DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep1 and Ecel1

DIOPT Version :9

Sequence 1:	NP_001284925.1	Gene:	Nep1 / 31547	FlyBaseID:	FBgn0029843	Length:	849	Species:	Drosophila melanogaster
Sequence 2:	NP_068544.2	Gene:	Ecel1 / 60417	RGDID:	61806	Length:	775	Species:	Rattus norvegicus

Alignment Length:	814	Identity:	272/814 - (33%)
Similarity:	432/814 - (53%)	Gaps:	51/814 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 QAPHQMQQQQQQQQQNKLPTVVFLAPDGSGGVGIQRGNPAQGNPGMVTGTGSHSDWL---LKESQ 108
            :||:.|.....:.|:     |.:::..|:||.   ||....  ||....:|..:...   |....
  Rat     2 EAPYSMTAHYDEFQE-----VKYVSRCGTGGA---RGTSLP--PGFPRSSGRSASGARSGLPRWN 56

  Fly   109 QRRRLLVLAIAFTVLGAAIGALAIYFASVHQRCHLYRLEPDNDDRPNGRWNQDSGSAHEGQDNIC 173
            :|...|:..:.|     |.|..||..|.:    .|..|.|....        ..|:..||    |
  Rat    57 RREVCLLSGLVF-----AAGLCAILAAML----ALKYLGPGAAG--------TGGACPEG----C 100

  Fly   174 MTQECVRTAASLLSA-MDLNSDPCEDFFQYACGTWNKMHPIPEDRSSISTFEVLSDQQQVILRAV 237
            ..::....||..||| :|.:.|||:||:.:|||.|.:.|.||:|:.:..|...:.:|.:..||.:
  Rat   101 PERKAFARAARFLSANLDASIDPCQDFYSFACGGWLRRHAIPDDKLTYGTIAAIGEQNEERLRRL 165

  Fly   238 LEEPIDERDNKATIKAKTFFKSCMDIPQIRKIGTGRLKQVLQSLGGWPV---IERNWSPPADLSV 299
            |..|.......|..|.:.||:||:|:.:|.::|...:.:|::..|||.:   .:|..:...||:
  Rat   166 LARPTGGPGGAAQRKVRAFFRSCLDMREIERLGPRPMLEVIEDCGGWDLGGAADRPGAARWDLN- 229

  Fly   300 ERLMGQLRLNYSEPVMIELYVGADDKNSSVNILQMDQLQYALPSRDYYLKESSANDR--RAYHRY 362
             ||:.:.:..||...:..|.|..||:|||..::::||....||.|..||.:...:::  .||..:
  Rat   230 -RLLYKAQGVYSAAALFSLTVSLDDRNSSRYVIRIDQDGLTLPERTLYLAQDEESEKVLAAYKVF 293

  Fly   363 MTQVALLLGADPATAAAELEKVVLFETQLVNVSLPEAD--RHDTSLVYRKMLLPELQELVPEVQW 425
            |.::..|||||.....|  ::::..|.:|.|:|:.|.|  |.|.|.||.|:.|.:||::.|.:||
  Rat   294 MERLLRLLGADAVEQKA--QEILQLEQRLANISVSEYDDLRRDVSSVYNKVTLGQLQKITPHLQW 356

  Fly   426 QEYLQAALGPGIPLQEDEPLVTYGLHYLTEMGKILAHTDRRVVHNYMLWRLVMSLMSHMIDEYQR 490
            :..|......  ...|:|.:|.....|:.::.:::..|.||::|||::||:|:.|..|:...::.
  Rat   357 KWLLDQIFQE--DFSEEEEVVLLATDYMQQVSQLIRSTPRRILHNYLVWRVVVVLSEHLSPPFRE 419

  Fly   491 ERVEFRKILMGIQSERTRWSQCVEWTNKKLGVAVGALFIRDNFNQESKEVALEMIHTIRAAFNEL 555
            ...|..|.:.|....:.....|:...|:..|:|:||||:.::|:..||....:::..|:....:.
  Rat   420 ALHELAKEMEGNDKPQELARVCLGQANRHFGMALGALFVHEHFSAASKAKVQQLVEDIKYILGQR 484

  Fly   556 LAENDWMDDETRAVAKEKADSMNERIGYPELLTNATELEQEYVNLTIVPDNFINNVLSILQWESE 620
            |.|.||||.:|:|.|:.|...|...:|||:.|.....:::|| ...:....:..|:|:.:::..:
  Rat   485 LEELDWMDAQTKAAARAKLQYMMVMVGYPDFLLKPEAVDKEY-EFEVHEKTYFKNILNSIRFSIQ 548

  Fly   621 KMLRLLRQPVDKEKWTTEPAVVNAFYNPNKNDIVFPAGILQPLFYSQHFPKSLNYGGIGVVIGHE 685
            ..::.:||.|||..|...|..:||:|.||||.:|||||||||..|...||:||||||||.:||||
  Rat   549 LSVKKIRQEVDKSTWLLPPQALNAYYLPNKNQMVFPAGILQPTLYDPDFPQSLNYGGIGTIIGHE 613

  Fly   686 ITHGFDDKGRQFDKEGNMMQWWNNATIEAFRERTQCVIDQYSRYKINEVDMFMDGRMTQGENIAD 750
            :|||:||.|.|:|:.||::.||..|:...|..:.:|::..|..:.:  .:..::|:.|.||||||
  Rat   614 LTHGYDDWGGQYDRSGNLLHWWTEASYSRFLHKAECIVRLYDNFTV--YNQRVNGKHTLGENIAD 676

  Fly   751 NGGLKQAFRAYKKWETLHGREQQLPGLNMTHDQLFFLNYAQIWCGSMRPEDALTKIRSAVHSPGF 815
            .||||.|:.||:||...||.|..|..|..||:||||:.:||.||...|.:....::.:..|:|..
  Rat   677 MGGLKLAYYAYQKWVREHGPEHPLHRLKYTHNQLFFIAFAQNWCIKRRSQSIYLQVLTDKHAPEH 741

  Fly   816 VRVLGPLSNSRDFASAYKCPLGSTMNPAEKCSVW 849
            .||||.:|...:|..|:.||..|.|||..|||||
  Rat   742 YRVLGSVSQFEEFGRAFHCPKDSPMNPVHKCSVW 775

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep1	NP_001284925.1	M13	194..847	CDD:189000	233/659 (35%)
Ecel1	NP_068544.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	23..51		8/32 (25%)
Ecel1	NP_068544.2	M13	121..773	CDD:341056	233/660 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG61902
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100162
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.830