DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep1 and Nepl19

DIOPT Version :9

Sequence 1:	NP_001284925.1	Gene:	Nep1 / 31547	FlyBaseID:	FBgn0029843	Length:	849	Species:	Drosophila melanogaster
Sequence 2:	NP_651644.1	Gene:	Nepl19 / 43411	FlyBaseID:	FBgn0039612	Length:	671	Species:	Drosophila melanogaster

Alignment Length:	747	Identity:	181/747 - (24%)
Similarity:	325/747 - (43%)	Gaps:	140/747 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   140 RCHLYRLEPDNDDRPNGR---WNQDSGSAHEGQDNICMTQECVR--TAASLLSAMDLNSDPCEDF 199
            |.||...:|..|.|...|   .:|.:.||:        .|..:|  .:|.:.|.|..::|.||:|
  Fly    23 RGHLLTGQPAIDLRIQAREQLISQSNDSAY--------VQRLMRLSKSAEMRSYMQQDADACENF 79

  Fly   200 FQYACGTWNKMHP----IPEDRSSIS-TFEVLSDQQQVILRAVLEEPID-ERDNKATIKAKTFFK 258
            :.|:||.|.:::|    .|.:.:.:. ..:..|.:||    .::|:|.: |.|..|.::.|.|:.
  Fly    80 YDYSCGNWPQINPANDAYPRETNFVQLLLKAYSHKQQ----RLMEQPANVETDEVAVLRLKEFYA 140

  Fly   259 SCMDIPQI-RKIGTGRLKQVLQSLGGWPVIE---RNWSPPADLSVERLMGQLRLNYSEPVMIELY 319
            ||:...|: ..:...:|::::...|..||:.   :.| |..:......:.:::..|...:::...
  Fly   141 SCLLFRQVPEDLYRRQLQEIVADFGRMPVLSLPGQEW-PAEEFDWLDTVARIKRQYGFDILLLFQ 204

  Fly   320 VGADDKNSSVNILQMDQLQYALPSRDYYLKESSANDRRAYHRYMTQVALLLGADPATAAAELEKV 384
            ..||.       :.:.|.:..||         .||.:.........:...||.||..|.....::
  Fly   205 QSADR-------IYVGQPKQILP---------EANRKAVAEDIANHLERHLGVDPKVAVTTAREI 253

  Fly   385 VLFETQLVNVSLPEADRHDTSLVYRKMLLPELQELVPEVQWQEYLQAALGPGIPLQEDEPLVTYG 449
            ..||.::..:.:   ||...  |..|:..|...:.|...:..::::..|..  .|..:|.|..:.
  Fly   254 TEFEQKIAAIMV---DRRVG--VMSKLYTPSDADYVDVSKLTQFVETVLDR--ELLANESLYQHV 311

  Fly   450 LHYLTEMGKILAHTDRRVVHNYMLWRLVMSLMSHMIDEYQRERVEFRKILMGIQSERTRWSQCVE 514
            ..||.::.:::..|...|:.||:.    ..|:.|...|.....||                |||.
  Fly   312 PDYLMKIDELVTETPPHVLANYVF----NELLKHFYYERAESVVE----------------QCVS 356

  Fly   515 WTNKKLGVAVGALFIRDNFNQESKEVALEMIHTI----RAAFNELLAEN--DWMDDETRAVAKEK 573
            ......|..:..:.    |.|...|..|:.|:.:    :.:|..:|..:  :|:..|||....|:
  Fly   357 RVRDLFGELLDHML----FEQYEDEGTLKDIYVVWQQLQRSFRGVLQNSSANWLVPETREQLLEQ 417

  Fly   574 ADSMNERI-GYPELLTNATELEQEYVNLTIVPDNFINNVLSILQWESEKMLRLLRQPVDKEKWTT 637
            .::.:..| ||.|:  |.|   |.|..|.:.|.::::|:.:||..:|   ||:        |..|
  Fly   418 LNTTSLVINGYAEV--NFT---QRYEELHLKPRDYLHNLRTILNHQS---LRV--------KVKT 466

  Fly   638 EPAVVNAFYNPNKNDIVFPAGILQPLF-YSQHFPKSLNYGGIGVVIGHEITHGFDDKGRQFDKEG 701
            :.:|.   |:|....::.|..:|||.| :|:::||::.||.:|.::..::.|..:|..:
  Fly   467 QTSVT---YDPVGKRVLLPVALLQPNFLWSRYYPKAVRYGSLGTLLAQQLAHSLEDASK------ 522

  Fly   702 NMMQWWNNATIEAFRERTQCVIDQYSRYKIN-----EVDMFMDGRMTQGENIADNGGLKQAFRAY 761
                 |:..:...:.:|..|..:||.|.::|     |.|:       |.||||||..::.|:.||
  Fly   523 -----WDAKSFAEYSKRKSCFKEQYGRLRLNGHYLPESDL-------QAENIADNLAIQVAYHAY 575

  Fly   762 KKW-----ETLHGREQQLPGLNMTHDQLFFLNYAQIWCGSMRPEDALTKIRSA----VHSPGFVR 817
            ::.     .:..|.| .||.||:...:||||::||:||     .||..:.|..    :.:|..:|
  Fly   576 RRLLAELDPSFLGSE-SLPQLNLGSRRLFFLSFAQLWC-----NDANEQFRDKQSLFLGTPNALR 634

  Fly   818 VLGPLSNSRDFASAYKCPLGSTMNPAEKCSVW 849
            |||.|||.|.|...:.|...|.|...:||.::
  Fly   635 VLGALSNFRAFGRDFNCGTASRMTSPQKCQLF 666

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep1	NP_001284925.1	M13	194..847	CDD:189000	165/684 (24%)
Nepl19	NP_651644.1	PepO	67..657	CDD:226118	165/684 (24%)
Nepl19	NP_651644.1	M13	73..664	CDD:189000	165/685 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454960
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850