Protein Alignment Nep1 and Ece2

DIOPT Version :10

• Sequence 1: NP_511056.2
• Gene: Nep1 / 31547
• FlyBaseID: FBgn0029843
• Length: 849
• Species: Drosophila melanogaster
• Sequence 2: XP_038944493.2
• Gene: Ece2 / 408243
• RGDID: 1303039
• Length: 789
• Species: Rattus norvegicus
• Alignment Length: 737
• Identity: 278/737 - (37%)
• Similarity: 426/737 - (57%)
• Gaps: 57/737 - (7%)

  Fly    74 GSGG--VGIQRGNPAQGNPGMVTGTG-SHSDWLLKESQQRRRL---------LVLAIAFTVLGA- 125
            ||||  |..:|..........||..| :..|.|...||:|.|.         ||||....||.|
  Rat    87 GSGGSMVEYKRAKLQDEELPEVTVEGRAIQDSLEVGSQKRTRQLFGSHTQLELVLAGLILVLAAL 151

  Fly   126 AIGALAIYFASVHQRCHLYRLEPDNDDRPNGRWNQDSGSAHEGQDNICMTQECVRTAASLLSAMD 190
            .:|.|...:...|:       :|                .|    :.|:|:.|:|.|..:|.::|
  Rat   152 LLGCLVALWVQYHR-------DP----------------VH----STCITEACIRVAGKILESLD 189

  Fly   191 LNSDPCEDFFQYACGTWNKMHPIPEDRSSISTFEVLSDQQQVILRAVLEEPIDERDNKATIKAKT 255
            ....||:||:|::||.|.:.:|:|..||..:||..|.||.|.||:.:||.......::|..|.::
  Rat   190 RGVSPCQDFYQFSCGGWIRRNPLPSGRSRWNTFNSLWDQNQAILKHLLENSTFNSSSEAERKTRS 254

  Fly   256 FFKSCMDIPQIRKIGTGRLKQVLQSLGGWPVIERNWSPPADLSVERLMGQLRL---NYSEPVMIE 317
            |:.||:.:.:|.|:|...|:.::..:|||     |.:.|.|  .:..|..|:.   .|.......
  Rat   255 FYLSCLHLERIEKLGAKPLQDLIDKIGGW-----NITGPWD--EDNFMEVLKAVAGTYRAAPFFT 312

  Fly   318 LYVGADDKNSSVNILQMDQLQYALPSRDYYLKESSANDR--RAYHRYMTQVALLLGADPATAAAE 380
            :|||||.|:|:.||:|:||....||||||||.. :||::  .||..||.::.:|||..|.:..|:
  Rat   313 VYVGADSKSSNSNIIQVDQSGLFLPSRDYYLNR-TANEKVLAAYLDYMVELGMLLGGQPTSTRAQ 376

  Fly   381 LEKVVLFETQLVNVSLPEADRHDTSLVYRKMLLPELQELVPEVQWQEYLQAALGPGIPLQEDEPL 445
            :::|:..|.||..:::|:..|.|...:|.||.:.|||.|.|.:.|.|:|...|.| :.|.:.||:
  Rat   377 MQQVLELEIQLATITVPQDQRRDEEKIYHKMSISELQTLAPSMDWLEFLSFLLSP-LELGDSEPV 440

  Fly   446 VTYGLHYLTEMGKILAHTDRRVVHNYMLWRLVMSLMSHMIDEYQRERVEFRKILMGIQSERT-RW 509
            |.||..||.::.:::..|:..:::||::|.||....|.:...::..:.:..:.|.|.:...| ||
  Rat   441 VVYGTEYLQQVSELINRTEPSILNNYLIWNLVQKTTSSLDQRFETAQEKLLETLYGTKKSCTPRW 505

  Fly   510 SQCVEWTNKKLGVAVGALFIRDNFNQESKEVALEMIHTIRAAFNELLAENDWMDDETRAVAKEKA 574
            ..|:..|:..||.|:|:||::..|:::|||:|..||..|||||.|.|....|||::||..|||||
  Rat   506 QTCISNTDDALGFALGSLFVKATFDRQSKEIAEGMISEIRAAFEETLENLVWMDEKTRLAAKEKA 570

  Fly   575 DSMNERIGYPELLTNATELEQEYVNLTIVPDNFINNVLSILQWESEKMLRLLRQPVDKEKWTTEP 639
            |::.:.||:|:.:....||:..|....:..|:|..|:|::..:.::.|...||:|..:::|:..|
  Rat   571 DAIYDMIGFPDFILEPRELDDVYDGYEVSEDSFFQNMLNLYNFSAKVMADQLRKPPSRDQWSMTP 635

  Fly   640 AVVNAFYNPNKNDIVFPAGILQPLFYSQHFPKSLNYGGIGVVIGHEITHGFDDKGRQFDKEGNMM 704
            ..|||:|.|.||:|||||||||..||:.:.||:||:||||||:|||:||.|||:||::|:|||:.
  Rat   636 QTVNAYYLPTKNEIVFPAGILQAPFYAHNHPKALNFGGIGVVMGHELTHAFDDQGREYDQEGNLR 700

  Fly   705 QWWNNATIEAFRERTQCVIDQYSRYKINEVDMFMDGRMTQGENIADNGGLKQAFRAYKKWETLHG 769
            .||.|.::.||:..|.|:.:||::|::|  ...::|..|.|||||||||||.|:.|||.|...||
  Rat   701 PWWQNESLTAFQNHTACMEEQYNQYQVN--GERLNGLQTLGENIADNGGLKAAYNAYKAWLRKHG 763

  Fly   770 REQQLPGLNMTHDQLFFLNYAQ 791
            .||.||.:.:|:.||||:.:||
  Rat   764 EEQPLPAVGLTNHQLFFVGFAQ 785

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nep1	NP_511056.2	M13	194..847	CDD:341056	244/604 (40%)
Ece2	XP_038944493.2	None