DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep1 and Nepl20

DIOPT Version :9

Sequence 1:	NP_001284925.1	Gene:	Nep1 / 31547	FlyBaseID:	FBgn0029843	Length:	849	Species:	Drosophila melanogaster
Sequence 2:	NP_651645.1	Gene:	Nepl20 / 43412	FlyBaseID:	FBgn0039613	Length:	700	Species:	Drosophila melanogaster

Alignment Length:	750	Identity:	201/750 - (26%)
Similarity:	348/750 - (46%)	Gaps:	89/750 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 IYFASVHQRCHLYRLEPDNDDRPNGRWNQDSGSAHEGQDNICMTQECVR--TAASLLSAMDLNSD 194
            |:.|| |....|....|.::|..|             ||...| :|.:|  .||.:.|.|:...|
  Fly     8 IWIAS-HVLSVLVLAAPTSEDVLN-------------QDTPYM-KELMRQAKAAEIESFMNQKVD 57

  Fly   195 PCEDFFQYACGTWNKMHPIPEDR-SSISTFEVLSDQQQVILRAVLEEPIDERDNKATIKAKTFFK 258
            ||:||:.::||.:.:::.....| .:...||.|:......:..:|..|.|..|....|:.|.|::
  Fly    58 PCKDFYAFSCGNYKRINSALNMRVLTTGVFETLTKGLNRKILKMLNTPHDSHDTPEDIQVKHFYE 122

  Fly   259 SCMDIPQIRKIGTGRLKQVLQSLGGWPVIERNWSPPADLSVERLMGQLRLNYSEPVMIELYVGAD 323
            ||:.|.::....:.:||:::...|..|::|.:.....|........::...|....:|.:.|..|
  Fly   123 SCLQIKELNSTYSEKLKRLIAEFGTMPLLEGSSWQEDDFDWLNTTARMAHRYGIMSIIGVGVATD 187

  Fly   324 DKNSSVNILQMDQLQYALPSRDYYLKESSANDRRAYHRYMTQVALL----LGADPATAAAELEKV 384
            ..|:..||:.::|.::.|.:|..|:...:|..|:   .|...:.|:    ||.....|....:::
  Fly   188 FANNQKNIIYINQQEFPLKTRSMYMDNETAIYRQ---NYQNNIQLILEKYLGVKDELARKAAKEM 249

  Fly   385 VLFETQLVNVSLPEADRHDTSLVYRKML----LPELQE-LVPEVQWQEYLQAALGPGIPLQEDEP 444
            ..||..|.: .|.:.::|   |..|.::    :.||:| ..|.:...:.:..::|..|    .:.
  Fly   250 FEFEVDLAH-GLVDNNKH---LNLRDLIELLTVAELRERYAPTLDTDQLIFVSMGEKI----SDK 306

  Fly   445 LVTYGLHYLTEMGKILAHTDRRVVHNYMLWRLVMSLMSHMIDEYQRERVEFRKILMGIQSERTRW 509
            :..|...|...:.:::..|.:..|.||:..||:.               ||.:...|:..:.|
  Fly   307 VYEYNRRYQQNLVEVIERTPKSTVANYLFLRLIW---------------EFIQKPSGVAEKPT-- 354

  Fly   510 SQCVEWTNKKLGVAVGALFIRDNFNQESKEVALEMIHTIRAAFNELLAEN---DWMDDETRAVAK 571
            ..||::|.......:..:..|...|::|......|.|.:::.|.|.|..:   ||::..||::|.
  Fly   355 EACVDFTKTYFAKNLDNMIYRRYKNEKSSREIDSMWHQLKSTFKETLLSSPALDWIEPSTRSLAI 419

  Fly   572 EKADSMNERI-GYPELLTNATELEQEYVNLTIVPDNFINNVLSILQWESEKMLRLLRQPVDKEKW 635
            .|.::|...: .|  :..|.||   |:.:|.:...:.:.|:..:...::::|.:|..||
  Fly   420 AKLEAMTLEVNNY--VKENFTE---EFADLNLQNTDCVENLRQVQMLQAKQMRQLYHQP------ 473

  Fly   636 TTEPAVVNAF--YNPN----KNDIVFPAGILQPLF-YSQHFPKSLNYGGIGVVIGHEITHGFDDK 693
             .:|......  |.|:    :|.|..|..:|||.: :|..:|.::.:|.:..:||||:.|||||.
  Fly   474 -AKPLEAGELLSYTPSNILLENSIKVPVALLQPFYIWSDVYPNAVMFGTLAYLIGHELIHGFDDS 537

  Fly   694 GRQFDKEGNMMQWWNNATIEAFRERTQCVIDQYSRYKINEVDMFMDGRMTQGENIADNGGLKQAF 758
            ||:||::||...||:..:...|.:|..|...||.||..:.:.  :.....|.||||||||::.|:
  Fly   538 GRKFDEKGNSKDWWDEKSSSNFLKRRDCFTKQYGRYVYDGIQ--LKESTAQSENIADNGGMRLAY 600

  Fly   759 RAYKKWE----TLHGREQQ-----LPGLNMTHDQLFFLNYAQIWCGSMRPEDALTKIRSAVHSPG 814
            .||:||.    ||....|.     ||.|..|..||||:::||.||..:.|:....::.:..|.||
  Fly   601 TAYRKWYENQLTLPNGAQDMTKETLPNLRYTAKQLFFISFAQSWCNDVHPKVKALQVSTDDHMPG 665

  Fly   815 FVRVLGPLSNSRDFASAYKCPLGSTMNPAEKCSVW 849
            ..||:|.|||..:|:..:.|..||.|||.|||.::
  Fly   666 KFRVIGTLSNFEEFSKEFNCHAGSAMNPIEKCILY 700

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep1	NP_001284925.1	M13	194..847	CDD:189000	183/682 (27%)
Nepl20	NP_651645.1	PepO	50..691	CDD:226118	180/682 (26%)
Nepl20	NP_651645.1	M13	56..697	CDD:189000	182/682 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454963
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850