DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep1 and MMEL1

DIOPT Version :9

Sequence 1:	NP_001284925.1	Gene:	Nep1 / 31547	FlyBaseID:	FBgn0029843	Length:	849	Species:	Drosophila melanogaster
Sequence 2:	NP_258428.2	Gene:	MMEL1 / 79258	HGNCID:	14668	Length:	779	Species:	Homo sapiens

Alignment Length:	803	Identity:	321/803 - (39%)
Similarity:	462/803 - (57%)	Gaps:	54/803 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 DGSGGVGIQRGNPAQGNPGMVTGTGSHSDWLLKESQQRRRLLVLAIAFTVLGAAIGALAIYFAS- 136
            :|..|:....|...|..||.:.|                .||:|.:..|   ||:.||.:.:|.
Human     5 EGPVGMVESAGRAGQKRPGFLEG----------------GLLLLLLLVT---AALVALGVLYADR 50

  Fly   137 --------VHQRCHLYRLEPDNDDRPNGRWNQDSGSAHEGQD--NICMTQECVRTAASLLSAMDL 191
                    ..:.|.|.........:|.|        ..|.|:  .:|.|..||..||.:|..||.
Human    51 RGKQLPRLASRLCFLQEERTFVKRKPRG--------IPEAQEVSEVCTTPGCVIAAARILQNMDP 107

  Fly   192 NSDPCEDFFQYACGTWNKMHPIPEDRSSISTFEVLSDQQQVILRAVLEEPIDERDNKATIKAKTF 256
            .::||:||:|:|||.|.:.|.|||..|..|.|:||.|:.:|||:||||.. ..:|..|..||:|.
Human   108 TTEPCDDFYQFACGGWLRRHVIPETNSRYSIFDVLRDELEVILKAVLENS-TAKDRPAVEKARTL 171

  Fly   257 FKSCMDIPQIRKIGTGRLKQVLQSLGGWPVIERNWSPPADL--SVERLMGQLRLNYSEPVMIELY 319
            ::|||:...|.|.|:..|..:|:.:|||||....|:....|  .:||.:..:...::..|:|:|:
Human   172 YRSCMNQSVIEKRGSQPLLDILEVVGGWPVAMDRWNETVGLEWELERQLALMNSQFNRRVLIDLF 236

  Fly   320 VGADDKNSSVNILQMDQLQYALPSRDYYLK-ESSANDRRAYHRYMTQVALL------LGADPATA 377
            :..||:|||.:|:.:||....:|||:||.. .|:...|.||.::|..||.|      |..|....
Human   237 IWNDDQNSSRHIIYIDQPTLGMPSREYYFNGGSNRKVREAYLQFMVSVATLLREDANLPRDSCLV 301

  Fly   378 AAELEKVVLFETQLVNVSLPEADRHDTSLVYRKMLLPELQEL--VPEVQWQEYLQAALGP-GIPL 439
            ..::.:|:..||||...::|:.:|||...:|.:|.|.|||..  :....|..::|..|.. .|.|
Human   302 QEDMVQVLELETQLAKATVPQEERHDVIALYHRMGLEELQSQFGLKGFNWTLFIQTVLSSVKIKL 366

  Fly   440 QEDEPLVTYGLHYLTEMGKILAHTDRRVVHNYMLWRLVMSLMSHMIDEYQRERVEFRKILMGIQS 504
            ..||.:|.||:.||..:..|:.....|.:.||::||||:..:..:...::..||.:||.|.|...
Human   367 LPDEEVVVYGIPYLQNLENIIDTYSARTIQNYLVWRLVLDRIGSLSQRFKDTRVNYRKALFGTMV 431

  Fly   505 ERTRWSQCVEWTNKKLGVAVGALFIRDNFNQESKEVALEMIHTIRAAFNELLAENDWMDDETRAV 569
            |..||.:||.:.|..:..|||:|::|:.|..:||.:..|:|..:|..|.|.|.|..|||:|::..
Human   432 EEVRWRECVGYVNSNMENAVGSLYVREAFPGDSKSMVRELIDKVRTVFVETLDELGWMDEESKKK 496

  Fly   570 AKEKADSMNERIGYPELLTNA--TELEQEYVNLTIVPDNFINNVLSILQWESEKMLRLLRQPVDK 632
            |:|||.|:.|:||:|:.:...  ..|::||.||....|.:..|.|..|:..:::.||.||:.||.
Human   497 AQEKAMSIREQIGHPDYILEEMNRRLDEEYSNLNFSEDLYFENSLQNLKVGAQRSLRKLREKVDP 561

  Fly   633 EKWTTEPAVVNAFYNPNKNDIVFPAGILQPLFYSQHFPKSLNYGGIGVVIGHEITHGFDDKGRQF 697
            ..|....|||||||:||:|.||||||||||.|:|:..|::||:||||:||||||||||||.||.|
Human   562 NLWIIGAAVVNAFYSPNRNQIVFPAGILQPPFFSKEQPQALNFGGIGMVIGHEITHGFDDNGRNF 626

  Fly   698 DKEGNMMQWWNNATIEAFRERTQCVIDQYSRYKINEVD-MFMDGRMTQGENIADNGGLKQAFRAY 761
            ||.||||.||:|.:.:.|||:::|:|.||..|..:..| ..::|..|.|||||||||::||::||
Human   627 DKNGNMMDWWSNFSTQHFREQSECMIYQYGNYSWDLADEQNVNGFNTLGENIADNGGVRQAYKAY 691

  Fly   762 KKWETLHGREQQLPGLNMTHDQLFFLNYAQIWCGSMRPEDALTKIRSAVHSPGFVRVLGPLSNSR 826
            .||....|::||||||::||:||||:||||:||||.|||.|:..|::.||||...||||.|.|..
Human   692 LKWMAEGGKDQQLPGLDLTHEQLFFINYAQVWCGSYRPEFAIQSIKTDVHSPLKYRVLGSLQNLA 756

  Fly   827 DFASAYKCPLGSTMNPAEKCSVW 849
            .||..:.|..|:.|:|.|:|.||
Human   757 AFADTFHCARGTPMHPKERCRVW 779

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep1	NP_001284925.1	M13	194..847	CDD:189000	287/667 (43%)
MMEL1	NP_258428.2	PepO	102..779	CDD:226118	291/677 (43%)
MMEL1	NP_258428.2	M13	111..777	CDD:189000	287/666 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	264	1.000	Domainoid score	I1924
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	579	1.000	Inparanoid score	I1026
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG61902
OrthoDB	1	1.010	-	-		D157132at33208
OrthoFinder	1	1.000	-	-		FOG0000538
OrthoInspector	1	1.000	-	-		otm41857
orthoMCL	1	0.900	-	-		OOG6_100162
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3535
SonicParanoid	1	1.000	-	-		X2533
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.870