DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nep1 and MME

DIOPT Version :10

Sequence 1:NP_511056.2 Gene:Nep1 / 31547 FlyBaseID:FBgn0029843 Length:849 Species:Drosophila melanogaster
Sequence 2:NP_000893.2 Gene:MME / 4311 HGNCID:7154 Length:750 Species:Homo sapiens


Alignment Length:702 Identity:290/702 - (41%)
Similarity:416/702 - (59%) Gaps:27/702 - (3%)


- Green bases have known domain annotations that are detailed below.


  Fly   170 DNICMTQECVRTAASLLSAMDLNSDPCEDFFQYACGTWNKMHPIPEDRSSISTFEVLSDQQQVIL 234
            |.||.:.:|:::||.|:..||..::||.|||:||||.|.|.:.|||..|....|::|.|:.:|:|
Human    54 DGICKSSDCIKSAARLIQNMDATTEPCTDFFKYACGGWLKRNVIPETSSRYGNFDILRDELEVVL 118

  Fly   235 RAVLEEPIDERDNKATIKAKTFFKSCMDIPQIRKIGTGRLKQVLQSLGGWPVIERNWSPP--ADL 297
            :.||:||..| |..|..|||..::||::...|...|...|.::|..:.||||...||...  |..
Human   119 KDVLQEPKTE-DIVAVQKAKALYRSCINESAIDSRGGEPLLKLLPDIYGWPVATENWEQKYGASW 182

  Fly   298 SVERLMGQLRLNYSEPVMIELYVGADDKNSSVNILQMDQLQYALPSRDYY-----LKESSANDRR 357
            :.|:.:.||...|.:.|:|.|:||.|||||..:::.:||.:..|||||||     .||:..    
Human   183 TAEKAIAQLNSKYGKKVLINLFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKEACT---- 243

  Fly   358 AYHRYMTQVALL------LGADPATAAAELEKVVLFETQLVNVSLPEADRHDTSLVYRKMLLPEL 416
            ||..:|..||.|      |..|....|.|:.||:..|.::.|.:....||:|..|:|.||.|.::
Human   244 AYVDFMISVARLIRQEERLPIDENQLALEMNKVMELEKEIANATAKPEDRNDPMLLYNKMTLAQI 308

  Fly   417 Q-ELVPEV-----QWQEYLQAALGP-GIPLQEDEPLVTYGLHYLTEMGKILAHTDRRVVHNYMLW 474
            | ....|:     .|..:....:.. .|.:..:|.:|.|...|||::..||.....|.:.|.|.|
Human   309 QNNFSLEINGKPFSWLNFTNEIMSTVNISITNEEDVVVYAPEYLTKLKPILTKYSARDLQNLMSW 373

  Fly   475 RLVMSLMSHMIDEYQRERVEFRKILMGIQSERTRWSQCVEWTNKKLGVAVGALFIRDNFNQESKE 539
            |.:|.|:|.:...|:..|..|||.|.|..||...|.:|..:.|..:..|||.|::...|..|||.
Human   374 RFIMDLVSSLSRTYKESRNAFRKALYGTTSETATWRRCANYVNGNMENAVGRLYVEAAFAGESKH 438

  Fly   540 VALEMIHTIRAAFNELLAENDWMDDETRAVAKEKADSMNERIGYP-ELLTNATELEQEYVNLTIV 603
            |..::|..||..|.:.|.:..|||.||:..|:|||.::.|||||| ::::|..:|..||:.|...
Human   439 VVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERIGYPDDIVSNDNKLNNEYLELNYK 503

  Fly   604 PDNFINNVLSILQWESEKMLRLLRQPVDKEKWTTEPAVVNAFYNPNKNDIVFPAGILQPLFYSQH 668
            .|.:..|::..|::...|.|:.||:.|||::|.:..|||||||:..:|.||||||||||.|:|..
Human   504 EDEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAAVVNAFYSSGRNQIVFPAGILQPPFFSAQ 568

  Fly   669 FPKSLNYGGIGVVIGHEITHGFDDKGRQFDKEGNMMQWWNNATIEAFRERTQCVIDQYSRYKINE 733
            ...||||||||:||||||||||||.||.|:|:|:::.||...:...|:|::||::.||..:..:.
Human   569 QSNSLNYGGIGMVIGHEITHGFDDNGRNFNKDGDLVDWWTQQSASNFKEQSQCMVYQYGNFSWDL 633

  Fly   734 V-DMFMDGRMTQGENIADNGGLKQAFRAYKKWETLHGREQQLPGLNMTHDQLFFLNYAQIWCGSM 797
            . ...::|..|.||||||||||.||:|||:.:...:|.|:.||||::.|.||||||:||:|||:.
Human   634 AGGQHLNGINTLGENIADNGGLGQAYRAYQNYIKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTY 698

  Fly   798 RPEDALTKIRSAVHSPGFVRVLGPLSNSRDFASAYKCPLGSTMNPAEKCSVW 849
            |||.|:..|::.|||||..|::|.|.||.:|:.|:.|...|.|||.:||.||
Human   699 RPEYAVNSIKTDVHSPGNFRIIGTLQNSAEFSEAFHCRKNSYMNPEKKCRVW 750

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nep1NP_511056.2 M13 194..847 CDD:341056 278/674 (41%)
MMENP_000893.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..20
Stop-transfer sequence. /evidence=ECO:0000255 16..23
M13 79..748 CDD:341056 278/673 (41%)
Blue background indicates that the domain is not in the aligned region.

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