIGALAIYFASVHQRCHLYRLEPDNDDRPNGRWNQDSGSAHEGQDNICMTQECVRTAASLLSAM 189
             .:|.|.......|:       :|.:                    :.|:|:.|:|.|..:|.::
Human   119 LLLGCLVALGVQYHR-------DPSH--------------------STCLTEACIRVAGKILESL 156

  Fly   190 DLNSDPCEDFFQYACGTWNKMHPIPEDRSSISTFEVLSDQQQVILRAVLEEPIDERDNKATIKAK 254
            |....|||||:|::||.|.:.:|:|:.||..:||..|.||.|.||:.:||.......::|..|.:
Human   157 DRGVSPCEDFYQFSCGGWIRRNPLPDGRSRWNTFNSLWDQNQAILKHLLENTTFNSSSEAEQKTQ 221

  Fly   255 TFFKSCMDIPQIRKIGTGRLKQVLQSLGGWPVIERNWSPPADLSVERLMGQLRL---NYSEPVMI 316
            .|:.||:.:.:|.::|...|:.:::.:|||     |.:.|.|  .:..|..|:.   .|......
Human   222 RFYLSCLQVERIEELGAQPLRDLIEKIGGW-----NITGPWD--QDNFMEVLKAVAGTYRATPFF 279

  Fly   317 ELYVGADDKNSSVNILQMDQLQYALPSRDYYLKESSANDR--RAYHRYMTQVALLLGADPATAAA 379
            .:|:.||.|:|:.|::|:||....||||||||.. :||::  .||..||.::.:|||..|.:...
Human   280 TVYISADSKSSNSNVIQVDQSGLFLPSRDYYLNR-TANEKVLTAYLDYMEELGMLLGGRPTSTRE 343

  Fly   380 ELEKVVLFETQLVNVSLPEADRHDTSLVYRKMLLPELQELVPEVQWQEYLQAALGPGIPLQEDEP 444
            ::::|:..|.||.|:::|:..|.|...:|.||.:.|||.|.|.:.|.|:|...|.| :.|.:.||
Human   344 QMQQVLELEIQLANITVPQDQRRDEEKIYHKMSISELQALAPSMDWLEFLSFLLSP-LELSDSEP 407

  Fly   445 LVTYGLHYLTEMGKILAHTDRRVVHNYMLWRLVMSLMSHMIDEYQRERVEFRKILMGIQSERT-R 508
            :|.||:.||.::.:::..|:..:::||::|.||....|.:...::..:.:..:.|.|.:.... |
Human   408 VVVYGMDYLQQVSELINRTEPSILNNYLIWNLVQKTTSSLDRRFESAQEKLLETLYGTKKSCVPR 472

  Fly   509 WSQCVEWTNKKLGVAVGALFIRDNFNQESKEVALEMIHTIRAAFNELLAENDWMDDETRAVAKEK 573
            |..|:..|:..||.|:|:||::..|:::|||:|..||..||.||.|.|.:..|||::||..||||
Human   473 WQTCISNTDDALGFALGSLFVKATFDRQSKEIAEGMISEIRTAFEEALGQLVWMDEKTRQAAKEK 537

  Fly   574 ADSMNERIGYPELLTNATELEQEYVNLTIVPDNFINNVLSILQWESEKMLRLLRQPVDKEKWTTE 638
            ||::.:.||:|:.:....||:..|....|..|:|..|:|::..:.::.|...||:|..:::|:..
Human   538 ADAIYDMIGFPDFILEPKELDDVYDGYEISEDSFFQNMLNLYNFSAKVMADQLRKPPSRDQWSMT 602

  Fly   639 PAVVNAFYNPNKNDIVFPAGILQPLFYSQHFPKSLNYGGIGVVIGHEITHGFDDKGRQFDKEGNM 703
            |..|||:|.|.||:|||||||||..||:::.||:||:||||||:|||:||.|||:||::|||||:
Human   603 PQTVNAYYLPTKNEIVFPAGILQAPFYARNHPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNL 667

  Fly   704 MQWWNNATIEAFRERTQCVIDQYSRYKINEVDMFMDGRMTQGENIADNGGLKQAFRAYKKWETLH 768
            ..||.|.::.|||..|.|:.:||::|::|  ...::||.|.|||||||||||.|:.|||.|...|
Human   668 RPWWQNESLAAFRNHTACMEEQYNQYQVN--GERLNGRQTLGENIADNGGLKAAYNAYKAWLRKH 730

  Fly   769 GREQQLPGLNMTHDQLFFLNYAQIWCGSMRPEDALTKIRSAVHSPGFVRVLGPLSNSRDFASAYK 833
            |.|||||.:.:|:.||||:.:||:||....||.:...:.:..|||...||||.|||||||...:.
Human   731 GEEQQLPAVGLTNHQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFG 795

  Fly   834 CPLGSTMNPAEKCSVW 849
            ||:||.|||.:.|.||
Human   796 CPVGSPMNPGQLCEVW 811

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep1	NP_001284925.1	M13	194..847	CDD:189000	269/658 (41%)
ECE2	NP_001093590.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	22..64		11/42 (26%)
ECE2	NP_001093590.1	M13	160..809	CDD:189000	269/659 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H56679
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG61902
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	1	1.000	-	-		FOG0000538
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100162
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.930