DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep1 and Nepl14

DIOPT Version :9

Sequence 1:	NP_001284925.1	Gene:	Nep1 / 31547	FlyBaseID:	FBgn0029843	Length:	849	Species:	Drosophila melanogaster
Sequence 2:	NP_651097.1	Gene:	Nepl14 / 42700	FlyBaseID:	FBgn0039023	Length:	696	Species:	Drosophila melanogaster

Alignment Length:	757	Identity:	188/757 - (24%)
Similarity:	314/757 - (41%)	Gaps:	162/757 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   168 GQD------NICMTQECVRTAASLLSAMDLNS------DPCEDFFQYACGTWNKMHPIPEDRSSI 220
            |:|      .|..:::.||.:    .|.|:.|      |||.||:.||||.|         :|::
  Fly    27 GEDLPPPFQRIYQSEQTVRRS----KAQDMGSHVNKSIDPCVDFYAYACGNW---------KSTL 78

  Fly   221 STFEVLSDQQQVILRAVLEEPIDERDNKATIKAKTFFKSCMDIPQIRKIGTGR--LKQVLQSLGG 283
            :..:.|..|....|..::||.:...|:....:||..||||:. .|..:....:  |.:.:...||
  Fly    79 TPQQQLQQQTDRELLLLVEEAVRREDSVIVRQAKELFKSCVS-AQAHQSQQQQHFLSEFINQNGG 142

  Fly   284 WPVI----------ERNWSPPADLSVERLMGQLRLNYSEPVMIELYVGADDKNSSVNILQMDQLQ 338
            :|.:          :.||     |||   :|.|||.|...::|.|.||.:..|.:.|.|.:.:..
  Fly   143 FPAVPGSQWAVHHHDYNW-----LSV---LGGLRLRYGMDILIGLRVGYNYGNVNENSLYLSEPS 199

  Fly   339 YALPSRDYYLKESSAND---RRAYHRYMTQVA--LLLGAD-PATAAAELEKVVLFETQLV----N 393
            ..:|:.......|...|   ....||..:::.  |.||.| .|..||:   ::.||.:|.    .
  Fly   200 TLIPTELCTRNRSDIRDSIYEPLEHRVASELKSWLALGHDESARLAAD---ILSFEHELCGGMKG 261

  Fly   394 VSLPEADRHDTSLV--YRKMLLPELQELVPEVQWQEYLQAALGPGIPLQEDEPLVTYGLHYLTEM 456
            .|....|..:...:  |.:..|.|....: |:....|::|:.|..|    .:|:......|..::
  Fly   262 GSFESWDAEEQLYLANYTRKTLREFSNSI-ELDLDSYVRASFGQDI----YKPVYMAAPEYFRQL 321

  Fly   457 GKILAHTDRRVVHNYMLWRLVMSLMSHMIDEYQRERVEFRKILMGIQSERTRWSQCVEWTNKKLG 521
            .:.::..:..:|.||:::|.| |.::..:|    :|.:.||            .:|:|.|.:.|.
  Fly   322 KRTVSAHNISLVANYIMYRAV-SALNFPLD----DRPQLRK------------RECLERTKELLP 369

  Fly   522 VAVGALFIRDNFNQESKEVALEMIH-TIRAAFNELLAENDWMDDETRAVAKEKADSMN------E 579
            .|:|.|:.| .|..|...:.|:.:: |::.|..:.|.. :|:.:.|:.|.:||..::.      |
  Fly   370 TALGELYAR-QFGTEDGRIDLDNLYDTLKTALRQSLGA-EWLVEGTQRVGQEKLRNLKLQMPTYE 432

  Fly   580 RIGYPELLTNATELEQEYVNLTIVPDNFINNVLSILQWESEKMLRLLRQ----PVDKEKWTTEPA 640
            |   |.:|....|....:.||        ..:|.::|  |::..||..:    |.|    ..|..
  Fly   433 R---PVILKLQLERGNYWQNL--------RQLLGVVQ--SQRNNRLFEEFLPAPTD----PVEAY 480

  Fly   641 VVNAFYNPNKNDIVFPAGILQPLFYSQHFPKSLNYGGIGVVIGHEITHGFDDKGRQFDKEGNMMQ 705
            .......|.:..:.....:|||..|...:..::.|..:||.:..::...|||.           .
  Fly   481 EARVRLRPVQRRLDMGLALLQPPAYDPRYGHAIRYATLGVQLAQQLVMAFDDP-----------H 534

  Fly   706 W---------WNNATIEAFRERTQCV---IDQYSRYKINEVDMFMDGRMTQGENIADNGGLKQAF 758
            |         |:..|...:..|:.|.   :|.|.|..::.....          |.|:..:..||
  Fly   535 WSVGLLERDNWDGQTAWQYHIRSNCFARQVDNYLRPNVSATTQL----------ITDSAAINVAF 589

  Fly   759 RAYKKW--------ETLHGREQQLPGLNMTHDQLFFLNYAQIWCG--SMRPEDALTK----IRSA 809
            |||..|        :.....::.||.||.::..||||.|||..|.  ..||.|....    :.||
  Fly   590 RAYLTWLGFQEPNNDFTKLTKETLPDLNYSNTALFFLAYAQEHCSLEEARPRDEQGTPEGYLYSA 654

  Fly   810 VHSPGFVRVL--GPLSNSRDFASAYKCPLGSTMNPAEKCSVW 849
            ..:..:.|:|  |||.||.:|||.::||:||.||||.||.::
  Fly   655 RQNHTWTRLLVNGPLRNSVEFASEFRCPIGSPMNPASKCIIY 696

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep1	NP_001284925.1	M13	194..847	CDD:189000	179/715 (25%)
Nepl14	NP_651097.1	M13	60..693	CDD:189000	178/715 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469684
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850