DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep1 and goe

DIOPT Version :9

Sequence 1:	NP_001284925.1	Gene:	Nep1 / 31547	FlyBaseID:	FBgn0029843	Length:	849	Species:	Drosophila melanogaster
Sequence 2:	NP_001285350.1	Gene:	goe / 32660	FlyBaseID:	FBgn0027528	Length:	879	Species:	Drosophila melanogaster

Alignment Length:	898	Identity:	173/898 - (19%)
Similarity:	334/898 - (37%)	Gaps:	203/898 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 LEELSATVVSPLLGQQQVQH--QAPHQMQQQQQQQQQNKLPTVVFLAPDGSGGVGIQRGNPAQGN 89
            |:::..:..:||...||..|  ...|...:..:..:|:.|..|   |..|:||          ..
  Fly    38 LQQIEGSETAPLTTNQQKLHMDDGSHLTPKDLEAARQDALNEV---AAGGAGG----------RT 89

  Fly    90 PGMVTGTGSHS----------------DWLLKESQQRRRLLVLAIAFTVLGAAIGALAIYFASVH 138
            |..:|...:|.                |.|:..|::||   :|.:....|.|.:..:.|...:..
  Fly    90 PAAITPNSTHPSANGLRALLLPGRRSFDALMSLSRKRR---ILYVTTACLCALLLLIIILLLAFW 151

  Fly   139 QRCHLYRLEPDNDDRPNGRWNQDSGSAHEGQDNICMTQECVRTAASLLSAMDLNSDPCEDFFQYA 203
            .....|...|                       :|:.:|||.::..||...:.:..||.:.:::|
  Fly   152 PEVPFYLRAP-----------------------LCLDKECVESSRQLLLWANTSKSPCHETYEWA 193

  Fly   204 CGT-----------------WNKMHPIPEDRSSISTFEVLSDQQQV--ILRAVLEEPIDERDNKA 249
            ||.                 ||              :|..::.|::  :.|.:...| :.::...
  Fly   194 CGNFASDYANHEYFVIKRGEWN--------------YETYNEYQELNELNRFIAMLP-NSQEGSV 243

  Fly   250 TIKAKTFFKSCMDIPQIRKIGTG-RLKQVLQSLGGWPVIE-----RNWSPPADLSVERLMGQLRL 308
            .....:.::||.:...:.|..:. .||:.:.::.||....     ::|      ..:|::..|:.
  Fly   244 ESTVSSLYRSCRETDVLDKSQSDLLLKRAINAVYGWQAFRDSNRLQSW------EYKRVLVVLQA 302

  Fly   309 NYSEPVMIELYVGADDKNSSVN----ILQMDQLQYALPSRDYYLKESSANDRRAYHRYMTQVALL 369
            .:.    |..|.....:|...|    ::.:|:.:..||.:.:|..::.....|.|...:...|:.
  Fly   303 KHG----IFPYYRVTVENGFSNPHDYVITLDEGELGLPDKYFYGNDADEEVVRGYKLLLRDFAIN 363

  Fly   370 LGADPATAAAELEKVVLFETQLVNVSLPEADRHDTSLVYRKMLLPELQELVPEVQWQEYLQAALG 434
            :|.....|....:.:..:|.::|| .:.:|.......:.:.|.|.:|:...|.:...|.|| |:.
  Fly   364 MGIVSREADLFADDIFHYERRIVN-HIEDAKADANRPINKLMRLADLKIKAPSLPILESLQ-AIF 426

  Fly   435 PGIPLQEDEPLVTYGLHYLTEMGKILAHTDRRVVHNYMLWRLVMSLMSHMIDEYQRERVEFRKIL 499
            |...:.||..::......:..:..:|:.:|::.::|:::|.|...::.|:..||:.....|...|
  Fly   427 PKTKITEDTEVLVRDPEVMHALSVLLSTSDKKPINNFIVWSLARKMLPHLSKEYRTLAETFDHAL 491

  Fly   500 MGIQSERTRWSQCVEWTNKKLGVAVGALFIRD---------------NFNQESKEVALEMIHTIR 549
            .|..:...||..|.:.....|..||.||..:.               |..|.::|:...|..::|
  Fly   492 YGRTASYPRWLICSKVVRDWLPFAVDALQQQPPRQQFETMTSKSRGLNKTQGNEELLKLMFFSLR 556

  Fly   550 AAFNELLAENDWMDDETRAVAKEKADSMNERIGYP-ELLTNATELEQEYVNLTIVPDNFINNVLS 613
            ....:.|.:..|::...|...::|.:.|..:.|.| |:|...|.|.|.|..|      .:|||..
  Fly   557 NQLKDSLEQAKWLEPAARQFIQKKLNEMRLQFGIPDEVLQQPTYLAQYYNEL------ILNNVFF 615

  Fly   614 I--LQW-------ESEKMLRLLR--QPVDKEKWTTEPAVVNAFYNPNKNDIVFPAGILQPLFYSQ 667
            :  |:|       :.||.|..|.  ..:..|.:|.:.....|:.| ..|.::....::...:|..
  Fly   616 VEHLEWIWTFRRSQMEKKLGPLAILDVIVSEMYTRDNPQAIAYSN-KLNMLLVSKVLISSNYYDY 679

  Fly   668 HFPKSLNYGGIGVVIGHEITHGFDDKGRQFDKEG------------------------------N 702
            .:|.::|:..||..|...:...|.....||:.:.                              .
  Fly   680 RYPVAVNFARIGTDILEALIDNFSTFLLQFNTQSTDISDAAPEIRYAQPDVNCLAAGQPPRLVHE 744

  Fly   703 MMQWWNNA------TIEAFRERTQCVIDQYSRYKINEVDMFMDGRMTQGENIADNGGLKQAFRAY 761
            :.:..:||      |:.|.|...:.:    |.: :|.:|.   |...||      .|:.||
  Fly   745 LNELSSNALKSFHVTLSAARTAARAL----SNF-VNAIDA---GSAIQG------SGIDQA---- 791

  Fly   762 KKWETLH-GREQQLPGL-NMTHDQLFFLNYAQIWCGSMRPEDALTKIRSAVHS 812
            ..:|.|. .|..::||| :...::||.|:|.|..|.:...:....:|:..|.|
  Fly   792 NTYEALGLTRRLRIPGLRSFNENELFTLSYMQQHCSTTIADKDYARIKPLVES 844

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep1	NP_001284925.1	M13	194..847	CDD:189000	139/713 (19%)
goe	NP_001285350.1	GluZincin	184..>694	CDD:301352	106/543 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469691
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000538
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.840