DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep1 and Nep3

DIOPT Version :9

Sequence 1:	NP_001284925.1	Gene:	Nep1 / 31547	FlyBaseID:	FBgn0029843	Length:	849	Species:	Drosophila melanogaster
Sequence 2:	NP_001245775.1	Gene:	Nep3 / 33005	FlyBaseID:	FBgn0031081	Length:	786	Species:	Drosophila melanogaster

Alignment Length:	815	Identity:	298/815 - (36%)
Similarity:	452/815 - (55%)	Gaps:	71/815 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 FLAPDGSGGVGIQRGNPAQGNPGM-VTGTGSHSDWLLKESQQRRRLL-----VLAIAFTVLGAAI 127
            |...|.|...|||. |.|.|:.|| :....:.:.|..:...:..:.|     |:||....|
  Fly     9 FTEDDSSSIGGIQL-NEATGHTGMQIRYHTARATWNWRSRNKTEKWLLITTFVMAITIFTL---- 68

  Fly   128 GALAIYF---ASVHQRCHLYRLEPDNDDRPNGRWNQDSGSAHEGQDNICMTQECVRTAASLLSAM 189
              |.:.|   .|.....|:..::|...|.|:            |.:..|:.:.|:..::.:|.::
  Fly    69 --LIVLFTDGGSSDATKHVLHVQPHQKDCPS------------GNELPCLNKHCIFASSEILKSI 119

  Fly   190 DLNSDPCEDFFQYACGTWNKMHPIPEDRSSISTFEVLSDQQQVILRAVLEEPIDERDNKATIKAK 254
            |:..|||:||:.|:|..|.|.:||||.:|:..||..|....|:|:|.|||:|.....:.|..|||
  Fly   120 DVTVDPCDDFYGYSCNQWIKNNPIPEGKSTWGTFGKLEQMNQLIIRNVLEKPAKSFKSDAERKAK 184

  Fly   255 TFFKSCMDIPQ-IRKIGTGRLKQVLQSLGGWPVIE-----RNWSPPADLSVERLMGQLRLNYSEP 313
            .:::||:|..: :.|:|...:..:|..:|||.|.:     .||:....|.:      |...|:..
  Fly   185 VYYESCLDADEHMEKLGAKPMNDLLLQIGGWNVTKSGYNVANWTMGHTLKI------LHNKYNFN 243

  Fly   314 VMIELYVGADDKNSSVNILQMDQLQYALPSRDYYLKESSANDRRA---YHRYMTQVALLLGADPA 375
            .:....:|.||||||.:::|:||....||:.||| ...:.|.|:.   |..|||:|.:||||:.:
  Fly   244 CLFGWAIGEDDKNSSRHVIQIDQGGLTLPTADYY-NNKTDNHRKVLNEYIEYMTKVCVLLGANES 307

  Fly   376 TAAAELEKVVLFETQLVNVSLPEADRHDTSLVYRKMLLPELQELVPEVQWQEYLQAALG-PGIPL 439
            .|.|::..|:.||.:|.|:::|..||.:...:|..|.|.:|.:|.|.:.|.::...|:. .|..:
  Fly   308 DARAQMIGVINFEKKLANITIPLEDRRNEEAMYHPMQLRQLSKLAPFLNWTDHFDNAMQMVGRRV 372

  Fly   440 QEDEPLVTYGLHYL------------TEMGKILAHTDRRVVHNYMLWRLVMSLMSHMIDEYQRER 492
            .:||.:|.|...:|            ||.|||       .::||::|:.|.:|.|.:...::...
  Fly   373 TDDEVVVVYAPDFLKNLSDIILKMEQTEEGKI-------TLNNYLVWQAVRTLTSCLSKPFRDAY 430

  Fly   493 VEFRKILMGIQSERTRWSQCVEWTNKKLGVAVGALFIRDNFNQESKEVALEMIHTIRAAFNELLA 557
            ...||.|||.......|..||..||..:|.||||:|:|..|:.|||..|.:||..||.||...|.
  Fly   431 KGVRKALMGSDGGEEIWRYCVSDTNNVVGFAVGAIFVRQAFHGESKPAAEQMIAEIREAFKMNLQ 495

  Fly   558 ENDWMDDETRAVAKEKADSMNERIGYPELLTNATELEQEYVNLTIVPDNFINNVLSILQWESEKM 622
            ...|:|.:||..|.|||:.:::.||:|:.:.:..||:::|..|.|.|:.:..|.:.:..:..:..
  Fly   496 NLTWVDKQTREKAIEKANQISDMIGFPDYILDPVELDKKYAELNITPNAYFENNIQVAIYNLKSN 560

  Fly   623 LRLLRQPVDKEKWTTEPAVVNAFYNPNKNDIVFPAGILQPLFYSQHFPKSLNYGGIGVVIGHEIT 687
            |:.|.|||:|..|...|..|||:|.|.||.|||||||||..|:..:.|||||:|.:|||:|||:|
  Fly   561 LKRLDQPVNKTNWGMTPQTVNAYYTPTKNQIVFPAGILQTPFFDINNPKSLNFGAMGVVMGHELT 625

  Fly   688 HGFDDKGRQFDKEGNMMQWWNNATIEAFRERTQCVIDQYSRYKINEVDMFMDGRMTQGENIADNG 752
            |.|||:||::||.||:.:||::.:||.|.|:::|:..|||.||:|  ...::|:.|.||||||||
  Fly   626 HAFDDQGREYDKFGNINRWWDSKSIERFNEKSECIARQYSGYKMN--GRTLNGKQTLGENIADNG 688

  Fly   753 GLKQAFRAYKKWETLHGRE---QQLPGLNMTHDQLFFLNYAQIWCGSMRPEDALTKIRSAVHSPG 814
            |||.|:.||::  |...|:   .:|||||:||.||||:::||:||.|...|..|.::....|||.
  Fly   689 GLKAAYHAYQR--TKSDRDVDILKLPGLNLTHSQLFFVSFAQVWCSSTTDETNLLQMEKDPHSPS 751

  Fly   815 FVRVLGPLSNSRDFASAYKCPLGSTMNPAEKCSVW 849
            ..||:|.|||.::||..::|..|..|||.|||.||
  Fly   752 QFRVIGTLSNMKEFAEVFQCKPGKRMNPTEKCEVW 786

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep1	NP_001284925.1	M13	194..847	CDD:189000	266/677 (39%)
Nep3	NP_001245775.1	M13	123..784	CDD:189000	266/678 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454967
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG61902
OrthoDB	1	1.010	-	-		D17125at7147
OrthoFinder	1	1.000	-	-		FOG0000538
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100162
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	8	7.760