DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nep1 and PHEX

DIOPT Version :9

Sequence 1:	NP_001284925.1	Gene:	Nep1 / 31547	FlyBaseID:	FBgn0029843	Length:	849	Species:	Drosophila melanogaster
Sequence 2:	NP_000435.3	Gene:	PHEX / 5251	HGNCID:	8918	Length:	749	Species:	Homo sapiens

Alignment Length:	784	Identity:	266/784 - (33%)
Similarity:	428/784 - (54%)	Gaps:	61/784 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 MVTGTGSHSDWLLKESQQRRRLLVLAIAFT-VLGAAI-----GALAIYFASVHQRCHLYRLEPDN 150
            |...|||..:...|.::..|..||:.:..| |||..:     |.|::
Human     1 MEAETGSSVETGKKANRGTRIALVVFVGGTLVLGTILFLVSQGLLSL------------------ 47

  Fly   151 DDRPNGRWNQDSGSAHEGQDNICMTQECVRTAASLLSAMDLNSDPCEDFFQYACGTWNKMHPIPE 215
                            :.:...|:..||:..||::||.::|:.|||::||::||..|...:||||
Human    48 ----------------QAKQEYCLKPECIEAAAAILSKVNLSVDPCDNFFRFACDGWISNNPIPE 96

  Fly   216 DRSSISTFEVLSDQQQVILRAVLEEPID-ERDNKATIKAKTFFKSCMDIPQIRKIGTGRLKQVLQ 279
            |..|...:..|.....:.|:.:||:.|. .||.:|..|||..:.|||:...|.|.....|..:|:
Human    97 DMPSYGVYPWLRHNVDLKLKELLEKSISRRRDTEAIQKAKILYSSCMNEKAIEKADAKPLLHILR 161

  Fly   280 -SLGGWPVIERNWSPPA-----DLSVERLMGQLRLNYSEPVMIELYVGADDKNSSVNILQMDQLQ 338
             |...|||:|.|..|..     ..|:.:.:...|..||..|.|.|||..|||.|:.:||::||..
Human   162 HSPFRWPVLESNIGPEGVWSERKFSLLQTLATFRGQYSNSVFIRLYVSPDDKASNEHILKLDQAT 226

  Fly   339 YALPSRDYYLKES--SANDRRAYHRYMTQVALLLGADPATAAAELEKVVLFETQLVNVSLPEADR 401
            .:|..|:.||..|  :.:.|.|.:::|...|:||||:.:.|..:::.|:..|.::..:.:|..:|
Human   227 LSLAVREDYLDNSTEAKSYRDALYKFMVDTAVLLGANSSRAEHDMKSVLRLEIKIAEIMIPHENR 291

  Fly   402 HDTSLVYRKMLLPELQELVPEVQWQEYLQAALGPGI-----PLQEDEPLVTYGLHYLTEMGKILA 461
             .:..:|.||.:.||..::|:..|..|::..:...:     .:...|.:|.....|..::.:||.
Human   292 -TSEAMYNKMNISELSAMIPQFDWLGYIKKVIDTRLYPHLKDISPSENVVVRVPQYFKDLFRILG 355

  Fly   462 HTDRRVVHNYMLWRLVMSLMSHMIDEYQRERVEFRKILMGIQSERTRWSQCVEWTNKKLGVAVGA 526
            ...::.:.||::||:|.|.:.::...:|...:||.:::.|..:...:|.:||.:....|...||.
Human   356 SERKKTIANYLVWRMVYSRIPNLSRRFQYRWLEFSRVIQGTTTLLPQWDKCVNFIESALPYVVGK 420

  Fly   527 LFIRDNFNQESKEVALEMIHTIRAAFNELL-AENDWMDDETRAVAKEKADSMNERIGYPELLTNA 590
            :|:...|.::.||:..|::..:|.||.::| .||:|||..|:..|||||.::..::||||.:.|.
Human   421 MFVDVYFQEDKKEMMEELVEGVRWAFIDMLEKENEWMDAGTKRKAKEKARAVLAKVGYPEFIMND 485

  Fly   591 TELEQEYVNLTIVPDNFINNVLSILQWESEKMLRLLRQPVDKEKWTTEPAVVNAFYNPNKNDIVF 655
            |.:.::...:.....::..|||...::.::.....||:.|.|.:|.|.|..|||||:.:.|.|.|
Human   486 THVNEDLKAIKFSEADYFGNVLQTRKYLAQSDFFWLRKAVPKTEWFTNPTTVNAFYSASTNQIRF 550

  Fly   656 PAGILQ-PLFYSQHFPKSLNYGGIGVVIGHEITHGFDDKGRQFDKEGNMMQWWNNATIEAFRERT 719
            |||.|| |.|:...:|:||:||.|||::|||.|||||:.||::||.||:..||:..:.|.|:|:|
Human   551 PAGELQKPFFWGTEYPRSLSYGAIGVIVGHEFTHGFDNNGRKYDKNGNLDPWWSTESEEKFKEKT 615

  Fly   720 QCVIDQYSRYKINEVDMFMDGRMTQGENIADNGGLKQAFRAYKKW--ETLHGREQQ-LPGLNMTH 781
            :|:|:|||.|...:..:.:.|:.|.||||||||||::|||||:||  :...|.|:. |||:..|:
Human   616 KCMINQYSNYYWKKAGLNVKGKRTLGENIADNGGLREAFRAYRKWINDRRQGLEEPLLPGITFTN 680

  Fly   782 DQLFFLNYAQIWCGSMRPEDALTKIRSAVHSPGFVRVLGPLSNSRDFASAYKCPLGSTMNPA-EK 845
            :|||||:||.:.|.|.|||.|..:::...|||...||.|.:||..:|..|:.||..||||.. :.
Human   681 NQLFFLSYAHVRCNSYRPEAAREQVQIGAHSPPQFRVNGAISNFEEFQKAFNCPPNSTMNRGMDS 745

  Fly   846 CSVW 849
            |.:|
Human   746 CRLW 749

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep1	NP_001284925.1	M13	194..847	CDD:189000	242/672 (36%)
PHEX	NP_000435.3	M13	74..747	CDD:189000	242/673 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG61902
OrthoDB	1	1.010	-	-		D157132at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.930